Wolfgang C Winkelmayer

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 63:2280-5. 2003
  2. ncbi C-reactive protein and body mass index independently predict mortality in kidney transplant recipients
    Wolfgang C Winkelmayer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 4:1148-54. 2004
  3. ncbi Habitual caffeine intake and the risk of hypertension in women
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    JAMA 294:2330-5. 2005
  4. ncbi Impact of Medicaid prior authorization on angiotensin-receptor blockers: can policy promote rational prescribing?
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Health Aff (Millwood) 26:800-7. 2007
  5. pmc A randomized, double-blind, placebo-controlled trial of calcium acetate on serum phosphorus concentrations in patients with advanced non-dialysis-dependent chronic kidney disease
    Wajeh Qunibi
    Department of Medicine, University of Texas Health Sciences Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    BMC Nephrol 12:9. 2011
  6. ncbi Poor short-term survival and low use of cardiovascular medications in elderly dialysis patients after acute myocardial infarction
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Kidney Dis 47:301-8. 2006
  7. pmc Pottransplantation anemia: management and rationale
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3 030, Boston, MA 02120, USA
    Clin J Am Soc Nephrol 3:S49-55. 2008
  8. ncbi Pharmacoepidemiology of anemia in kidney transplant recipients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:1347-52. 2004
  9. pmc Use of recommended medications after myocardial infarction in Austria
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Eur J Epidemiol 23:153-62. 2008
  10. ncbi Benzodiazepine use and mortality of incident dialysis patients in the United States
    W C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Kidney Int 72:1388-93. 2007

Detail Information

Publications99

  1. ncbi Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 63:2280-5. 2003
    ..The effect of the glutamate carboxypeptidase II GCP2 1561C>T and the reduced folate carrier 1 RFC1 80G>A polymorphisms on folate and total homocysteine (tHcy) plasma levels of kidney transplant patients are unknown...
  2. ncbi C-reactive protein and body mass index independently predict mortality in kidney transplant recipients
    Wolfgang C Winkelmayer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 4:1148-54. 2004
    ..Furthermore, we were not able to detect any effect modification between CRP and body mass index on the outcomes under study. We conclude that CRP predicts all-cause mortality, but not allograft loss in stable KTR...
  3. ncbi Habitual caffeine intake and the risk of hypertension in women
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    JAMA 294:2330-5. 2005
    ..Caffeine acutely increases blood pressure, but the association between habitual consumption of caffeinated beverages and incident hypertension is uncertain...
  4. ncbi Impact of Medicaid prior authorization on angiotensin-receptor blockers: can policy promote rational prescribing?
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital Harvard Medical School, Boston, Massachusetts, USA
    Health Aff (Millwood) 26:800-7. 2007
    ..3 percent per quarter; alternative approaches were unsuccessful. These findings have important implications for the development of rational drug reimbursement policy under Medicare Part D and other health insurance plans...
  5. pmc A randomized, double-blind, placebo-controlled trial of calcium acetate on serum phosphorus concentrations in patients with advanced non-dialysis-dependent chronic kidney disease
    Wajeh Qunibi
    Department of Medicine, University of Texas Health Sciences Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    BMC Nephrol 12:9. 2011
    ..This trial was conducted to examine the efficacy and safety of calcium acetate in controlling serum phosphorus in pre-dialysis patients with CKD...
  6. ncbi Poor short-term survival and low use of cardiovascular medications in elderly dialysis patients after acute myocardial infarction
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Kidney Dis 47:301-8. 2006
    ..Their use and association with mortality in elderly dialysis patients after MI have not been studied sufficiently...
  7. pmc Pottransplantation anemia: management and rationale
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3 030, Boston, MA 02120, USA
    Clin J Am Soc Nephrol 3:S49-55. 2008
    ..Given the lack of large, well-designed, prospective studies, the consequences of anemia, the response to treatment, and the cost-effectiveness of treatment in the posttransplantation setting are also poorly understood...
  8. ncbi Pharmacoepidemiology of anemia in kidney transplant recipients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:1347-52. 2004
    ..05) and tacrolimus (P = 0.02) were associated with a lower HCT. The authors conclude that PTA is prevalent and undertreated in KTR. Several medications that are possibly modifiable correlates of PTR deserve further study...
