Midori Yenari

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Direct protection of cultured neurons from ischemia-like injury by minocycline
    Wendy C Huang
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Anat Cell Biol 43:325-31. 2010
  2. pmc Therapeutic hypothermia after cardiac arrest: experience at an academically affiliated community-based veterans affairs medical center
    Maulik P Shah
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94121, USA
    Stroke Res Treat 2011:791639. 2011
  3. pmc The immune modulating properties of the heat shock proteins after brain injury
    Jong Youl Kim
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA
    Anat Cell Biol 46:1-7. 2013
  4. pmc Microglial P2Y12 deficiency/inhibition protects against brain ischemia
    Corey M Webster
    Department of Neurology, University of California, San Francisco and the San Francisco Veteran s Affairs Medical Center, San Francisco, California, United States of America
    PLoS ONE 8:e70927. 2013
  5. pmc Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets
    J Y Kim
    Dept of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 4150 Clement Street, San Francisco, CA 94121, USA
    Curr Med Chem 21:2076-97. 2014
  6. pmc Influence of therapeutic hypothermia on regeneration after cerebral ischemia
    M A Yenari
    Department of Neurology, University of California, and San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Front Neurol Neurosci 32:122-8. 2013
  7. doi request reprint Neuroprotective mechanisms of hypothermia in brain ischaemia
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, California 94143 0248, USA
    Nat Rev Neurosci 13:267-78. 2012
  8. ncbi request reprint NOX inhibitors as a therapeutic strategy for stroke and neurodegenerative disease
    Belinda Cairns
    Takeda San Francisco, South San Francisco, CA 94080, USA
    Curr Drug Targets 13:199-206. 2012
  9. ncbi request reprint Pathophysiology of acute ischemic stroke
    Midori A Yenari
    Department of Neurosurgery, Stanford University, Stanford, Calif 94305 5487, USA
    Cleve Clin J Med 71:S25-7. 2004
  10. pmc Metabolic downregulation: a key to successful neuroprotection?
    Midori Yenari
    Department of Neurology, University of California, San Francisco, San Francisco Veterans Affairs Medical Center, San, San Francisco, CA 94121, USA
    Stroke 39:2910-7. 2008

Research Grants

  1. Inflammatory Mechanisms in Cerebral Ischemia
    Midori A Yenari; Fiscal Year: 2010
  2. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2001
  3. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2007
  4. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2006
  5. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2004
  6. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2005
  7. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2004
  8. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2002
  9. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2003
  10. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2002

Collaborators

Detail Information

Publications62

  1. pmc Direct protection of cultured neurons from ischemia-like injury by minocycline
    Wendy C Huang
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Anat Cell Biol 43:325-31. 2010
    ..Thus, anti-inflammatory treatments appear to be directly protective of neurons from in vitro ischemia...
  2. pmc Therapeutic hypothermia after cardiac arrest: experience at an academically affiliated community-based veterans affairs medical center
    Maulik P Shah
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94121, USA
    Stroke Res Treat 2011:791639. 2011
    ..This study demonstrates the feasibility of implementing, a cooling protocol a community setting, and the role of neurologists in ensuring effective hospital-wide implementation...
  3. pmc The immune modulating properties of the heat shock proteins after brain injury
    Jong Youl Kim
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, CA, USA
    Anat Cell Biol 46:1-7. 2013
    ..In this review, we will focus on underlying inflammatory mechanisms and Hsp70 in acute neurological injury...
  4. pmc Microglial P2Y12 deficiency/inhibition protects against brain ischemia
    Corey M Webster
    Department of Neurology, University of California, San Francisco and the San Francisco Veteran s Affairs Medical Center, San Francisco, California, United States of America
    PLoS ONE 8:e70927. 2013
    ..It is also the inhibitory target of the widely used antiplatelet drug, clopidogrel. Thus, inhibiting this GPCR in microglia should inhibit microglial mediated neurotoxicity following ischemic brain injury...
