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Genomes and GenesSpecies | Timothy WilensSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Effect of prior stimulant treatment for attention-deficit/hyperactivity disorder on subsequent risk for cigarette smoking and alcohol and drug use disorders in adolescentsTimothy E Wilens
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Arch Pediatr Adolesc Med 162:916-21. 2008..To examine the effects of early stimulant treatment on subsequent risk for cigarette smoking and substance use disorders (SUDs) in adolescents with attention-deficit/hyperactivity disorder (ADHD)...
Impact of substance use disorder on ADHD and its treatmentTimothy E Wilens
Department of Pediatric Psychopharmacology, Massachusetts General Hospital, USA
J Clin Psychiatry 68:e20. 2007..SUD also complicates the diagnosis of adult ADHD. Fortunately, pharmacologic treatment of ADHD does not appear to increase the risk for development of SUD in ADHD patients...
Correlates of alcohol use in adults with ADHD and comorbid alcohol use disorders: exploratory analysis of a placebo-controlled trial of atomoxetineTimothy E Wilens
Massachusetts General Hospital, Boston, MA 02114, USA
Curr Med Res Opin 27:2309-20. 2011..Attention-deficit/hyperactivity disorder (ADHD) and substance use disorder are often comorbid in adults. The effects of ADHD treatment on comorbid alcohol use disorder have not been extensively studied...- Family-based association study of the BDNF, COMT and serotonin transporter genes and DSM-IV bipolar-I disorder in childrenEric Mick
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
BMC Psychiatry 9:2. 2009..In this report we test for association with genes coding brain-derived neurotrophic factor (BDNF), the serotonin transporter (SLC6A4), and catechol-O-methyltransferase (COMT)... - A controlled trial of extended-release guanfacine and psychostimulants for attention-deficit/hyperactivity disorderTimothy E Wilens
Massachusetts General Hospital, Boston, MA, USA
J Am Acad Child Adolesc Psychiatry 51:74-85.e2. 2012.... - Do individuals with ADHD self-medicate with cigarettes and substances of abuse? Results from a controlled family study of ADHDTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Addict 16:14-21; quiz 22-3. 2007..More than one-third of adolescents and young adults endorsed using cigarettes and substances for self medication. Studies clarifying the role of self-medication in substance use disorders are necessary... - Association of bipolar and substance use disorders in parents of adolescents with bipolar disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, and Department of Psychiatry, Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Psychiatry 62:129-34. 2007..We have previously shown that juvenile bipolar disorder (BPD) is a risk for substance use disorders (SUD). Here we examine the expression of both disorders in families of youth with BPD to evaluate the familial risk mechanism... - Neuronal nicotinic receptor agonists for the treatment of attention-deficit/hyperactivity disorder: focus on cognitionTimothy E Wilens
Massachusetts General Hospital, Pediatric Psychopharmacology Research Unit, Yawkey Center for Outpatient Care Yaw 6A, Boston, MA 02114, USA
Biochem Pharmacol 74:1212-23. 2007..Further understanding of the effects of novel neuronal nAChR agonists on specific aspects of cognitive functioning in ADHD is required to assess the full potential of this approach... - When ADHD and substance use disorders intersect: relationship and treatment implicationsTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Curr Psychiatry Rep 9:408-14. 2007..In contrast, medication treatment alone of adults with ADHD and current SUD is inadequate for both ADHD and SUD. Stimulant diversion continues to be of concern, particularly in older adolescents and young adults... - Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literatureTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 47:21-31. 2008..The purpose of this systematic review of the literature is to evaluate the extent and characteristics of stimulant misuse and diversion in attention-deficit/hyperactivity disorder (ADHD) and non-ADHD individuals... - The nature of the relationship between attention-deficit/hyperactivity disorder and substance useTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 68:4-8. 2007..Individuals with SUD and ADHD have a more severe and complicated course of SUD. Pharmacotherapeutic treatment of ADHD in children reduces the risk for later cigarette smoking and SUD in adulthood... - Attention deficit hyperactivity disorder and substance use disordersTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 163:2059-63. 2006 - Mechanism of action of agents used in attention-deficit/hyperactivity disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychiatry 67:32-8. 2006..Elucidating the various mechanisms of action of ADHD medications may lead to better choices in matching potential response to the characteristics (e.g., genotype) of individuals... - Stimulants and sudden death: what is a physician to do?Timothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Pediatrics 118:1215-9. 2006..Recently, a US Food and Drug Administration advisory committee raised concerns about cardiovascular risks and sudden death in children and adolescents with attention-deficit/hyperactivity disorder who are receiving stimulants... - Long-term atomoxetine treatment in adolescents with attention-deficit/hyperactivity disorderTimothy E Wilens
