SAM SUNGHYUN YOON

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Adult primary retroperitoneal teratoma
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston 02114, USA
    Surgery 137:663-4. 2005
  2. pmc Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α
    Yeo Jung Kim
    Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Int J Cancer 132:29-41. 2013
  3. doi Surgical placement of biologic mesh spacers prior to external beam radiation for retroperitoneal and pelvic tumors
    Sam S Yoon
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts Electronic address
    Pract Radiat Oncol 3:199-208. 2013
  4. pmc Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas
    Sam S Yoon
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 81:1081-90. 2011
  5. ncbi Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Yawkey 7B 7926, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Ann Surg Oncol 13:353-62. 2006
  6. pmc Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 74:1207-16. 2009
  7. doi Lymphadenectomy for gastric adenocarcinoma: should west meet east?
    Sam S Yoon
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Oncologist 14:871-82. 2009
  8. pmc Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study
    Andrew X Zhu
    Division of Hematology Oncology, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 27:3027-35. 2009
  9. pmc Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas
    Sam S Yoon
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 17:1515-29. 2010
  10. ncbi Radiation therapy for control of soft-tissue sarcomas resected with positive margins
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 67:1460-9. 2007

Research Grants

Collaborators

Detail Information

Publications26

  1. ncbi Adult primary retroperitoneal teratoma
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston 02114, USA
    Surgery 137:663-4. 2005
  2. pmc Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1α
    Yeo Jung Kim
    Department of Cancer Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Int J Cancer 132:29-41. 2013
    ..HIF-1α inhibition blocks this evasive resistance and augments destruction of the tumor vasculature...
  3. doi Surgical placement of biologic mesh spacers prior to external beam radiation for retroperitoneal and pelvic tumors
    Sam S Yoon
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts Electronic address
    Pract Radiat Oncol 3:199-208. 2013
    ..To determine the feasibility of surgical placement of biologic mesh spacers to displace bowel and other radiation-sensitive organs prior to external beam radiation for difficult retroperitoneal and pelvic tumors...
  4. pmc Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomas
    Sam S Yoon
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 81:1081-90. 2011
    ..We sought to examine the safety and efficacy of bevacizumab (BV) and RT in soft tissue sarcomas and explore biomarkers to help determine the treatment response...
  5. ncbi Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastases
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Yawkey 7B 7926, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Ann Surg Oncol 13:353-62. 2006
    ..Circulating angiogenic factors in patients with colorectal cancer liver metastases may promote tumor growth and contribute to liver regeneration after partial hepatectomy...
  6. pmc Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma
    Sam S Yoon
    Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 74:1207-16. 2009
    ..The present study examined SU and radiotherapy (RT) in a genetically engineered mouse model of soft tissue sarcoma (STS)...
  7. doi Lymphadenectomy for gastric adenocarcinoma: should west meet east?
    Sam S Yoon
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Oncologist 14:871-82. 2009
    ..This article provides an update on the current literature regarding the extent of lymphadenectomy for gastric adenocarcinoma...
  8. pmc Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II study
    Andrew X Zhu
    Division of Hematology Oncology, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 27:3027-35. 2009
    ..To assess the safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma (HCC) and explore biomarkers for sunitinib response...
  9. pmc Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomas
    Sam S Yoon
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 17:1515-29. 2010
    ..We sought to reduce local recurrence for retroperitoneal sarcomas by using a coordinated strategy of advanced radiation techniques and aggressive en-bloc surgical resection...
  10. ncbi Radiation therapy for control of soft-tissue sarcomas resected with positive margins
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 67:1460-9. 2007
    ..Positive margins (PM) remain after surgery in some soft-tissue sarcoma (STS) patients. We investigated the efficacy of radiation therapy (RT) in STS patients with PM...
  11. pmc Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomas
    Thomas F DeLaney
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 74:732-9. 2009
    ..Negative surgical margins are uncommon; hence, doses of >or=66 Gy are recommended. A Phase II clinical trial evaluated high-dose photon/proton XRT for spine sarcomas...