  9. pmc Use of recommended medications after myocardial infarction in Austria
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Eur J Epidemiol 23:153-62. 2008
    ..001). We conclude that recommended medications were underused in Austrian MI survivors. Quality indicators should be established and interventions be implemented to ensure maximum secondary prevention after MI...
  10. ncbi Benzodiazepine use and mortality of incident dialysis patients in the United States
    W C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Kidney Int 72:1388-93. 2007
    ..Further studies are needed to elucidate the safety of these drugs in the dialysis population, which may lead to cautious and restrictive utilization of omega-receptor agonists in dialysis patients...
  11. ncbi Percentage of hypochromic red blood cells is an independent risk factor for mortality in kidney transplant recipients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics and Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 4:2075-81. 2004
    ..Larger studies on the association between anemia and these outcomes are warranted...
  12. ncbi Predialysis nephrologist care and access to kidney transplantation in the United States
    W C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics and the Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Transplant 7:872-9. 2007
    ..Earlier and more frequent predialysis nephrologist care were associated with greater access to the KT wait-list as well as a higher rate of KT, indicating that LNC may augment existing inequalities that impair access to KT...
  13. ncbi A J-shaped association between high-sensitivity C-reactive protein and mortality in kidney transplant recipients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, and Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Transpl Int 20:505-11. 2007
    ..In contrast to the general population, the association between hs-CRP and mortality in KTRs is not linear, but J-shaped, suggesting that KTRs with very low hs-CRP may also be at increased risk of death...
  14. ncbi Identification of individuals with CKD from Medicare claims data: a validation study
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Kidney Dis 46:225-32. 2005
    ..The validity of this approach to identify patients with CKD has not been sufficiently studied...
  15. ncbi A prospective study of anaemia and long-term outcomes in kidney transplant recipients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Nephrol Dial Transplant 21:3559-66. 2006
    ..However, no evidence is currently available that anaemia is actually associated with such risks in KTR...
  16. ncbi Underuse of ACE inhibitors and angiotensin II receptor blockers in elderly patients with diabetes
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Kidney Dis 46:1080-7. 2005
    ..However, little is known about the adequacy of adherence to these guidelines in elderly patients with diabetes and predictors of such appropriate ACE-inhibitor or ARB use...
  17. ncbi Efficacy and safety of angiotensin II receptor blockade in elderly patients with diabetes
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont St, Suite 3030, Boston, MA 02120, USA
    Diabetes Care 29:2210-7. 2006
    ....
  18. ncbi Assessing health state utilities in elderly patients at cardiovascular risk
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Med Decis Making 26:247-54. 2006
    ..Health state preferences can be a crucial component of cost-effectiveness analyses, but off-the-shelf health state utilities specifically for older people are not available...
  19. ncbi Kidney function and use of recommended medications after myocardial infarction in elderly patients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Clin J Am Soc Nephrol 1:796-801. 2006
    ..Differences in other characteristics such as age, rather than kidney function, may be responsible for much or all the reported reduction in use of preventive medications after MI seen in patients with chronic kidney disease...
  20. pmc Associations of kidney function with cardiovascular medication use after myocardial infarction
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02120, USA
    Clin J Am Soc Nephrol 3:1415-22. 2008
    ..It is unknown whether adherence to recommended medications after myocardial infarction (MI) differs by kidney function...
  21. doi Altitude and all-cause mortality in incident dialysis patients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, 1620 Tremont St, Ste 3 030, Boston, MA 02120, USA
    JAMA 301:508-12. 2009
    ..Increased iron availability caused by activation of hypoxia-induced factors at higher altitude may explain this finding. Hypoxia-induced factors are also involved in other pathways that may affect morbidity and mortality...
  22. doi Impact of reimbursement changes on statin use among patients with diabetes in Austria
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Wien Klin Wochenschr 122:89-94. 2010
    ..These have used various instruments to steer appropriate use of such treatment. It was the purpose of this study to examine the effect of two reimbursement policy changes of statin therapy in patients with diabetes in Austria...
  23. doi Nonselective and cyclooxygenase-2-selective NSAIDs and acute kidney injury
    Wolfgang C Winkelmayer
    The Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Med 121:1092-8. 2008
    ..We undertook a large pharmacoepidemiologic analysis of the risk of acute kidney injury among older adults using nonselective NSAIDs or cyclooxygenase (COX)-2 inhibitors...
