Richard Wurtman

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. doi request reprint A Nutrient Combination that Can Affect Synapse Formation
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Mass Ave, 46 5009, Cambridge, MA 02139, USA
    Nutrients 6:1701-10. 2014
  2. pmc Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats
    Nick van Wijk
    Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition, PO Box 7005, 6700 CA, Wageningen, The Netherlands
    Nutr Metab (Lond) 9:49. 2012
  3. doi request reprint Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Metabolism 62:S27-9. 2013
  4. ncbi request reprint Effect of oral CDP-choline on plasma choline and uridine levels in humans
    R J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biochem Pharmacol 60:989-92. 2000
  5. pmc Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Metabolism 57:S6-10. 2008
  6. ncbi request reprint Narcolepsy and the hypocretins
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Metabolism 55:S36-9. 2006
  7. ncbi request reprint Genes, stress, and depression
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, and Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02139, USA
    Metabolism 54:16-9. 2005
  8. ncbi request reprint Ramelteon: a novel treatment for the treatment of insomnia
    Richard Wurtman
    Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 46 5023B, 43 Vassar Street, Cambridge, MA 02139, USA
    Expert Rev Neurother 6:957-64. 2006
  9. ncbi request reprint Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides
    R J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Nutr Health Aging 13:189-97. 2009
  10. doi request reprint Use of phosphatide precursors to promote synaptogenesis
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Nutr 29:59-87. 2009

Research Grants

  1. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 2003
  2. NEURAL AND ENDOCRINE REGULATION OF BRAIN AND BEHAVIOR
    Richard Wurtman; Fiscal Year: 2003
  3. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 2007
  4. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 1980

