J J Worthington

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Nefazodone for social phobia: a clinical case series
    J J Worthington
    Anxiety Disorders Program, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 8:131-3. 1998
  2. ncbi request reprint Treatment of antidepressant-induced sexual dysfunction
    John J Worthington
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Drugs Today (Barc) 39:887-96. 2003
  3. ncbi request reprint Ropinirole for antidepressant-induced sexual dysfunction
    J J Worthington
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Int Clin Psychopharmacol 17:307-10. 2002
  4. ncbi request reprint Timing of onset of antidepressant response with fluoxetine treatment
    A A Nierenberg
    Depression and Clinical Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:1423-8. 2000
  5. ncbi request reprint Sertraline in the treatment of panic disorder: a flexible-dose multicenter trial
    M H Pollack
    Anxiety Disorders Program, Department of Psychiatry, Massachusetts General Hospital, Boston 02114 3117, USA
    Arch Gen Psychiatry 55:1010-6. 1998
  6. doi request reprint The role of anxiety sensitivity in sleep disturbance in panic disorder
    E A Hoge
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114 2790, USA
    J Anxiety Disord 25:536-8. 2011
  7. ncbi request reprint A comparison of the efficacy of clonazepam and cognitive-behavioral group therapy for the treatment of social phobia
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Anxiety Disord 14:345-58. 2000
  8. ncbi request reprint Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression
    D Mischoulon
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman St, WAC 812, Boston, MA 02114, USA
    J Psychosom Res 49:183-7. 2000
  9. ncbi request reprint An open trial of oral sildenafilin antidepressant-induced sexual dysfunction
    M Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Mass 02114, USA
    Psychother Psychosom 67:328-31. 1998
  10. ncbi request reprint Citalopram for social phobia: a clinical case series
    N M Simon
    Anxiety Disorders Program, Massachusetts General Hospital, Boston 02114, USA
    Prog Neuropsychopharmacol Biol Psychiatry 25:1469-74. 2001

Detail Information

Publications37

  1. ncbi request reprint Nefazodone for social phobia: a clinical case series
    J J Worthington
    Anxiety Disorders Program, Massachusetts General Hospital, Boston, USA
    Depress Anxiety 8:131-3. 1998
    ..Results from this case series suggest that nefazodone may be an effective treatment for social phobia and that formal randomized trials are warranted...
  2. ncbi request reprint Treatment of antidepressant-induced sexual dysfunction
    John J Worthington
    Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Drugs Today (Barc) 39:887-96. 2003
    ..Because sexual dysfunction can lead to treatment noncompliance and depression relapse, this is an issue that should be addressed by clinicians at initiation and throughout the course of treatment...
  3. ncbi request reprint Ropinirole for antidepressant-induced sexual dysfunction
    J J Worthington
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    Int Clin Psychopharmacol 17:307-10. 2002
    ..The addition of ropinirole may represent a potentially useful treatment strategy for antidepressant-induced sexual dysfunction...
  4. ncbi request reprint Timing of onset of antidepressant response with fluoxetine treatment
    A A Nierenberg
    Depression and Clinical Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 157:1423-8. 2000
    ..The purpose of this study was to assess the time until onset of antidepressant response with fluoxetine treatment...
  5. ncbi request reprint Sertraline in the treatment of panic disorder: a flexible-dose multicenter trial
    M H Pollack
    Anxiety Disorders Program, Department of Psychiatry, Massachusetts General Hospital, Boston 02114 3117, USA
    Arch Gen Psychiatry 55:1010-6. 1998
    ..We examined the efficacy and safety of the serotonin selective reuptake inhibitor sertraline hydrochloride in patients with panic disorder...
  6. doi request reprint The role of anxiety sensitivity in sleep disturbance in panic disorder
    E A Hoge
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114 2790, USA
    J Anxiety Disord 25:536-8. 2011
    ..Our data suggest that sleep disturbance, and in particular sleep latency, in PD may be partly due to high levels of AS, which can be targeted with cognitive-behavioral therapeutic strategies...
  7. ncbi request reprint A comparison of the efficacy of clonazepam and cognitive-behavioral group therapy for the treatment of social phobia
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston 02114, USA
    J Anxiety Disord 14:345-58. 2000
    ....
  8. ncbi request reprint Anemia and macrocytosis in the prediction of serum folate and vitamin B12 status, and treatment outcome in major depression
    D Mischoulon
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, 15 Parkman St, WAC 812, Boston, MA 02114, USA
    J Psychosom Res 49:183-7. 2000
    ..We wished to determine whether anemia or macrocytosis predict hypofolatemia, low B12, or refractoriness to antidepressants...
  9. ncbi request reprint An open trial of oral sildenafilin antidepressant-induced sexual dysfunction
    M Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, Mass 02114, USA
    Psychother Psychosom 67:328-31. 1998
    ..The goal of our study was to evaluate its efficacy in a small sample of outpatients with antidepressant-induced sexual dysfunction...
