Christopher I Wright

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Novel fearful faces activate the amygdala in healthy young and elderly adults
    Christopher I Wright
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, 13th St, Bldg 149, CNY 2613, Charlestown, MA 02129, USA
    Neurobiol Aging 27:361-74. 2006
  2. ncbi request reprint Brain correlates of negative and positive visuospatial priming in adults
    Christopher I Wright
    Psychiatric Neuroimaging Research Program and Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 30:983-91. 2006
  3. ncbi request reprint Neuroanatomical correlates of extraversion and neuroticism
    Christopher I Wright
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 16:1809-19. 2006
  4. pmc Neuroanatomical correlates of personality in the elderly
    Christopher I Wright
    Laboratory of Aging and Emotion, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Bldg 149, CNY 2628, Charlestown, MA 02129, USA
    Neuroimage 35:263-72. 2007
  5. ncbi request reprint A functional magnetic resonance imaging study of amygdala responses to human faces in aging and mild Alzheimer's disease
    Christopher I Wright
    Laboratory of Aging and Emotion of the Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 62:1388-95. 2007
  6. ncbi request reprint Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortex
    Christopher I Wright
    Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroimage 18:660-9. 2003
  7. pmc Neural correlates of novelty and face-age effects in young and elderly adults
    Christopher I Wright
    Laboratory of Aging and Emotion, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, CNY 2, Charlestown, MA 02129, USA
    Neuroimage 42:956-68. 2008
  8. ncbi request reprint Brain correlates of negative visuospatial priming in healthy children
    Christopher I Wright
    Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 2, Charlestown, MA 02129, USA
    Psychiatry Res 139:41-52. 2005
  9. ncbi request reprint Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia
    Daphne J Holt
    Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
    Schizophr Res 82:153-62. 2006
  10. ncbi request reprint A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Depress Anxiety 25:496-505. 2008

