Fan Yang

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc The study of abnormal bone development in the Apert syndrome Fgfr2+/S252W mouse using a 3D hydrogel culture model
    Fan Yang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 45 Carleton Street, E25 342, Cambridge, MA 02142, USA
    Bone 43:55-63. 2008
  2. pmc High throughput optimization of stem cell microenvironments
    Fan Yang
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Comb Chem High Throughput Screen 12:554-61. 2009
  3. pmc Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D
    Fan Yang
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 45 Carleton Street, E25 342, Cambridge, Massachusetts 02139, USA
    Biomacromolecules 11:1909-14. 2010
  4. pmc Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles
    Fan Yang
    Department of Chemical Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:3317-22. 2010
  5. pmc Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation
    Seung Woo Cho
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biochem Biophys Res Commun 376:158-63. 2008
  6. pmc Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds
    Christoffer K Abrahamsson
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Tissue Eng Part A 16:3709-18. 2010
  7. ncbi request reprint Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse
    Yingli Wang
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Development 132:3537-48. 2005
  8. ncbi request reprint Bioresponsive phosphoester hydrogels for bone tissue engineering
    Dong An Wang
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Tissue Eng 11:201-13. 2005
  9. ncbi request reprint The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells
    Fan Yang
    Department of Biomedical Engineering, Johns Hopkins University, 3400 North Charles Street Clark Hall 106, Baltimore, MD 21218, USA
    Biomaterials 26:5991-8. 2005
  10. doi request reprint Inhibition of a novel sperm gelatinase in prawn sperm by the male reproduction-related Kazal-type peptidase inhibitor
    Ye Li
    Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Zijingang Campus, Hangzhou, Zhejiang, PR China
    Mol Reprod Dev 75:1327-37. 2008

Collaborators

  • Hyoungshin Park
  • Daniel G Anderson
  • Ying Mei
  • Byung Soo Kim
  • Jordan J Green
  • Yingli Wang
  • Zijun Zhang
  • Michael Goldberg
  • Daniel S Kohane
  • Jean F Welter
  • Arnold I Caplan
  • J H Elisseeff
  • Xiao Feng Yang
  • Yan Zhang
  • Wei Jun Yang
  • Ye Li
  • Chen Zhuo Feng
  • Jianwen Liu
  • Jin Shu Yang
  • Ya Qing He
  • Christoffer K Abrahamsson
  • Robert Langer
  • Seung Woo Cho
  • Mo Ran Wang
  • Hongzhong Wu
  • Zhong Min Dai
  • Jian Jun Liu
  • Zeyu Xiong
  • Johann M G Reyes
  • Dong An Wang
  • Xenia Beebe
  • Christoph U Herborn
  • Guanchao Jiang
  • Jonathan M Brunger
  • Farshid Guilak
  • Lisa E Freed
  • Piia K Valonen
  • Qiaobing Xu
  • Tsuyoshi Ohira
  • Lauren Hartle
  • Wen Ming Ma
  • Jie Qiong Dai
  • Hiromichi Nagasawa
  • Sun Mi Son
  • Xia Ding
  • Khalid Mahmood
  • Yufeng Qin
  • Xiao Jing Zhu
  • Su Chen
  • Jiyu Li
  • Shuya Cui
  • Yan Yan
  • Enli Liu
  • Irene H Chen
  • Josef Prchal
  • Srdan Verstovsek
  • Roy S Chuck
  • Shi you Zhou
  • Douglas B Murphy
  • Jia Min Chen
  • Richard T Silver
  • Jian fan He
  • Sara Fermanian
  • Hong Yang
  • Samantha Herretes
  • Yangyang Chen
  • Hong Wang
  • Hyukjin Lee
  • Christopher G Williams
  • Nicholas Cher
  • Zhenkun Ma
  • Jacques Bara
  • Stefan G Ruehm
  • Stevan W Djuric
  • Xavier Violas
  • Claire Corot
  • Michael J Mitten
  • Philippe Robert
  • Jorg F Debatin
  • Christine Laclédère
  • Mai H Bui
  • Angela M Nilius
  • K C Kim
  • Vincent F La Russa
  • Hana Safah
  • Melanie Ehrlich
  • Sherrie Price
  • Liang Cheng Li
  • Qi Jin
  • Marilyn Li

