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Genomes and Genes | Midori YenariSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Publications
Neuroprotective mechanisms of hypothermia in brain ischaemiaMidori A Yenari
Department of Neurology, University of California, San Francisco, California 94143 0248, USA
Nat Rev Neurosci 13:267-78. 2012..It is likely that no single factor can explain the neuroprotection provided by hypothermia, but understanding its myriad effects may shed light on important neuroprotective mechanisms...
NOX inhibitors as a therapeutic strategy for stroke and neurodegenerative diseaseBelinda Cairns
Takeda San Francisco, South San Francisco, CA 94080, USA
Curr Drug Targets 13:199-206. 2012....- Gene therapy and hypothermia for stroke treatmentMidori A Yenari
Department of Neurosurgery, Stanford University, California 94305, USA
Ann N Y Acad Sci 993:54-68; discussion 79-81. 2003.... - Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitroMidori A Yenari
Department of Neurology, University of California, San Francisco Veterans Affairs Medical Center, California 94121, USA
Stroke 37:1087-93. 2006..We determined the effect of microglia on the BBB and its primary constituents, endothelial cells (ECs) and astrocytes, after ischemia using in vivo and in vitro models... - Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB)Midori A Yenari
Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, United States
Neurochem Int 49:164-9. 2006..These data suggest that the protective effect of hypothermia on cerebral injury is, in part, related to NFkappaB inhibition due to decreased activity of IKK... 
Metabolic downregulation: a key to successful neuroprotection?Midori Yenari
Department of Neurology, University of California, San Francisco, San Francisco Veterans Affairs Medical Center, San, San Francisco, CA 94121, USA
Stroke 39:2910-7. 2008..In fact, hypothermia is already being used at many centers to improve neurological outcome from cardiac arrest...- Pathophysiology of acute ischemic strokeMidori A Yenari
Department of Neurosurgery, Stanford University, Stanford, Calif 94305-5487, USA
Cleve Clin J Med 71:S25-7. 2004 - Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protectionMidori A Yenari
Department of Neurology, University of California, San Francisco, Caifornia 94121, USA
Ann N Y Acad Sci 1053:74-83. 2005..We suggest that HSPs are capable of protecting brain cells from lethal insults through a variety of mechanisms and should be explored as a potential therapy against stroke and other neurodegenerative diseases... - Cellular and molecular events underlying ischemia-induced neuronal apoptosisZhen Zheng
Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
Drug News Perspect 16:497-503. 2003..In this review, we examine some of these findings and their potential therapeutic implications for ischemic stroke... - Therapeutic hypothermia for brain ischemia: where have we come and where do we go?Midori A Yenari
Department of Neurology, University of California, San Francisco, CA 94121, USA
Stroke 41:S72-4. 2010..We review the state of therapeutic hypothermia in ischemic and hemorrhagic stroke and provide an outlook for its role in stroke therapy... - Brain 11: what's new in stroke research?Midori A Yenari
Department of Neurology, University of California, San Francisco, San Francisco, CA 94121, USA
Expert Rev Neurother 11:1235-7. 2011..In addition, there was a focus on how the peripheral circulation contributes to such types of brain injury... - Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathwaysRachid Kacimi
Dept, Neurology, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco 94121 USA
J Inflamm (Lond) 8:7. 2011..LPS is a classic TLR4 agonist, and is used here to model aspects of brain conditions where TLR4 stimulation occurs... - Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C releaseHeng Zhao
Department of Neurosurgery, Stanford University, Stanford, CA 94305-5327, USA
Stroke 35:572-7. 2004..CONCLUSIONS: Postischemic mild hypothermia extended the time window for gene therapy neuroprotection using Bcl-2 and reduced cytochrome c release... - Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activityHeng Zhao
Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive R200, Stanford, CA 94305 5327, USA
J Neurochem 85:1026-36. 2003..This suggests a potential therapeutic strategy for stroke... - Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemiaCarla M Webster
Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
Neurobiol Dis 33:301-12. 2009..However, NFkappaB regulatory proteins were not affected by hypothermia. The inflammatory response following GCI and hypothermia's anti-inflammatory mechanism is different from that observed in FCI... - FasL shedding is reduced by hypothermia in experimental strokeLiping Liu
Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, California, USA