Research Grants

  1. Emotional Stimulus Processing in Normal Aging & Mild AD
    Christopher Wright; Fiscal Year: 2006

Detail Information

Publications38

  1. ncbi request reprint Novel fearful faces activate the amygdala in healthy young and elderly adults
    Christopher I Wright
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, 13th St, Bldg 149, CNY 2613, Charlestown, MA 02129, USA
    Neurobiol Aging 27:361-74. 2006
    ..However, there were significantly greater activations in the inferior temporal cortex in the young versus elderly subjects...
  2. ncbi request reprint Brain correlates of negative and positive visuospatial priming in adults
    Christopher I Wright
    Psychiatric Neuroimaging Research Program and Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Neuroimage 30:983-91. 2006
    ..In conjunction with functional MRI, this visuospatial priming task may be useful for studying the pathophysiology of neuropsychiatric disorders in which deficient inhibitory processing or excessive facilitation is a feature...
  3. ncbi request reprint Neuroanatomical correlates of extraversion and neuroticism
    Christopher I Wright
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Cereb Cortex 16:1809-19. 2006
    ..In contrast, no such correlations were observed for the volume of the amygdala. The results suggest that specific aspects of regional prefrontal anatomy are associated with specific personality traits...
  4. pmc Neuroanatomical correlates of personality in the elderly
    Christopher I Wright
    Laboratory of Aging and Emotion, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Bldg 149, CNY 2628, Charlestown, MA 02129, USA
    Neuroimage 35:263-72. 2007
    ..The results suggest differences in the regional neuroanatomic correlates of specific personality traits with aging. We speculate that this relates to the influences of age-related structural changes in the PFC...
  5. ncbi request reprint A functional magnetic resonance imaging study of amygdala responses to human faces in aging and mild Alzheimer's disease
    Christopher I Wright
    Laboratory of Aging and Emotion of the Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 62:1388-95. 2007
    ..The current study investigates functional alterations in the amygdala in aging and mild AD, and their relationships with neuropsychiatric symptoms...
  6. ncbi request reprint Novelty responses and differential effects of order in the amygdala, substantia innominata, and inferior temporal cortex
    Christopher I Wright
    Psychiatric Neuroimaging Research Group, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroimage 18:660-9. 2003
    ....
  7. pmc Neural correlates of novelty and face-age effects in young and elderly adults
    Christopher I Wright
    Laboratory of Aging and Emotion, Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, CNY 2, Charlestown, MA 02129, USA
    Neuroimage 42:956-68. 2008
    ..e., an age in-group effect). Differences in anatomic localization and behavioral results suggest that novelty and age in-group effects were differentially processed in the amygdala...
  8. ncbi request reprint Brain correlates of negative visuospatial priming in healthy children
    Christopher I Wright
    Martinos Imaging Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 2, Charlestown, MA 02129, USA
    Psychiatry Res 139:41-52. 2005
    ..In conjunction with fMRI, the visuospatial priming task described in the current study may be useful for studying the pathophysiology of childhood-onset neuropsychiatric disorders characterized by deficient inhibitory processing...
  9. ncbi request reprint Increased medial temporal lobe activation during the passive viewing of emotional and neutral facial expressions in schizophrenia
    Daphne J Holt
    Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02129, USA
    Schizophr Res 82:153-62. 2006
    ..Here we tested whether MTL responses to human faces in schizophrenia are abnormal when unconstrained by a cognitive task and measured relative to a low-level baseline (fixation) condition...
  10. ncbi request reprint A functional MRI study of amygdala responses to angry schematic faces in social anxiety disorder
    Karleyton C Evans
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Depress Anxiety 25:496-505. 2008
    ..However, extending earlier findings in healthy subjects, schematic faces appear more effective for probing amygdala responses to arousal-based (Angry versus Neutral) as opposed to valence-based (Angry versus Happy) contrasts...
  11. pmc Differential hemodynamic response in affective circuitry with aging: an FMRI study of novelty, valence, and arousal
    Yoshiya Moriguchi
    Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Cogn Neurosci 23:1027-41. 2011
    ..These findings have relevance for understanding age-related differences in memory and affect regulation...
  12. pmc Amygdala and fusiform gyrus temporal dynamics: responses to negative facial expressions
    Jennifer C Britton
    Psychiatric Neuroimaging Research Program and Martinos Biomedical Imaging Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    BMC Neurosci 9:44. 2008