Detail Information

Publications27

  1. pmc The study of abnormal bone development in the Apert syndrome Fgfr2+/S252W mouse using a 3D hydrogel culture model
    Fan Yang
    Department of Chemical Engineering, Massachusetts Institute of Technology, 45 Carleton Street, E25 342, Cambridge, MA 02142, USA
    Bone 43:55-63. 2008
    ..Complementary to in vivo findings, this 3D hydrogel culture system provides an effective in vitro venue to study the pathogenesis of Apert syndrome caused by the analogous mutation in humans...
  2. pmc High throughput optimization of stem cell microenvironments
    Fan Yang
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Comb Chem High Throughput Screen 12:554-61. 2009
    ..In contrast to conventional approaches, screening combinatorial libraries can result in the discovery of unexpected material solutions to these complex problems...
  3. pmc Combinatorial extracellular matrices for human embryonic stem cell differentiation in 3D
    Fan Yang
    David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 45 Carleton Street, E25 342, Cambridge, Massachusetts 02139, USA
    Biomacromolecules 11:1909-14. 2010
    ..The 3D matrices described herein may provide a useful platform for studying the interactive ECM signaling in influencing stem cell differentiation...
  4. pmc Genetic engineering of human stem cells for enhanced angiogenesis using biodegradable polymeric nanoparticles
    Fan Yang
    Department of Chemical Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:3317-22. 2010
    ..These results indicate that stem cells engineered with biodegradable polymer nanoparticles may be therapeutic tools for vascularizing tissue constructs and treating ischemic disease...
  5. pmc Delivery of small interfering RNA for inhibition of endothelial cell apoptosis by hypoxia and serum deprivation
    Seung Woo Cho
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biochem Biophys Res Commun 376:158-63. 2008
    ..The present study demonstrates that TNFR-1 and SHP-1 may be useful targets for the treatment of myocardial or hindlimb ischemia...
  6. pmc Chondrogenesis and mineralization during in vitro culture of human mesenchymal stem cells on three-dimensional woven scaffolds
    Christoffer K Abrahamsson
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Tissue Eng Part A 16:3709-18. 2010
    ..These findings merit consideration when developing grafts for osteochondral defect repair...
  7. ncbi request reprint Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse
    Yingli Wang
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Development 132:3537-48. 2005
    ..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype...
  8. ncbi request reprint Bioresponsive phosphoester hydrogels for bone tissue engineering
    Dong An Wang
    Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland 21218, USA
    Tissue Eng 11:201-13. 2005
    ..In summary, phosphate-PEG-derived hydrogels increase gene expression of bone-specific markers, secretion of bone-related matrix, and mineralization and may have a potential impact on bone-engineering therapies...
  9. ncbi request reprint The effect of incorporating RGD adhesive peptide in polyethylene glycol diacrylate hydrogel on osteogenesis of bone marrow stromal cells
    Fan Yang
    Department of Biomedical Engineering, Johns Hopkins University, 3400 North Charles Street Clark Hall 106, Baltimore, MD 21218, USA
    Biomaterials 26:5991-8. 2005
    ..In conclusion, we have demonstrated that RGD-conjugated PEODA hydrogel promotes the osteogenesis of MSCs in a dosage-dependent manner, with 2.5 mm being optimal concentration...
  10. doi request reprint Inhibition of a novel sperm gelatinase in prawn sperm by the male reproduction-related Kazal-type peptidase inhibitor
    Ye Li
    Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Zijingang Campus, Hangzhou, Zhejiang, PR China
    Mol Reprod Dev 75:1327-37. 2008
    ..The data presented in this study provided evidence that MRPINK has an inhibitory effect on the gelatinolytic activity as well as proteolytic activity of prawn sperm and specifically blocks the activity of MSG...
  11. doi request reprint The DNA methyltransferase-2 gene in the prawn Macrobrachium rosenbergii: characteristics and expression patterns during ovarian and embryonic development
    Chen Zhuo Feng
    Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Zijingang Campus, Hangzhou, Zhejiang 310058, PR China
    Zoolog Sci 24:1059-65. 2007
    ..Moreover, Mar-Dnmt2 mRNA obviously decreased during embryonic development. On the other hand, DNA methylation was detected in this study; about 0.05% of cytosine residues were found to be methylated in the DNA of M. rosenbergii...
  12. doi request reprint Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo
    Yan Dong Wang
    Department of Gene Regulation and Drug Discovery, Beckman Research Institute of City of Hope National Medical Center, Duarte, CA 91010, USA
    Mol Endocrinol 22:1622-32. 2008
    ..In conclusion, our results suggest a novel role of FXR in modulating liver cell apoptosis...
  13. doi request reprint Identification of the orotidine-5'-monophosphate decarboxylase gene of the oleaginous yeast Rhodosporidium toruloides
    Fan Yang
    Division of Biotechnology, Dalian Institute of Chemical Physics, CAS, Dalian 116023, People s Republic of China
    Yeast 25:623-30. 2008
    ..cerevisiae...
  14. doi request reprint Efficient inhibition of ovarian cancer growth and prolonged survival by transfection with a novel pro-apoptotic gene, hPNAS-4, in a mouse model. In vivo and in vitro results
    Fan Yang
    Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, PR China
    Oncology 75:137-44. 2008
