Gerald N Wogan

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Does perinatal antiretroviral therapy create an iatrogenic cancer risk?
    Gerald N Wogan
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Environ Mol Mutagen 48:210-4. 2007
  2. ncbi request reprint Environmental and chemical carcinogenesis
    Gerald N Wogan
    Biological Engineering Division, Massachusetts Institute of Technology, Room 26 009, Cambridge, MA 02139, USA
    Semin Cancer Biol 14:473-86. 2004
  3. ncbi request reprint Carbon dioxide modulation of peroxynitrite-induced mutagenesis of the supF gene in pSP189
    Burcak Pamir
    Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 16:487-92. 2003
  4. pmc Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species
    Ming Wei Chao
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Sci 130:48-59. 2012
  5. ncbi request reprint Mutagenesis of the supF gene of pSP189 replicating in AD293 cells cocultivated with activated macrophages: roles of nitric oxide and reactive oxygen species
    Min Young Kim
    Biological Engineering Division and Chemistry Department, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 19:1483-91. 2006
  6. pmc A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver
    Roongtiwa Wattanawaraporn
    Department of Biological Engineering and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Sci 128:326-33. 2012
  7. ncbi request reprint AlkB influences the chloroacetaldehyde-induced mutation spectra and toxicity in the pSP189 supF shuttle vector
    Min Young Kim
    Department of Biological Engineering, Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Chem Res Toxicol 20:1075-83. 2007
  8. pmc Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice
    Leslie L Woo
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Sci 122:38-44. 2011
  9. pmc Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells
    Chun Qi Li
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 19:399-406. 2006
  10. pmc Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease
    Charles G Knutson
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 110:E2332-41. 2013

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Does perinatal antiretroviral therapy create an iatrogenic cancer risk?
    Gerald N Wogan
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Environ Mol Mutagen 48:210-4. 2007
    ..They further emphasize the importance of continued surveillance of these children for increased cancer risk and indicate a need for efforts to develop less genotoxic alternative agents...
  2. ncbi request reprint Environmental and chemical carcinogenesis
    Gerald N Wogan
    Biological Engineering Division, Massachusetts Institute of Technology, Room 26 009, Cambridge, MA 02139, USA
    Semin Cancer Biol 14:473-86. 2004
    ..These mutations presumably arise via DNA damage by environmental or endogenous agents, but it remains to be determined whether the acquisition of a mutator phenotype is a necessary event during tumor progression...
  3. ncbi request reprint Carbon dioxide modulation of peroxynitrite-induced mutagenesis of the supF gene in pSP189
    Burcak Pamir
    Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 16:487-92. 2003
    ..Remaining mutations were located almost exclusively at cytosine residues. It is evident from these data that reactive intermediates formed through reaction of ONOO(-) with CO(2) play an important role in the mutagenicity of ONOO(-)...
  4. pmc Genotoxicity of 2,6- and 3,5-dimethylaniline in cultured mammalian cells: the role of reactive oxygen species
    Ming Wei Chao
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Sci 130:48-59. 2012
    ....
  5. ncbi request reprint Mutagenesis of the supF gene of pSP189 replicating in AD293 cells cocultivated with activated macrophages: roles of nitric oxide and reactive oxygen species
    Min Young Kim
    Biological Engineering Division and Chemistry Department, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 19:1483-91. 2006
    ....
  6. pmc A single neonatal exposure to aflatoxin b1 induces prolonged genetic damage in two loci of mouse liver
    Roongtiwa Wattanawaraporn
    Department of Biological Engineering and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Sci 128:326-33. 2012
    ..Using two genetic loci, the data show a strong preference for the induction of GC to TA mutations in mice, which is the dominant mutation seen in people exposed to aflatoxin...
  7. ncbi request reprint AlkB influences the chloroacetaldehyde-induced mutation spectra and toxicity in the pSP189 supF shuttle vector
    Min Young Kim
    Department of Biological Engineering, Center for Environmental Health Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Chem Res Toxicol 20:1075-83. 2007
    ..These results suggest that the AlkB protein contributes to the elimination of exocyclic DNA base adducts, suppressing the toxic and mutagenic consequences induced by this damage and contributing to genetic stability...
  8. pmc Aflatoxin B1-DNA adduct formation and mutagenicity in livers of neonatal male and female B6C3F1 mice
    Leslie L Woo
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Sci 122:38-44. 2011
    ..The gender difference in the subsequent development of HCC highlights the importance of elucidating additional factors that modulate HCC development...
  9. pmc Threshold effects of nitric oxide-induced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells
    Chun Qi Li
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 19:399-406. 2006
    ..Furthermore, recombinational repair of DNA may contribute to resistance to NO(*) toxicity and potentially increase the risk of mutagenesis. The p53 plays a central role in these responses in human lymphoblastoid cells...
  10. pmc Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease
    Charles G Knutson
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02138, USA
    Proc Natl Acad Sci U S A 110:E2332-41. 2013
    ..These data point to innate immunity as a major determinant of serum and tissue profiles and provide insight into IBD disease processes. ..
