Zhongcong Xie

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation
    Yuanlin Dong
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 7:e39386. 2012
  2. pmc Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization
    Yiying Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e27019. 2011
  3. ncbi request reprint Sevoflurane inhibits neurogenesis and the Wnt-catenin signaling pathway in mouse neural progenitor cells
    Y Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Room 4310, Charlestown, MA 02129 2060, USA
    Curr Mol Med 13:1446-54. 2013
  4. pmc General anesthetics and β-amyloid protein
    Zhongcong Xie
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 4310, Charlestown, MA 02129, United States Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 47:140-6. 2013
  5. pmc Cerebrospinal fluid aβ to tau ratio and postoperative cognitive change
    Zhongcong Xie
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Ann Surg 258:364-9. 2013
  6. ncbi request reprint Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons
    Y Dong
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    Curr Mol Med 13:488-98. 2013
  7. pmc RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing
    Zhongcong Xie
    Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    Transl Neurodegener 1:8. 2012
  8. pmc Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore
    Yiying Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Room 4310, Charlestown, MA, 02129 2060, USA
    Med Gas Res 2:20. 2012
  9. pmc The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo
    Zhongcong Xie
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Ann Neurol 64:618-27. 2008
  10. ncbi request reprint Alzheimer's disease and post-operative cognitive dysfunction
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street M3725, Charlestown, MA 02129 4404, USA
    Exp Gerontol 41:346-59. 2006

