Torunn I Yock

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Risk of second cancers after photon and proton radiotherapy: a review of the data
    Torunn I Yock
    Massachusetts General Hospital, Department of Radiation Oncology, 100 Blossom Street, COX LL, Boston, MA 02114 2617, USA
    Health Phys 103:577-85. 2012
  2. ncbi request reprint The effect of delaying radiation therapy for systemic chemotherapy on local-regional control in breast cancer
    Torunn I Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Breast Cancer Res Treat 84:161-71. 2004
  3. ncbi request reprint Local control in pelvic Ewing sarcoma: analysis from INT-0091--a report from the Children's Oncology Group
    Torunn I Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 24:3838-43. 2006
  4. ncbi request reprint Proton radiotherapy for orbital rhabdomyosarcoma: clinical outcome and a dosimetric comparison with photons
    Torunn Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 63:1161-8. 2005
  5. ncbi request reprint Technology insight: Proton beam radiotherapy for treatment in pediatric brain tumors
    Torunn I Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Oncol 1:97-103; quiz 1 p following 111. 2004
  6. ncbi request reprint Natural history and role of radiation in patients with supratentorial and infratentorial WHO grade II ependymomas: results from a population-based study
    Ayal A Aizer
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Massachusetts General Hospital, 55 Fruit Street, Lunder LL3, Boston, MA, 02114, USA
    J Neurooncol 115:411-9. 2013
  7. doi request reprint Proton radiation therapy for pediatric medulloblastoma and supratentorial primitive neuroectodermal tumors: outcomes for very young children treated with upfront chemotherapy
    Rachel B Jimenez
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 87:120-6. 2013
  8. doi request reprint Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses
    Roshan V Sethi
    Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts
    Int J Radiat Oncol Biol Phys 88:655-63. 2014
  9. doi request reprint Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma: clinical outcomes and dosimetry compared to intensity-modulated radiation therapy
    Shane E Cotter
    Harvard Radiation Oncology Program, Boston, Massachusetts 02114, USA
    Int J Radiat Oncol Biol Phys 81:1367-73. 2011
  10. pmc Proton radiotherapy for parameningeal rhabdomyosarcoma: clinical outcomes and late effects
    Stephanie K Childs
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 82:635-42. 2012

Detail Information

Publications38

  1. doi request reprint Risk of second cancers after photon and proton radiotherapy: a review of the data
    Torunn I Yock
    Massachusetts General Hospital, Department of Radiation Oncology, 100 Blossom Street, COX LL, Boston, MA 02114 2617, USA
    Health Phys 103:577-85. 2012
    ..The most serious and life threatening side effect of radiotherapy that affects both children and adults is radiation-induced second primary cancers...
  2. ncbi request reprint The effect of delaying radiation therapy for systemic chemotherapy on local-regional control in breast cancer
    Torunn I Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Breast Cancer Res Treat 84:161-71. 2004
    ..It remains controversial as to whether the administration of chemotherapy prior to radiation following the surgical treatment for localized breast cancer compromises local control...
  3. ncbi request reprint Local control in pelvic Ewing sarcoma: analysis from INT-0091--a report from the Children's Oncology Group
    Torunn I Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 24:3838-43. 2006
    ..We investigated the relationship between the type of local control modality, surgery, radiation (RT) or both (S + RT), and subsequent risk for local failure (LF) in patients with nonmetastatic pelvic Ewing sarcoma treated on INT-0091...
  4. ncbi request reprint Proton radiotherapy for orbital rhabdomyosarcoma: clinical outcome and a dosimetric comparison with photons
    Torunn Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 63:1161-8. 2005
    ..However, the late effects of photon radiation compromise function and cosmetic outcome. Proton radiation can provide excellent tumor dose distributions while sparing normal tissues better than photon irradiation...
  5. ncbi request reprint Technology insight: Proton beam radiotherapy for treatment in pediatric brain tumors
    Torunn I Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Oncol 1:97-103; quiz 1 p following 111. 2004
    ..This review discusses the characteristics of proton radiation, and describes examples of pediatric brain tumor patients who would benefit most from this form of treatment...