  5. pmc Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets
    J Y Kim
    Dept of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, San Francisco, California 4150 Clement Street, San Francisco, CA 94121, USA
    Curr Med Chem 21:2076-97. 2014
    ..A better understanding of the roles of the different immune cells and their temporal profile of damage versus repair will help to clarify more effective modulation of inflammation post stroke. ..
  6. pmc Influence of therapeutic hypothermia on regeneration after cerebral ischemia
    M A Yenari
    Department of Neurology, University of California, and San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
    Front Neurol Neurosci 32:122-8. 2013
    ..In this chapter, we will provide up-to-date data from experimental studies and clinical reports on the effect of therapeutic hypothermia on neuroregeneration, with perspectives on future research. ..
  7. doi request reprint Neuroprotective mechanisms of hypothermia in brain ischaemia
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, California 94143 0248, USA
    Nat Rev Neurosci 13:267-78. 2012
    ..It is likely that no single factor can explain the neuroprotection provided by hypothermia, but understanding its myriad effects may shed light on important neuroprotective mechanisms...
  8. ncbi request reprint NOX inhibitors as a therapeutic strategy for stroke and neurodegenerative disease
    Belinda Cairns
    Takeda San Francisco, South San Francisco, CA 94080, USA
    Curr Drug Targets 13:199-206. 2012
    ....
  9. ncbi request reprint Pathophysiology of acute ischemic stroke
    Midori A Yenari
    Department of Neurosurgery, Stanford University, Stanford, Calif 94305 5487, USA
    Cleve Clin J Med 71:S25-7. 2004
  10. pmc Metabolic downregulation: a key to successful neuroprotection?
    Midori Yenari
    Department of Neurology, University of California, San Francisco, San Francisco Veterans Affairs Medical Center, San, San Francisco, CA 94121, USA
    Stroke 39:2910-7. 2008
    ..In fact, hypothermia is already being used at many centers to improve neurological outcome from cardiac arrest...
  11. ncbi request reprint Influence of hypothermia on post-ischemic inflammation: role of nuclear factor kappa B (NFkappaB)
    Midori A Yenari
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 4150 Clement St, San Francisco, CA 94121, United States
    Neurochem Int 49:164-9. 2006
    ..These data suggest that the protective effect of hypothermia on cerebral injury is, in part, related to NFkappaB inhibition due to decreased activity of IKK...
  12. ncbi request reprint Microglia potentiate damage to blood-brain barrier constituents: improvement by minocycline in vivo and in vitro
    Midori A Yenari
    Department of Neurology, University of California, San Francisco Veterans Affairs Medical Center, California 94121, USA
    Stroke 37:1087-93. 2006
    ..We determined the effect of microglia on the BBB and its primary constituents, endothelial cells (ECs) and astrocytes, after ischemia using in vivo and in vitro models...
  13. ncbi request reprint Antiapoptotic and anti-inflammatory mechanisms of heat-shock protein protection
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, Caifornia 94121, USA
    Ann N Y Acad Sci 1053:74-83. 2005
    ..We suggest that HSPs are capable of protecting brain cells from lethal insults through a variety of mechanisms and should be explored as a potential therapy against stroke and other neurodegenerative diseases...
  14. ncbi request reprint Cellular and molecular events underlying ischemia-induced neuronal apoptosis
    Zhen Zheng
    Department of Neurosurgery, Stanford University School of Medicine, Stanford, California 94305, USA
    Drug News Perspect 16:497-503. 2003
    ..In this review, we examine some of these findings and their potential therapeutic implications for ischemic stroke...
  15. pmc Endotoxin-activated microglia injure brain derived endothelial cells via NF-κB, JAK-STAT and JNK stress kinase pathways
    Rachid Kacimi
    Dept, Neurology, University of California, San Francisco and San Francisco Veterans Affairs Medical Center, San Francisco 94121 USA
    J Inflamm (Lond) 8:7. 2011
    ..LPS is a classic TLR4 agonist, and is used here to model aspects of brain conditions where TLR4 stimulation occurs...