Massachusetts General Hospital, Department of Psychiatry, Boston, Massachusetts, USA
J Pediatr 149:112-9. 2006..To determine the efficacy and safety of atomoxetine in adolescent subjects treated for attention-deficit/hyperactivity disorder (ADHD) for up to 2 years... - An open-label study of the tolerability of mixed amphetamine salts in adults with attention-deficit/hyperactivity disorder and treated primary essential hypertensionTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston 02114, USA
J Clin Psychiatry 67:696-702. 2006.... - Characteristics of adolescents and young adults with ADHD who divert or misuse their prescribed medicationsTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 45:408-14. 2006..As part of a 10-year longitudinal study of youths with ADHD, the authors evaluated medication diversion or misuse at the last follow-up period... - ABT-089, a neuronal nicotinic receptor partial agonist, for the treatment of attention-deficit/hyperactivity disorder in adults: results of a pilot studyTimothy E Wilens
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Biol Psychiatry 59:1065-70. 2006..This pilot study was designed to evaluate ABT-089, a neuronal nicotinic receptor partial agonist, as treatment for adult attention-deficit/hyperactivity disorder (ADHD)... - Do children and adolescents with ADHD respond differently to atomoxetine?Timothy E Wilens
Massachusetts General Hospital, Boston, MA 02114 3117, USA
J Am Acad Child Adolesc Psychiatry 45:149-57. 2006..Here the authors report data contrasting the efficacy and tolerability of atomoxetine between children and adolescents with attention-deficit/hyperactivity disorder (ADHD)... - Multisite controlled study of OROS methylphenidate in the treatment of adolescents with attention-deficit/hyperactivity disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, YAW 6 6A, 32 Fruit Street, Boston, MA 02114, USA
Arch Pediatr Adolesc Med 160:82-90. 2006..Despite the persistence of attention-deficit/hyperactivity disorder (ADHD) into adolescence, little is known about the efficacy and tolerability of stimulant medications in this age group... - Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: a controlled studyTimothy E Wilens
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
Drug Alcohol Depend 95:188-98. 2008..Clinicians should carefully screen adolescents with bipolar disorder for substance and cigarette use... - Atomoxetine treatment of adults with ADHD and comorbid alcohol use disordersTimothy E Wilens
Massachusetts General Hospital, 55 Fruit Street, YAW 6900, Boston, MA 02114, USA
Drug Alcohol Depend 96:145-54. 2008..The study aim was to determine if atomoxetine was superior to placebo in improving ADHD and alcohol use in recently abstinent adults with ADHD and comorbid alcohol use disorder... - An update on the pharmacotherapy of attention-deficit/hyperactivity disorder in adultsTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Child Psychiatry Service, Massachusetts General Hospital, Boston, MA, USA
Expert Rev Neurother 11:1443-65. 2011..The aggregate literature shows that the stimulants and catecholaminergic nonstimulants investigated had a clinically significant beneficial effect on treating ADHD in adults... - Does ADHD predict substance-use disorders? A 10-year follow-up study of young adults with ADHDTimothy E Wilens
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston MA 02114, USA
J Am Acad Child Adolesc Psychiatry 50:543-53. 2011..The main aims of this study were to identify clinically meaningful characteristics of children that predicted the future development of SUDs and to see whether the role of these characteristics varied by sex... - The intersection of attention-deficit/hyperactivity disorder and substance abuseTimothy E Wilens
Pediatric Psychopharmacology Unit, and Center for Addiction Medicine, Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, Boston, MA 02114, USA
Curr Opin Psychiatry 24:280-5. 2011..In this report more recent work exploring the developmental relationship between ADHD and SUDs and associated concurrent disorders is discussed... - Do executive function deficits predict later substance use disorders among adolescents and young adults?Timothy E Wilens
