Research Topics
| J WozniakSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
Research Grants
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Detail Information
Publications
Heterogeneity of irritability in attention-deficit/hyperactivity disorder subjects with and without mood disordersEric Mick
Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
Biol Psychiatry 58:576-82. 2005..We hypothesized that irritability is a heterogeneous symptom distinguished by severity and that attending to this heterogeneity would impact the relationship between irritability and bipolar disorder...- Omega-3 fatty acid monotherapy for pediatric bipolar disorder: a prospective open-label trialJanet Wozniak
Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Boston, MA 02138, USA
Eur Neuropsychopharmacol 17:440-7. 2007..To test the effectiveness and safety of omega-3 fatty acids (Omegabrite(R) brand) in the treatment of pediatric bipolar disorder (BPD)... 
Comparison of open-label, 8-week trials of olanzapine monotherapy and topiramate augmentation of olanzapine for the treatment of pediatric bipolar disorderJanet Wozniak
Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Department of Psychiatry at Harvard Medical School, Boston, Massachusetts, USA
J Child Adolesc Psychopharmacol 19:539-45. 2009..The aim of this study was to test the efficacy and safety of olanzapine + topiramate versus olanzapine monotherapy in the treatment of bipolar disorder (BPD) and treatment-attendant weight gain in children and adolescents...- Further evidence for robust familiality of pediatric bipolar I disorder: results from a very large controlled family study of pediatric bipolar I disorder and a meta-analysisJanet Wozniak
Massachusetts General Hospital, 55 Fruit St, Yawkey 6A, Boston, MA 02114, USA
J Clin Psychiatry 73:1328-34. 2012..To determine the risk for bipolar I disorder in first-degree relatives of children with DSM-IV bipolar I disorder via meta-analysis and expanded controlled study... 
Discriminant and concurrent validity of a simplified DSM-based structured diagnostic instrument for the assessment of autism spectrum disorders in youth and young adultsGagan Joshi
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
BMC Psychiatry 11:204. 2011..To evaluate the concurrent and discriminant validity of a brief DSM-based structured diagnostic interview for referred individuals with autism spectrum disorders (ASDs)...- High level of persistence of pediatric bipolar-I disorder from childhood onto adolescent years: a four year prospective longitudinal follow-up studyJanet Wozniak
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts General Hospital, Boston, MA 02114, United States
J Psychiatr Res 45:1273-82. 2011..To examine the longitudinal course of pediatric bipolar (BP)-I disorder in youth transitioning from childhood into adolescence... - The clinical characteristics of unipolar vs. bipolar major depression in ADHD youthJanet Wozniak
Pediatric Psychopharmacology Research Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Affect Disord 82:S59-69. 2004..To investigate the characteristics of unipolar vs. bipolar depression in youth using a sample of children referred for a study on attention deficit hyperactivity disorder (ADHD)... - A controlled family study of children with DSM-IV bipolar-I disorder and psychiatric co-morbidityJ Wozniak
Clinical and Research Program in Pediatric Psychopharmacology and Adult ADHD at Massachusetts General Hospital, Boston, MA 02114, USA
Psychol Med 40:1079-88. 2010..To estimate the spectrum of familial risk for psychopathology in first-degree relatives of children with unabridged DSM-IV bipolar-I disorder (BP-I)... - Recognizing and managing bipolar disorder in childrenJanet Wozniak
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02138, USA
J Clin Psychiatry 66:18-23. 2005.... - How cardinal are cardinal symptoms in pediatric bipolar disorder? An examination of clinical correlatesJanet Wozniak
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 58:583-8. 2005..The main goal of this study was to test whether the hypothesized cardinal symptom of euphoria results in differences in clinical correlates in bipolar youth ascertained with no a priori assumptions about cardinal symptoms... - Diagnostic and therapeutic dilemmas in the management of pediatric-onset bipolar disorderJ Wozniak
