Sean M Wu

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Harnessing the potential of induced pluripotent stem cells for regenerative medicine
    Sean M Wu
    Cardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Boston 02114, Massachusetts, USA
    Nat Cell Biol 13:497-505. 2011
  2. pmc Platypnea-Orthodeoxia Syndrome in Two Previously Healthy Adults: A Case-based Review
    Leon M Ptaszek
    Cardiology Division, Massachusetts General Hospital, Boston, MA 02114
    Clin Med Cardiol 3:37-43. 2009
  3. doi Mesp1 at the heart of mesoderm lineage specification
    Sean M Wu
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 3:1-2. 2008
  4. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
  5. pmc Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation
    Serge Gregoire
    Department of Medicine, Division of Cardiology, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA
    Circ Res 112:900-10. 2013
  6. pmc Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5
    Jenny X Chen
    Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Circ Res 111:50-5. 2012
  7. pmc Generation of functional ventricular heart muscle from mouse ventricular progenitor cells
    Ibrahim J Domian
    Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza, CPZN 3200, 185 Cambridge Street, Boston, MA 02114 2790, USA
    Science 326:426-9. 2009
  8. pmc Isolation and functional characterization of pluripotent stem cell-derived cardiac progenitor cells
    Xiaojing Huang
    Cardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Curr Protoc Stem Cell Biol . 2010
  9. pmc Epigenetic mechanisms in cardiac development and disease
    Marcus Vallaster
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, 02114, USA
    Acta Biochim Biophys Sin (Shanghai) 44:92-102. 2012
  10. pmc Developmental and regenerative biology of multipotent cardiovascular progenitor cells
    Anthony C Sturzu
    CPZN 3224 Simches Building, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Circ Res 108:353-64. 2011

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc Harnessing the potential of induced pluripotent stem cells for regenerative medicine
    Sean M Wu
    Cardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Boston 02114, Massachusetts, USA
    Nat Cell Biol 13:497-505. 2011
    ..We believe that a better understanding of the molecular basis of pluripotency, cellular reprogramming and lineage-specific differentiation of iPSCs is necessary for progress in regenerative medicine...
  2. pmc Platypnea-Orthodeoxia Syndrome in Two Previously Healthy Adults: A Case-based Review
    Leon M Ptaszek
    Cardiology Division, Massachusetts General Hospital, Boston, MA 02114
    Clin Med Cardiol 3:37-43. 2009
    ..Symptoms and positional oxygen desaturation resolved after device placement in both cases. In addition, these patients remain symptom-free 30 months after device implantation...
  3. doi Mesp1 at the heart of mesoderm lineage specification
    Sean M Wu
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Stem Cell 3:1-2. 2008
    ..In this issue of Cell Stem Cell, Lindsley et al. (2008) and Bondue et al. (2008) use embryonic stem cells to identify a key role for Mesp1 in this process...
  4. pmc Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
    Bin Zhou
    Harvard Stem Cell Institute and Department of Cardiology, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nature 454:109-13. 2008
    ..These results identify Wt1(+) epicardial cells as previously unrecognized cardiomyocyte progenitors, and lay the foundation for future efforts to harness the cardiogenic potential of these progenitors for cardiac regeneration and repair...
  5. pmc Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation
    Serge Gregoire
    Department of Medicine, Division of Cardiology, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA
    Circ Res 112:900-10. 2013
    ..Cardiogenesis is regulated by a complex interplay between transcription factors. However, little is known about how these interactions regulate the transition from mesodermal precursors to cardiac progenitor cells (CPCs)...
  6. pmc Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5
    Jenny X Chen
    Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Circ Res 111:50-5. 2012
    ..Direct reprogramming of fibroblasts into cardiomyocytes is a novel strategy for cardiac regeneration. However, the key determinants involved in this process are unknown...
  7. pmc Generation of functional ventricular heart muscle from mouse ventricular progenitor cells
    Ibrahim J Domian
    Cardiovascular Research Center, Massachusetts General Hospital, Charles River Plaza, CPZN 3200, 185 Cambridge Street, Boston, MA 02114 2790, USA
    Science 326:426-9. 2009
    ....
  8. pmc Isolation and functional characterization of pluripotent stem cell-derived cardiac progenitor cells
    Xiaojing Huang
    Cardiovascular Research Center, Division of Cardiology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Curr Protoc Stem Cell Biol . 2010
    ..The protocols described here can be applied to both embryonic and induced pluripotent stem cells and can easily be adapted to transgenic lines carrying other cardiac cell lineage reporters...
  9. pmc Epigenetic mechanisms in cardiac development and disease
    Marcus Vallaster
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, 02114, USA
    Acta Biochim Biophys Sin (Shanghai) 44:92-102. 2012
    ..Furthermore, we speculate that an epigenetic signature, comprised of TF occupancy, histone modifications, and overall chromatin organization, is an underlying mechanism that governs cardiac morphogenesis and disease...
  10. pmc Developmental and regenerative biology of multipotent cardiovascular progenitor cells
    Anthony C Sturzu
    CPZN 3224 Simches Building, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114, USA
    Circ Res 108:353-64. 2011
    ..We believe that a detailed understanding of cardiogenesis will inform future applications of cardiovascular progenitor cells in heart failure therapy and regenerative medicine...
  11. pmc Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm
    Marc C Engels
    Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA Laboratory of Experimental Cardiology, Department of Cardiology, Heart Center Leiden, Leiden University Medical Center, Leiden, The Netherlands
    Stem Cells 32:1493-502. 2014
    ..Insulin or IGF treatment could provide an effective strategy to increase the PSC-based generation of CPCs and cardiomyocytes for applications in regenerative medicine...
  12. pmc Multipotent stem cells in cardiac regenerative therapy
    Ravi Karra
    Brigham and Women s Hospital, Department of Medicine, 75 Francis Street, Boston, MA 02115, USA
    Regen Med 3:189-98. 2008
    ....
  13. ncbi Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart
    Sean M Wu
    Division of Hematology Oncology, Children s Hospital, Boston, MA 02115, USA
    Cell 127:1137-50. 2006
    ..5(+) cells from mouse embryos and demonstrated their capacity for bipotential differentiation in vivo. Taken together, these results support the existence of a common precursor for cardiovascular lineages in the mammalian heart...
  14. pmc Origin of cardiac progenitor cells in the developing and postnatal heart
    Elizabeth N Kuhn
    Cardiovascular Research Center, Cambridge, Massachusetts, USA
    J Cell Physiol 225:321-5. 2010
    ....
  15. pmc Origins and fates of cardiovascular progenitor cells
    Sean M Wu
    Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell 132:537-43. 2008
    ..Elucidating the origins and lineage relationships of these cell populations will accelerate clinical applications such as drug screening and cell therapy as well as shedding light on the pathogenic mechanisms underlying cardiac diseases...
  16. pmc iPS cell modeling of cardiometabolic diseases
    Kenta Nakamura
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Cardiovasc Transl Res 6:46-53. 2013
    ..In this article, we discuss the excitement and challenges of modeling cardiometabolic diseases using iPS cell and their potential to revolutionize translational research...
  17. doi Reprogramming of mouse, rat, pig, and human fibroblasts into iPS cells
    Kuppusamy Rajarajan
    Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Curr Protoc Mol Biol . 2012
    ..This unit describes the procedure for the generation of iPSCs from mouse, rat, pig and human fibroblasts...

Research Grants2

  1. Cardiac Progenitor Cells in Development and Disease
    Sean Wu; Fiscal Year: 2007
    ..In addition they will help to launch the applicant's career as an independent investigator in the Harvard research community. ..