J W Winkelman
Affiliation: Massachusetts General Hospital
- Restless legs syndrome and central nervous system gamma-aminobutyric acid: preliminary associations with periodic limb movements in sleep and restless leg syndrome symptom severityJohn W Winkelman
Department of Psychiatry, Harvard Medical School, Boston, MA, USA Departments of Psychiatry and Neurology, Sleep Disorders Clinical Research Program, Massachusetts General Hospital, Boston, MA, USA Electronic address
Sleep Med 15:1225-30. 2014..However, levels of these transmitters in other RLS-related brain areas and levels of the most common inhibitory neurotransmitter, gamma-aminobutyric acid (GABA), have not been assessed...
- Sensory symptoms in restless legs syndrome: the enigma of painJohn W Winkelman
Brigham and Women s Hospital, Division of Sleep Medicine, 221 Longwood Ave, Boston, MA 02115, United States Electronic address
Sleep Med 14:934-42. 2013..Future studies are needed to better understand the experiential and biologic aspects of altered sensory experiences in RLS. ..
- Randomized polysomnography study of gabapentin enacarbil in subjects with restless legs syndromeJohn W Winkelman
Brigham and Women s Hospital Sleep Health Center, Brighton, Massachusetts, USA
Mov Disord 26:2065-72. 2011....
- Lack of hippocampal volume differences in primary insomnia and good sleeper controls: an MRI volumetric study at 3 TeslaJohn W Winkelman
Division of Sleep Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
Sleep Med 11:576-82. 2010..Loss of HV in PI might be due to chronic hyperarousal and/or chronic sleep debt. The aim of this study was to replicate the earlier pilot report while employing a larger sample, more rigorous screening criteria, and objective sleep data...
- Polysomnographic and health-related quality of life correlates of restless legs syndrome in the Sleep Heart Health StudyJohn W Winkelman
Harvard Medical School, Boston, MA, USA
Sleep 32:772-8. 2009..The objective of this study was to analyze sleep by PSG in a population-based sample with symptoms of RLS...
- Reduced brain GABA in primary insomnia: preliminary data from 4T proton magnetic resonance spectroscopy (1H-MRS)John W Winkelman
Division of Sleep Medicine, Brigham and Women s Hospital, Harvard Medical School, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
Sleep 31:1499-506. 2008..Proton magnetic resonance spectroscopy (1H-MRS) can non-invasively determine GABA levels in human brain. Our objective was to assess GABA levels in unmedicated individuals with PI, using 1H-MRS...
- Efficacy and safety of pramipexole in restless legs syndromeJ W Winkelman
Division of Sleep Medicine, Brigham and Women s Hospital Sleep Health Center, 1505 Commonwealth Avenue, Brighton, MA 02135, USA
Neurology 67:1034-9. 2006..Pramipexole was well tolerated: The most frequent adverse events with higher occurrence in the pramipexole group were nausea (19.0% vs 4.7%) and somnolence (10.1% vs 4.7%)..
- Clinical and polysomnographic features of sleep-related eating disorderJ W Winkelman
Sleep Disorders Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
J Clin Psychiatry 59:14-9. 1998..However, no current nosology accurately characterizes these patients. Physicians should be aware of the existence of the disorder and the value of referring patients with sleep-related eating disorder to a sleep disorders center...
- Schizophrenia, obesity, and obstructive sleep apneaJ W Winkelman
Sleep Disorders Program, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02459, USA
J Clin Psychiatry 62:8-11. 2001..This study evaluated the risk factors for obstructive sleep apnea in psychiatric patients...
- The evoked heart rate response to periodic leg movements of sleepJ W Winkelman
Sleep Disorders Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Sleep 22:575-80. 1999..It appears premature to conclude that periodic leg movements of sleep not associated with visible EEG arousal are clinically insignificant...
- Myoglobin, creatine kinase MB, and cardiac troponin-I to assess reperfusion after thrombolysis for acute myocardial infarction: results from TIMI 10AM J Tanasijevic
Clinical Laboratories, Brigham and Women s Hospital, Boston, MA 02115, USA
Am Heart J 134:622-30. 1997..The availability of a reliable, noninvasive serum marker of reperfusion may permit early identification of patients with occlusion after thrombolysis who might benefit from further interventions...
- Considering the causes of RLSJ W Winkelman
Departments of Medicine and Psychiatry, Harvard Medical School, Boston, MA, USA
Eur J Neurol 13:8-14. 2006..How these three identified aetiological factors, namely dopaminergic dysfunction, impaired iron homeostasis and genetic disposition, are inter-related in the genesis of RLS remains unclear...