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Clin Psychiatry 62:10-5. 2001..Treatment requires a combined pharmacotherapy approach to address issues of comorbidity. Atypical antipsychotic medications have provided promising treatment results, but additional controlled clinical trials are needed... - Can a subtype of conduct disorder linked to bipolar disorder be identified? Integration of findings from the Massachusetts General Hospital Pediatric Psychopharmacology Research ProgramJoseph Biederman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA
Biol Psychiatry 53:952-60. 2003..Our data suggest that when BPD and CD co-occur in children, both are correctly diagnosed. In these comorbid cases, CD symptoms should not be viewed as secondary to BPD, and manic symptoms should not be viewed as secondary to CD... - Risperidone treatment for juvenile bipolar disorder: a retrospective chart reviewJ A Frazier
Child Psychiatry Department, Massachusetts General Hospital, Harvard Medical School, Boston, USA
J Am Acad Child Adolesc Psychiatry 38:960-5. 1999..To investigate the effectiveness and tolerability of the atypical neuroleptic risperidone in the treatment of juvenile mania... - Heterogeneity of childhood conduct disorder: further evidence of a subtype of conduct disorder linked to bipolar disorderJ Wozniak
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Affect Disord 64:121-31. 2001..Furthermore, they suggest that the comorbid condition of CD+BPD may be a distinct nosological entity. This suggests that clinicians treating CD or BPD children should consider the treatment implications of this comorbid condition... - Parsing pediatric bipolar disorder from its associated comorbidity with the disruptive behavior disordersT J Spencer
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114-3139, USA
Biol Psychiatry 49:1062-70. 2001..What was previously considered refractory ADHD, oppositionality, aggression, and conduct disorder may respond after mood stabilization. We review these issues in this article... - Defining a developmental subtype of bipolar disorder in a sample of nonreferred adults by age at onsetEric Mick
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts, USA
J Child Adolesc Psychopharmacol 13:453-62. 2003..This pattern of correlates is consistent with findings documented in children with pediatric bipolar disorder and supports the hypothesis that child-onset bipolar disorder may represent a developmental subtype of the disorder... - Systematic chart review of the pharmacologic treatment of comorbid attention deficit hyperactivity disorder in youth with bipolar disorderJ Biederman
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Boston, USA
J Child Adolesc Psychopharmacol 9:247-56. 1999..Although TCAs can be helpful in the management of ADHD children with manic symptoms, these drugs should be used with caution since they can also have a destabilizing effect on manic symptoms... - A prospective open-label trial of extended-release carbamazepine monotherapy in children with bipolar disorderGagan Joshi
Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 20:7-14. 2010..The aim of this study was to evaluate the safety and efficacy of extended release carbamazepine (CBZ-ER) monotherapy in the treatment of pediatric bipolar disorder (BD)... - Neurocognitive impairment in unaffected siblings of youth with bipolar disorderA E Doyle
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Child Psychiatry Service, 55 Fruit Street, Boston, MA 02114, USA
Psychol Med 39:1253-63. 2009..The current study investigated whether these neurocognitive impairments index the familial risk underlying the diagnosis... - Is bipolar disorder a risk for cigarette smoking in ADHD youth?T E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
Am J Addict 9:187-95. 2000..These data coupled with the literature strongly suggest that juveniles with BPD need to be carefully monitored for the early initiation of cigarette smoking and substance abuse... - Clinical characteristics of comorbid obsessive-compulsive disorder and bipolar disorder in children and adolescentsGagan Joshi
Pediatric Psychopharmacology Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Bipolar Disord 12:185-95. 2010.... - Convergence between structured diagnostic interviews and clinical assessment on the diagnosis of pediatric-onset maniaJanet Wozniak
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 53:938-44. 2003..CONCLUSIONS: In children referred for evaluation of suspected bipolar disorder, a structured interview diagnosis of mania is very likely to be corroborated by a clinical interview... - Risk for switch from unipolar to bipolar disorder in youth with ADHD: a long term prospective controlled studyJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, United States