    ..Percent signal changes within anatomic regions-of-interest (amygdala and fusiform gyrus) were calculated to examine the temporal dynamics of neural response and any response differences based on face type...
  13. ncbi request reprint Brain activation during implicit sequence learning in individuals with trichotillomania
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Psychiatry Res 154:233-40. 2007
    ..Future studies directly comparing OCD and TTM subjects are warranted to confirm the specificity of abnormal striatal and hippocampal findings during implicit sequence learning in OCD...
  14. ncbi request reprint Functional magnetic resonance imaging study of regional brain activation during implicit sequence learning in obsessive-compulsive disorder
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    Biol Psychiatry 61:330-6. 2007
    ..Here, we used the SRT and functional magnetic resonance imaging (fMRI) to replicate prior results in a larger sample and to test for relationships between regional activation and OCD symptom dimensions...
  15. ncbi request reprint Amygdala responses to human faces in obsessive-compulsive disorder
    Paul A Cannistraro
    Psychiatric Neuroimaging Research Program, Department of Psychiatry, Massachusetts General Hospital, Building 149, Thirteenth Street, Charlestown, MA 02129, USA
    Biol Psychiatry 56:916-20. 2004
    ..To assess the amygdala response to emotional faces in obsessive-compulsive disorder (OCD) using functional magnetic resonance imaging (fMRI)...
  16. ncbi request reprint Amygdala and insular responses to emotionally valenced human faces in small animal specific phobia
    Christopher I Wright
    Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 54:1067-76. 2003
    ..However, it is not clear to what extent this concept applies across anxiety disorders. Several studies have examined brain function in specific phobias but did not demonstrate amygdala responses or use specific probes of the amygdala...
  17. ncbi request reprint Enhanced amygdala responses to emotional versus neutral schematic facial expressions
    Christopher I Wright
    Psychiatric Neuroimaging Research Group and Nuclear Magnetic Resonance Center, Massachusetts General Hospital, Harvard Medical School, 13th St, Bldg 149, CNY 9, Charlestown, MA 02129, USA
    Neuroreport 13:785-90. 2002
    ....
  18. ncbi request reprint Differential amygdala habituation to neutral faces in young and elderly adults
    Michelle M Wedig
    Psychiatric Neuroimaging Research Program, Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, 2nd Floor, Charlestown, MA 02129, USA
    Neurosci Lett 385:114-9. 2005
    ..We conclude that, in healthy elderly adults, the amygdala retains its adaptive habituation response, but speculate that intrinsic changes in amygdala anatomy during aging may modulate its laterality...
  19. ncbi request reprint Sustained activation of the hippocampus in response to fearful faces in schizophrenia
    Daphne J Holt
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 57:1011-9. 2005
    ..Using functional magnetic resonance imaging (fMRI), we tested the hypothesis that habituation of the medial temporal lobe is reduced in schizophrenia...
  20. ncbi request reprint Inhibited and uninhibited infants "grown up": adult amygdalar response to novelty
    Carl E Schwartz
    Developmental Psychopathology Research Group, Department of Psychiatry, Massachusetts General Hospital MGH, Harvard Medical School, 13th Street, Building 149, CNY 9, Charlestown, MA 02129, USA
    Science 300:1952-3. 2003
    ....
  21. ncbi request reprint Brain habituation during repeated exposure to fearful and neutral faces: a functional MRI study
    Hakan Fischer
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Brain Res Bull 59:387-92. 2003
    ..These results indicate that brain regions involved in novelty detection and memory processing habituate at similar rates regardless of whether the face in focus displays an aversive emotional expression or not...
  22. pmc Hemispheric differences in amygdala contributions to response monitoring
    Frida E Polli
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neuroreport 20:398-402. 2009
    ....
  23. pmc The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 19:497-510. 2009
    ....
  24. ncbi request reprint A magnetic resonance imaging study of cortical thickness in animal phobia
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital East, 2nd Floor, Building 149, 13th Street, Charlestown, MA 02129, USA
    Biol Psychiatry 55:946-52. 2004
    ....
  25. ncbi request reprint Differential amygdalar response to novel versus newly familiar neutral faces: a functional MRI probe developed for studying inhibited temperament
    Carl E Schwartz
    Developmental Psychopathology Research Group CES, Massachusetts General Hospital, Charlestown 02129, USA
    Biol Psychiatry 53:854-62. 2003
    ..Prior neuroimaging studies of the amygdala in humans to date have focused principally on responses to emotional stimuli, primarily aversive, rather than to novelty per se...