  12. ncbi Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factors
    Namali T Fernando
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Clin Cancer Res 14:1529-39. 2008
    ..Thrombospondin-1 (Tsp1), endostatin, and tumstatin are extracellular matrix-associated proteins that inhibit angiogenesis. We examined the mechanisms by which tumor cells may bypass the antiangiogenic effects of these endogenous regulators...
  13. pmc New metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinoma
    Ugwuji N Maduekwe
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Ann Surg Oncol 17:1267-77. 2010
    ..The ratio of metastatic to examined nodes (N ratio) is an effective prognostic tool, but has not been examined in Western patients undergoing primarily D1 lymphadenectomy...
  14. ncbi Chemotherapy is an effective first line treatment for early stage gastric mucosa-associated lymphoid tissue lymphoma
    Sam S Yoon
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Yawkey 7B 7926, 55 Fruit Street, Boston, MA 02113, USA
    Cancer Treat Rev 32:139-43. 2006
  15. ncbi An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local control
    Bokyong Kim
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 77:843-50. 2010
    ..We retrospectively analyzed the pattern of local failure (LF) to help elucidate optimal field design...
  16. pmc Differential effects of VEGFR-1 and VEGFR-2 inhibition on tumor metastases based on host organ environment
    Yoon Jin Lee
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 70:8357-67. 2010
    ..Thus, therapies inhibiting specific VEGFRs should consider the targeted sites of metastatic disease...
  17. ncbi Case records of the Massachusetts General Hospital. Case 22-2007. A woman with a family history of gastric and breast cancer
    Daniel C Chung
    Gastroenterology Unit, Massachusetts General Hospital, USA
    N Engl J Med 357:283-91. 2007
  18. pmc The diminishing role of surgery in the treatment of gastric lymphoma
    Sam S Yoon
    Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
    Ann Surg 240:28-37. 2004
    ..This article reviews the pathogenesis, diagnosis, and treatment of patients with primary gastric lymphoma, with special attention to the changing role of surgery...
  19. ncbi Resection of recurrent ovarian or fallopian tube carcinoma involving the liver
    Sam S Yoon
    Hepatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gynecol Oncol 91:383-8. 2003
    ..Patients who develop recurrent ovarian of fallopian tube carcinoma involving the liver often have disease refractory to chemotherapy and carry a poor prognosis. The impact of aggressive resection in this patient population is unclear...
  20. ncbi Diagnosis, management, and outcomes of 115 patients with hepatic hemangioma
    Sam S Yoon
    Hepatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Am Coll Surg 197:392-402. 2003
    ....
  21. pmc Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1
    Yoon Jin Lee
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Cancer Res 70:948-56. 2010
    ..Collectively, our results indicate that the antiangiogenic activity of TSP1 is differentially regulated by ADAMTS1 in the liver and lung, emphasizing the concept that regulation of angiogenesis is varied in different tissue environments...
  22. pmc Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1
    Kwan Hyuck Baek
    Vascular Biology Program, Department of Surgery, Children s Hospital Boston, Massachusetts 02115, USA
    Nature 459:1126-30. 2009
    ....
  23. doi Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomas
    Ugwuji N Maduekwe
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
    Ann Surg Oncol 16:1356-63. 2009
    ..The utility of sentinel lymph node biopsy (SLNB) for patients with these sarcoma subtypes is unknown...
  24. doi Leiomyoma and leiomyosarcoma arising from the round ligament of the uterus
    John C Kirkham
    Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
    J Am Coll Surg 207:452. 2008
  25. ncbi Angiogenic profile of soft tissue sarcomas based on analysis of circulating factors and microarray gene expression
    Sam S Yoon
    Department of Surgery, Massachusetts General Hospital, Division of Surgical Oncology, Harvard Medical School, Boston, Massachusetts, USA
    J Surg Res 135:282-90. 2006
    ..The aim of this study was to develop profiles of angiogenesis-related gene and protein expression for various histologic subtypes of soft tissue sarcomas (STS) growing in different sites...
  26. ncbi Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene
    Timothy M Pawlik
    Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114 2696, USA
    Cancer 95:1171-81. 2002
    ..rRp450 is a novel replication-conditional HSV-1 mutant that expresses both the endogenous herpes viral thymidine kinase gene and the rat p450 CYP2B1 transgene; p450 bioactivates such cancer prodrugs as cyclophosphamide...

Research Grants2

  1. Bevacizumab and radiation therapy for sarcomas
    Sam Yoon; Fiscal Year: 2006
    ..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. ..
  2. Bevacizumab and radiation therapy for sarcomas
    Sam Yoon; Fiscal Year: 2007
    ..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. ..