Bin Ye

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi New technologies for the identification of markers for early detection of ovarian cancer
    Christina A Bandera
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02138, USA
    Curr Opin Obstet Gynecol 15:51-5. 2003
  2. pmc Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium
    Lifang Zhang
    Obstetrics and Gynecology Department, Peking University People s Hospital, Beijing, China
    Reprod Biol Endocrinol 8:74. 2010
  3. ncbi Recent technical strategies to identify diagnostic biomarkers for ovarian cancer
    Bin Ye
    Harvard Medical School, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Dana Farber Harvard Cancer Center, Boston, MA 02115, USA
    Expert Rev Proteomics 4:121-31. 2007
  4. ncbi Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine
    Bin Ye
    Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, 221 Longwood Avenue, LMRC 601B, Boston, MA 02115, USA
    Clin Cancer Res 12:432-41. 2006
  5. ncbi Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence
    Bin Ye
    Laboratory of Gynecologic Oncology and Epidemiology, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, USA
    Cancer Lett 251:43-52. 2007
  6. ncbi Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry
    Bin Ye
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Dana Farber Harvard Cancer Center, Boston, MA 02115, USA
    Clin Cancer Res 9:2904-11. 2003
  7. pmc Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer
    Margarita Aponte
    Laboratory of Gynecologic Oncology and Epidemiology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Dana Farber Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 68:5839-48. 2008
  8. doi Use of a combination of approaches to identify and validate relevant tumor-associated antigens and their corresponding autoantibodies in ovarian cancer patients
    Audrey Gagnon
    Laboratory of Gynecologic Oncology, Division of Gynecology Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Cancer Res 14:764-71. 2008
  9. ncbi Discovery and application of protein biomarkers for ovarian cancer
    Audrey Gagnon
    Laboratory of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Obstet Gynecol 20:9-13. 2008
  10. pmc Blood and urine markers for ovarian cancer: a comprehensive review
    Kathryn L Terry
    Ob Gyn Center Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, MA, USA
    Dis Markers 20:53-70. 2004