J Neurochem 106:541-50. 2008..Hypothermia prevented total FasL decreases, and most of it remained membrane-bound. These findings reveal new observations regarding the effect of mild hypothermia on the Fas/FasL and MMP systems... - Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemiaStephen Kelly
Department of Neurosurgery, Stanford University, CA 94305-5487, USA
Exp Neurol 188:378-86. 2004..These data show that Chir025-mediated inhibition of GSK3beta is neuroprotective and that the mechanism is probably not anti-apoptotic... - Gene therapy in neurological diseaseMidori A Yenari
Department of Neurosurgery and Neurology, Stanford University School of Medicine, CA, USA
Methods Mol Med 104:75-88. 2005..Although application to clinical stroke is probably remote, viral vector-mediated gene therapy provides a unique and powerful tool in the study of molecular mechanisms involved in brain injury... - Mild hypothermia inhibits inflammation after experimental stroke and brain inflammationHolly Deng
Departments of Neurosurgery, Stanford University, Stanford, Calif, USA
Stroke 34:2495-501. 2003..This suggests that hypothermia can attenuate factors contributing to delayed ischemic injury... - Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injuryRona G Giffard
Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
J Exp Biol 207:3213-20. 2004..Protection from ischemia and ischemia-like injury by chaperones thus involves at least anti-apoptotic, anti-necrotic and anti-protein aggregation mechanisms... - Anti-inflammatory effects of the 70 kDa heat shock protein in experimental strokeZhen Zheng
Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
J Cereb Blood Flow Metab 28:53-63. 2008..The findings of the present work establish an anti-inflammatory role for Hsp70 in the context of brain ischemia as a novel mechanism of protection... - Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us?Derk W Krieger
Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
Stroke 35:1482-9. 2004..With that in mind, a critical review of the pertinent literature is presented, taking into consideration potential limitations in translating such laboratory work to the clinical level... - Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammationHyung Soo Han
Department of Neurology, Stanford University Medical Center, Stanford, California 94305, USA
J Neurosci 22:3921-8. 2002..We conclude that mild hypothermia significantly inhibits the inflammatory response by affecting microglial iNOS-NO generation. Therapies directed against microglia or their activation may be useful in treating stroke... - Glucose and NADPH oxidase drive neuronal superoxide formation in strokeSang Won Suh
Department of Neurology, University of California, San Francisco, CA, USA
Ann Neurol 64:654-63. 2008..Here, we evaluated superoxide production by neuronal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase as a possible link between glucose metabolism and neuronal death in ischemia-reperfusion... - Therapeutic hypothermia: neuroprotective mechanismsLiping Liu
Dept of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, Neurology 127, 4150 Clement St, San Francisco, CA 94121, USA
Front Biosci 12:816-25. 2007..Therapeutic hypothermia is likely to undergo phase III clinical trials in various clinical settings. Novel technologies are being developed to optimize the safety and efficacy of this promising approach... - Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2Stephen Kelly
Department of Neurosurgery, Stanford University, Stanford, CA 94305-5327, USA
Ann Neurol 52:160-7. 2002..We show that HSP72 overexpression protects cornu ammonis 1 region of the hippocampus neurons from global cerebral ischemia, and that this protection may be mediated in part by increased Bcl-2 expression... - Pyruvate protects against experimental stroke via an anti-inflammatory mechanismQing Wang
Department of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, CA 94121, USA
Neurobiol Dis 36:223-31. 2009..Pyruvate protects against ischemia possibly by blocking inflammation, but lactate itself does not appear to explain pyruvate's anti-inflammatory properties... - Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental strokeHyung Soo Han
Department of Neurosurgery, Stanford University Medical Center, Stanford, California 94305, U.S.A
J Cereb Blood Flow Metab 23:589-98. 2003..These data suggest that the protective effect of hypothermia on cerebral injury is, in part, related to NFkappaB inhibition due to decreased activity of IKK... - A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microgliaChristine L Hsieh
University of California, San Francisco, and the San Francisco VA Medical Center, San Francisco, California, USA
J Neurochem 109:1144-56. 2009..TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair... - Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemiaXian Nan Tang
Department of Neurology, University of California San Francisco, San Francisco, CA 94121, USA