  24. doi Comparison of cardiovascular outcomes in elderly patients with diabetes who initiated rosiglitazone vs pioglitazone therapy
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, 1620 Tremont St, Ste 3030, Boston, MA 02120, USA
    Arch Intern Med 168:2368-75. 2008
    ..We compared cardiovascular outcomes and mortality between patients initiating pioglitazone vs rosiglitazone therapy...
  25. pmc Angiotensin inhibition after myocardial infarction: does drug class matter?
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    J Gen Intern Med 21:1242-7. 2006
    ..Little is known about their relative use after MI in typical care settings, and about their relative effectiveness outside the clinical trial setting...
  26. pmc Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States
    Amy Devlin
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 63:1642-53. 2011
    ..We aimed to identify sociodemographic and clinical factors associated with variation in initial kidney replacement therapies among LN ESRD patients...
  27. pmc Epidemiology and sociodemographics of systemic lupus erythematosus and lupus nephritis among US adults with Medicaid coverage, 2000-2004
    Candace H Feldman
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 65:753-63. 2013
    ..This study was undertaken to investigate the epidemiology and sociodemographics of SLE and LN in the low-income US Medicaid population...
  28. pmc Prevalence of atrial fibrillation and warfarin use in older patients receiving hemodialysis
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Nephrol 25:341-53. 2012
    ..Little is known about the use of warfarin in hemodialysis (HD) patients with atrial fibrillation (AF). We studied temporal trends of AF among older HD patients, and of warfarin use among those with AF...
  29. doi Improvements in long-term mortality after myocardial infarction and increased use of cardiovascular drugs after discharge: a 10-year trend analysis
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    J Am Coll Cardiol 51:1247-54. 2008
    ..We sought to assess the relationship between increasing use of cardiovascular medications and trends in long-term prognosis after myocardial infarction (MI) in the elderly...
  30. pmc Effectiveness and safety of warfarin initiation in older hemodialysis patients with incident atrial fibrillation
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 6:2662-8. 2011
    ..Although generally recommended in atrial fibrillation (AF) patients, the effectiveness and safety of oral anticoagulation in dialysis patients with AF is unknown...
  31. pmc Prevalence, incidence, and demographics of systemic lupus erythematosus and lupus nephritis from 2000 to 2004 among children in the US Medicaid beneficiary population
    Linda T Hiraki
    Harvard School of Public Health and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Rheum 64:2669-76. 2012
    ..To investigate the nationwide prevalence, incidence, and sociodemographics of systemic lupus erythematosus (SLE) and lupus nephritis among children in the US Medicaid beneficiary population...
  32. ncbi A propensity analysis of late versus early nephrologist referral and mortality on dialysis
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 14:486-92. 2003
    ..Further research is needed to identify patients at particular risk so that interventions to prevent early deaths on dialysis in LR patients can be developed and tested...
  33. ncbi Associations between MTHFR 1793G>A and plasma total homocysteine, folate, and vitamin B in kidney transplant recipients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 67:1980-5. 2005
    ....
  34. pmc End-stage renal disease due to lupus nephritis among children in the US, 1995-2006
    Linda T Hiraki
    Harvard School of Public Health and Brigham and Women s Hospital, Boston, Massachusetts, USA
    Arthritis Rheum 63:1988-97. 2011
    ..To identify predictors of wait-listing for kidney transplantation, kidney transplantation, and mortality among children with lupus nephritis-associated end-stage renal disease (ESRD)...
  35. ncbi Comparing mortality of elderly patients on hemodialysis versus peritoneal dialysis: a propensity score approach
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 13:2353-62. 2002
    ....
  36. pmc Trends in the incidence, demographics, and outcomes of end-stage renal disease due to lupus nephritis in the US from 1995 to 2006
    Karen H Costenbader
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Arthritis Rheum 63:1681-8. 2011
    ....
  37. ncbi Nephrologist care and mortality in patients with chronic renal insufficiency
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Arch Intern Med 162:2002-6. 2002
    ..We sought to determine whether early or frequent access to nephrologist care prior to the initiation of dialysis was associated with a difference in mortality rates in the first year after dialysis began...