J Affect Disord 119:16-21. 2009..To investigate whether ADHD is a risk factor for switches from unipolar to bipolar disorder over time... - An open-label trial of aripiprazole monotherapy in children and adolescents with bipolar disorderJoseph Biederman
Joint Program in Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
CNS Spectr 12:683-9. 2007..Aripiprazole is a novel second-generation antipsychotic approved for the treatment of bipolar disorder in adults but there is no systematic data available in pediatric bipolar disorder... - The Child Behavior Checklist-Pediatric Bipolar Disorder profile predicts a subsequent diagnosis of bipolar disorder and associated impairments in ADHD youth growing up: a longitudinal analysisJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Yawkey Center, Suite 6A, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 70:732-40. 2009..To examine the predictive utility of the Child Behavior Checklist-Pediatric Bipolar Disorder (CBCL-PBD) profile to help identify children at risk for bipolar disorder... - Can bipolar disorder-specific neuropsychological impairments in children be identified?Aude Henin
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Cambridge, MA 02138, USA
J Consult Clin Psychol 75:210-20. 2007..Thus, comorbidity with ADHD may account for many of the neuropsychological deficits observed in children with bipolar disorder... - Examination of concordance between maternal and youth reports in the diagnosis of pediatric bipolar disorderJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit Street, Warren 705, Boston, MA 02114, USA
Bipolar Disord 11:298-306. 2009..To this end we compared discordant (mother positive and youth negative) and concordant (mother and youth positive) cases... - Family-based genome-wide association scan of attention-deficit/hyperactivity disorderEric Mick
Massachusetts General Hospital, 55 Fruit Street Warren 705, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 49:898-905.e3. 2010..We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD... - Is psychopharmacologic treatment associated with neuropsychological deficits in bipolar youth?Aude Henin
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 185 Alewife Brook Pkwy, Suite 2000, Cambridge, MA 02138, USA
J Clin Psychiatry 70:1178-85. 2009..To evaluate the impact of psychopharmacologic treatments on neuropsychological functioning in bipolar youth... - Cognitive development in adults with attention-deficit/hyperactivity disorder: a controlled study in medication-naive adults across the adult life cycleJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit St, YAW 6A 6900, Boston, MA 02114, USA
J Clin Psychiatry 72:11-6. 2011.... - A prospective open-label trial of lamotrigine monotherapy in children and adolescents with bipolar disorderJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
CNS Neurosci Ther 16:91-102. 2010..To evaluate the safety and efficacy of lamotrigine monotherapy as an acute treatment of bipolar mood elevation in children with bipolar spectrum disorders... - Child behavior checklist clinical scales discriminate referred youth with autism spectrum disorder: a preliminary studyJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
J Dev Behav Pediatr 31:485-90. 2010.... - Impact of obsessive-compulsive disorder on the antimanic response to olanzapine therapy in youth with bipolar disorderGagan Joshi
Pediatric Psychopharmacology Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
Bipolar Disord 12:196-204. 2010..To compare antimanic response to olanzapine therapy in youth with bipolar disorder (BPD) based on the status of comorbidity with obsessive-compulsive disorder (OCD)... - An open-label trial of risperidone in children and adolescents with bipolar disorderJoseph Biederman
Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 15:311-7. 2005..The aim of this study was to evaluate the potential of risperidone as a treatment of pediatric bipolar disorder... - A prospective follow-up study of pediatric bipolar disorder in boys with attention-deficit/hyperactivity disorderJoseph Biederman
WACC 725, Massachusetts General Hospital, Pediatric Psychopharmacology Unit, MGH, 55 Fruit Street, Boston, MA 02114, USA
J Affect Disord 82:S17-23. 2004.... - Further evidence of unique developmental phenotypic correlates of pediatric bipolar disorder: findings from a large sample of clinically referred preadolescent children assessed over the last 7 yearsJoseph Biederman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
J Affect Disord 82:S45-58. 2004..A comparison of the prevalence, clinical correlates, and patterns of comorbidity among children with bipolar disorder (BPD) assessed in the early 1990s (1st cohort) with those evaluated over the last 7 years (2nd cohort)... - Aripiprazole in the treatment of pediatric bipolar disorder: a systematic chart reviewJoseph Biederman