Collaborators

Detail Information

Publications46

  1. doi request reprint A Nutrient Combination that Can Affect Synapse Formation
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Mass Ave, 46 5009, Cambridge, MA 02139, USA
    Nutrients 6:1701-10. 2014
    ....
  2. pmc Combined dietary folate, vitamin B-12, and vitamin B-6 intake influences plasma docosahexaenoic acid concentration in rats
    Nick van Wijk
    Nutricia Advanced Medical Nutrition, Danone Research, Centre for Specialised Nutrition, PO Box 7005, 6700 CA, Wageningen, The Netherlands
    Nutr Metab (Lond) 9:49. 2012
    ..abstract:..
  3. doi request reprint Personalized medicine strategies for managing patients with parkinsonism and cognitive deficits
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Metabolism 62:S27-9. 2013
    ....
  4. ncbi request reprint Effect of oral CDP-choline on plasma choline and uridine levels in humans
    R J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biochem Pharmacol 60:989-92. 2000
    ..Hence, it seems likely that the circulating substrates through which oral citicoline increases membrane phosphatide synthesis in the brains of humans involve uridine and choline, and not cytidine and choline as in rats...
  5. pmc Synapse formation and cognitive brain development: effect of docosahexaenoic acid and other dietary constituents
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Metabolism 57:S6-10. 2008
    ..It is proposed that these substances are part of a regulatory mechanism through which plasma composition influences brain development...
  6. ncbi request reprint Narcolepsy and the hypocretins
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Metabolism 55:S36-9. 2006
    ..The association of narcolepsy with a deficiency in a specific neurotransmitter, in this case, hypocretin, is reminiscent of the associations between Parkinson disease and dopamine, or early Alzheimer disease and acetylcholine...
  7. ncbi request reprint Genes, stress, and depression
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, and Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02139, USA
    Metabolism 54:16-9. 2005
    ..It may be asked whether people who lack a psychiatric history should be advised to avoid stressful environments if they are found to carry the SS or SL alleles...
  8. ncbi request reprint Ramelteon: a novel treatment for the treatment of insomnia
    Richard Wurtman
    Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 46 5023B, 43 Vassar Street, Cambridge, MA 02139, USA
    Expert Rev Neurother 6:957-64. 2006
    ..No comparison study has been performed to determine whether the recommended dose of ramelteon 8 mg has any advantage over physiologic doses of melatonin (0.3 mg), particularly for long-term use...
  9. ncbi request reprint Synapse formation is enhanced by oral administration of uridine and DHA, the circulating precursors of brain phosphatides
    R J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    J Nutr Health Aging 13:189-97. 2009
    ..A treatment that increased the formation of neurites and dendritic spines might reverse this loss, thereby increasing the number of synapses and slowing the decline in cognition...
  10. doi request reprint Use of phosphatide precursors to promote synaptogenesis
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Annu Rev Nutr 29:59-87. 2009
    ..A preparation containing these compounds is being tested for treating Alzheimer's disease...
  11. doi request reprint Non-nutritional uses of nutrients
    Richard J Wurtman
    Massachusetts Institute of Technology, 77 Mass Ave, Cambridge, MA 02139, USA
    Eur J Pharmacol 668:S10-5. 2011
    ..Nutrient mixtures chosen for their pharmacologic effects (and general lack of serious side-effects) are presently used for ameliorating several conditions, and more such uses can be anticipated...
  12. pmc Nutritional modifiers of aging brain function: use of uridine and other phosphatide precursors to increase formation of brain synapses
    Richard J Wurtman
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nutr Rev 68:S88-101. 2010
    ..If similar increases occur in human brain, administration of these compounds to patients with diseases that cause loss of brain synapses, such as Alzheimer's disease, could be beneficial...
  13. ncbi request reprint Effects of normal meals rich in carbohydrates or proteins on plasma tryptophan and tyrosine ratios
    Richard J Wurtman
    Clinical Research Center, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139, USA
    Am J Clin Nutr 77:128-32. 2003
    ..Although carbohydrate-rich, protein-free formula diets have been shown to elevate, and high-protein diets to depress, the tryptophan-LNAA ratio, few data are available about this ratio's responses to actual meals...
  14. doi request reprint Fibromyalgia and the complex regional pain syndrome: similarities in pathophysiology and treatment
    Richard J Wurtman
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Metabolism 59:S37-40. 2010
    ..Ketamine's widespread illegal use as a recreational agent probably precludes developing it as a general treatment of centrally mediated pain disorders; however, its efficacy suggests that related, to-be-discovered agents could be useful...
  15. ncbi request reprint Synaptic proteins and phospholipids are increased in gerbil brain by administering uridine plus docosahexaenoic acid orally
    Richard J Wurtman
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 43 Vassar Street, 46 5023B MIT, Cambridge, MA 02139, USA
    Brain Res 1088:83-92. 2006
    ..Alzheimer's disease brains contain fewer and smaller synapses and reduced levels of synaptic proteins, membrane phosphatides, choline and DHA. The three phosphatide precursors might thus be useful in treating this disease...
  16. pmc Dietary uridine enhances the improvement in learning and memory produced by administering DHA to gerbils
    Sarah Holguin
    Massachusetts Institute of Technology, 43 Vassar St, 46 5023, Cambridge, MA 02139, USA
    FASEB J 22:3938-46. 2008
    ..These findings demonstrate that a treatment that increases synaptic membrane content can enhance cognitive functions in normal animals...
  17. pmc Oral administration of circulating precursors for membrane phosphatides can promote the synthesis of new brain synapses