  6. ncbi request reprint Natural history and role of radiation in patients with supratentorial and infratentorial WHO grade II ependymomas: results from a population-based study
    Ayal A Aizer
    Harvard Radiation Oncology Program, Department of Radiation Oncology, Massachusetts General Hospital, 55 Fruit Street, Lunder LL3, Boston, MA, 02114, USA
    J Neurooncol 115:411-9. 2013
    ..Observation, with radiation reserved as a salvage option, may be a reasonable postoperative strategy in this population...
  7. doi request reprint Proton radiation therapy for pediatric medulloblastoma and supratentorial primitive neuroectodermal tumors: outcomes for very young children treated with upfront chemotherapy
    Rachel B Jimenez
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 87:120-6. 2013
    ..To report the early outcomes for very young children with medulloblastoma or supratentorial primitive neuroectodermal tumor (SPNET) treated with upfront chemotherapy followed by 3-dimensional proton radiation therapy (3D-CPT)...
  8. doi request reprint Patterns of failure after proton therapy in medulloblastoma; linear energy transfer distributions and relative biological effectiveness associations for relapses
    Roshan V Sethi
    Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts
    Int J Radiat Oncol Biol Phys 88:655-63. 2014
    ..Here we report the patterns of failure after the use of protons, compare it to that in the available photon literature, and determine the LET and RBE values in areas of recurrence...
  9. doi request reprint Proton radiotherapy for pediatric bladder/prostate rhabdomyosarcoma: clinical outcomes and dosimetry compared to intensity-modulated radiation therapy
    Shane E Cotter
    Harvard Radiation Oncology Program, Boston, Massachusetts 02114, USA
    Int J Radiat Oncol Biol Phys 81:1367-73. 2011
    ....
  10. pmc Proton radiotherapy for parameningeal rhabdomyosarcoma: clinical outcomes and late effects
    Stephanie K Childs
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 82:635-42. 2012
    ..To report the clinical outcome and late side effect profile of proton radiotherapy in the treatment of children with parameningeal rhabdomyosarcoma (PM-RMS)...
  11. pmc Proton radiotherapy for pediatric central nervous system ependymoma: clinical outcomes for 70 patients
    Shannon M Macdonald
    This paper was presented at the International Symposium on Pediatric Neuro Oncology on June 24, 2012, in Toronto, Canada Corresponding Author Shannon MacDonald, MD, Massachusetts General Hospital, Department of Radiation Oncology, Yawkey 112, 30 Fruit Street, Boston, MA 02114
    Neuro Oncol 15:1552-9. 2013
    ..Proton radiotherapy (PRT) spares healthy tissues outside the target region, but reports of clinical outcomes are scarce. We report outcomes for 70 patients treated with PRT for intracranial ependymoma...
  12. doi request reprint Early clinical outcomes using proton radiation for children with central nervous system atypical teratoid rhabdoid tumors
    Karen De Amorim Bernstein
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Radiat Oncol Biol Phys 86:114-20. 2013
    ..Irradiation improves survival but has traditionally been avoided in patients under the age of 3 due to the increasing risk of neurocognitive side effects. We report the first cohort of AT/RT patients treated with proton therapy...
  13. doi request reprint Delayed diagnosis in children with intracranial germ cell tumors
    Roshan V Sethi
    Harvard Medical School, Massachusetts General Hospital, Boston, MA
    J Pediatr 163:1448-53. 2013
    ..To review symptoms and provider history in a large cohort of patients with germ cell tumors (GCTs) to highlight the variety of manifestations and assess the effect of delayed diagnosis on outcomes...
  14. pmc Prospective study of health-related quality of life for children with brain tumors treated with proton radiotherapy
    Karen A Kuhlthau
    Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 30:2079-86. 2012
    ..We describe the health-related quality of life (HRQoL) of a cohort of children with brain tumors treated with proton radiotherapy...
  15. doi request reprint Proton radiotherapy for high-risk pediatric neuroblastoma: early outcomes and dose comparison
    Jona A Hattangadi
    Harvard Radiation Oncology Program, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 83:1015-22. 2012
    ....