  16. pmc Therapeutic hypothermia for brain ischemia: where have we come and where do we go?
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, CA 94121, USA
    Stroke 41:S72-4. 2010
    ..We review the state of therapeutic hypothermia in ischemic and hemorrhagic stroke and provide an outlook for its role in stroke therapy...
  17. ncbi request reprint Gene therapy and hypothermia for stroke treatment
    Midori A Yenari
    Department of Neurosurgery, Stanford University, California 94305, USA
    Ann N Y Acad Sci 993:54-68; discussion 79-81. 2003
    ....
  18. doi request reprint Brain 11: what's new in stroke research?
    Midori A Yenari
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94121, USA
    Expert Rev Neurother 11:1235-7. 2011
    ..In addition, there was a focus on how the peripheral circulation contributes to such types of brain injury...
  19. ncbi request reprint Mild postischemic hypothermia prolongs the time window for gene therapy by inhibiting cytochrome C release
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, CA 94305 5327, USA
    Stroke 35:572-7. 2004
    ..5 hours after stroke but not when delivered 5 hours after stroke onset. Here we determine whether hypothermia prolongs the therapeutic window for gene therapy...
  20. ncbi request reprint Gene therapy in neurological disease
    Midori A Yenari
    Department of Neurosurgery and Neurology, Stanford University School of Medicine, CA, USA
    Methods Mol Med 104:75-88. 2005
    ..Although application to clinical stroke is probably remote, viral vector-mediated gene therapy provides a unique and powerful tool in the study of molecular mechanisms involved in brain injury...
  21. ncbi request reprint Bcl-2 overexpression protects against neuron loss within the ischemic margin following experimental stroke and inhibits cytochrome c translocation and caspase-3 activity
    Heng Zhao
    Department of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive R200, Stanford, CA 94305 5327, USA
    J Neurochem 85:1026-36. 2003
    ..This suggests a potential therapeutic strategy for stroke...
  22. ncbi request reprint Glycogen synthase kinase 3beta inhibitor Chir025 reduces neuronal death resulting from oxygen-glucose deprivation, glutamate excitotoxicity, and cerebral ischemia
    Stephen Kelly
    Department of Neurosurgery, Stanford University, CA 94305 5487, USA
    Exp Neurol 188:378-86. 2004
    ..These data show that Chir025-mediated inhibition of GSK3beta is neuroprotective and that the mechanism is probably not anti-apoptotic...
  23. pmc Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia
    Carla M Webster
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121, USA
    Neurobiol Dis 33:301-12. 2009
    ..However, NFkappaB regulatory proteins were not affected by hypothermia. The inflammatory response following GCI and hypothermia's anti-inflammatory mechanism is different from that observed in FCI...
  24. pmc FasL shedding is reduced by hypothermia in experimental stroke
    Liping Liu
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, California, USA
    J Neurochem 106:541-50. 2008
    ..Hypothermia prevented total FasL decreases, and most of it remained membrane-bound. These findings reveal new observations regarding the effect of mild hypothermia on the Fas/FasL and MMP systems...
  25. ncbi request reprint Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke
    Zhen Zheng
    Department of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, San Francisco, California 94121, USA
    J Cereb Blood Flow Metab 28:53-63. 2008
    ..The findings of the present work establish an anti-inflammatory role for Hsp70 in the context of brain ischemia as a novel mechanism of protection...
  26. ncbi request reprint Chaperones, protein aggregation, and brain protection from hypoxic/ischemic injury
    Rona G Giffard
    Department of Anesthesia, Stanford University, Stanford, CA 94305, USA
    J Exp Biol 207:3213-20. 2004
    ..Protection from ischemia and ischemia-like injury by chaperones thus involves at least anti-apoptotic, anti-necrotic and anti-protein aggregation mechanisms...
