JING RUEY JOANNA YEH

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc In vivo chemical screening for modulators of hematopoiesis and hematological diseases
    Yiyun Zhang
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Adv Hematol 2012:851674. 2012
  2. pmc Targeted gene disruption in somatic zebrafish cells using engineered TALENs
    Jeffry D Sander
    Nat Biotechnol 29:697-8. 2011
  3. pmc Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation
    Jing Ruey J Yeh
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 5:236-43. 2009
  4. ncbi request reprint A Wnt inhibitor with a twist
    Jing Ruey J Yeh
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Chem Biol 18:1518-20. 2011
  5. pmc Zebrafish small molecule screen in reprogramming/cell fate modulation
    Jing Ruey J Yeh
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Methods Mol Biol 636:317-27. 2010
  6. ncbi request reprint AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression
    Jing Ruey J Yeh
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 135:401-10. 2008
  7. pmc Heritable and precise zebrafish genome editing using a CRISPR-Cas system
    Woong Y Hwang
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 8:e68708. 2013
  8. pmc Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs
    Lindsay Cade
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA
    Nucleic Acids Res 40:8001-10. 2012
  9. pmc Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival
    Farshid Dayyani
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Blood 111:4338-47. 2008
  10. doi request reprint Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases
    Woong Y Hwang
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, 02129, USA
    Methods Mol Biol 1311:317-34. 2015

Collaborators

  • Xi Chen
  • Yi Zhang
  • Woong Y Hwang
  • Randall T Peterson
  • J Keith Joung
  • Deepak Reyon
  • Jeffry D Sander
  • Lindsay Cade
  • Andrew P W Gonzales
  • Benjamin P Kleinstiver
  • Yanfang Fu
  • Shengdar Q Tsai
  • Cyd Khayter
  • Chetana Sachidanandan
  • Farshid Dayyani
  • Ved V Topkar
  • Nhu T Nguyen
  • Martin J Aryee
  • Zhuyun Li
  • Zongli Zheng
  • Michelle S Prew
  • Prakriti Kaini
  • Morgan L Maeder
  • Samir Patel
  • Eun Young Ahn
  • David A Sweetser
  • Erica Tobey
  • Dong Er Zhang
  • Irwin D Bernstein
  • Jianfeng Wang
  • Quinn P Peterson

Detail Information

Publications16

  1. pmc In vivo chemical screening for modulators of hematopoiesis and hematological diseases
    Yiyun Zhang
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Adv Hematol 2012:851674. 2012
    ..Furthermore, the compounds discovered in zebrafish screens have become promising therapeutic candidates against leukemia and included in a clinical trial for enhancing hematopoietic stem cells during hematopoietic cell transplantation...
  2. pmc Targeted gene disruption in somatic zebrafish cells using engineered TALENs
    Jeffry D Sander
    Nat Biotechnol 29:697-8. 2011
  3. pmc Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation
    Jing Ruey J Yeh
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    Nat Chem Biol 5:236-43. 2009
    ..This approach may open doors for developing therapeutics targeting oncogene function within leukemic stem cells...
  4. ncbi request reprint A Wnt inhibitor with a twist
    Jing Ruey J Yeh
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Chem Biol 18:1518-20. 2011
    ..this issue of Chemistry & Biology)...
  5. pmc Zebrafish small molecule screen in reprogramming/cell fate modulation
    Jing Ruey J Yeh
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Methods Mol Biol 636:317-27. 2010
    ..The methods discussed herein may be broadly applicable for identifying small molecules that modulate other cell fate decisions...
  6. ncbi request reprint AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression
    Jing Ruey J Yeh
    Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Development 135:401-10. 2008
    ..Thus, this zebrafish model facilitates in vivo dissection of AML1-ETO-mediated signaling, and will enable large-scale chemical screens to identify suppressors of the in vivo effects of AML1-ETO...
  7. pmc Heritable and precise zebrafish genome editing using a CRISPR-Cas system
    Woong Y Hwang
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
    PLoS ONE 8:e68708. 2013
    ..Together, these advances expand the utility of the CRISPR-Cas system in the zebrafish beyond somatic indel formation to heritable and precise genome modifications. ..
  8. pmc Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs
    Lindsay Cade
    Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA
    Nucleic Acids Res 40:8001-10. 2012
    ..Our results suggest that construction of one to two heterodimeric TALEN pairs for any given gene will, in most cases, enable researchers to rapidly generate knockout zebrafish...
  9. pmc Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival
    Farshid Dayyani
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Blood 111:4338-47. 2008
    ..This study is the first to implicate the TLEs as potential tumor suppressor genes in myeloid leukemia...
  10. doi request reprint Targeted Mutagenesis in Zebrafish Using CRISPR RNA-Guided Nucleases
    Woong Y Hwang
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, 02129, USA
    Methods Mol Biol 1311:317-34. 2015
    ..These methods can be easily implemented in any lab and may also potentially be extended for use in other organisms...
  11. pmc AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway
    Yiyun Zhang
    Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA, USA
    Blood 121:4906-16. 2013
    ....
  12. pmc Methods for targeted mutagenesis in zebrafish using TALENs
    Woong Y Hwang
    Cardiovascular Research Center, Massachusetts General Hospital, 149 13th Street, Room 4201, Charlestown, MA 02129, USA Department of Medicine, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA
    Methods 69:76-84. 2014
    ..These methods should enable zebrafish researchers to quickly generate targeted mutations at their genes-of-interest. ..
  13. pmc Engineered CRISPR-Cas9 nucleases with altered PAM specificities
    Benjamin P Kleinstiver
    1 Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA 2 Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA 3 Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 523:481-5. 2015
    ..Our findings provide broadly useful SpCas9 variants and, more importantly, establish the feasibility of engineering a wide range of Cas9s with altered and improved PAM specificities. ..
  14. pmc Identification of a novel retinoid by small molecule screening with zebrafish embryos
    Chetana Sachidanandan
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 3:e1947. 2008
    ....
  15. ncbi request reprint Chemical genetics: adding to the developmental biology toolbox
    Jing Ruey J Yeh
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Dev Cell 5:11-9. 2003
    ..New uses for old teratogens as well as novel chemical modulators of development have begun to fill this void...
  16. pmc Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest
    Jing Ruey J Yeh
    Department of Molecular, Yale University, New Haven, CT 06520 8103, USA
    Proc Natl Acad Sci U S A 103:10379-84. 2006
    ..Together, these results demonstrate an essential role for MetAP-2 in angiogenesis and indicate that MetAP-2 is responsible for the endothelial cell growth arrest induced by Fg and its derivatives...