Research Topics
| Christopher I WrightSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Novel fearful faces activate the amygdala in healthy young and elderly adultsChristopher I Wright
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, 13th St, Bldg 149, CNY 2613, Charlestown, MA 02129, USA
Neurobiol Aging 27:361-74. 2006..However, there were significantly greater activations in the inferior temporal cortex in the young versus elderly subjects...- Brain correlates of negative and positive visuospatial priming in adultsChristopher I Wright
Psychiatric Neuroimaging Research Program and Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Neuroimage 30:983-91. 2006..In conjunction with functional MRI, this visuospatial priming task may be useful for studying the pathophysiology of neuropsychiatric disorders in which deficient inhibitory processing or excessive facilitation is a feature... - Neuroanatomical correlates of extraversion and neuroticismChristopher I Wright
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Cereb Cortex 16:1809-19. 2006..In contrast, no such correlations were observed for the volume of the amygdala. The results suggest that specific aspects of regional prefrontal anatomy are associated with specific personality traits... 
Neuroanatomical correlates of personality in the elderlyChristopher I Wright
Laboratory of Aging and Emotion, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Bldg 149, CNY 2628, Charlestown, MA 02129, USA
Neuroimage 35:263-72. 2007..The results suggest differences in the regional neuroanatomic correlates of specific personality traits with aging. We speculate that this relates to the influences of age-related structural changes in the PFC...- A functional magnetic resonance imaging study of amygdala responses to human faces in aging and mild Alzheimer's diseaseChristopher I Wright
Laboratory of Aging and Emotion of the Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 62:1388-95. 2007..The current study investigates functional alterations in the amygdala in aging and mild AD, and their relationships with neuropsychiatric symptoms... - Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortexChristopher I Wright
Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
Neuroimage 18:660-9. 2003.... - Neural correlates of novelty and face-age effects in young and elderly adultsChristopher I Wright
Laboratory of Aging and Emotion, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, CNY 2, Charlestown, MA 02129, USA
Neuroimage 42:956-68. 2008..e., an age in-group effect). Differences in anatomic localization and behavioral results suggest that novelty and age in-group effects were differentially processed in the amygdala... - Brain correlates of negative visuospatial priming in healthy childrenChristopher I Wright
Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 2, Charlestown, MA 02129, USA
Psychiatry Res 139:41-52. 2005..In conjunction with fMRI, the visuospatial priming task described in the current study may be useful for studying the pathophysiology of childhood-onset neuropsychiatric disorders characterized by deficient inhibitory processing... - Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophreniaDaphne J Holt
Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
Schizophr Res 82:153-62. 2006..Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition... - A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorderKarleyton C Evans
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Depress Anxiety 25:496-505. 2008..However, extending earlier findings in healthy subjects, schematic faces appear more effective for probing amygdala responses to arousal-based (Angry versus Neutral) as opposed to valence-based (Angry versus Happy) contrasts... - Differential hemodynamic response in affective circuitry with aging: an FMRI study of novelty, valence, and arousalYoshiya Moriguchi
Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Cogn Neurosci 23:1027-41. 2011..These findings have relevance for understanding age-related differences in memory and affect regulation... - Amygdala and fusiform gyrus temporal dynamics: responses to negative facial expressionsJennifer C Britton
Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
BMC Neurosci 9:44. 2008..Percent signal changes within anatomic regions-of-interest (amygdala and fusiform gyrus) were calculated to examine the temporal dynamics of neural response and any response differences based on face type... - Brain activation during implicit sequence learning in individuals with trichotillomaniaScott L Rauch
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Psychiatry Res 154:233-40. 2007..Future studies directly comparing OCD and TTM subjects are warranted to confirm the specificity of abnormal striatal and hippocampal findings during implicit sequence learning in OCD... - Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorderScott L Rauch
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
Biol Psychiatry 61:330-6. 2007..Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions... - Amygdala responses to human faces in obsessive-compulsive disorderPaul A Cannistraro
Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital, Building 149, Thirteenth Street, Charlestown, MA 02129, USA
Biol Psychiatry 56:916-20. 2004..Therefore, the present findings are consistent with abnormal amygdala function in OCD and are of a character that may distinguish OCD from other anxiety disorders... - Amygdala and insular responses to emotionally valenced human faces in small animal specific phobiaChristopher I Wright
Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 54:1067-76. 2003..g., posttraumatic stress disorder). This suggests a restricted role for the amygdala in specific phobia. The insular hyperresponsivity to fearful versus neutral faces in the subjects with specific phobias warrants further study... - Differential amygdala habituation to neutral faces in young and elderly adultsMichelle M Wedig
Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, 2nd Floor, Charlestown, MA 02129, USA
Neurosci Lett 385:114-9. 2005..We conclude that, in healthy elderly adults, the amygdala retains its adaptive habituation response, but speculate that intrinsic changes in amygdala anatomy during aging may modulate its laterality... - Enhanced amygdala responses to emotional versus neutral schematic facial expressionsChristopher I Wright
Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY-9, Charlestown, MA 02129, USA