  11. pmc Nitric oxide produced endogenously is responsible for hypoxia-induced HIF-1α stabilization in colon carcinoma cells
    Rajdeep Chowdhury
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 25:2194-202. 2012
    ..Our results support a regulatory mechanism of HIF-1α during hypoxia in which endogenously generated NO and ROS promote inhibition of PHD2 activity, probably by its S-nitrosation...
  12. pmc Delivery method, target gene structure, and growth properties of target cells impact mutagenic responses to reactive nitrogen and oxygen species
    Min Young Kim
    Biological Engineering Department, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 25:873-83. 2012
    ..Taken together, these results indicate that cell type and proximity to generator cells are critical determinants of cytotoxic and genotoxic responses induced by NO• and reactive species produced by activated macrophages...
  13. ncbi request reprint Biological role of glutathione in nitric oxide-induced toxicity in cell culture and animal models
    Chun Qi Li
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Free Radic Biol Med 39:1489-98. 2005
    ..Murine macrophages maintained GSH homeostasis when exposed to endogenously produced NO(.). In RcsX lymphoma-bearing mice, upregulation of de novo synthesis of GSH appeared to be a response to the toxic effects of NO(.)...
  14. pmc Transimination of quinone imines: a mechanism for embedding exogenous redox activity into the nucleosome
    Wenjie Ye
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
    Chem Res Toxicol 25:2627-9. 2012
    ..Consequently, quinone imines can be embedded in the nucleosome and may be expected to produce ROS in maximal proximity to the genome...
  15. pmc Endogenously produced nitric oxide mitigates sensitivity of melanoma cells to cisplatin
    Luiz C Godoy
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:20373-8. 2012
    ..The underlying mechanisms may thus represent potential targets for adjuvant strategies to improve the efficacy of chemotherapy...
  16. doi request reprint AFB(1) -induced mutagenesis of the gpt gene in AS52 cells
    Roongtiwa Wattanawaraporn
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Environ Mol Mutagen 53:567-73. 2012
    ..The results demonstrate the importance of metabolism, chromosomal location, transcription and selection conditions on mutational spectra...
  17. pmc Alkyl hydroperoxide reductase is required for Helicobacter cinaedi intestinal colonization and survival under oxidative stress in BALB/c and BALB/c interleukin-10-/- mice
    Nisanart Charoenlap
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Infect Immun 80:921-8. 2012
    ..Collectively, these data suggest that H. cinaedi ahpC not only contributes to protecting the organism against oxidative stress but also alters its pathogenic properties in vivo...
  18. pmc Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells
    Chun Qi Li
    Department of Biological Engineering and Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 106:14547-51. 2009
    ..Collectively, these results show that the Nrf2-Keap1 signaling pathway mediates protective cellular responses to mitigate *NO-induced damage and may contribute to the relative resistance of HCT116 to *NO-induced cytotoxicity...
  19. ncbi request reprint Thresholds of nitric oxide-mediated toxicity in human lymphoblastoid cells
    Chen Wang
    Department of Chemical Engineering, and Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 16:1004-13. 2003
    ..In general, the NH32 cells were much more resistant to NO-induced damage and death than TK6 cells, demonstrating that p53 status is an important determinant of NO-induced cytotoxicity...
  20. pmc Nitric oxide-induced genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells expressing wild-type and mutant p53
    Chun Qi Li
    Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 99:10364-9. 2002
    ..Thus, Apaf-1 and XIAP may play important roles in the regulation of p53-mediated apoptotic responses...
  21. pmc A system for exposing molecules and cells to biologically relevant and accurately controlled steady-state concentrations of nitric oxide and oxygen
    Vasileios Dendroulakis
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Nitric Oxide 27:161-8. 2012
    ..We also determined that components of culture media do not affect the steady-state levels of NO or O(2) in the device. This system provides critical control of NO delivery for in vitro models of NO biology and chemistry...
  22. pmc Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer
    Aswin Mangerich
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:E1820-9. 2012
    ..The results also reveal features of cell stress response that point to microbial pathophysiology and mechanisms of cell senescence as important mechanistic links to cancer...
  23. doi request reprint The rational design of nitric oxide selectivity in single-walled carbon nanotube near-infrared fluorescence sensors for biological detection
    Jong Ho Kim
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Chem 1:473-81. 2009
    ..We also demonstrate the potential of the optical sensor for in vivo detection of NO in a mouse model...
  24. pmc Monocyclic aromatic amines as potential human carcinogens: old is new again
    Paul L Skipper
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Carcinogenesis 31:50-8. 2010
    ....
  25. ncbi request reprint Mutagenesis of the supF gene by stereoisomers of 1,2,3,4-diepoxybutane
    Min Young Kim
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 20:790-7. 2007
    ..Our results are consistent with the stereospecific induction of promutagenic nucleobase adducts other than G-G cross-links by DEB stereoisomers...
  26. ncbi request reprint Apoptosis induced by capsaicin and resveratrol in colon carcinoma cells requires nitric oxide production and caspase activation
    Min Young Kim
    Department of Biological Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Anticancer Res 29:3733-40. 2009
    ....