  27. ncbi request reprint Mild hypothermia inhibits inflammation after experimental stroke and brain inflammation
    Holly Deng
    Departments of Neurosurgery, Stanford University, Stanford, Calif, USA
    Stroke 34:2495-501. 2003
    ..Protection may be due in part to inhibiting inflammation. To clarify, we examined leukocyte infiltration, microglial activation, and adhesion molecule expression in models of stroke and pure brain inflammation...
  28. doi request reprint Glucose and NADPH oxidase drive neuronal superoxide formation in stroke
    Sang Won Suh
    Department of Neurology, University of California, San Francisco, CA, USA
    Ann Neurol 64:654-63. 2008
    ..Here, we evaluated superoxide production by neuronal nicotinamide adenine dinucleotide phosphate (NADPH) oxidase as a possible link between glucose metabolism and neuronal death in ischemia-reperfusion...
  29. ncbi request reprint Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation
    Hyung Soo Han
    Department of Neurology, Stanford University Medical Center, Stanford, California 94305, USA
    J Neurosci 22:3921-8. 2002
    ..We conclude that mild hypothermia significantly inhibits the inflammatory response by affecting microglial iNOS-NO generation. Therapies directed against microglia or their activation may be useful in treating stroke...
  30. ncbi request reprint Therapeutic hypothermia for acute ischemic stroke: what do laboratory studies teach us?
    Derk W Krieger
    Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Stroke 35:1482-9. 2004
    ..With that in mind, a critical review of the pertinent literature is presented, taking into consideration potential limitations in translating such laboratory work to the clinical level...
  31. ncbi request reprint Therapeutic hypothermia: neuroprotective mechanisms
    Liping Liu
    Dept of Neurology, University of California, San Francisco and the San Francisco Veterans Affairs Medical Center, Neurology 127, 4150 Clement St, San Francisco, CA 94121, USA
    Front Biosci 12:816-25. 2007
    ..Therapeutic hypothermia is likely to undergo phase III clinical trials in various clinical settings. Novel technologies are being developed to optimize the safety and efficacy of this promising approach...
  32. ncbi request reprint Gene transfer of HSP72 protects cornu ammonis 1 region of the hippocampus neurons from global ischemia: influence of Bcl-2
    Stephen Kelly
    Department of Neurosurgery, Stanford University, Stanford, CA 94305 5327, USA
    Ann Neurol 52:160-7. 2002
    ..We show that HSP72 overexpression protects cornu ammonis 1 region of the hippocampus neurons from global cerebral ischemia, and that this protection may be mediated in part by increased Bcl-2 expression...
  33. ncbi request reprint Mild hypothermia inhibits nuclear factor-kappaB translocation in experimental stroke
    Hyung Soo Han
    Department of Neurosurgery, Stanford University Medical Center, Stanford, California 94305, U S A
    J Cereb Blood Flow Metab 23:589-98. 2003
    ..These data suggest that the protective effect of hypothermia on cerebral injury is, in part, related to NFkappaB inhibition due to decreased activity of IKK...
  34. pmc Pyruvate protects against experimental stroke via an anti-inflammatory mechanism
    Qing Wang
    Department of Neurology, University of California, San Francisco and Veterans Affairs Medical Center, CA 94121, USA
    Neurobiol Dis 36:223-31. 2009
    ..Pyruvate protects against ischemia possibly by blocking inflammation, but lactate itself does not appear to explain pyruvate's anti-inflammatory properties...
  35. pmc A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia
    Christine L Hsieh
    University of California, San Francisco, and the San Francisco VA Medical Center, San Francisco, California, USA
    J Neurochem 109:1144-56. 2009
    ..TREM2 and TREM2-L form a receptor-ligand pair connecting microglia with apoptotic neurons, directing removal of damaged cells to allow repair...
  36. ncbi request reprint Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
    J Cereb Blood Flow Metab 25:1119-29. 2005
    ..Thus, biphasic cytochrome c release occurs after transient global ischemia and mild hypothermia protects against ischemic damage by blocking the second phase of cytochrome c release, possibly by blocking caspase activity...