  16. doi request reprint Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 79:121-9. 2011
    ....
  17. doi request reprint A dosimetric comparison of proton and intensity-modulated photon radiotherapy for pediatric parameningeal rhabdomyosarcomas
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 74:179-86. 2009
    ..We compared tumor and normal tissue dosimetry of proton radiation therapy with intensity-modulated radiation therapy (IMRT) for pediatric parameningeal rhabdomyosarcomas (PRMS)...
  18. pmc Bifocal intracranial tumors of nongerminomatous germ cell etiology: diagnostic and therapeutic implications
    Ayal A Aizer
    Harvard Radiation Oncology Program, Boston, Massachusetts, USA
    Neuro Oncol 15:955-60. 2013
    ..We sought to characterize the association between bifocal intracranial tumors and NGGCT histology...
  19. pmc Second nonocular tumors among survivors of retinoblastoma treated with contemporary photon and proton radiotherapy
    Roshan V Sethi
    Harvard Medical School, Boston, Massachusetts
    Cancer 120:126-33. 2014
    ..Proton RT allows for significant sparing of nontarget tissue. The current study compared the risk of second malignancy in patients with retinoblastoma who were treated with photon and proton RT...
  20. doi request reprint Breast cancer after treatment of Hodgkin's lymphoma: risk factors that really matter
    Mohamed A Alm El-Din
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 73:69-74. 2009
    ..To evaluate the risk of breast cancer (BC) and the contributing risk factors in women after supradiaphragmatic irradiation (SDI) for Hodgkin's lymphoma (HL)...
  21. doi request reprint Surveillance of craniopharyngioma cyst growth in children treated with proton radiotherapy
    Karen M Winkfield
    Harvard Radiation Oncology Program, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 73:716-21. 2009
    ..The aim of this study was to report our experience with cyst enlargement during conformal proton RT for children with craniopharyngioma and to make recommendations regarding mid-treatment surveillance...
  22. ncbi request reprint Proton radiotherapy for solid tumors of childhood
    Shane E Cotter
    Department of Radiation Oncology, Brigham and Women s Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA
    Technol Cancer Res Treat 11:267-78. 2012
    ..Furthermore, clinical data are now emerging that begin to quantify the benefit in decreased late treatment effects while maintaining excellent cancer control rates...
  23. pmc Proton-based radiotherapy for unresectable or incompletely resected osteosarcoma
    I Frank Ciernik
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Cancer 117:4522-30. 2011
    ..A study was undertaken to assess clinical outcome and the role of proton therapy for local control of osteosarcoma (OSA)...
  24. doi request reprint Incidence of second malignancies among patients treated with proton versus photon radiation
    Christine S Chung
    Department of Radiation Oncology, Alta Bates Summit Medical Center, Berkeley, California, USA
    Int J Radiat Oncol Biol Phys 87:46-52. 2013
    ..The objective of this study was to compare the incidence of second cancers in patients treated with proton radiation with a population-based cohort of matched patients treated with photon radiation...
  25. pmc Physiologic and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation
    Stephanie C Krejcarek
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 68:646-9. 2007
    ..We evaluated the radiographic appearance of the vertebral bodies in children treated with proton craniospinal irradiation (CSI) to illustrate the distal edge effect of proton radiotherapy...
  26. doi request reprint Proton beam therapy following resection for childhood ependymoma
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Cox 340, 100 Blossom Street, Boston, MA 02114, USA
    Childs Nerv Syst 26:285-91. 2010
    ..Proton radiation therapy is a form of radiation with physical properties that can provide an advantage in normal tissue sparing compared to the more commonly used photon therapy...
  27. ncbi request reprint The risk of radiation-induced second cancers in the high to medium dose region: a comparison between passive and scanned proton therapy, IMRT and VMAT for pediatric patients with brain tumors
    Maryam Moteabbed
    Massachusetts General Hospital, Boston, MA 02114, USA Harvard Medical School, Boston, MA 02115, USA
    Phys Med Biol 59:2883-99. 2014
    ..When planning treatments and deciding on the treatment modality, the probability of second cancer incidence should be carefully examined and weighed against the possibility of developing acute side effects for each patient individually. ..
