KARL WITTRUP

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. doi request reprint Targeted cytolysins synergistically potentiate cytoplasmic delivery of gelonin immunotoxin
    Christopher M Pirie
    Corresponding Author K Dane Wittrup, Massachusetts Institute of Technology, Building 76 261, 77 Massachusetts Avenue, Cambridge, MA 02139
    Mol Cancer Ther 12:1774-82. 2013
  2. doi request reprint Effect of small-molecule-binding affinity on tumor uptake in vivo: a systematic study using a pretargeted bispecific antibody
    Kelly Davis Orcutt
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cancer Ther 11:1365-72. 2012
  3. ncbi request reprint Protein engineering by cell-surface display
    K D Wittrup
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Biotechnol 12:395-9. 2001

Collaborators

  • Christopher M Pirie
  • Kelly Davis Orcutt
  • David V Liu
  • John J Rhoden
  • John V Frangioni
  • Benjamin Ruiz-Yi

Detail Information

Publications3

  1. doi request reprint Targeted cytolysins synergistically potentiate cytoplasmic delivery of gelonin immunotoxin
    Christopher M Pirie
    Corresponding Author K Dane Wittrup, Massachusetts Institute of Technology, Building 76 261, 77 Massachusetts Avenue, Cambridge, MA 02139
    Mol Cancer Ther 12:1774-82. 2013
    ..Targeted potentiation shows promise for enhancing cytoplasmic delivery of other macromolecular payloads such as DNA, siRNA, and miRNA...
  2. doi request reprint Effect of small-molecule-binding affinity on tumor uptake in vivo: a systematic study using a pretargeted bispecific antibody
    Kelly Davis Orcutt
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cancer Ther 11:1365-72. 2012
    ..We use relations derived from the model to develop design criteria for the future development of small-molecule agents for targeted cancer therapeutics...
  3. ncbi request reprint Protein engineering by cell-surface display
    K D Wittrup
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Biotechnol 12:395-9. 2001
    ..The promise of cell-surface display for directed evolution is being realized, with significant improvements recently reported in protein ligand binding affinity, stability, expression and enzymatic activity...

Research Grants23

  1. Interdepartmental Biotechnology Training Program
    KARL WITTRUP; Fiscal Year: 2007
    ..We have instituted minority recruitment outreach efforts during faculty seminar visits to other institutions. ..
  2. Engineered Antibody EGFR Antagonist Cancer Therapeutics
    KARL D WITTRUP; Fiscal Year: 2010
    ....
  3. Foundations of Pretargeted Radioimmunotherapy
    KARL D WITTRUP; Fiscal Year: 2010
    ..Mathematical modeling and protein biotechnology are essential components of the project. ..
  4. Engineering and Analysis of T cell CD3 and IL2R Signals
    KARL WITTRUP; Fiscal Year: 2007
    ..These studies will provide insights into T cell regulation as well as develop CDS and IL-2 stimulatory molecules of potential therapeutic value. ..
  5. Engineered Antibody EGFR Antagonist Cancer Therapeutics
    KARL WITTRUP; Fiscal Year: 2006
    ..abstract_text> ..
  6. PROTEIN QUALITY CONTROL IN THE ENDOPLASMIC RETICULUM
    KARL WITTRUP; Fiscal Year: 2001
    ....
  7. Foundations of Pretargeted Radioimmunotherapy
    KARL WITTRUP; Fiscal Year: 2009
    ..This hypothesis informs the planned efforts in protein engineering, cell culture, and in vivo biodistribution studies. ..