    Mehmet Cansev
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    Alzheimers Dement 4:S153-68. 2008
    ..Conceivably, this treatment might have use in patients with the synaptic loss that characterizes Alzheimer's disease or other neurodegenerative diseases or occurs after stroke or brain injury...
  18. doi request reprint Giving uridine and/or docosahexaenoic acid orally to rat dams during gestation and nursing increases synaptic elements in brains of weanling pups
    Mehmet Cansev
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, USA
    Dev Neurosci 31:181-92. 2009
    ..Administering these phosphatide precursors to lactating mothers or infants could be useful for treating developmental disorders characterized by deficient synapses...
  19. ncbi request reprint The effect of a novel dietary intervention on weight loss in psychotropic drug-induced obesity
    Judith J Wurtman
    TRIAD Weight Management Center, McLean Hospital, Belmont, Mass, USA
    Psychopharmacol Bull 36:55-9. 2002
    ..001). A treatment program that included a high carbohydrate dietary supplement caused as much weight loss among patients on psychotropic drugs as among control obese patients, without blocking the drugs' therapeutic effects...
  20. ncbi request reprint Dietary cytidine (5')-diphosphocholine supplementation protects against development of memory deficits in aging rats
    Lisa A Teather
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 45 Carleton Street, E25 604, Cambridge, MA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:711-7. 2003
    ..These findings suggest that early-aged rats display a selective impairment in hippocampal-dependent long-term memory, and that dietary CDP-choline supplementation can protect against this deficit...
  21. ncbi request reprint Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes
    Lisa A Teather
    Department of Brain and Cognitive Science, Massachusetts Institute of Technology 45 Carleton Street, E25 604, Cambridge, MA 02139, USA
    Neurosci Lett 340:177-80. 2003
    ..e. piroxicam and SC-560) failed to significantly do so. These data suggest that COX-2 is responsible for PAF-mediated PGE(2) release in primary astrocytes...
  22. pmc Polyunsaturated fatty acids stimulate phosphatidylcholine synthesis in PC12 cells
    U Ingrid Richardson
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biochim Biophys Acta 1771:558-63. 2007
    ..DHA was preferentially incorporated into phosphatidylethanolamine (PE) and phosphatidylserine (PS), while AA predominated in phosphatidylcholine (PC)...
  23. ncbi request reprint Environmental conditions influence hippocampus-dependent behaviours and brain levels of amyloid precursor protein in rats
    Lisa A Teather
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 45 Carleton Street, Cambridge, MA 02139, USA
    Eur J Neurosci 16:2405-15. 2002
    ....
  24. pmc Oral supplementation with docosahexaenoic acid and uridine-5'-monophosphate increases dendritic spine density in adult gerbil hippocampus
    Toshimasa Sakamoto
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain Res 1182:50-9. 2007
    ..Our findings provide a possible explanation for the effects of DHA on behavior and also suggest a strategy to treat cognitive disorders resulting from synapse loss...
  25. ncbi request reprint Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats
    Lisa A Teather
    Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 45 Carleton Street, E25 604, Cambridge, MA 02139, USA
    Psychopharmacology (Berl) 163:430-3. 2002
    ..Evidence suggests that PAF exerts cellular actions through a plasma membrane receptor as well as via intracellular (microsomal) PAF binding sites...
  26. ncbi request reprint Stimulation of CDP-choline synthesis by uridine or cytidine in PC12 rat pheochromocytoma cells
    U Ingrid Richardson
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain Res 971:161-7. 2003
    ..Hence uridine treatment was unlikely to inhibit the conversion of endogenous CDP-choline to PC. These results suggest the possibility that uridine may also enhance PC synthesis in intact brain...
  27. ncbi request reprint Chronic administration of UMP ameliorates the impairment of hippocampal-dependent memory in impoverished rats
    Lisa A Teather
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Nutr 136:2834-7. 2006
    ..These results suggest that IC rats do not use and/or remember their spatial strategies for task solving as well as EC rats, and that long-term dietary supplementation with UMP alleviates this dysfunction...
  28. pmc Dietary CDP-choline supplementation prevents memory impairment caused by impoverished environmental conditions in rats
    Lisa A Teather
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Learn Mem 12:39-43. 2005
    ....
  29. ncbi request reprint Effect of a 5-HT(2C) serotonin agonist, dexnorfenfluramine, on amyloid precursor protein metabolism in guinea pigs
    Anibal A Arjona
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain Res 951:135-40. 2002
    ..Hence 5-HT(2C) receptors, which apparently are localized to the brain, may represent useful targets for the development of treatments for Alzheimer's disease...
  30. ncbi request reprint Inhibition of platelet-activating factor receptors in hippocampal plasma membranes attenuates the inflammatory nociceptive response in rats
    Lisa A Teather
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Brain Res 1097:230-3. 2006
    ..These findings suggest that hippocampal plasma membrane PAF receptors, but not intracellular PAF binding sites, mediate tonic inflammatory pain processing in rats...
  31. ncbi request reprint Platelet-activating factor increases prostaglandin E(2) release from astrocyte-enriched cortical cell cultures
    Lisa A Teather
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 45 Carleton Street, E25 604 Cambridge, MA 02139, USA
    Brain Res 946:87-95. 2002
    ..Based on the present findings, we hypothesize that intracellular PAF is a physiologic stimulus of PGE(2) production in astrocytes...
  32. doi request reprint Report of two double-blind randomized placebo-controlled pilot studies of a carbohydrate-rich nutrient mixture for treatment of seasonal affective disorder (SAD)
    David Mischoulon