  28. ncbi request reprint Radiation therapy for pediatric central nervous system tumors
    Karen E Hoffman
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
    J Child Neurol 24:1387-96. 2009
    ..The long-term clinical benefits of proton radiation in the pediatric population are just beginning to be reported in the literature...
  29. ncbi request reprint Cardiac blood biomarkers in patients receiving thoracic (chemo)radiation
    Kevin R Kozak
    Harvard Radiation Oncology Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Lung Cancer 62:351-5. 2008
    ..Thus, contemporary thoracic (chemo)radiation does not commonly result in elevations of serum TnT, CK-MB or NT-proBNP. Elevations in these markers during treatment merit further evaluation...
  30. ncbi request reprint Proton stereotactic radiotherapy for persistent adrenocorticotropin-producing adenomas
    Joshua H Petit
    Department of Radiation Oncology, Massachusetts General Hospital, 100 Blossom Street, Cox 347, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 93:393-9. 2008
    ..Until recently, proton stereotactic radiotherapy (PSR) was available at only two U.S. centers; use will increase as proton facilities are under development...
  31. ncbi request reprint Case records of the Massachusetts General Hospital. Case 20-2007. An 11-year-old boy with a calcified mass in the nose
    Michael J Cunningham
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, USA
    N Engl J Med 356:2721-30. 2007
  32. doi request reprint Assessment of radiation-induced second cancer risks in proton therapy and IMRT for organs inside the primary radiation field
    Harald Paganetti
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 57:6047-61. 2012
    ..The risk depends on treatment planning parameters, i.e. an analysis based on our formalism could be applied within treatment planning programs to guide treatment plans for pediatric patients...
  33. ncbi request reprint Role of radiation therapy in pediatric cancer
    Iris C Gibbs
    Department of Radiation Oncology, Stanford Cancer Center, School of Medicine, Stanford University, 875 Blake Wilbur Drive, Stanford, CA 94305 5847, USA
    Hematol Oncol Clin North Am 20:455-70. 2006
    ....
  34. pmc Ultrasensitive measurement of hotspot mutations in tumor DNA in blood using error-suppressed multiplexed deep sequencing
    Azeet Narayan
    Department of Therapeutic Radiology, Yale University, New Haven, Connecticut, USA
    Cancer Res 72:3492-8. 2012
    ..Our findings suggest that the deep sequencing approach described here may be applied to the development of a practical diagnostic test that measures tumor-derived DNA levels in blood...
  35. ncbi request reprint Changes in cerebral cortex of children treated for medulloblastoma
    Arthur K Liu
    Harvard Combined Radiation Oncology Program, Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 68:992-8. 2007
    ..Using high-resolution magnetic resonance imaging, we measured the thickness of the cerebral cortex in a group of medulloblastoma patients and a group of normally developing children...
  36. ncbi request reprint Long-term durability of PSA failure-free survival after radiotherapy for localized prostate cancer
    Torunn I Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 54:420-6. 2002
    ..To determine the durability of prostate-specific antigen (PSA) progression-free survival beyond 5 years in patients biochemically free of relapse 5 years after external beam radiotherapy (EBRT)...
  37. ncbi request reprint Radiation dose to the lens during craniospinal irradiation-an improvement in proton radiotherapy technique
    David M Cochran
    Division of Health Sciences and Technology, Harvard Medical School and Massachusetts Institute of Technology, Cambridge, MA, USA
    Int J Radiat Oncol Biol Phys 70:1336-42. 2008
    ..To evaluate the effect of angle modification of cranial field proton beam therapy on the radiation dose delivered to the lens during craniospinal irradiation (CSI)...
  38. ncbi request reprint Phase II study of thalidomide in patients with unresectable hepatocellular carcinoma
    Albert Y Lin
    Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA
    Cancer 103:119-25. 2005
    ..Therefore, the authors initiated a study to assess the efficacy and toxicity of thalidomide in patients with advanced HCC as primary and secondary endpoints, respectively...