  38. pmc Trends in adherence to secondary prevention medications in elderly post-myocardial infarction patients
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Pharmacoepidemiol Drug Saf 17:1189-96. 2008
    ..Poor levels of medication adherence for patients with coronary heart disease (CHD) have been documented but it is unclear whether adherence has improved over time...
  39. ncbi Fasting plasma total homocysteine levels and mortality and allograft loss in kidney transplant recipients: a prospective study
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Am Soc Nephrol 16:255-60. 2005
    ..The clinical utility of homocysteine-lowering therapy, such as multivitamin therapy, to reduce the rates of these end points needs to be studied...
  40. ncbi Ten-year trends of cardiovascular drug use after myocardial infarction among community-dwelling persons > or =65 years of age
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 100:1061-7. 2007
    ..The underuse of statins and BBs was marked in black patients and did not improve over time...
  41. doi Gender differences in the management and prognosis of myocardial infarction among patients > or = 65 years of age
    Soko Setoguchi
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 101:1531-6. 2008
    ..Men, especially those aged > or =75 years, however, had worse short- and long-term prognoses compared with women of a similar age. The mortality was highest and the gender effect was more pronounced during the MI hospitalizations...
  42. doi ACE inhibitor and angiotensin II type 1 receptor antagonist therapies in elderly patients with diabetes mellitus: are they underutilized?
    Lamioko Shika Pappoe
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, USA
    Drugs Aging 27:87-94. 2010
    ....
  43. pmc Preventive health care measures before and after start of renal replacement therapy
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    J Gen Intern Med 17:588-95. 2002
    ..To describe utilization of preventive health care measures in patients with chronic kidney disease (CKD), both in the year prior to onset of renal replacement therapy (RRT), and in the first year of RRT...
  44. ncbi Delayed nephrologist referral and inadequate vascular access in patients with advanced chronic kidney failure
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Division of Nephrology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Clin Epidemiol 55:711-6. 2002
    ..17; 1.71)]. Inadequate development of vascular access for renal replacement therapy in patients with late nephrologist referral unnecessarily contributes to the burden of disease experienced by this vulnerable patient population...
  45. ncbi Effects of TCN2 776C>G on vitamin B, folate, and total homocysteine levels in kidney transplant patients
    Wolfgang C Winkelmayer
    The Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 65:1877-81. 2004
    ..Controversy exists regarding the possible associations between a single nucleotide polymorphism of the transcobalamin II encoding gene (TCN2 776C>G) and plasma levels of vitamin B(12), folate, or total homocysteine...
  46. ncbi Analysis of the cardiovascular risk profile in stable kidney transplant recipients after 50% cyclosporine reduction
    Waichi Wong
    Transplantation Unit, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, USA
    Clin Transplant 18:341-8. 2004
    ..Hence, a reduction in CsA dosage in kidney transplant recipients (KTR) may improve long-term outcomes. We analyzed the effects of 50% CsA dose reduction on the CVD risk profile in stable KTR...
  47. ncbi Effects of single-nucleotide polymorphisms in MTHFR and MTRR on mortality and allograft loss in kidney transplant recipients
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Boston, MA 02120, USA
    Kidney Int 68:2857-62. 2005
    ..The methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, an important determinant of plasma tHcy concentrations, could therefore constitute an important prognostic marker...
  48. pmc HMG-CoA reductase inhibitors in kidney transplant recipients receiving tacrolimus: statins not associated with improved patient or graft survival
    Nizar Younas
    Department of Medicine, Renal Electrolyte Division, University of Pittsburgh, Pittsburgh, PA, USA
    BMC Nephrol 11:5. 2010
    ..We evaluated the predictors of statin use following kidney transplantation and examined its association with patient and allograft survival...
  49. pmc Use of secondary prevention medications among adults with reduced kidney function
    Tara I Chang
    Division of Nephrology, Department of Medicine, Stanford University, Palo Alto, California, USA
    Clin J Am Soc Nephrol 7:604-11. 2012
    ....
  50. ncbi Hetastarch and bleeding complications after coronary artery surgery
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 124:1437-42. 2003
    ..To determine whether intraoperative HES use is associated with an increased risk of postoperative bleeding following coronary artery bypass graft (CABG) surgery...