Neuroreport 13:785-90. 2002.... - Sustained activation of the hippocampus in response to fearful faces in schizophreniaDaphne J Holt
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 57:1011-9. 2005..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that habituation of the medial temporal lobe is reduced in schizophrenia... - Brain habituation during repeated exposure to fearful and neutral faces: a functional MRI studyHakan Fischer
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Brain Res Bull 59:387-92. 2003..These results indicate that brain regions involved in novelty detection and memory processing habituate at similar rates regardless of whether the face in focus displays an aversive emotional expression or not... - Inhibited and uninhibited infants "grown up": adult amygdalar response to noveltyCarl E Schwartz
Developmental Psychopathology Research Group, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, 13th Street, Building 149, CNY 9, Charlestown, MA 02129, USA
Science 300:1952-3. 2003.... - Differential amygdalar response to novel versus newly familiar neutral faces: a functional MRI probe developed for studying inhibited temperamentCarl E Schwartz
Developmental Psychopathology Research Group (CES, Massachusetts General Hospital, Charlestown 02129, USA
Biol Psychiatry 53:854-62. 2003..We propose that this experimental paradigm will be useful for examining brain responses to novelty in different temperamental groups, as well as various psychiatric disorders... - The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individualsBradford C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
Cereb Cortex 19:497-510. 2009.... - Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concertMohammed R Milad
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
Biol Psychiatry 62:446-54. 2007..The aim of the present study is to investigate the mediating anatomy of extinction recall in healthy humans... - Hemispheric differences in amygdala contributions to response monitoringFrida E Polli
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neuroreport 20:398-402. 2009.... - A magnetic resonance imaging study of cortical thickness in animal phobiaScott L Rauch
Department of Psychiatry, Massachusetts General Hospital-East, 2nd Floor, Building 149, 13th Street, Charlestown, MA 02129, USA
Biol Psychiatry 55:946-52. 2004..Further research will be necessary to replicate these findings and to determine their specificity as well as their pathophysiologic significance... - Neuroimaging studies of amygdala function in anxiety disordersScott L Rauch
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
Ann N Y Acad Sci 985:389-410. 2003..We conclude that such tools hold great promise for facilitating progress in relevant basic neuroscience as well as clinical research domains... - Functional magnetic resonance imaging evidence for a lack of striatal dysfunction during implicit sequence learning in individuals with animal phobiaBrian Martis
Massachusetts General Hospital, Harvard Medical School, USA
Am J Psychiatry 161:67-71. 2004..This approach offers promise for demonstrating diagnostic specificity across different neuropsychiatric disorders based on the presence or absence of deficient striatal activation... - Novelty as a dimension in the affective brainMariann R Weierich
Department of Psychiatry, MGH and the Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
Neuroimage 49:2871-8. 2010..The results also suggest that novelty is a critical stimulus dimension for amygdala engagement (in addition to valence and arousal)... - The amygdala and the experience of affectLisa Feldman Barrett
Department of Psychology, Boston College, Massachusetts General Hospital, MA 02167, USA
Soc Cogn Affect Neurosci 2:73-83. 2007..The results are consistent with the interpretation that the amygdala contributes to negative affective experience by increasing perceptual sensitivity for negative stimuli... - A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorderLisa M Shin
Department of Psychology, Tufts University, Medford, Mass, USA
Arch Gen Psychiatry 62:273-81. 2005.... - D-cycloserine inhibits amygdala responses during repeated presentations of facesJennifer C Britton
Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
CNS Spectr 12:600-5. 2007..However, the underlying brain mechanisms mediating this fear reduction have yet to be determined... - Enhanced occipital and anterior cingulate activation in men but not in women during exposure to angry and fearful male facesHakan Fischer
Aging Research Center, Karolinska Institute, Box 6401, 113 82 Stockholm, Sweden
Cogn Affect Behav Neurosci 4:326-34. 2004..Hence, we suggest that the elevated occipital and anterior cingulate activation in men during confrontation with other angry and fearful males may reflect enhanced vigilance in a potentially dangerous situation... - False recognition of emotional word lists in aging and Alzheimer diseaseAndrew E Budson
Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA 01730, USA
Cogn Behav Neurol 19:71-8. 2006..To examine 3 different aspects of the emotional memory effect in aging and Alzheimer disease (AD): item-specific recollection, gist memory, and recognition response bias... - Age-differential patterns of brain activation during perception of angry facesHakan Fischer
Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Olivecronas vag 4, Box 6401, 113 82 Stockholm, Sweden
Neurosci Lett 386:99-104. 2005.... - Sex-differential brain activation during exposure to female and male facesHakan Fischer
Aging Research Center, Division of Geriatric Epidemiology, NEUROTEC Karolinska Institutet, Box 6401, 11382 Stockholm, Sweden
Neuroreport 15:235-8. 2004..The sex-differential nature of this activation pattern may reflect sex differences in cognitive style and attentional processes when confronting faces of the opposite sex... - Dorsal anterior cingulate function in posttraumatic stress disorderLisa M Shin
Department of Psychology, Tufts University, Medford, MA 02155, USA
J Trauma Stress 20:701-12. 2007 - Individual differences in learning the affective value of others under minimal conditionsEliza Bliss-Moreau
Department of Psychology, Boston College, Chestnut Hill, MA 02467, USA
Emotion 8:479-93. 2008..Finally, Study 4 demonstrated that initial learning persisted over a period of 2 days. Implications for affective processing and person perception are discussed...
Research Grants
- Emotional Stimulus Processing in Normal Aging & Mild ADChristopher Wright; Fiscal Year: 2006....