KARL WITTRUP

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Targeted cytolysins synergistically potentiate cytoplasmic delivery of gelonin immunotoxin
    Christopher M Pirie
    Corresponding Author K Dane Wittrup, Massachusetts Institute of Technology, Building 76 261, 77 Massachusetts Avenue, Cambridge, MA 02139
    Mol Cancer Ther 12:1774-82. 2013
  2. pmc Effect of small-molecule-binding affinity on tumor uptake in vivo: a systematic study using a pretargeted bispecific antibody
    Kelly Davis Orcutt
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cancer Ther 11:1365-72. 2012
  3. ncbi request reprint Protein engineering by cell-surface display
    K D Wittrup
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Biotechnol 12:395-9. 2001

Research Grants

Collaborators

  • Christopher M Pirie
  • Kelly Davis Orcutt
  • David V Liu
  • John V Frangioni
  • Benjamin Ruiz-Yi
  • John J Rhoden

Detail Information

Publications3

  1. pmc Targeted cytolysins synergistically potentiate cytoplasmic delivery of gelonin immunotoxin
    Christopher M Pirie
    Corresponding Author K Dane Wittrup, Massachusetts Institute of Technology, Building 76 261, 77 Massachusetts Avenue, Cambridge, MA 02139
    Mol Cancer Ther 12:1774-82. 2013
    ..Targeted potentiation shows promise for enhancing cytoplasmic delivery of other macromolecular payloads such as DNA, siRNA, and miRNA...
  2. pmc Effect of small-molecule-binding affinity on tumor uptake in vivo: a systematic study using a pretargeted bispecific antibody
    Kelly Davis Orcutt
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cancer Ther 11:1365-72. 2012
    ..We use relations derived from the model to develop design criteria for the future development of small-molecule agents for targeted cancer therapeutics...
  3. ncbi request reprint Protein engineering by cell-surface display
    K D Wittrup
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Curr Opin Biotechnol 12:395-9. 2001
    ..The promise of cell-surface display for directed evolution is being realized, with significant improvements recently reported in protein ligand binding affinity, stability, expression and enzymatic activity...

Research Grants2

  1. PROTEIN QUALITY CONTROL IN THE ENDOPLASMIC RETICULUM
    KARL WITTRUP; Fiscal Year: 2001
    ....
  2. Engineering and Analysis of T cell CD3 and IL2R Signals
    KARL WITTRUP; Fiscal Year: 2008
    ..These studies will provide insights into T cell regulation as well as develop CDS and IL-2 stimulatory molecules of potential therapeutic value. ..