Research Topics
| SAM SUNGHYUN YOONSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
Adult primary retroperitoneal teratomaSam S Yoon
Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Boston 02114, USA
Surgery 137:663-4. 2005- Phase II study of neoadjuvant bevacizumab and radiotherapy for resectable soft tissue sarcomasSam S Yoon
Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 81:1081-90. 2011..We sought to examine the safety and efficacy of bevacizumab (BV) and RT in soft tissue sarcomas and explore biomarkers to help determine the treatment response... - Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcomaSam S Yoon
Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 74:1207-16. 2009..The present study examined SU and radiotherapy (RT) in a genetically engineered mouse model of soft tissue sarcoma (STS)... - Lymphadenectomy for gastric adenocarcinoma: should west meet east?Sam S Yoon
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Oncologist 14:871-82. 2009..This article provides an update on the current literature regarding the extent of lymphadenectomy for gastric adenocarcinoma... - Profile of plasma angiogenic factors before and after hepatectomy for colorectal cancer liver metastasesSam S Yoon
Department of Surgery, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, Yawkey 7B 7926, 55 Fruit Street, Boston, Massachusetts 02114, USA
Ann Surg Oncol 13:353-62. 2006..Circulating angiogenic factors in patients with colorectal cancer liver metastases may promote tumor growth and contribute to liver regeneration after partial hepatectomy... - Phase II study of high-dose photon/proton radiotherapy in the management of spine sarcomasThomas F DeLaney
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 74:732-9. 2009..Negative surgical margins are uncommon; hence, doses of >or=66 Gy are recommended. A Phase II clinical trial evaluated high-dose photon/proton XRT for spine sarcomas... - Radiation therapy for control of soft-tissue sarcomas resected with positive marginsThomas F DeLaney
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 67:1460-9. 2007..Positive margins (PM) remain after surgery in some soft-tissue sarcoma (STS) patients. We investigated the efficacy of radiation therapy (RT) in STS patients with PM... - Efficacy, safety, and potential biomarkers of sunitinib monotherapy in advanced hepatocellular carcinoma: a phase II studyAndrew X Zhu
Division of Hematology Oncology, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Oncol 27:3027-35. 2009..To assess the safety and efficacy of sunitinib in patients with advanced hepatocellular carcinoma (HCC) and explore biomarkers for sunitinib response... - Proton-beam, intensity-modulated, and/or intraoperative electron radiation therapy combined with aggressive anterior surgical resection for retroperitoneal sarcomasSam S Yoon
Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
Ann Surg Oncol 17:1515-29. 2010..We sought to reduce local recurrence for retroperitoneal sarcomas by using a coordinated strategy of advanced radiation techniques and aggressive en-bloc surgical resection... - New metastatic lymph node ratio system reduces stage migration in patients undergoing D1 lymphadenectomy for gastric adenocarcinomaUgwuji N Maduekwe
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Ann Surg Oncol 17:1267-77. 2010..The ratio of metastatic to examined nodes (N ratio) is an effective prognostic tool, but has not been examined in Western patients undergoing primarily D1 lymphadenectomy... - Tumor escape from endogenous, extracellular matrix-associated angiogenesis inhibitors by up-regulation of multiple proangiogenic factorsNamali T Fernando
Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Clin Cancer Res 14:1529-39. 2008..Thrombospondin-1 (Tsp1), endostatin, and tumstatin are extracellular matrix-associated proteins that inhibit angiogenesis. We examined the mechanisms by which tumor cells may bypass the antiangiogenic effects of these endogenous regulators... - An effective preoperative three-dimensional radiotherapy target volume for extremity soft tissue sarcoma and the effect of margin width on local controlBokyong Kim
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 77:843-50. 2010..We retrospectively analyzed the pattern of local failure (LF) to help elucidate optimal field design... - Chemotherapy is an effective first line treatment for early stage gastric mucosa-associated lymphoid tissue lymphomaSam S Yoon
Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Yawkey 7B-7926, 55 Fruit Street, Boston, MA 02113, USA
Cancer Treat Rev 32:139-43. 2006 - Diagnosis, management, and outcomes of 115 patients with hepatic hemangiomaSam S Yoon
Hepatobiliary Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA
J Am Coll Surg 197:392-402. 2003..In asymptomatic or minimally symptomatic patients, hepatic hemangiomas usually have a benign course and can be observed... - Differential effects of VEGFR-1 and VEGFR-2 inhibition on tumor metastases based on host organ environmentYoon Jin Lee
Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 70:8357-67. 2010..Thus, therapies inhibiting specific VEGFRs should consider the targeted sites of metastatic disease... - Resection of recurrent ovarian or fallopian tube carcinoma involving the liverSam S Yoon
Hepatobiliary Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Gynecol Oncol 91:383-8. 2003.... - Case records of the Massachusetts General Hospital. Case 22-2007. A woman with a family history of gastric and breast cancerDaniel C Chung
Gastroenterology Unit, Massachusetts General Hospital, USA
N Engl J Med 357:283-91. 2007 - The diminishing role of surgery in the treatment of gastric lymphomaSam S Yoon
Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA
Ann Surg 240:28-37. 2004..CONCLUSION: The treatment of gastric lymphoma continues to evolve, and surgical resection is now uncommonly a part of the initial management strategy... - Role of sentinel lymph node biopsy in the staging of synovial, epithelioid, and clear cell sarcomasUgwuji N Maduekwe
Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA
Ann Surg Oncol 16:1356-63. 2009..The utility of sentinel lymph node biopsy (SLNB) for patients with these sarcoma subtypes is unknown... - Variable inhibition of thrombospondin 1 against liver and lung metastases through differential activation of metalloproteinase ADAMTS1Yoon Jin Lee
Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Cancer Res 70:948-56. 2010..Collectively, our results indicate that the antiangiogenic activity of TSP1 is differentially regulated by ADAMTS1 in the liver and lung, emphasizing the concept that regulation of angiogenesis is varied in different tissue environments... - Angiogenic profile of soft tissue sarcomas based on analysis of circulating factors and microarray gene expressionSam S Yoon
Department of Surgery, Massachusetts General Hospital, Division of Surgical Oncology, Harvard Medical School, Boston, Massachusetts, USA
J Surg Res 135:282-90. 2006..Comparison of STS to normal tissues reveals a panel of upregulated genes that may be targets for future therapies... - Leiomyoma and leiomyosarcoma arising from the round ligament of the uterusJohn C Kirkham
Massachusetts General Hospital, and Harvard Medical School, Boston, MA, USA
J Am Coll Surg 207:452. 2008 - Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1Kwan Hyuck Baek
Vascular Biology Program, Department of Surgery, Children s Hospital Boston, Massachusetts 02115, USA
Nature 459:1126-30. 2009.... - Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgeneTimothy M Pawlik
Division of Surgical Oncology, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston 02114-2696, USA
Cancer 95:1171-81. 2002..Oncolysis induced by HSV-1 replication combined with cyclophosphamide prodrug activation warrants further investigation as a potential therapy for colon carcinoma liver metastases...
Research Grants
- Bevacizumab and radiation therapy for sarcomasSam Yoon; Fiscal Year: 2007..This study explores a novel combination of the anti-angiogenic agent bevacizumab and radiation therapy for the treatment of STS. ..