  37. ncbi request reprint Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke
    Jong Eun Lee
    Departments of Neurosurgery, Neurology, and Radiology, Stanford University, Stanford, California, USA
    J Neurosurg 103:289-97. 2005
    ..In this study the authors explored the relationship between hypothermia and MMPs and whether BBB preservation resulting from mild hypothermia therapy is due to alterations in MMP expression...
  38. ncbi request reprint Post-ischemic inflammation: molecular mechanisms and therapeutic implications
    Zhen Zheng
    Department of Neurosurgery Stanford University School of Medicine, Stanford, USA
    Neurol Res 26:884-92. 2004
    ..This review focuses on some recent advances regarding the regulation of inflammatory signaling pathways, the detrimental effects of post-ischemic inflammation and the potential molecular targets for ischemic stroke therapy...
  39. ncbi request reprint Heat shock proteins and neuroprotection
    Midori A Yenari
    Department of Neurosurgery, Stanford University, 1201 Welch Road, MSLS Building P304, Stanford, CA 94305 3487, USA
    Adv Exp Med Biol 513:281-99. 2002
    ..This review will cover these studies, along with potential mechanisms by which Hsp70 might mediate cellular protection...
  40. ncbi request reprint Effects of mild hypothermia on superoxide anion production, superoxide dismutase expression, and activity following transient focal cerebral ischemia
    Carolina M Maier
    Department of Neurosurgery, Stanford University, California 94305 5487, USA
    Neurobiol Dis 11:28-42. 2002
    ..Our results suggest that the neuroprotective effect of mild hypothermia may be due, in part, to a reduction in neuronal and endothelial O(-*)(2) production during early reperfusion...
  41. pmc Combination therapy with hypothermia for treatment of cerebral ischemia
    Xian N Tang
    Department of Neurology, University of California, San Francisco and San Francisco Veterans Administration Medical Center, San Francisco, California 94121, USA
    J Neurotrauma 26:325-31. 2009
    ..The experimental data nevertheless seem to favor a combinatorial approach. Thus, in order to apply hypothermia to a broader range of patients, combination strategies should be further investigated...
  42. ncbi request reprint Protein kinase C delta mediates cerebral reperfusion injury in vivo
    Rachel Bright
    Department of Molecular Pharmacology, Stanford Stroke Center, Stanford University School of Medicine, Stanford, California 94305 5174, USA
    J Neurosci 24:6880-8. 2004
    ..These data support a deleterious role for deltaPKC during reperfusion and suggest that deltaV1-1 delivery, even hours after commencement of reperfusion, may provide a therapeutic advantage after cerebral ischemia...
  43. ncbi request reprint Many mechanisms for hsp70 protection from cerebral ischemia
    Rona G Giffard
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305, USA
    J Neurosurg Anesthesiol 16:53-61. 2004
    ..Despite these new insights into the ways in which Hsp70 functions as an anti-death protein, further surprises are likely as we continue to gain insight into the functioning of this multifaceted protein...
  44. ncbi request reprint Mild hypothermia decreases GSK3beta expression following global cerebral ischemia
    Stephen Kelly
    Department of Neurosurgery, Stanford University, Stanford, CA 94121, USA
    Neurocrit Care 2:212-7. 2005
    ..This article reports that GSK3beta expression following global cerebral ischemia (GCI) is altered by the neuroprotectant, mild hypothermia (33 degrees C)...
  45. ncbi request reprint Bcl-2 transfection via herpes simplex virus blocks apoptosis-inducing factor translocation after focal ischemia in the rat
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, CA, USA
    J Cereb Blood Flow Metab 24:681-92. 2004
    ..Our data also suggest that AIF translocated into nuclei after cytochrome c was released into the cytosol. Bcl-2 transfection in the peri-infarct region blocked nuclear AIF translocation and improved cortical neuron survival...