Clinical and Research Program in Pediatric Psychopharmacology, PediatricPsychopharmacology Unit, Massachusetts General Hospital, 55 Parkman Street, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 50:141-9. 2011..Therefore, we examined whether earlier EFD was a risk factor for subsequent cigarette smoking and SUD and further explored the relationship between EFD and SUD... - Safety and efficacy of ABT-089 in pediatric attention-deficit/hyperactivity disorder: results from two randomized placebo-controlled clinical trialsTimothy E Wilens
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, 55 Fruit Street, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 50:73-84.e1. 2011..To assess the safety and efficacy of ABT-089, a novel α(4)β(2) neuronal nicotinic receptor partial agonist, vs. placebo in children with attention-deficit/hyperactivity disorder (ADHD)... - Understanding attention-deficit/hyperactivity disorder from childhood to adulthoodTimothy E Wilens
Timothy E Wilens, MD, Pediatric Psychopharmacology Unit, YAW 6A, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
Postgrad Med 122:97-109. 2010..Pharmacotherapy, including stimulants, noradrenergic agents, α-agonists, and antidepressants, plays a fundamental role in the long-term management of ADHD... - A controlled trial of the methylphenidate transdermal system on before-school functioning in children with attention-deficit/hyperactivity disorderTimothy E Wilens
Massachusetts General Hospital, 55 Fruit St, YAW 6900, Boston, MA 02114, USA
J Clin Psychiatry 71:548-56. 2010..Our aim was to examine the effects of the methylphenidate transdermal system (MTS) on before-school ADHD symptoms and functioning in children with ADHD... - Presenting ADHD symptoms, subtypes, and comorbid disorders in clinically referred adults with ADHDTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, YAW 6A, 55 Fruit Street, Boston, MA 02114, USA
J Clin Psychiatry 70:1557-62. 2009..Comorbidity among adults with ADHD is also of great interest due to the high rates of psychiatric comorbidity, which can lead to a more persistent ADHD among adults... - An open study of adjunct OROS-methylphenidate in children and adolescents who are atomoxetine partial responders: I. EffectivenessTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
J Child Adolesc Psychopharmacol 19:485-92. 2009..This study evaluated the effectiveness of adding OROS methylphenidate (MPH) to children who are partial responders to atomoxetine (ATMX) in the treatment of attention-deficit/hyperactivity disorder (ADHD)... - Does conduct disorder mediate the development of substance use disorders in adolescents with bipolar disorder? A case-control family studyTimothy E Wilens
Massachusetts General Hospital, Pediatric Psychopharmacology Unit, Boston, MA 02114, USA
J Clin Psychiatry 70:259-65. 2009..However, because bipolar disorder and CD are frequently comorbid in the young, the impact of CD in mediating SUD in bipolar disorder youth remains unclear... - Concordance between cigarette smoking and the modified Fagerström Tolerance Questionnaire in controlled studies of ADHDTimothy E Wilens
Pediatric Psychopharmacology Program, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Am J Addict 17:491-6. 2008..68). Clinicians and researchers using the mFTQ in adolescents and young adults should consider a cutoff score of 3 to be indicative of cigarette smoking... - A randomized controlled trial of a novel mixed monoamine reuptake inhibitor in adults with ADHDTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Behav Brain Funct 4:24. 2008..abstract:.. - Effects of methylphenidate on the catecholaminergic system in attention-deficit/hyperactivity disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 28:S46-53. 2008..Overall, the changes in catecholaminergic tone clinically manifest as improvements in attention deficit, distractibility, and motor hyperactivity in patients with ADHD... - Varying the wear time of the methylphenidate transdermal system in children with attention-deficit/hyperactivity disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 47:700-8. 2008..The objectives of this study were to determine the efficacy, duration of action, and safety of methylphenidate transdermal system worn for variable times by children (ages 6-12) diagnosed with ADHD... - An open trial of adjunctive donepezil in attention-deficit/hyperactivity disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, YAW 6A, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 15:947-55. 2005..We sought to determine if donepezil, used adjunctively to stimulant medication, would improve residual symptoms of ADHD and EF deficits... - ADHD treatment with once-daily OROS methylphenidate: final results from a long-term open-label studyTimothy Wilens