Pediatric Psychopharmacology Research Office, Massachusetts General Hospital, Boston, MA 02114, USA
CNS Spectr 10:141-8. 2005..Pediatric bipolar disorder is a serious neuropsychiatric disorder associated with high levels of morbidity and disability... - Risk of substance use disorders in adolescents with bipolar disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Child Psychiatric Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 43:1380-6. 2004..Considering the public health importance of this issue, the authors now report on a controlled study of adolescents with and without BPD to evaluate the risk of SUD... - Clinical correlates of bipolar disorder in a large, referred sample of children and adolescentsJoseph Biederman
Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA
J Psychiatr Res 39:611-22. 2005..To compare the prevalence, clinical correlates, and comorbidity among children and adolescents with bipolar disorder (BPD) assessed in the early 1990s (first cohort) with those evaluated over the last 7 years (second cohort)... - Patterns of comorbidity and dysfunction in clinically referred preschool and school-age children with bipolar disorderTimothy E Wilens
Johnson and Johnson Center for the Study of Pediatric Psychopathology, Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 13:495-505. 2003..This study reports on the clinical characteristics, psychiatric comorbidity, and functioning of preschoolers identified with BPD who were referred to a pediatric psychiatric clinic... - Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age childrenJoseph Biederman
Pediatric Psychopharmacology Research Department, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 58:589-94. 2005..To evaluate short-term safety and efficacy of atypical antipsychotics in a single-site, prospective, open-label, 8-week study of risperidone and olanzapine monotherapy in preschoolers with bipolar disorder (BPD)... - Absence of gender differences in pediatric bipolar disorder: findings from a large sample of referred youthJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology of the Child Psychiatry Service, Massachusetts General Hospital, Pediatric Psychopharmacology Unit WACC 725, 15 Parkman Street, Boston, MA 02114, USA
J Affect Disord 83:207-14. 2004..Because little is known about gender differences in pediatric bipolar disorder, we evaluated whether gender moderates the expression of pediatric bipolar disorder in a large clinical sample... - Risperidone for the treatment of affective symptoms in children with disruptive behavior disorder: a post hoc analysis of data from a 6-week, multicenter, randomized, double-blind, parallel-arm studyJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Boston, 02114, USA
Clin Ther 28:794-800. 2006..Preliminary data from open-label trials in children suggest that these agents might be effective in treating pediatric bipolar disorder, however... - Can adults with attention-deficit/hyperactivity disorder be distinguished from those with comorbid bipolar disorder? Findings from a sample of clinically referred adultsTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 54:1-8. 2003..We now evaluate the clinical characteristics of referred adults with (n = 24) and without BPD (n = 27)... - A prospective open-label treatment trial of ziprasidone monotherapy in children and adolescents with bipolar disorderJoseph Biederman
Massachusetts General Hospital, Pediatric Psychopharmacology Research Department, 32 Fruit Street, Yawkey Center for Outpatient Care Yaw 6A, Boston, MA 02114, USA
Bipolar Disord 9:888-94. 2007..To assess the effectiveness and tolerability of ziprasidone for treating pediatric mania... - Impact of executive function deficits in youth with bipolar I disorder: a controlled studyJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
Psychiatry Res 186:58-64. 2011..Youth with BP-I disorder and EFDs are at high risk for significant impairments in academic functioning... - Prescribing patterns for treatment of pediatric bipolar disorder in a specialty clinicMona P Potter
Clinical and Research Programs in Pediatric Psychopharmacology and Adult ADHD, Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
J Child Adolesc Psychopharmacol 19:529-38. 2009..The aim of this study was to describe prescribing practices in the treatment of pediatric bipolar disorder in a university practice setting... - Current concepts in the validity, diagnosis and treatment of paediatric bipolar disorderJoseph Biederman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114 3139, USA