  51. ncbi How well do patients report noncompliance with antihypertensive medications?: a comparison of self-report versus filled prescriptions
    Philip S Wang
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Pharmacoepidemiol Drug Saf 13:11-9. 2004
    ..Although self-reports are often the only means available in routine practice, their accuracy and agreement with other data sources remain questionable...
  52. pmc The effect of altitude on dosing and response to erythropoietin in ESRD
    M Alan Brookhart
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    J Am Soc Nephrol 19:1389-95. 2008
    ..Furthermore, resistance to EPO decreased with elevation. Our results suggest that ESRD patients living at high altitude either increase endogenous EPO production or respond better to endogenous and exogenous EPO...
  53. ncbi Health economic evaluations: the special case of end-stage renal disease treatment
    Wolfgang C Winkelmayer
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Med Decis Making 22:417-30. 2002
    ..Uses of the cost-effectiveness ratio of $55,000/LY for center hemodialysis as a lower boundary of society's willingness to pay for an additional life-year can be supported under certain assumptions...
  54. doi Trends in the use and outcomes of implantable cardioverter-defibrillators in patients undergoing dialysis in the United States
    David M Charytan
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Am J Kidney Dis 58:409-17. 2011
    ..Sudden cardiac death constitutes the leading cause of death in patients receiving dialysis. Little is known about the trends in implantable cardioverter-defibrillator (ICD) use and the outcomes of such device placement...
  55. doi Predialysis nephrology care of older patients approaching end-stage renal disease
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arch Intern Med 171:1371-8. 2011
    ..Little is known about trends in the timing of first nephrology consultation and associated outcomes among older patients initiating dialysis...
  56. ncbi Trends in relative mortality between Hispanic and non-Hispanic whites initiating dialysis: a retrospective study of the US Renal Data System
    Cristina M Arce
    Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA
    Am J Kidney Dis 62:312-21. 2013
    ..It is unknown whether this association differs by age, has changed over time, or is due to differential access to kidney transplantation...
  57. ncbi Trends in acute kidney injury, associated use of dialysis, and mortality after cardiac surgery, 1999 to 2008
    Colin R Lenihan
    Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA
    Ann Thorac Surg 95:20-8. 2013
    ..The last decade has seen major changes in the complexity of cardiac surgical candidates and in the number and type of cardiac surgical procedures being performed...
  58. doi Altitude and the risk of cardiovascular events in incident US dialysis patients
    Wolfgang C Winkelmayer
    Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA, USA
    Nephrol Dial Transplant 27:2411-7. 2012
    ..We hypothesized that higher altitude would be associated with lower rates of cardiovascular events due to an altered physiological response of dialysis patients to altitude induced hypoxia...
  59. ncbi Strategies for the management of suspected heparin-induced thrombocytopenia: a cost-effectiveness analysis
    Amanda R Patrick
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham, Massachusetts 02120, USA
    Pharmacoeconomics 25:949-61. 2007
    ..Drugs used to treat HIT are costly and may carry an increased risk of bleeding...
  60. ncbi Early erythropoietin therapy is associated with improved growth in children with chronic kidney disease
    Michael Boehm
    Kinderdialyse, Department of Pediatrics, Medical University Vienna, Vienna, Austria, and Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Pediatr Nephrol 22:1189-93. 2007
    ..Almost two thirds of referred children, however, experienced no catch-up growth during follow-up. Further study is needed to better define the optimal timing and intensity of nephrologist care in children with kidney disease...
  61. ncbi Hydroxyethyl starch and change in renal function in patients undergoing coronary artery bypass graft surgery
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 64:1046-9. 2003
    ..We sought to study the question in a formal analysis of postoperative change in renal function in patients undergoing coronary artery bypass graft (CABG) surgery...
  62. pmc Risk factors of short-term mortality after acute nonvariceal upper gastrointestinal bleeding in patients on dialysis: a population-based study
    Ju Yeh Yang
    Division of Nephrology, Department of Medicine, Stanford University School of Medicine, 1070 Arastradero Rd, Suite 313, Palo Alto, CA 94304, USA
    BMC Nephrol 14:97. 2013
    ..We examined the associations among demographic characteristics, dialysis-specific features, and comorbid conditions with short-term mortality after ANVUGIB among patients on dialysis...