Collaborators

Detail Information

Publications53

  1. pmc Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aβ generation
    Yuanlin Dong
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 7:e39386. 2012
    ..These findings will promote more studies to determine the effects of anesthetics on tau phosphorylation...
  2. pmc Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aβ oligomerization
    Yiying Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, United States of America
    PLoS ONE 6:e27019. 2011
    ....
  3. ncbi request reprint Sevoflurane inhibits neurogenesis and the Wnt-catenin signaling pathway in mouse neural progenitor cells
    Y Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Room 4310, Charlestown, MA 02129 2060, USA
    Curr Mol Med 13:1446-54. 2013
    ..Ultimately these efforts would lead to safer anesthesia care and better postoperative outcomes in children. ..
  4. pmc General anesthetics and β-amyloid protein
    Zhongcong Xie
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Room 4310, Charlestown, MA 02129, United States Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 47:140-6. 2013
    ..We further discuss the future direction of the research determining the effects of anesthetics on β-amyloid protein accumulation. ..
  5. pmc Cerebrospinal fluid aβ to tau ratio and postoperative cognitive change
    Zhongcong Xie
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Ann Surg 258:364-9. 2013
    ..Determination of biomarker and neuropathogenesis of postoperative cognitive change (POCC) or postoperative cognitive dysfunction...
  6. ncbi request reprint Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons
    Y Dong
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    Curr Mol Med 13:488-98. 2013
    ..These findings will encourage further studies to determine the underlying mechanism by which isoflurane and other anesthetics promote Alzheimer's disease neuropathogenesis and induce cognitive dysfunction...
  7. pmc RNAi-mediated knock-down of Dab and Numb attenuate Aβ levels via γ-secretase mediated APP processing
    Zhongcong Xie
    Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    Transl Neurodegener 1:8. 2012
    ..g. Notch, might be avoided...
  8. pmc Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore
    Yiying Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Room 4310, Charlestown, MA, 02129 2060, USA
    Med Gas Res 2:20. 2012
    ..abstract:..
  9. pmc The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo
    Zhongcong Xie
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Ann Neurol 64:618-27. 2008
    ..However, the in vivo relevance has not been addressed...
  10. ncbi request reprint Alzheimer's disease and post-operative cognitive dysfunction
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street M3725, Charlestown, MA 02129 4404, USA
    Exp Gerontol 41:346-59. 2006
    ..More studies to assess the potential relationship between anesthesia/surgery and AD dementia are, therefore, urgently needed...
  11. pmc RNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation
    Yuanlin Dong
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060 USA
    Med Gas Res 1:5. 2011
    ..abstract:..
  12. pmc Nitrous oxide plus isoflurane induces apoptosis and increases beta-amyloid protein levels
    Yu Zhen
    Department of Anesthesia, Critical Care and Pain Medicine, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    Anesthesiology 111:741-52. 2009
    ..The authors set out to assess the effects of nitrous oxide and/or isoflurane on apoptosis and beta-amyloid (Abeta) levels in H4 human neuroglioma cells and primary neurons from naïve mice...
  13. pmc The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions
    Bin Zhang
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    J Biol Chem 283:11866-75. 2008
    ..Pending in vivo confirmation, these data may have profound implications for anesthesia care in elderly patients, and especially those with AD...
  14. ncbi request reprint The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 4404, USA
    Anesthesiology 104:988-94. 2006
    ....
  15. ncbi request reprint The inhalation anesthetic isoflurane induces a vicious cycle of apoptosis and amyloid beta-protein accumulation
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Charlestown, Massachusetts 02129 2060, USA
    J Neurosci 27:1247-54. 2007
    ..Accumulation of aggregated Abeta in the media can then promote apoptosis. The result is a vicious cycle of isoflurane-induced apoptosis, Abeta generation and aggregation, and additional rounds of apoptosis, leading to cell death...
  16. pmc The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels
    Yuanlin Dong
    Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Arch Neurol 66:620-31. 2009
    ..Subjects Naive mice, H4 human neuroglioma cells, and H4 human neuroglioma cells stably transfected to express full-length amyloid precursor protein...
  17. ncbi request reprint RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    J Biol Chem 282:4318-25. 2007
    ..These findings suggest that pharmacologically blocking interaction of APP with ShcC and Fe65 may provide novel therapeutic strategies against AD...
  18. pmc The mitochondrial pathway of anesthetic isoflurane-induced apoptosis
    Yiying Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    J Biol Chem 285:4025-37. 2010
    ..These findings, which have identified at least partially the molecular mechanism by which isoflurane induces apoptosis, will promote more studies aimed at studying the potential neurotoxic effects of anesthetics...
  19. pmc Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment
    Xia Shen
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    Anesthesiology 118:502-15. 2013
    ..The authors therefore have established an animal model with single versus multiple exposures of anesthetic(s) in young versus adult mice, aiming to distinguish the role of different types of anesthesia in cognitive impairment...
  20. ncbi request reprint Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion
    Mikko Hiltunen
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Biol Chem 281:32240-53. 2006
    ..These findings suggest that changes in UBQLN1 steady-state levels affect APP trafficking and processing, thereby influencing the generation of Abeta...
  21. ncbi request reprint Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory
    Yiying Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA
    Ann Neurol 71:687-98. 2012