J Nucl Med 48:1822-8. 2007..We now explore the feasibility of using (99m)Tc-annexin V, an in vivo marker of apoptosis, with SPECT to monitor the antiapoptotic effects of minocycline therapy... - Combination therapy with hypothermia for treatment of cerebral ischemiaXian N Tang
Department of Neurology, University of California, San Francisco and San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
J Neurotrauma 26:325-31. 2009..The experimental data nevertheless seem to favor a combinatorial approach. Thus, in order to apply hypothermia to a broader range of patients, combination strategies should be further investigated... - Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the ratHeng Zhao
Department of Neurosurgery, Stanford University, Stanford, CA, USA
J Cereb Blood Flow Metab 24:681-92. 2004..Our data also suggest that AIF translocated into nuclei after cytochrome c was released into the cytosol. Bcl-2 transfection in the peri-infarct region blocked nuclear AIF translocation and improved cortical neuron survival... - Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental strokeJong Eun Lee
Departments of Neurosurgery, Neurology, and Radiology, Stanford University, Stanford, California, USA
J Neurosurg 103:289-97. 2005..CONCLUSIONS: The authors conclude that mild hypothermia attenuates BBB disruption, decreases MMP expression, and suppresses MMP activity... - Use of diffusion weighted MRI to predict the occurrence and severity of hemorrhagic transformation in a rabbit model of embolic strokeAlessandro Adami
Department of Neurology and Neurological Sciences, Stanford University, CA 94305-5487, USA
Brain Res 944:32-9. 2002..25% vs. no HT: 12%, 5.00-16.00% (median, 25th-75th %, P<0.001). Petechial HT when percentages were in the intermediate range. Quantitative analysis of initial ADC value might identify individual stroke patients at risk of severe HT... - Effects of mild hypothermia on superoxide anion production, superoxide dismutase expression, and activity following transient focal cerebral ischemiaCarolina M Maier
Department of Neurosurgery, Stanford University, California 94305-5487, USA
Neurobiol Dis 11:28-42. 2002..Our results suggest that the neuroprotective effect of mild hypothermia may be due, in part, to a reduction in neuronal and endothelial O(-*)(2) production during early reperfusion... - Heat shock proteins and neuroprotectionMidori A Yenari
Department of Neurosurgery, Stanford University, 1201 Welch Road, MSLS Building P304, Stanford, CA 94305-3487, USA
Adv Exp Med Biol 513:281-99. 2002..This review will cover these studies, along with potential mechanisms by which Hsp70 might mediate cellular protection... - Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of coolingMurat Karabiyikoglu
Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, Stanford, California, USA
J Neurosurg 98:1271-6. 2003..This may have important implications for understanding the mechanism of hypothermic neuroprotection and for stroke therapy... - Many mechanisms for hsp70 protection from cerebral ischemiaRona G Giffard
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
J Neurosurg Anesthesiol 16:53-61. 2004..Despite these new insights into the ways in which Hsp70 functions as an anti-death protein, further surprises are likely as we continue to gain insight into the functioning of this multifaceted protein... - Catalase over-expression protects striatal neurons from transient focal cerebral ischemiaWenping Gu
Departments of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive R200, Stanford, CA 94305-5327, USA
Neuroreport 15:413-6. 2004..Thus, the timing of catalase over-expression relative to ischemia is a critical variable determining its potential therapeutic value... - Protein kinase C delta mediates cerebral reperfusion injury in vivoRachel Bright
Department of Molecular Pharmacology, Stanford Stroke Center, Stanford University School of Medicine, Stanford, California 94305-5174, USA
J Neurosci 24:6880-8. 2004..These data support a deleterious role for deltaPKC during reperfusion and suggest that deltaV1-1 delivery, even hours after commencement of reperfusion, may provide a therapeutic advantage after cerebral ischemia... - Mild hypothermia decreases GSK3beta expression following global cerebral ischemiaStephen Kelly
Department of Neurosurgery, Stanford University, Stanford, CA 94121, USA
Neurocrit Care 2:212-7. 2005..No significant changes in phosphorylated GSK3beta expression were observed. CONCLUSION: These data suggest that GSK3beta plays a role in GCI pathology that can be altered by mild hypothermia... - Post-ischemic inflammation: molecular mechanisms and therapeutic implicationsZhen Zheng
Department of Neurosurgery Stanford University School of Medicine, Stanford, USA
Neurol Res 26:884-92. 2004..This review focuses on some recent advances regarding the regulation of inflammatory signaling pathways, the detrimental effects of post-ischemic inflammation and the potential molecular targets for ischemic stroke therapy... - Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermiaHeng Zhao