  27. pmc Sulforaphane-mediated reduction of aflatoxin B₁-N⁷-guanine in rat liver DNA: impacts of strain and sex
    Jeannette L A Fiala
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Sci 121:57-62. 2011
    ..No gender-specific responses to SF were observed. These results support the view that SF induction of liver GST activity may play a role in its chemoprotective activity...
  28. ncbi request reprint Nitric oxide as a modulator of apoptosis
    Chun Qi Li
    Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Room 26 009, Cambridge, MA 02139, USA
    Cancer Lett 226:1-15. 2005
    ..Multifaceted cellular defense systems including glutathione, antioxidant enzymes and Nrf2-Keap1 signaling participate in protective responses to mitigate damage by toxic levels of NO*...
  29. ncbi request reprint Effects of peroxynitrite dose and dose rate on DNA damage and mutation in the supF shuttle vector
    Min Young Kim
    Biological Engineering Division and Chemistry Department, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 18:76-86. 2005
    ..Furthermore, the results indicate that the chemistry of SIN-1-induced DNA damage differs substantially from native ONOO-, which suggests the need for caution in interpreting the biological relevance of SIN-1 as a surrogate for ONOO-...
  30. doi request reprint Present and future directions of translational research on aflatoxin and hepatocellular carcinoma. A review
    Gerald N Wogan
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 29:249-57. 2012
    ..This strategy could serve as a template for the development, validation and application of molecular and biochemical markers for other carcinogens and cancers as well as other chronic diseases resulting from environmental exposures...
  31. ncbi request reprint Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53
    Chun Qi Li
    Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 4307, USA
    Cancer Res 64:3022-9. 2004
    ..Collectively, these data show that NO* exposure activated a complex network of responses leading to p53-dependent apoptosis via both mitochondrial and Fas receptor pathways, which were abrogated in the presence of mutant p53...
  32. ncbi request reprint Hydroxyl-specific fluorescence labeling of ABP-deoxyguanosine, PhIP-deoxyguanosine, and AFB1-formamidopyrimidine with BODIPY-FL
    Hyun Gyung Jang
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Anal Biochem 359:151-60. 2006
    ....
  33. pmc Mutagenic potency of Helicobacter pylori in the gastric mucosa of mice is determined by sex and duration of infection
    Alexander Sheh
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:15217-22. 2010
    ..Earlier onset of severe gastric lesions and proinflammatory, Th1-biased responses in female C57BL/6 mice may have promoted mutagenesis by exposing the stomach to prolonged oxidative stress...
  34. pmc Mechanism-based triarylphosphine-ester probes for capture of endogenous RSNOs
    Uthpala Seneviratne
    Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Am Chem Soc 135:7693-704. 2013
    ....
  35. ncbi request reprint DNA adduct formation by 2,6-dimethyl-, 3,5-dimethyl-, and 3-ethylaniline in vivo in mice
    Paul L Skipper
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA skipper mit edu
    Chem Res Toxicol 19:1086-90. 2006
    ....
  36. ncbi request reprint Genotoxicity associated with NO production in macrophages and co-cultured target cells
    John C Zhuang
    Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Free Radic Biol Med 33:94-102. 2002
    ..Collectively, these results support the hypothesis that NO production by activated macrophages may contribute to genotoxic risks associated with chronic inflammation...
  37. ncbi request reprint Genotoxicity, mitochondrial damage, and apoptosis in human lymphoblastoid cells exposed to peroxynitrite generated from SIN-1
    Chun Qi Li
    Biological Engineering Division and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 15:527-35. 2002
    ..Thus, p53 status was an important determinant of SIN-1 induced mutagenesis and apoptosis in these two human lymphoblastoid cell lines...
  38. ncbi request reprint Detection and quantification of 4-ABP adducts in DNA from bladder cancer patients
    Beatriz Zayas
    Universidad Metropolitana, San Juan, Puerto Rico
    Carcinogenesis 28:342-9. 2007
    ..There was no correlation between levels of DNA and Hb adducts. The presence of DNA adducts in 44% of the subjects and high levels of Hb adducts in these non-smokers indicate environmental sources of exposure to 4-ABP...
  39. pmc Human tumor p53 mutations are selected for in mouse embryonic fibroblasts harboring a humanized p53 gene
    Zhipei Liu
    Department of Genetic Alterations in Carcinogenesis, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 101:2963-8. 2004
    ..We conclude that establishment of Hupki mouse fibroblasts in culture readily selects for p53 DBD mutations found in human tumors, providing a basis for generating experimental mutation patterns in human p53...
  40. ncbi request reprint Nitric oxide in cancer and chemoprevention
    Lorne J Hofseth
    Laboratory of Human Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Free Radic Biol Med 34:955-68. 2003
    ..These findings highlight the importance of further study of the use of NO inhibitors to inhibit human carcinogenesis...
  41. pmc JS-K, a GST-activated nitric oxide generator, induces DNA double-strand breaks, activates DNA damage response pathways, and induces apoptosis in vitro and in vivo in human multiple myeloma cells
    Tanyel Kiziltepe
    Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Blood 110:709-18. 2007
    ..Taken together, these data provide the preclinical rationale for the clinical evaluation of JS-K to improve patient outcome in MM...