  63. ncbi Validity of International Classification of Diseases, Ninth Revision, Clinical Modification Codes for Acute Renal Failure
    Sushrut S Waikar
    Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1688-94. 2006
    ..The excellent performance characteristics of ICD-9-CM codes for ARF-D suggest that administrative data sets may be particularly well suited for research endeavors that involve patients with ARF-D...
  64. ncbi Comparison of two dosages of thymoglobulin used as a short-course for induction in kidney transplantation
    Waichi Wong
    Renal and Transplantation Units, Massachusetts General Hospital and Harvard Medical School Boston, Boston, MA 02114, USA
    Transpl Int 19:629-35. 2006
    ..5 mg/kg/day regimen. A more profound T-cell clearance within the first 6 months postinduction therapy may translate into a decreased risk of immunological injury and improved long-term outcome after kidney transplantation...
  65. ncbi Chronic kidney disease as a risk factor for bleeding complications after coronary artery bypass surgery
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Kidney Dis 41:84-9. 2003
    ..The aim of the study is to define the role of chronic kidney disease (CKD) as a risk factor for postoperative bleeding in patients undergoing coronary artery bypass graft (CABG) surgery...
  66. ncbi Genetic aspects of hyperhomocysteinemia in chronic kidney disease
    Gere Sunder-Plassmann
    Department of Medicine III, Medical University Vienna, Vienna, Austria, and the Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Semin Nephrol 26:8-13. 2006
    ....
  67. ncbi Nononcologic use of human recombinant erythropoietin therapy in hospitalized patients
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02120, USA
    Arch Intern Med 167:840-6. 2007
    ..Little is known about the nature of rHuEPO use in hospitalized patients who receive rHuEPO therapy for nononcologic indications...
  68. ncbi The nephrologist's role in the management of calcium-phosphorus metabolism in patients with chronic kidney disease
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Kidney Int 63:1836-42. 2003
    ..In patients with chronic kidney disease (CKD), timely referral to a nephrologist has been shown to improve outcomes, but the specific care measures mediating these superior outcomes have not been sufficiently described...
  69. ncbi Renal dysfunction increases the risk of saphenous vein graft occlusion: results from the Post-CABG trial
    Gregory A Wellenius
    Cardiovascular Epidemiology Research Unit, Cardiovascular Division, Department of Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Deaconess 306, Boston, MA 02215, USA
    Atherosclerosis 193:414-20. 2007
    ..Saphenous vein grafts are common among patients with a history of coronary artery bypass graft (CABG) surgery. Chronic kidney disease (CKD) is an established cardiovascular risk factor, but its role in graft disease has not been evaluated...
  70. pmc Statins in elderly patients with acute coronary syndrome: an analysis of dose and class effects in typical practice
    Niteesh K Choudhry
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02120, USA
    Heart 93:945-51. 2007
    ..To compare the effectiveness of statins of different treatment intensity used to treat elderly patients with acute coronary syndrome (ACS) in typical care settings...
  71. ncbi Long-term trends of angiotensin-converting enzyme inhibitor and angiotensin-receptor blocker use after heart failure hospitalization in community-dwelling seniors
    Soko Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02120, United States
    Int J Cardiol 125:172-7. 2008
    ..Little is known about recent trends in the use of ACEI/ARB in community-dwelling seniors...
  72. ncbi The hepatotoxicity of antifungal medications in bone marrow transplant recipients
    Michael A Fischer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Clin Infect Dis 41:301-7. 2005
    ..Systemic antifungal medications can be lifesaving but can also have important toxicities. With a number of new antifungal drugs being introduced, there is a compelling need to define the toxicities associated with existing therapies...
  73. doi Temporal trends in adherence to cardiovascular medications in elderly patients after hospitalization for heart failure
    S Setoguchi
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin Pharmacol Ther 88:548-54. 2010
    ..Black race and dialysis treatment predicted poor adherence to any medications. Adherence to BBs and SL increased modestly over time, but overall nonadherence remained high...
  74. ncbi Associations between demographic factors and provider structures on cost and length of stay for hemodialysis patients with vascular access failure
    Louis Brenner
    Renal Division, Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 1:455-61. 2006
    ..It is concluded that gender and racial factors may influence VAF care. Over time, more VAF episodes are being treated in outpatient settings. Case management may lead to more outpatient treatment and shorter inpatient treatment of VAF...