    ..We transfected ovarian cancer cells and administered recombinant plasmid encoding hPNAS-4 to nude mice bearing ovarian cancer, aiming to evaluate the effect of hPNAS-4 against ovarian cancer in vitro and in vivo...
  15. ncbi request reprint [Study of growth inhibition of lung cancer cells by siRNA targeting mutant K-ras gene in vitro and in vivo]
    Zhi Ping Zhang
    Department of Thoracic Surgery, Peking University People s Hospital, Beijing 100044, China
    Zhonghua Wai Ke Za Zhi 45:1267-70. 2007
    ..To study the inhibitory effect of mutant K-ras gene depletion by small interfering RNA on the growth of lung cancer cell line-H441 cells in vitro and in vivo...
  16. ncbi request reprint Hematopoietic effect of fractions from the enzyme-digested colla corii asini on mice with 5-fluorouracil induced anemia
    Hongzhong Wu
    State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
    Am J Chin Med 35:853-66. 2007
    ..Identification of a specific peptide or protein is still required for the development of a novel medicine for anemia caused by malignancy or chemotherapy...
  17. ncbi request reprint Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides
    Xenia Beebe
    Infectious Disease Research, Abbott Laboratories, Abbott Park, IL 60064, USA
    Bioorg Med Chem Lett 14:2417-21. 2004
    ..A series of novel 6-O-arylpropargyl-9-oxime-ketolides was synthesized and evaluated against various pathogens. These new compounds show promising in vitro antibacterial potency and in vivo efficacy against macrolide resistant strains...
  18. ncbi request reprint [Nucleotides sequence analysis of EV71 Chinese strain SHZH98 3C segment]
    Ya Qing He
    Department of Microbiology, Shenzhen Centen Center for Disease Control and Prevention, Shenzhen 518020, China
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 17:354-7. 2003
    ..To study the EV71 Chinese strain SHZH98 and analyze its genetic evolution using 3c gene as index...
  19. ncbi request reprint Dark lumen magnetic resonance colonography in a rodent polyp model: initial experience and demonstration of feasibility
    Christoph U Herborn
    Department of Diagnostic and Interventional Radiology, University Hospital Essen, Germany
    Invest Radiol 39:723-7. 2004
    ..We sought to assess dark lumen magnetic resonance (MR) colonography for the detection of colon polyps in a rodent model with histology as the gold standard...
  20. ncbi request reprint Molecular cloning of Clock cDNA from the prawn, Macrobrachium rosenbergii
    Jin Shu Yang
    College of Life Sciences, Zhejiang University, 232 Wensan Road, Hangzhou, Zhejiang 310012, People s Republic of China
    Brain Res 1067:13-24. 2006
    ..No expression change was found under constant light (LL) or in heart and muscle...
  21. ncbi request reprint Metabolic changes in mesenchymal stem cells in osteogenic medium measured by autofluorescence spectroscopy
    Johann M G Reyes
    Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland 21117, USA
    Stem Cells 24:1213-7. 2006
    ..MSC metabolism increased upon placement in differentiating medium and with increasing cell density and contact. Redox fluorometry is a feasible, noninvasive technique for distinguishing MSCs from further differentiated cells...
  22. pmc An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions
    Zeyu Xiong
    Department of Pharmacology, Temple University School of Medicine, 3420 North Broad Street, Philadelphia, PA 19140, USA
    J Immunol 177:4907-16. 2006
    ..The eliciting antitumor immune response against unconventional Ag MPD6 in patients with myeloproliferative diseases suggests MPD6 as a potential target of novel immunotherapy...
  23. ncbi request reprint Knockdown of mutant K-ras expression by adenovirus-mediated siRNA inhibits the in vitro and in vivo growth of lung cancer cells
    Zhiping Zhang
    Department of Thoracic Surgery, People s Hospital, Peking University, Beijing, PR, China
    Cancer Biol Ther 5:1481-6. 2006
    ..These results indicate that adenovirus-mediated siRNA can specifically and efficiently target factors whose expression is altered in malignancy and may have the potential as a therapeutic modality to treat human lung cancer...
  24. ncbi request reprint [Study on the rapid detection of Dengue viruses by Taqman MGB real-time fluorescent PCR]
    Jian Jun Liu
    Shenzhen Center for Disease Control and Prevention, Shenzhen 518020, China
    Wei Sheng Yan Jiu 35:736-8. 2006
    ..To develop the Taqman MGB real-time fluorescent PCR assay for rapid detection of Dengue viruses...
  25. ncbi request reprint Prawn lipocalin: characteristics and expressional pattern in subepidermal adipose tissue during reproductive molting cycle
    Mo Ran Wang
    Institute of Cell Biology and Genetics, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang, 310058 PR China
    Comp Biochem Physiol B Biochem Mol Biol 147:222-9. 2007
    ....
  26. ncbi request reprint Studies on the cell-immunosuppressive mechanism of Oridonin from Isodon serra
    Jianwen Liu
    State Key Laboratory of Bioreactor Engineering and School of Pharmacy, East China University of Science and Technology, Shanghai 200237, PR China
    Int Immunopharmacol 7:945-54. 2007
    ....
  27. ncbi request reprint Imatinib (ST1571) provides only limited selectivity for CML cells and treatment might be complicated by silent BCR-ABL genes
    Guanchao Jiang
    Tulane Cancer Center and Humon Genetics Program, Tulane Medical School, New Orleans, Lousiana 70112, USA
    Cancer Biol Ther 2:103-8. 2003
    ..Our results indicate that IM is only partially specific for CML progenitor cells compared to normal hematopoietic progenitor cells and suggest that some CML cells may have a silent BCR-ABL oncogene that could interfere with therapy...