Massachusetts General Hospital, Pediatric Psychopharmacology, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 44:1015-23. 2005..This article presents final results from an open-label, multisite study of a once-daily formulation of methylphenidate (MPH), OROS MPH... - Blood pressure changes associated with medication treatment of adults with attention-deficit/hyperactivity disorderTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Psychiatry 66:253-9. 2005..To evaluate the effects of medications used in the treatment of adults with attention-deficit/hyperactivity disorder (ADHD) on blood pressure and pulse... - Attention-deficit/hyperactivity disorder in adultsTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114-3139, USA
JAMA 292:619-23. 2004 - Bupropion XL in adults with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled studyTimothy E Wilens
Pediatric Psychopharmacology Research, Yawkey Center for Outpatient Care, Massachusetts General Hospital, Boston, Massachusetts 021143 3117, USA
Biol Psychiatry 57:793-801. 2005..This study evaluated the efficacy and safety of an extended-release, once-daily formulation of bupropion (XL) in the treatment of adults with ADHD... - Attention-deficit/hyperactivity disorder and the substance use disorders: the nature of the relationship, subtypes at risk, and treatment issuesTimothy E Wilens
Substance Abuse Services, Pediatric Psychopharmacology Clinic, Massachusetts General Hospital, Boston 02114, USA
Psychiatr Clin North Am 27:283-301. 2004..Given the prevalence and major morbidity and impairment caused by SUD and ADHD. prevention and treatment strategies for these patients need to be developed and evaluated further... - Impact of ADHD and its treatment on substance abuse in adultsTimothy E Wilens
Department of Psychiatry, Harvard Medical School, Substance Abuse Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114 3117, USA
J Clin Psychiatry 65:38-45. 2004..Careful monitoring of patients during treatment is necessary to ensure compliance with the treatment plan... - Patterns of comorbidity and dysfunction in clinically referred preschool and school-age children with bipolar disorderTimothy E Wilens
Johnson and Johnson Center for the Study of Pediatric Psychopathology, Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
J Child Adolesc Psychopharmacol 13:495-505. 2003..This study reports on the clinical characteristics, psychiatric comorbidity, and functioning of preschoolers identified with BPD who were referred to a pediatric psychiatric clinic... - Alcohol, drugs, and attention-deficit/ hyperactivity disorder: a model for the study of addictions in youthTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Psychopharmacol 20:580-8. 2006..ADHD is an important antecedent disorder in children and adolescents worthy of further targeted preventive efforts to diminish the risk for cigarette smoking and SUD... - Risk of substance use disorders in adolescents with bipolar disorderTimothy E Wilens
Pediatric Psychopharmacology Unit, Child Psychiatric Service, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 43:1380-6. 2004..Considering the public health importance of this issue, the authors now report on a controlled study of adolescents with and without BPD to evaluate the risk of SUD... - Characteristics of adults with attention deficit hyperactivity disorder plus substance use disorder: the role of psychiatric comorbidityTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, MA, USA
Am J Addict 14:319-27. 2005..Clinicians need to be attentive to other psychiatric disorders that may occur in the large group of adults with ADHD + SUD... - A clinical perspective of attention-deficit/hyperactivity disorder into adulthoodTimothy E Wilens
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
J Clin Psychiatry 65:1301-13. 2004..Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric disorder that affects all age groups. Recent data on the clinical presentation, comorbidity, neurobiology, and treatment are reviewed... - Influence of parental SUD and ADHD on ADHD in their offspring: preliminary results from a pilot-controlled family studyTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Addict 14:179-87. 2005..Replication studies clarifying the nature and strength of the association are necessary... - The clinical dilemma of using medications in substance-abusing adolescents and adults with attention-deficit/hyperactivity disorder: what does the literature tell us?Timothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Pediatric Psychopharmacology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
J Child Adolesc Psychopharmacol 15:787-98. 2005..The role of pharmacological treatment for ADHD in these comorbid individuals remains unclear... - Evidence-based pharmacotherapy for attention-deficit hyperactivity disorderJoseph Biederman