Research Grants

Collaborators

Detail Information

Publications23

  1. ncbi New technologies for the identification of markers for early detection of ovarian cancer
    Christina A Bandera
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02138, USA
    Curr Opin Obstet Gynecol 15:51-5. 2003
    ..The ovarian cancer screening regimens in current use fail to identify disease at an early curable stage...
  2. pmc Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium
    Lifang Zhang
    Obstetrics and Gynecology Department, Peking University People s Hospital, Beijing, China
    Reprod Biol Endocrinol 8:74. 2010
    ..The major objective of this study was to explore and determine whether platelet activating factor (PAF) and receptor associated networking pathways might significantly induce malignant potential in BRCA1-mutant at-risk epithelial cells...
  3. ncbi Recent technical strategies to identify diagnostic biomarkers for ovarian cancer
    Bin Ye
    Harvard Medical School, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Dana Farber Harvard Cancer Center, Boston, MA 02115, USA
    Expert Rev Proteomics 4:121-31. 2007
    ..This review summarizes the different approaches used in the last decade and suggests which strategies should be adopted in the near future in order to lead to the successful identification of new ovarian cancer diagnostic biomarkers...
  4. ncbi Proteomic-based discovery and characterization of glycosylated eosinophil-derived neurotoxin and COOH-terminal osteopontin fragments for ovarian cancer in urine
    Bin Ye
    Laboratory of Gynecologic Oncology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, 221 Longwood Avenue, LMRC 601B, Boston, MA 02115, USA
    Clin Cancer Res 12:432-41. 2006
    ..The objective was to identify and characterize low molecular weight proteins/peptides in urine and their posttranslational modifications that might be used as a screening tool for ovarian cancer...
  5. ncbi Ginkgo biloba and ovarian cancer prevention: epidemiological and biological evidence
    Bin Ye
    Laboratory of Gynecologic Oncology and Epidemiology, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, USA
    Cancer Lett 251:43-52. 2007
    ..This combined epidemiological and biological data provide supportive evidence for further studies of the chemopreventive or therapeutic effects of Ginkgo and ginkgolides on ovarian cancer...
  6. ncbi Haptoglobin-alpha subunit as potential serum biomarker in ovarian cancer: identification and characterization using proteomic profiling and mass spectrometry
    Bin Ye
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Dana Farber Cancer Institute, Dana Farber Harvard Cancer Center, Boston, MA 02115, USA
    Clin Cancer Res 9:2904-11. 2003
    ..The objective of this study was to identify and characterize new serum biomarkers in ovarian cancer patients using mass spectrometric protein profiling and specific immunological assays...
  7. pmc Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer
    Margarita Aponte
    Laboratory of Gynecologic Oncology and Epidemiology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women s Hospital, Dana Farber Cancer Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer Res 68:5839-48. 2008
    ..We suggest that PAFR is an essential upstream target of Src and other signal pathways to control the PAF-mediated cancer progression...
  8. doi Use of a combination of approaches to identify and validate relevant tumor-associated antigens and their corresponding autoantibodies in ovarian cancer patients
    Audrey Gagnon
    Laboratory of Gynecologic Oncology, Division of Gynecology Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Cancer Res 14:764-71. 2008
    ..Indeed, many autoantibodies have recently been shown to correlate with cancer patient prognosis or to be suitable for detection of the disease...
  9. ncbi Discovery and application of protein biomarkers for ovarian cancer
    Audrey Gagnon
    Laboratory of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Obstet Gynecol 20:9-13. 2008
    ..To review the protein biomarker research field in ovarian cancer, including the discovered new biomarkers, biomarker panels, their potential clinical applications, and suggested strategies for biomarker discovery and development...
  10. pmc Blood and urine markers for ovarian cancer: a comprehensive review
    Kathryn L Terry
    Ob Gyn Center Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Boston, MA, USA
    Dis Markers 20:53-70. 2004
  11. pmc A proteomic analysis of IVF follicular fluid in women <or=32 years old
    Stephanie J Estes
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115 5804, USA
    Fertil Steril 92:1569-78. 2009
    ..To address the lack of predictors of IVF success by using proteomic biometrics...
  12. doi Surface-enhanced laser desorption/ionization mass spectrometry for protein and Peptide profiling of body fluids
    Audrey Gagnon
    Laboratory of Gynecologic Oncology, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Dana Farber Cancer Center, Boston, MA, USA
    Methods Mol Biol 441:41-56. 2008
    ..In this chapter, we provide a general guide to the profiling of proteins or peptides as well as biomarker discovery using the most common body fluids such as serum/plasma, nipple aspiration fluid, and urine...
  13. pmc Integration of cell phone imaging with microchip ELISA to detect ovarian cancer HE4 biomarker in urine at the point-of-care
    Shuqi Wang
    Demirci Bio Acoustic MEMS in Medicine BAMM Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Harvard MIT Health Sciences and Technology, Cambridge, MA 02139, USA
    Lab Chip 11:3411-8. 2011
    ....
  14. ncbi Prostate carcinoma tissue proteomics for biomarker discovery
    Yaxin Zheng
    Molecular Urology Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Cancer 98:2576-82. 2003
    ..Proteins were involved in various pathways that determine the behavior of a cell. Therefore, information regarding proteins may reveal drug targets and/or markers for early detection...
  15. ncbi Induction of apoptosis by phenylisocyanate derivative of quercetin: involvement of heat shock protein
    Bin Ye
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, PRC
    Anticancer Drugs 18:1165-71. 2007
    ..PHICNQ may trigger apoptosis in tumor cells through inhibition of heat shock protein 70 synthesis and expression...
  16. ncbi Expression profiling identifies three pathways altered in cellular immortalization: interferon, cell cycle, and cytoskeleton
    Aviva Levine Fridman
    Program in Molecular Biology and Human Genetics, Barbara Ann Karmanos Cancer Institute, and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 110 East Warren Ave, Detroit, Michigan 48201, USA
    J Gerontol A Biol Sci Med Sci 61:879-89. 2006
    ..The identification of the genes and pathways regulating immortalization will lead to a better understanding of cellular immortalization and molecular targets in cancer and aging...
  17. pmc Diagnostic markers of ovarian cancer by high-throughput antigen cloning and detection on arrays
    Madhumita Chatterjee
    Program in Molecular Biology and Human Genetics, Barbara Ann Karmanos Cancer Institute, Wayne State University, 110 East Warren, Detroit, MI 48201, USA
    Cancer Res 66:1181-90. 2006
    ..Further work with larger panels of antigens should provide a comprehensive set of markers with sufficient sensitivity and specificity suitable for clinical testing in high-risk populations...
  18. ncbi Protein profiling of complete mole and normal placenta using ProteinChip analysis on laser capture microdissected cells
    Jozsef Batorfi
    Department of Obstetrics and Gynecology, National Health Center, Budapest, Hungary
    Gynecol Oncol 88:424-8. 2003
    ..Further knowledge of protein expression in complete mole may advance our understanding of the pathogenesis of gestational trophoblastic diseases...
  19. ncbi Enhanced efficiency and specificity of ovarian cancer gene therapy in rats with a novel nonviral gene delivery system (GE7) via intraovarian artery perfusion approach
    Wei Jiang
    Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, PR China
    Cancer Gene Ther 12:810-7. 2005
    ..25+/-8.34 g) (P<.01). These findings indicated that the administration of GE7/HSV1-tk complex via the ovarian artery route could be a promising avenue of future human ovarian cancer treatment...
  20. doi Protein carbonhydrate Analysis: gel-based staining, liquid chromatography, mass spectrometry, and microarray screening
    Injae Shin
    Department of Chemistry, Yonsei University, Seoul 120 749, Korea
    Methods Mol Biol 441:19-39. 2008
    ..The advanced technology of the carbohydrate-based microarray system incorporates high-throughput analysis to extend the scope of biomedical research on carbohydrate-mediated molecular interactions...
  21. ncbi Liposomal quercetin efficiently suppresses growth of solid tumors in murine models
    Zhi Ping Yuan
    State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People s Republic of China
    Clin Cancer Res 12:3193-9. 2006
    ..To overcome this limitation, this study is aimed to develop liposomal quercetin and investigate its distribution in vivo and antitumor efficacy in vivo and in vitro...
  22. pmc Autoantibody approach for serum-based detection of head and neck cancer
    Ho Sheng Lin
    Department of Surgery, John D Dingell VA Medical Center, Wayne State University, Detroit, Michigan 48201, USA
    Cancer Epidemiol Biomarkers Prev 16:2396-405. 2007
    ....
  23. ncbi [Study on HPEC fingerprint of cultured Cordyceps militaris]
    Bin Ye
    College of Pharmacy, Jinan University, Guangzhou 510632, China
    Zhong Yao Cai 30:28-30. 2007
    ..To investigate the High Performance Capillary Electrophoresis (HPCE) fingerprint of cultured Cordyceps militaris (L.) Link...

Research Grants1

  1. Urine Protein Biomarker Exploration in Ovarian Cancer
    Bin Ye; Fiscal Year: 2006
    ..This project, if successful, could fundamentally shift the approach to the early detection of ovarian cancer and significantly improve the survival rate of cases detected. [unreadable] [unreadable]..