    ..However, the in vivo relevance, underlying mechanisms, and functional consequences of these findings remain largely to be determined...
  22. ncbi request reprint Hypocapnia induces caspase-3 activation and increases Abeta production
    Zhongcong Xie
    Genetics and Aging Research Unit, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129 4404, USA
    Neurodegener Dis 1:29-37. 2004
    ..Mutant forms of PS1 have been shown to sensitize cells to apoptotic cell death...
  23. pmc Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine
    Guohua Zhang
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    J Neurosci 28:4551-60. 2008
    ....
  24. pmc The potential dual effects of anesthetic isoflurane on Aβ-induced apoptosis
    Zhipeng Xu
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    Curr Alzheimer Res 8:741-52. 2011
    ..These findings would lead to more systematic studies to determine the potential dual effects of anesthetics on AD-associated neurotoxicity...
  25. pmc 2-Deoxy-D-glucose attenuates isoflurane-induced cytotoxicity in an in vitro cell culture model of H4 human neuroglioma cells
    Jun Zhang
    Geriatric Anesthesia Research Unit, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Room 4310, Charlestown, MA 02129 2060, USA
    Anesth Analg 113:1468-75. 2011
    ..Therefore, we sought to determine whether 2-DG can reduce caspase-3 activation and the increase in the levels of BACE and reactive oxygen species (ROS) induced by isoflurane...
  26. ncbi request reprint RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 4404, USA
    J Biol Chem 280:15413-21. 2005
    ..g. Notch, might be avoided...
  27. ncbi request reprint Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1
    Zhongcong Xie
    MassGeneral Institute for Neurodegenerative Disease, Department of NeurologyMassachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    J Mol Neurosci 25:67-77. 2005
    ..In summary, the metabolism of wt-PS1 and FAD-linked Delta9-PS1 is specifically and differentially affected by loss of function of PEN-2...
  28. pmc Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice
    Hui Zheng
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Anesthesiology 118:516-26. 2013
    ..The authors set out to assess the effects of the anesthetic sevoflurane on neurotoxicity in pregnant mice and on learning and memory in fetal and offspring mice...
  29. pmc The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-α, IL-6, and IL-1β
    Xu Wu
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    Neurobiol Aging 33:1364-78. 2012
    ..These results suggest that isoflurane may increase the levels of proinflammatory cytokines, which may cause neuroinflammation, leading to promotion of AD neuropathogenesis...
  30. pmc Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice
    Yan Lu
    Geriatric Anesthesia Research Unit, Departmentof Anesthesia, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    Anesthesiology 112:1404-16. 2010
    ....
  31. ncbi request reprint Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 4404, USA
    J Gerontol A Biol Sci Med Sci 61:1300-6. 2006
    ....
  32. pmc Peripheral surgical wounding and age-dependent neuroinflammation in mice
    Zhipeng Xu
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts
    PLoS ONE 9:e96752. 2014
    ..Pending further studies, anti-inflammatory therapies may reduce the risk of postoperative cognitive dysfunction in elderly patients. ..
  33. pmc Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice
    Zhipeng Xu
    1 Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060 2
    Sci Rep 4:3766. 2014
    ..These findings would likely promote more research to investigate the pathogenesis of POCD. ..
  34. pmc Sleep disturbance induces neuroinflammation and impairment of learning and memory
    Biao ZHu
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129 2060, USA
    Neurobiol Dis 48:348-55. 2012
    ..Pending further studies, these findings suggest that sleep disturbance-induced neuroinflammation and impairment of learning and memory may contribute to the development of cognitive function decline in hospitalized patients...
  35. pmc The potential dual effects of anesthetic isoflurane on hypoxia-induced caspase-3 activation and increases in β-site amyloid precursor protein-cleaving enzyme levels
    Chuxiong Pan
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, 149 13th St, Room 4310, Charlestown, MA 02129 2060, USA
    Anesth Analg 113:145-52. 2011
    ..We therefore sought to determine whether isoflurane can induce concentration-dependent dual effects on hypoxia-induced caspase-3 activation and increases in BACE levels: protection versus promotion...
  36. pmc Isoflurane decreases self-renewal capacity of rat cultured neural stem cells
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 115:754-63. 2011
    ..In models, isoflurane produces neural and behavioral deficits in vitro and in vivo. This study tested the hypothesis that neural stem cells are adversely affected by isoflurane such that it inhibits proliferation and kills these cells...
  37. pmc The effects of isoflurane and desflurane on cognitive function in humans
    Bin Zhang
    Department of Anesthesia, Capital Medical University, Beijing, People s Republic of China
    Anesth Analg 114:410-5. 2012
    ..However, the functional consequences of these effects have not been assessed. We therefore performed a pilot study to determine the effects of isoflurane and desflurane on cognitive function in humans...
  38. ncbi request reprint Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production
    Donna M Romano
    Department of Neurology, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, MA 02129 2060, USA
    Amyloid 13:86-92. 2006
    ....
  39. ncbi request reprint Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes
    Airong Li
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02128, USA
    Hum Mol Genet 16:2626-39. 2007
    ..Collectively, these data support in vivo functional interaction between UBQLN1 and the AD-associated genes, presenilin and APP, and provide further clues regarding the potential role of UBQLN1 in AD pathogenesis...
  40. doi request reprint Brief review: anesthetic neurotoxicity in the elderly, cognitive dysfunction and Alzheimer's disease
    Edward A Bittner
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129 2060, USA
    Can J Anaesth 58:216-23. 2011
    ..In this review, we summarize the evidence for anesthesia-induced neurotoxicity in the elderly, while highlighting the limitations of existing data, and we put the literature into perspective for the clinician...