  75. ncbi Comparing the costs, risks, and benefits of competing strategies for the primary prevention of venous thromboembolism
    Jerry Avorn
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 1620 Tremont Street, Suite 3030, Boston, MA 02120, USA
    Circulation 110:IV25-32. 2004
    ....
  76. ncbi Late nephrologist referral and access to renal transplantation
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Transplantation 73:1918-23. 2002
    ..Our aim was to explore a possible association between late nephrologist referral before onset of renal replacement therapy (RRT) and the likelihood of receiving a renal transplant...
  77. ncbi Predicting survival in patients requiring renal replacement therapy after cardiac surgery
    Marzia Leacche
    Division of Cardiac Surgery, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Ann Thorac Surg 81:1385-92. 2006
    ..We sought to develop and internally validate a prediction score for all-cause in-hospital mortality in patients who have acute renal failure and require renal replacement therapy after cardiac surgery...
  78. ncbi Determinants of delayed nephrologist referral in patients with chronic kidney disease
    W C Winkelmayer
    Divisions of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Kidney Dis 38:1178-84. 2001
    ....
  79. ncbi Late referral and modality choice in end-stage renal disease
    W C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 60:1547-54. 2001
    ....
  80. ncbi Propensity scores: help or hype?
    Wolfgang C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Harvard Medical School, Boston, USA
    Nephrol Dial Transplant 19:1671-3. 2004
  81. ncbi Optic neuropathy in uremia: an interdisciplinary emergency
    W C Winkelmayer
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Kidney Dis 37:E23. 2001
    ..Close collaboration among nephrologists, ophthalmologists, and neurologists is important in this interdisciplinary emergency...
  82. ncbi Patterns of co-occurrence of three single nucleotide polymorphisms of the 5,10-methylenetetrahydrofolate reductase gene in kidney transplant recipients
    W C Winkelmayer
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Eur J Clin Invest 34:613-8. 2004
    ..Only few reports have studied the prevalence of this polymorphism, especially in combination with other MTHFR mutations (677C > T, 1298A > C)...
  83. ncbi Anaemia after renal transplantation
    M Lorenz
    Department of Medicine III, Medical University of Vienna, Vienna, Austria, and Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women s Hospital, Boston, MA, USA
    Eur J Clin Invest 35:89-94. 2005
    ..A promising future aspect for risk reduction of cardiovascular disease includes the effect of erythropoietic agents on endothelial progenitor cells...
  84. ncbi Clinical presentation of myocardial infarction contributes to lower use of coronary angiography in patients with chronic kidney disease
    D M Charytan
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02120, USA
    Kidney Int 71:938-45. 2007
    ..However, the clinical features of MI do not account for its underuse in MI patients with CKD Stages 4/5. Whether reduced use of angiography in patients with advanced CKD is justified must be evaluated in formal risk-benefit analyses...
  85. ncbi Endothelial progenitor cells in kidney transplant recipients
    Sabine Steiner
    Division of Angiology, Department of Medicine II, Medical University Vienna, Vienna, Austria
    Transplantation 81:599-606. 2006
    ..Lower concentrations of endothelial progenitor cells (EPCs) may be associated with increased cardiovascular risk. EPC counts and their correlates have not yet been studied in kidney transplant recipients (KTR)...
  86. ncbi Prognostic associations between lipid markers and outcomes in kidney transplant recipients
    Elke S Schaeffner
    Department of Medicine, Charite Campus Virchow, Berlin, Germany
    Am J Kidney Dis 47:509-17. 2006
    ..Hyperlipidemia is highly prevalent in kidney transplant recipients, but the prognostic significance for mortality and allograft survival in these patients has not been established sufficiently...
  87. ncbi Methionine synthase reductase MTRR 66A > G has no effect on total homocysteine, folate, and Vitamin B12 concentrations in renal transplant patients
    Alexandra Feix
    Division of Nephrology and Dialysis, Department of Medicine III, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    Atherosclerosis 174:43-8. 2004
    ..In conclusion, MTRR 66A > G has no major effect on tHcy, folate, or Vitamin B(12) plasma concentrations in kidney graft recipients...