  46. ncbi request reprint Use of diffusion weighted MRI to predict the occurrence and severity of hemorrhagic transformation in a rabbit model of embolic stroke
    Alessandro Adami
    Department of Neurology and Neurological Sciences, Stanford University, CA 94305 5487, USA
    Brain Res 944:32-9. 2002
    ..25% vs. no HT: 12%, 5.00-16.00% (median, 25th-75th %, P<0.001). Petechial HT when percentages were in the intermediate range. Quantitative analysis of initial ADC value might identify individual stroke patients at risk of severe HT...
  47. ncbi request reprint Catalase over-expression protects striatal neurons from transient focal cerebral ischemia
    Wenping Gu
    Departments of Neurosurgery, Stanford University School of Medicine, 300 Pasteur Drive R200, Stanford, CA 94305 5327, USA
    Neuroreport 15:413-6. 2004
    ..Thus, the timing of catalase over-expression relative to ischemia is a critical variable determining its potential therapeutic value...
  48. ncbi request reprint Monitoring the protective effects of minocycline treatment with radiolabeled annexin V in an experimental model of focal cerebral ischemia
    Xian Nan Tang
    Department of Neurology, University of California San Francisco, San Francisco, CA 94121, USA
    J Nucl Med 48:1822-8. 2007
    ..We now explore the feasibility of using (99m)Tc-annexin V, an in vivo marker of apoptosis, with SPECT to monitor the antiapoptotic effects of minocycline therapy...
  49. ncbi request reprint Attenuation of nitric oxide synthase isoform expression by mild hypothermia after focal cerebral ischemia: variations depending on timing of cooling
    Murat Karabiyikoglu
    Department of Neurosurgery, Stanford Stroke Center, Stanford University Medical Center, Stanford, California, USA
    J Neurosurg 98:1271-6. 2003
    ..In this study the authors examined the influence of mild hypothermia on early expression of nitric oxide synthase (NOS) isoforms and peroxynitrite generation after experimental stroke...
  50. ncbi request reprint Neuroprotection: heat shock proteins
    Stephen Kelly
    Department of Neurosurgery, Stanford University Medical Center, California 94305 5487, USA
    Curr Med Res Opin 18:s55-60. 2002
    ....
  51. ncbi request reprint The application of HSP70 as a target for gene therapy
    Zhen Zheng
    Dept of Neurology, University of California, The San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Front Biosci 11:699-707. 2006
    ..Gaining insight into these recent advances may have profound implications in the development of HSP70-based clinical studies...
  52. ncbi request reprint Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke
    Midori A Yenari
    Department of Neurosurgery, Stanford University Medical Center, California, USA
    J Cereb Blood Flow Metab 22:29-38. 2002
    ..Furthermore, the authors show it is unlikely that mild hypothermia alters the intrinsic apoptotic pathway...
  53. pmc Hypothermia as a cytoprotective strategy in ischemic tissue injury
    Xian N Tang
    Department of Neurology, University of California, San Francisco, CA 94121, USA
    Ageing Res Rev 9:61-8. 2010
    ..This review will discuss the application of hypothermia especially as it pertains to its effects neurological outcome, cooling methods, and important parameters in optimizing hypothermic protection...
  54. pmc The inflammatory response in stroke
    Qing Wang
    Department of Neurology, University of California, San Francisco, San Francisco, CA 94121, USA
    J Neuroimmunol 184:53-68. 2007
    ....
  55. ncbi request reprint Mild hypothermia reduces apoptosis of mouse neurons in vitro early in the cascade
    Lijun Xu
    Department of Anesthesia, Stanford University School of Medicine, Stanford, California 94305 5117, USA
    J Cereb Blood Flow Metab 22:21-8. 2002
    ....
  56. ncbi request reprint Conditions of protection by hypothermia and effects on apoptotic pathways in a rat model of permanent middle cerebral artery occlusion
    Heng Zhao
    Department of Neurosurgery, Stanford University, Stanford, California 94305 5327, USA
    J Neurosurg 107:636-41. 2007
    ..This models a scenario in which the MCA remains occluded but partial reperfusion occurs through collateral vessels. The authors also determined whether hypothermia mediates ischemic damage by blocking apoptotic pathways...