  41. pmc Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitive impairment induced by isoflurane in aged mice
    Xiao min Li
    From the Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China X M L, M H J, G F Z, L L Q, M J, J J Y Department of Anesthesiology, Affiliate Hospital, Shandong Medical University of Traditional Chinese Medicine, Jinan, China F S Departments of Neurobiology and Pharmacology, Key Laboratory for Neurodegenerative Disease of Jiangsu Province, Nanjing Medical University, Nanjing, China J G and Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts Z X
    Anesthesiology 121:79-88. 2014
    ..The authors hypothesized that hippocampal NRG1-ErbB4 signaling is involved in isoflurane-induced cognitive impairments in aged mice...
  42. ncbi request reprint Neurotoxicity of general anesthetics: an update
    Phillip Vlisides
    Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    Curr Pharm Des 18:6232-40. 2012
    ....
  43. ncbi request reprint Altered hippocampal gene expression 2 days after general anesthesia in rats
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, MA, 02115, USA
    Eur J Pharmacol 549:71-8. 2006
    ..These results demonstrate that in rats general anesthesia is associated with persistent changes in hippocampal gene expression, suggesting that recovery of the brain from anesthesia is considerably slower than generally recognized...
  44. ncbi request reprint Inflammatory pain may induce cognitive impairment through an interlukin-6-dependent and postsynaptic density-95-associated mechanism
    Longqiu Yang
    From the Department of Anaesthesia, Critical Care and Pain Medicine, Geriatric Anaesthesia Research Unit, Massachusetts General Hospital of Harvard Medical School, Charlestown, Massachusetts
    Anesth Analg 119:471-80. 2014
    ..We therefore sought to establish a system to determine the effect of pain on cognitive function in mice...
  45. pmc Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice
    Haijun Shao
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P R China
    J Alzheimers Dis 41:499-513. 2014
    ....
  46. pmc Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA receptor 2B in mice
    Xiaoqin Zhang
    Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, 02129 2060, Department of Anesthesia, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, P R China, Department of Anesthesia, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P R China, and Massachusetts General Hospital Center for Translational Pain Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129 2060
    J Neurosci 33:17737-48. 2013
    ..These findings call for further investigation to determine the role of surgical incision-induced nociception in POCD. ..
  47. pmc Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults
    Arvind Palanisamy
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 114:521-8. 2011
    ..This study tested the hypothesis that fetal rats exposed to isoflurane during maternal anesthesia on gestational day 14, which corresponds to the second trimester in humans, would be behaviorally abnormal as adults...
  48. pmc Amyloid-β production via cleavage of amyloid-β protein precursor is modulated by cell density
    Can Zhang
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Diseases, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Alzheimers Dis 22:683-984. 2010
    ..g., novel drugs on AβPP processing and Aβ generation in cell-based systems. Moreover, it is interesting to speculate whether cell density changes in vivo may also affect AβPP processing and Aβ levels in the AD brain...
  49. ncbi request reprint Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery
    Deborah J Culley
    Harvard Medical School, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Anesthesiology 106:836-42. 2007
  50. ncbi request reprint Academic productivity of directors of ACGME-accredited residency programs in surgery and anesthesiology
    Deborah J Culley
    From the Department of Anesthesiology, Brigham and Women s Hospital, Boston, Massachusetts Department of Anesthesiology, University of Florida College of Medicine, Gainesville, Florida Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Department of Anesthesia and Perioperative Care, University of California at San Francisco, San Francisco, California and Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts
    Anesth Analg 118:200-5. 2014
    ....
  51. ncbi request reprint General anesthetic-induced neurotoxicity: an emerging problem for the young and old?
    Deborah J Culley
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Curr Opin Anaesthesiol 20:408-13. 2007
    ..We review this evidence and put the studies into perspective for the practicing clinician...
  52. ncbi request reprint Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation
    Zhongcong Xie
    Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129 2060, USA
    J Biol Chem 279:34130-7. 2004
    ..Collectively, these findings indicate that cellular sensitivity to caspase activation correlates with overall PS1 protein levels, particularly with levels of FL-PS1...
  53. ncbi request reprint Differential changes of alveolar gas concentrations during anesthetic induction of a patient with an absent right pulmonary artery
    Yandong Jiang
    Department of Anesthesia and Critical Care, 55 Fruit Street, CLN 309, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Anesth Analg 103:312-5, table of contents. 2006
    ..In conclusion, we report the rare case of unilateral pulmonary artery agenesis with systemic arterial collateralization and characterize the differences in gas exchange...

Research Grants6

  1. Functional Analysis of Alzheimer's Disease Genes
    Zhongcong Xie; Fiscal Year: 2007
    ..These studies should ultimately facilitate the development of strategies for prevention and treatment of AD. ..
  2. General Anesthesia and Alzheimer's Disease Neuropathogenesis
    Zhongcong Xie; Fiscal Year: 2010
    ..In the proposed research we will further characterize these effects and determine their up-stream mechanisms and down-stream consequences. ..
  3. General Anesthesia and Alzheimer's Disease Neuropathogenesis
    Zhongcong Xie; Fiscal Year: 2009
    ..In the proposed research we will further characterize these effects and determine their up-stream mechanisms and down-stream consequences. ..
  4. General Anesthesia and Alzheimer's Disease Neuropathogenesis
    Zhongcong Xie; Fiscal Year: 2010
    ..In the proposed research we will further characterize these effects and determine their up-stream mechanisms and down-stream consequences. ..