  88. doi Phosphate binder choice in dialysis patients: a call for evidence-based rather than marketing-based clinical practice
    Wolfgang C Winkelmayer
    Am J Kidney Dis 51:362-5. 2008
  89. doi Educational level as a determinant of access to and outcomes after kidney transplantation in the United States
    Elke S Schaeffner
    Department of Medicine, Charite Campus Virchow, Berlin, Germany
    Am J Kidney Dis 51:811-8. 2008
    ..Disparities in access to kidney transplantation exist, yet few studies investigated educational level as a determinant of access to and outcomes after kidney transplantation...
  90. ncbi Cost-effectiveness of fixed-dose combination of isosorbide dinitrate and hydralazine therapy for blacks with heart failure
    Derek C Angus
    Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Circulation 112:3745-53. 2005
    ..We assessed the resource use, costs of care, and cost-effectiveness of ISDN/HYD therapy in the A-HeFT trial population...
  91. ncbi The cost-effectiveness of maintaining higher hemoglobin targets with erythropoietin in hemodialysis patients
    Marcello Tonelli
    Division of Nephrology, University of Alberta, Edmonton, Alberta, Canada
    Kidney Int 64:295-304. 2003
    ..There is uncertainty regarding the appropriate target hemoglobin level in hemodialysis patients treated with erythropoietin (EPO)...
  92. ncbi Long-term patient and graft survival in the eurotransplant senior program: a single-center experience
    Veronika Fabrizii
    Division of Nephrology and Dialysis, Department of Internal Medicine III, Medical University of Vienna, Austria
    Transplantation 80:582-9. 2005
    ..The Eurotransplant Senior Program (ESP) was launched in 1999, targeted to increase the supply of donor kidneys to the elderly. This program requires local allocation of kidneys from cadaveric donors >>65 years to recipients >>65 years...
  93. ncbi The association between angiotensin converting enzyme inhibitor or angiotensin receptor blocker use during postischemic acute transplant failure and renal allograft survival
    Georg Heinze
    Core Unit of Medical Statistics and Informatics, Medical University of Vienna, Vienna, Austria
    Transplantation 82:1441-8. 2006
    ....
  94. ncbi Prognostic associations of serum calcium, phosphate and calcium phosphate concentration product with outcomes in kidney transplant recipients
    Elke S Schaeffner
    Department of Medicine, Charite Campus Virchow, Berlin, Germany
    Transpl Int 20:247-55. 2007
    ..High concentrations of serum phosphate and CaPO(4) product were associated with an increased risk for allograft loss in these KTR, whereas high serum calcium concentrations seemed to lower the risk...
  95. ncbi Patient and graft survival in older kidney transplant recipients: does age matter?
    Veronika Fabrizii
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, A 1090 Vienna, Austria
    J Am Soc Nephrol 15:1052-60. 2004
    ..68 to 1.53). After thorough control for confounding, 5-yr graft survival was not materially different by age group. Discrimination against older candidates for kidney transplantation on age-related grounds alone is not warranted...
  96. ncbi Angiotensin-converting enzyme inhibitor or angiotensin II type 1 receptor antagonist therapy is associated with prolonged patient and graft survival after renal transplantation
    Georg Heinze
    Core Unit of Medical Statistics and Informatics, Department of Nephrology, Medical University of Vienna, Austria
    J Am Soc Nephrol 17:889-99. 2006
    ..More frequent use of these medications may reduce the high incidence of death and renal allograft failure in these patients...
  97. ncbi Cardiovascular risk and the thiazolidinediones: déjà vu all over again?
    Daniel H Solomon
    JAMA 298:1216-8. 2007
  98. ncbi No associations between prolactin concentrations and response to erythropoiesis-stimulating agents in hemodialysis patients
    Markus Riegersperger
    Division of Nephrology and Dialysis, Department of Medicine III, Medical University Vienna, Vienna, Austria
    Am J Nephrol 27:390-6. 2007
    ..The effect of serum prolactin levels on the response to erythropoiesis-stimulating agents (ESA) in patients on chronic hemodialysis is unknown...
  99. pmc Medication adherence after myocardial infarction: a long way left to go
    Niteesh K Choudhry
    J Gen Intern Med 23:216-8. 2008