  26. ncbi request reprint Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert
    Mohammed R Milad
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Biol Psychiatry 62:446-54. 2007
    ..The aim of the present study is to investigate the mediating anatomy of extinction recall in healthy humans...
  27. ncbi request reprint Neuroimaging studies of amygdala function in anxiety disorders
    Scott L Rauch
    Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Ann N Y Acad Sci 985:389-410. 2003
    ..We conclude that such tools hold great promise for facilitating progress in relevant basic neuroscience as well as clinical research domains...
  28. ncbi request reprint Functional magnetic resonance imaging evidence for a lack of striatal dysfunction during implicit sequence learning in individuals with animal phobia
    Brian Martis
    Massachusetts General Hospital, Harvard Medical School, USA
    Am J Psychiatry 161:67-71. 2004
    ..This study investigated the neural substrates of implicit sequence learning in subjects with and without small animal phobia, in a follow-up to analogous studies of obsessive-compulsive disorder (OCD)...
  29. pmc Novelty as a dimension in the affective brain
    Mariann R Weierich
    Department of Psychiatry, MGH and the Athinoula A Martinos Center for Biomedical Imaging, Charlestown, MA 02129, USA
    Neuroimage 49:2871-8. 2010
    ..The results also suggest that novelty is a critical stimulus dimension for amygdala engagement (in addition to valence and arousal)...
  30. pmc The amygdala and the experience of affect
    Lisa Feldman Barrett
    Department of Psychology, Boston College, Massachusetts General Hospital, MA 02167, USA
    Soc Cogn Affect Neurosci 2:73-83. 2007
    ..The results are consistent with the interpretation that the amygdala contributes to negative affective experience by increasing perceptual sensitivity for negative stimuli...
  31. ncbi request reprint Sex-differential brain activation during exposure to female and male faces
    Hakan Fischer
    Aging Research Center, Division of Geriatric Epidemiology, NEUROTEC Karolinska Institutet, Box 6401, 11382 Stockholm, Sweden
    Neuroreport 15:235-8. 2004
    ..The sex-differential nature of this activation pattern may reflect sex differences in cognitive style and attentional processes when confronting faces of the opposite sex...
  32. ncbi request reprint Age-differential patterns of brain activation during perception of angry faces
    Hakan Fischer
    Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institute, Olivecronas vag 4, Box 6401, 113 82 Stockholm, Sweden
    Neurosci Lett 386:99-104. 2005
    ....
  33. ncbi request reprint A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, Mass, USA
    Arch Gen Psychiatry 62:273-81. 2005
    ..Previous functional neuroimaging studies have demonstrated exaggerated amygdala responses and diminished medial prefrontal cortex responses during the symptomatic state in posttraumatic stress disorder (PTSD)...
  34. ncbi request reprint D-cycloserine inhibits amygdala responses during repeated presentations of faces
    Jennifer C Britton
    Department of Psychiatry, The Mount Sinai School of Medicine, New York, NY, USA
    CNS Spectr 12:600-5. 2007
    ..However, the underlying brain mechanisms mediating this fear reduction have yet to be determined...
  35. ncbi request reprint False recognition of emotional word lists in aging and Alzheimer disease
    Andrew E Budson
    Geriatric Research Education Clinical Center, Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA 01730, USA
    Cogn Behav Neurol 19:71-8. 2006
    ..To examine 3 different aspects of the emotional memory effect in aging and Alzheimer disease (AD): item-specific recollection, gist memory, and recognition response bias...
  36. ncbi request reprint Enhanced occipital and anterior cingulate activation in men but not in women during exposure to angry and fearful male faces
    Hakan Fischer
    Aging Research Center, Karolinska Institute, Box 6401, 113 82 Stockholm, Sweden
    Cogn Affect Behav Neurosci 4:326-34. 2004
    ..Hence, we suggest that the elevated occipital and anterior cingulate activation in men during confrontation with other angry and fearful males may reflect enhanced vigilance in a potentially dangerous situation...
  37. ncbi request reprint Dorsal anterior cingulate function in posttraumatic stress disorder
    Lisa M Shin
    Department of Psychology, Tufts University, Medford, MA 02155, USA
    J Trauma Stress 20:701-12. 2007
  38. pmc Individual differences in learning the affective value of others under minimal conditions
    Eliza Bliss-Moreau
    Department of Psychology, Boston College, Chestnut Hill, MA 02467, USA
    Emotion 8:479-93. 2008
    ..Finally, Study 4 demonstrated that initial learning persisted over a period of 2 days. Implications for affective processing and person perception are discussed...

Research Grants1

  1. Emotional Stimulus Processing in Normal Aging & Mild AD
    Christopher Wright; Fiscal Year: 2006
    ....