    Clinical Research Center, Massachusetts Institute of Technology, Cambridge, MA, USA
    CNS Neurosci Ther 16:13-24. 2010
    ..The drink mix was well tolerated and treatment adherence was high. Both the active and placebo intervention were effective in alleviating symptoms of SAD. Replication studies in larger samples appear warranted...
  33. ncbi request reprint An animal model of antipsychotic-induced weight gain
    Anibal A Arjona
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, MIT E25 604, 45 Carleton Street, Cambridge, MA 02139, USA
    Behav Brain Res 152:121-7. 2004
    ..These data show that an animal model of OLAN-induced weight gain is readily generated, and suggest that the weight gain results at least in part from increased food intake, reduced gross motor activity, and enhanced feed efficiency...
  34. ncbi request reprint Dietary uridine-5'-monophosphate supplementation increases potassium-evoked dopamine release and promotes neurite outgrowth in aged rats
    Lei Wang
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    J Mol Neurosci 27:137-45. 2005
    ..Hence, UMP treatment not only enhances membrane phosphatide production but also can modulate two membrane-dependent processes, neurotransmitter release and neurite outgrowth, in vivo...
  35. pmc Dietary supplementation with uridine-5'-monophosphate (UMP), a membrane phosphatide precursor, increases acetylcholine level and release in striatum of aged rat
    Lei Wang
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    Brain Res 1133:42-8. 2007
    ..05). These data suggest that giving a uridine source may enhance some cholinergic functions, perhaps by increasing brain phosphatide levels...
  36. ncbi request reprint The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons
    Amy M Pooler
    Department of Brain and Cognitive Sciences, Harvard University Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Neurochem 97:716-23. 2006
    ..These data suggest that pravastatin treatment increases neurite outgrowth and may do so via inhibiting the activity of geranylgeranylated proteins such as RhoA...
  37. pmc Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease
    Mehmet Cansev
    Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, Cambridge, MA 02139, USA
    Neurosci Res 62:206-9. 2008
    ..Hence, giving uridine and DHA may partially restore dopaminergic neurotransmission in this model of Parkinson's disease...
  38. ncbi request reprint A Drosophila temperature-sensitive seizure mutant in phosphoglycerate kinase disrupts ATP generation and alters synaptic function
    Ping Wang
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Neurosci 24:4518-29. 2004
    ..Given the behavioral similarities between disruptions of PGK function in Drosophila and humans, the analysis of nubian animals may reveal conserved neuronal responses associated with altered ATP generation within the brain...
  39. pmc Chronic administration of DHA and UMP improves the impaired memory of environmentally impoverished rats
    Sarah Holguin
    Massachusetts Institute of Technology, Department of Brain and Cognitive Sciences, 43 Vassar Street, 46 5023, Cambridge, MA 02139, USA
    Behav Brain Res 191:11-6. 2008
    ..These findings suggest that giving DHA plus UMP can ameliorate memory deficits associated with rearing under impoverished conditions, and that this effect may be mediated in part through enhanced synthesis of brain membrane phosphatides...
  40. ncbi request reprint Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia
    Amy M Pooler
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neurosci Lett 362:127-30. 2004
    ..These data suggest that PGE2 is able to regulate the expression of APP, and that this effect may be mediated by the EP2 receptor and the cAMP signaling cascade...
  41. ncbi request reprint Oral L-glutamine increases GABA levels in striatal tissue and extracellular fluid
    Lei Wang
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    FASEB J 21:1227-32. 2007
    ..Moreover, the elevation in plasma and brain glutamine associated with hepatic failure may, by increasing brain GABA release, produce some of the manifestations of hepatic encephalopathy...
  42. ncbi request reprint Stress and the adrenocortical control of epinephrine synthesis
    Richard J Wurtman
    Massachusetts Institute of Technology, Cambridge 02139, USA
    Metabolism 51:11-4. 2002
    ..This control mechanism could be involved in the long-term consequences of stress...
  43. ncbi request reprint Effects of exogenous melatonin on sleep: a meta-analysis
    Amnon Brzezinski
    Department of Obstetrics and Gynecology, Hadassah Medical Center, Jerusalem, Israel
    Sleep Med Rev 9:41-50. 2005
    ..The sleep onset results were changed to 3.9 min (95% CI (2.5, 5.4)); sleep efficiency increased to 3.1% (95% CI (0.7, 5.5)); sleep duration increased to 13.7 min (95% CI (3.1, 24.3))...
  44. ncbi request reprint Cytidine and uridine increase striatal CDP-choline levels without decreasing acetylcholine synthesis or release
    Ismail H Ulus
    Department of Pharmacology and Clinical Pharmacology, Uludag University Medical School, Bursa, Turkey
    Cell Mol Neurobiol 26:563-77. 2006
    ..We examined whether adding cytidine or uridine to the slice medium, which increases the utilization of choline to form phospholipids, also decreases acetylcholine levels and release...
  45. ncbi request reprint 5-Hydroxy-L-tryptophan suppresses food intake in food-deprived and stressed rats
    Ahmed Amer
    Department of Pharmaceutical Sciences, Massachusetts College of Pharmacy and Health Sciences, Boston, MA, USA
    Pharmacol Biochem Behav 77:137-43. 2004
    ..5- to 2.3-fold). These observations suggest that 5-HTP may be useful in controlling the excessive food intake sometimes generated by stress, even if given without decarboxylase inhibitors or other drugs...

Research Grants24

  1. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 2003
    ..As before, we will attempt to apply our findings to the treatment of human diseases whenever possible. ..
  2. NEURAL AND ENDOCRINE REGULATION OF BRAIN AND BEHAVIOR
    Richard Wurtman; Fiscal Year: 2003
    ..abstract_text> ..
  3. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 2007
    ..abstract_text> ..
  4. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 1980
    ....