  10. ncbi request reprint Citalopram for social phobia: a clinical case series
    N M Simon
    Anxiety Disorders Program, Massachusetts General Hospital, Boston 02114, USA
    Prog Neuropsychopharmacol Biol Psychiatry 25:1469-74. 2001
    ..This series of patients improved significantly on all measures. Results suggest that citalopram may be a safe and effective treatment for social anxiety disorder...
  11. ncbi request reprint Childhood history of anxiety disorders among adults with social phobia: rates, correlates, and comparisons with patients with panic disorder
    M W Otto
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Depress Anxiety 14:209-13. 2001
    ....
  12. ncbi request reprint T3 blood levels and treatment outcome in depression
    D V Iosifescu
    Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Psychiatry Med 31:367-73. 2001
    ..CONCLUSION: Abnormal T3-RU levels are rather uncommon in outpatient depression and do not correlate with the response to antidepressant treatment or lack thereof...
  13. ncbi request reprint Personality disorders and depression
    M Fava
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Psychol Med 32:1049-57. 2002
    ....
  14. ncbi request reprint Body dysmorphic disorder in outpatients with major depression
    Andrew A Nierenberg
    Depression Research Program, Clinical Psychopharmacology Unit, Massachusetts General Hospital and The Consolidated Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    J Affect Disord 69:141-8. 2002
    ..The purpose of this study was to evaluate the rate of BDD in a cohort of consecutive outpatients with typical and atypical major depressive disorder...
  15. ncbi request reprint Olanzapine augmentation of fluoxetine for refractory generalized anxiety disorder: a placebo controlled study
    Mark H Pollack
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Biol Psychiatry 59:211-5. 2006
    ..We present one of the first randomized controlled trials for refractory GAD, comprising double blind augmentation with olanzapine or placebo for patients remaining symptomatic on fluoxetine...
  16. ncbi request reprint Aripiprazole augmentation of selective serotonin reuptake inhibitors for treatment-resistant major depressive disorder
    George I Papakostas
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychiatry 66:1326-30. 2005
    ..The purpose of this study was to test this hypothesis in depressed outpatients who have not experienced significant clinical improvement following an adequate trial of a selective serotonin reuptake inhibitor (SSRI)...
  17. ncbi request reprint The combination of duloxetine and bupropion for treatment-resistant major depressive disorder
    George I Papakostas
    Department of Psychiatry, Depression Clinical and Research Program, Massachusetts General Hospital, Boston, 02114, USA
    Depress Anxiety 23:178-81. 2006
    ..Although preliminary, these results suggest a possible role for the combination of duloxetine and bupropion for TRD...
  18. ncbi request reprint An open-label trial of risperidone augmentation for refractory anxiety disorders
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:381-5. 2006
    ..There is a paucity of data to support "next-step" treatments for the many patients with anxiety disorders who remain symptomatic after initial pharmacotherapy...
  19. ncbi request reprint A double-blind study of the efficacy of venlafaxine extended-release, paroxetine, and placebo in the treatment of panic disorder
    Mark H Pollack
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Depress Anxiety 24:1-14. 2007
    ..Adverse events were mild or moderate and similar between active treatment groups. Venlafaxine ER and paroxetine were effective and well tolerated in the treatment of panic disorder...
  20. ncbi request reprint Preliminary support for gender differences in response to fluoxetine for generalized anxiety disorder
    Naomi M Simon
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Depress Anxiety 23:373-6. 2006
    ..Larger placebo-controlled trials are needed to more definitively examine gender and treatment response in anxiety disorders...
  21. ncbi request reprint The relationship of anxiety disorders, anxiety sensitivity and pulmonary dysfunction with dyspnea-related distress and avoidance
    Naomi M Simon
    Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Nerv Ment Dis 194:951-7. 2006
    ....
  22. doi request reprint Quetiapine augmentation of paroxetine CR for the treatment of refractory generalized anxiety disorder: preliminary findings
    Naomi M Simon
    Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Psychopharmacology (Berl) 197:675-81. 2008
    ..More data are needed to guide "next step" strategies for patients with generalized anxiety disorder (GAD) remaining symptomatic despite initial pharmacotherapy...
  23. ncbi request reprint Aripiprazole as augmentation treatment of refractory generalized anxiety disorder and panic disorder
    Elizabeth A Hoge
    Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    CNS Spectr 13:522-7. 2008
    ..Individuals with anxiety disorders often remain symptomatic despite treatment with a first-line pharmacologic agent. More research examining pharmacotherapy augmentation strategies to improve outcomes is needed...
  24. ncbi request reprint Fluoxetine for vestibular dysfunction and anxiety: a prospective pilot study
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital, WACC 815, Boston, MA 02114, USA
    Psychosomatics 46:334-9. 2005
    ..The data add to the literature suggesting a role for selective serotonin reuptake inhibitors in the treatment of dizziness and anxiety...