  57. doi request reprint Therapeutic hypothermia for acute stroke
    Patrick D Lyden
    Neurology and Research Services of the San Diego Veteran s Administration Medical Center, Department of Neurosciences, University of California, San Diego, CA, USA
    Int J Stroke 1:9-19. 2006
    ..Therapeutic hypothermia is promising, but further Phase 1 and Phase 2 development efforts are needed to ensure that cooling of stroke patients is safe, before definitive efficacy trials...
  58. pmc epsilonPKC confers acute tolerance to cerebral ischemic reperfusion injury
    Rachel Bright
    Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA 94305 5174, USA
    Neurosci Lett 441:120-4. 2008
    ..Here we demonstrate the role of acute and transient epsilonPKC in early cerebral tolerance in vivo and suggest that extra-parenchymal mechanisms, such as vasoconstriction, may contribute to the conferred protection...
  59. pmc Does inflammation after stroke affect the developing brain differently than adult brain?
    Zinaida S Vexler
    Department of Neurology, University of California, San Francisco, CA 94143 0663, USA
    Dev Neurosci 31:378-93. 2009
    ..Finally, we discuss emerging data on both the supportive and adverse roles of inflammation in plasticity and repair after stroke...
  60. ncbi request reprint Cellular targets of brain inflammation in stroke
    Hyung Soo Han
    Department of Physiology, Kyungpook National University School of Medicine, Daegu, Korea
    Curr Opin Investig Drugs 4:522-9. 2003
    ..Whether these targets will be useful in the development of therapies for the treatment of stroke in humans is far from clear, but they provide fertile ground for scientific investigation...
  61. ncbi request reprint The 70 kDa heat shock protein suppresses matrix metalloproteinases in astrocytes
    Jong Eun Lee
    Department of Anatomy, College of Medicine, Room 136 A, Yonsei University, 134 Shinchon dong, Seodaemun Ku, Seoul 120 752, Korea
    Neuroreport 15:499-502. 2004
    ..Zymograms and Western blots showed that Hsp70 over-expression suppressed MMP-2 and MMP-9. These findings suggest that Hsp70 may protect by regulating MMPs...

Research Grants11

  1. Inflammatory Mechanisms in Cerebral Ischemia
    Midori A Yenari; Fiscal Year: 2010
    ..Understanding how TREM2 affects inflammation during stroke could lead to the identification of appropriate treatments. ..
  2. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2001
    ..The results of this study should provide insight into the protective role of hypothermia, and may suggest anti-inflammatory targets for stroke treatment. ..
  3. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2007
    ..These studies should provide uniqae insights into a new mechanism by which HSP70 may protect against injury following cerebral ischemic and ischemia-like insults. ..
  4. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2006
    ..These studies should provide uniqae insights into a new mechanism by which HSP70 may protect against injury following cerebral ischemic and ischemia-like insults. ..
  5. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2004
    ..These studies should provide uniqae insights into a new mechanism by which HSP70 may protect against injury following cerebral ischemic and ischemia-like insults. ..
  6. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2005
    ..These studies should provide uniqae insights into a new mechanism by which HSP70 may protect against injury following cerebral ischemic and ischemia-like insults. ..
  7. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2004
    ..These studies should provide uniqae insights into a new mechanism by which HSP70 may protect against injury following cerebral ischemic and ischemia-like insults. ..
  8. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2002
    ..The results of this study should provide insight into the protective role of hypothermia, and may suggest anti-inflammatory targets for stroke treatment. ..
  9. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2003
    ..The results of this study should provide insight into the protective role of hypothermia, and may suggest anti-inflammatory targets for stroke treatment. ..
  10. Inflammatory Mechanisms in Cerebral Ischemia
    Midori Yenari; Fiscal Year: 2002
    ..The results of this study should provide insight into the protective role of hypothermia, and may suggest anti-inflammatory targets for stroke treatment. ..