Department of Neurosurgery, Stanford University, Stanford, California 94305-5327, USA
J Cereb Blood Flow Metab 25:1119-29. 2005..Thus, biphasic cytochrome c release occurs after transient global ischemia and mild hypothermia protects against ischemic damage by blocking the second phase of cytochrome c release, possibly by blocking caspase activity... - Hypothermia as a cytoprotective strategy in ischemic tissue injuryXian N Tang
Department of Neurology, University of California, San Francisco, CA 94121, USA
Ageing Res Rev 9:61-8. 2010..This review will discuss the application of hypothermia especially as it pertains to its effects neurological outcome, cooling methods, and important parameters in optimizing hypothermic protection... - Neuroprotection: heat shock proteinsStephen Kelly
Department of Neurosurgery, Stanford University Medical Center, California 94305-5487, USA
Curr Med Res Opin 18:s55-60. 2002.... - The inflammatory response in strokeQing Wang
Department of Neurology, University of California, San Francisco, San Francisco, CA 94121, USA
J Neuroimmunol 184:53-68. 2007.... - Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascadeLijun Xu
Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305-5117, USA
J Cereb Blood Flow Metab 22:21-8. 2002.... - Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusionHeng Zhao
Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
J Neurosurg 107:636-41. 2007..This models a scenario in which the MCA remains occluded but partial reperfusion occurs through collateral vessels. The authors also determined whether hypothermia mediates ischemic damage by blocking apoptotic pathways... - Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental strokeMidori A Yenari
Department of Neurosurgery, Stanford University Medical Center, California, USA
J Cereb Blood Flow Metab 22:29-38. 2002..Furthermore, the authors show it is unlikely that mild hypothermia alters the intrinsic apoptotic pathway... - The application of HSP70 as a target for gene therapyZhen Zheng
Dept. of Neurology, University of California, The San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Front Biosci 11:699-707. 2006..Gaining insight into these recent advances may have profound implications in the development of HSP70-based clinical studies... - Therapeutic hypothermia for acute strokePatrick D Lyden
Neurology and Research Services of the San Diego Veteran s Administration Medical Center, Department of Neurosciences, University of California, San Diego, CA, USA
Int J Stroke 1:9-19. 2006..Therapeutic hypothermia is promising, but further Phase 1 and Phase 2 development efforts are needed to ensure that cooling of stroke patients is safe, before definitive efficacy trials... - epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injuryRachel Bright
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
Neurosci Lett 441:120-4. 2008..Here we demonstrate the role of acute and transient epsilonPKC in early cerebral tolerance in vivo and suggest that extra-parenchymal mechanisms, such as vasoconstriction, may contribute to the conferred protection... - Does inflammation after stroke affect the developing brain differently than adult brain?Zinaida S Vexler
Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
Dev Neurosci 31:378-93. 2009..Finally, we discuss emerging data on both the supportive and adverse roles of inflammation in plasticity and repair after stroke... - Cellular targets of brain inflammation in strokeHyung Soo Han
Department of Physiology, Kyungpook National University School of Medicine, Daegu, Korea
Curr Opin Investig Drugs 4:522-9. 2003..Whether these targets will be useful in the development of therapies for the treatment of stroke in humans is far from clear, but they provide fertile ground for scientific investigation... - The 70 kDa heat shock protein suppresses matrix metalloproteinases in astrocytesJong Eun Lee
Department of Anatomy, College of Medicine, Room 136 A, Yonsei University, 134 Shinchon dong, Seodaemun Ku, Seoul 120 752, Korea
Neuroreport 15:499-502. 2004..Zymograms and Western blots showed that Hsp70 over-expression suppressed MMP-2 and MMP-9. These findings suggest that Hsp70 may protect by regulating MMPs...
Research Grants
- Inflammatory Mechanisms in Cerebral IschemiaMidori A Yenari; Fiscal Year: 2010..Understanding how TREM2 affects inflammation during stroke could lead to the identification of appropriate treatments. ..
- Inflammatory Mechanisms in Cerebral IschemiaMidori Yenari; Fiscal Year: 2007..These studies should provide uniqae insights into a new mechanism by which HSP70 may protect against injury following cerebral ischemic and ischemia-like insults. ..
- Inflammatory Mechanisms in Cerebral IschemiaMidori Yenari; Fiscal Year: 2003..The results of this study should provide insight into the protective role of hypothermia, and may suggest anti-inflammatory targets for stroke treatment. ..