  25. ncbi request reprint Aripiprazole as an augmentor of selective serotonin reuptake inhibitors in depression and anxiety disorder patients
    John J Worthington
    Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital, Boston, Massachusetts, USA
    Int Clin Psychopharmacol 20:9-11. 2005
    ..Because this is a retrospective case review, further prospective studies are required to confirm these findings...
  26. ncbi request reprint S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine
    Jonathan E Alpert
    Depression Clinical and Research Program, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychopharmacol 24:661-4. 2004
    ..The purpose of this open trial was to evaluate the safety, tolerability, and efficacy of oral S-adenosyl-L-methionine as an antidepressant adjunct among partial and nonresponders to serotonin reuptake inhibitors or venlafaxine...
  27. ncbi request reprint Hypothyroidism and hyperthyroidism in anxiety disorders revisited: new data and literature review
    Naomi M Simon
    Anxiety Disorders Program, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, WAC 815, Boston, MA 02114, USA
    J Affect Disord 69:209-17. 2002
    ..The need for thyroid screening of patients presenting with panic disorder (PD), social phobia (SP) or generalized anxiety disorder (GAD) remains uncertain...
  28. ncbi request reprint A novel cognitive-behavioral approach for treatment-resistant drug dependence
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Subst Abuse Treat 23:335-42. 2002
    ..Reasons for differential performance by women and men and future directions for this new treatment are discussed...
  29. ncbi request reprint Lithium augmentation of nortriptyline for subjects resistant to multiple antidepressants
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Psychopharmacol 23:92-5. 2003
    ..More definitive data await the outcome of the NIMH Sequential Treatment Alternatives to Relieve Depression (STAR*D) study...
  30. ncbi request reprint Nortriptyline for treatment-resistant depression
    Andrew A Nierenberg
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, 02114, USA
    J Clin Psychiatry 64:35-9. 2003
    ..This study assesses the efficacy of nortriptyline for patients with treatment-resistant major depression...
  31. ncbi request reprint Valproic acid for the treatment of social anxiety disorder
    Gustavo Kinrys
    Massachusetts General Hospital, Boston 02114, USA
    Int Clin Psychopharmacol 18:169-72. 2003
    ..The results from this open-label trial suggest the potential efficacy of valproic acid for the treatment of social anxiety disorder. Placebo-controlled trials are indicated to confirm these findings...
  32. ncbi request reprint Hopelessness and suicidal ideation in outpatients with treatment-resistant depression: prevalence and impact on treatment outcome
    George I Papakostas
    Depression Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, WACC 812, 15 Parkman Street, Boston, Massachusetts, 02114, USA
    J Nerv Ment Dis 191:444-9. 2003
    ..Furthermore, a full 6-week trial of NT, a relatively noradrenergic tricyclic antidepressant, may be particularly useful in patients who have failed to respond to several antidepressants and also report significant hopelessness...
  33. ncbi request reprint Combined paroxetine and clonazepam treatment strategies compared to paroxetine monotherapy for panic disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    J Psychopharmacol 17:276-82. 2003
    ..Initiating combined treatment followed by benzodiazepine taper after a few weeks may provide early benefit while avoiding the potential adverse consequences of long-term combination therapy...
  34. ncbi request reprint Bupropion sustained release for panic disorder
    Naomi M Simon
    Department of Psychiatry, Harvard University, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Psychopharmacol Bull 37:66-72. 2003
    ..Although results may be influenced by the open nature of this trial, our findings suggest that bupropion SR may be effective for the treatment of panic disorder. Further controlled study of its efficacy for this condition are warranted...
  35. ncbi request reprint An open-label study of levetiracetam for the treatment of social anxiety disorder
    Naomi M Simon
    Center for Anxiety and Traumatic Stress Related Disorders, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Clin Psychiatry 65:1219-22. 2004
    ..Levetiracetam thus warrants systematic evaluation as a treatment option for anxiety disorders...
  36. ncbi request reprint A pilot, open study of sertraline in outpatients with treatment-resistant depression (TRD) or with a history of TRD who responded but later relapsed
    George I Papakostas
    Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, 156 Parkman Street, WACC 812, Boston, MA 02114, USA
    Int Clin Psychopharmacol 18:293-6. 2003
    ....
  37. ncbi request reprint Levetiracetam as adjunctive therapy for refractory anxiety disorders
    Gustavo Kinrys
    Anxiety Disorders Research Program, Cambridge Health Alliance, Cambridge, MA 02139, USA
    J Clin Psychiatry 68:1010-3. 2007
    ..We present a retrospective analysis that assessed the efficacy and tolerability of adjunctive levetiracetam, a novel anticonvulsant agent, in the treatment of refractory anxiety...