Int J Neuropsychopharmacol 6:293-300. 2003..The goal of this article is to review our work and the extant literature within this framework to describe the evidence supporting bipolar disorder in children as a valid clinical diagnosis... - Alternative treatments in pediatric bipolar disorderMona Potter
Department of Child and Adolescent Psychiatry, Massachusetts General Hospital and McLean Hospital, Yawkey Center for Outpatient Care, 55 Fruit Street, Boston, MA 02114, USA
Child Adolesc Psychiatr Clin N Am 18:483-514, xi. 2009..Across the board, more research is necessary and warranted regarding the long-term safety and efficacy of available complementary and alternative treatments for the management of pediatric BPD... - Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in childrenEric Mick
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
BMC Psychiatry 9:2. 2009..In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT)... - Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)Eric Mick
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 147:1182-5. 2008..These data provide suggestive evidence supporting a role for SLC6A3 in the etiology of pediatric bipolar disorder... - Parsing the comorbidity between bipolar disorder and anxiety disorders: a familial risk analysisJanet Wozniak
Pediatric Psychopharmacology Unit of the Child Psychiatry Service, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Child Adolesc Psychopharmacol 12:101-11. 2002..Thus, we investigated the familial association between BPD and ANX among the first-degree relatives of children with BPD with and without comorbid ANX... - Examining the association between pediatric bipolar disorder and anxiety disorders in psychiatrically referred children and adolescentsTerri L Harpold
Clinical and Research Program in Pediatric Psychopharmacology, Johnson and Johnson Center for the Study of Pediatric Psychopathology, Massachusetts General Hospital and Harvard Medical School, USA
J Affect Disord 88:19-26. 2005..Considering the morbidity and dysfunction as well as the differing therapeutic needs associated with bipolar and anxiety symptomatology, appropriate therapeutic approaches will be needed for the management of youth with this comorbidity... - Pediatric bipolar disorder: the new perspective on severe mood dysfunction in childrenJanet Wozniak
J Child Adolesc Psychopharmacol 13:449-51. 2003 - Pharmacological management of new-onset bipolar disorderChristopher J Kratochvil
Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE 68198-5581, USA
J Am Acad Child Adolesc Psychiatry 44:1198-200. 2005 - Differences in brain chemistry in children and adolescents with attention deficit hyperactivity disorder with and without comorbid bipolar disorder: a proton magnetic resonance spectroscopy studyConstance M Moore
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
Am J Psychiatry 163:316-8. 2006.... - Olanzapine versus placebo in the treatment of adolescents with bipolar maniaMauricio Tohen
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
Am J Psychiatry 164:1547-56. 2007..The purpose of this study was to evaluate the efficacy and safety of olanzapine for the treatment of acute manic or mixed episodes associated with bipolar disorder in adolescents... - Mania, glutamate/glutamine and risperidone in pediatric bipolar disorder: a proton magnetic resonance spectroscopy study of the anterior cingulate cortexConstance M Moore
Brain Imaging Center, McLean Hospital, Belmont, MA 02478, USA
J Affect Disord 99:19-25. 2007..In this study, we hypothesized that the children with BPD in need of treatment would have lower Glx/Cr compared with the children with BPD being stably treated with risperidone... - Methodological issues and controversies in clinical trials with child and adolescent patients with bipolar disorder: report of a consensus conferenceGabrielle A Carlson
Department of Psychiatry, Stony Brook University Putnam Hall, Stony Brook, NY 11794 8790, USA
J Child Adolesc Psychopharmacol 13:13-27. 2003..To achieve consensus among researchers, pharmaceutical industry representatives, federal regulatory agency staff, and family advocates on a template for clinical trials of acute mania/bipolar disorder in children and adolescents...
Research Grants
- Longitudinal Family Study of Pediatric Bipolar DisorderJanet Wozniak; Fiscal Year: 2007..This follow-up study of children and adolescents with bipolar disorder seeks to contribute valuable information regarding the longitudinal course and outcome of pediatric-onset bipolar disorder in multiple domains. ..