Massachusetts General Hospital, ACC 725, Boston, MA 02114, USA
Int J Neuropsychopharmacol 7:77-97. 2004..Further, more research is needed on the efficacy of treatment for comorbid ADHD, use of combined medications, and the combination of medication and psychosocial treatment... - Cardiovascular effects of longer-term, high-dose OROS methylphenidate in adolescents with attention deficit hyperactivity disorderPaul Hammerness
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02138, USA
J Pediatr 155:84-9, 89.e1. 2009..To examine the effects of high doses of extended-release methylphenidate (OROS MPH) on cardiovascular variables in adolescents with attention deficit hyperactivity disorder (ADHD)... - A large, double-blind, randomized clinical trial of methylphenidate in the treatment of adults with attention-deficit/hyperactivity disorderThomas Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Biol Psychiatry 57:456-63. 2005..A previous, pilot study by our group suggested that these results were due to inadequate dosing... - Comorbidity in pediatric bipolar disorderGagan Joshi
Pervasive Developmental Disorders Program, Clinical and Research Programs in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, 32 Fruit Street, Boston, MA 02114, USA
Child Adolesc Psychiatr Clin N Am 18:291-319, vii-viii. 2009..Future longitudinal studies to address the relationship and the impact of comorbid disorders on course and therapeutic response over time are required in youth with BPD... - Family based association study of pediatric bipolar disorder and the dopamine transporter gene (SLC6A3)Eric Mick
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Am J Med Genet B Neuropsychiatr Genet 147:1182-5. 2008..These data provide suggestive evidence supporting a role for SLC6A3 in the etiology of pediatric bipolar disorder... - An open study of adjunct OROS-methylphenidate in children who are atomoxetine partial responders: II. Tolerability and pharmacokineticsPaul Hammerness
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Harvard Medical School, Boston Massachusetts, USA
J Child Adolesc Psychopharmacol 19:493-9. 2009..The aim of this study was to evaluate the tolerability of adding OROS methylphenidate (MPH) to children who are partial responders to atomoxetine (ATMX) in the treatment of attention-deficit/hyperactivity disorder (ADHD)... - Stimulant treatment of adult attention-deficit/hyperactivity disorderThomas Spencer
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Psychiatr Clin North Am 27:361-72. 2004..As in childhood ADHD, medication remains a key component of treatment for adults with ADHD. More studies are needed to evaluate the efficacy and safety of stimulants over the long-term and their impact on quality of life... - Family based association analysis of statistically derived quantitative traits for drug use in ADHD and the dopamine transporter geneJessica Lasky-Su
Genetics Research Program and Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY 13210, and Pediatric psychopharmacology Unit, Massachusetts General Hospital, Boston, USA
Addict Behav 31:1088-99. 2006..A sliding window of analysis of 3 SNPs also resulted in only nominal associations. CONCLUSIONS: SNPs in DAT do not appear to be associated with the phenotypes generated from drug frequency variables among individuals with ADHD... - Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: a case seriesRobert L Doyle
Department of Psychiatry, Harvard Medical School, USA
J Atten Disord 9:543-9. 2006..Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD... - ADHD treatment with once-daily OROS methylphenidate: interim 12-month results from a long-term open-label studyTimothy Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, 15 Parkman Street, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 42:424-33. 2003..This article reports an interim analysis of a 24-month study evaluating the 12-month tolerability and effectiveness of a once-daily OROS formulation of methylphenidate (OROS MPH) in children with ADHD... - Novel treatments for attention-deficit/hyperactivity disorder in childrenThomas J Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, USA
J Clin Psychiatry 63:16-22. 2002.... - Plasma methylphenidate concentrations in youths treated with high-dose osmotic release oral system formulationJonathan R Stevens
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, Massachusetts 02138, USA
J Child Adolesc Psychopharmacol 20:49-54. 2010.... - Familial transmission of derived phenotypes for molecular genetic studies of substance use disordersStephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, 750 East Adams St, Syracuse, NY 13210, USA
Drug Alcohol Depend 92:100-7. 2008..001; cognitive impairment: OR=1.33, p=0.04); in offspring, baseline psychopathology predicted SUD at follow-up assessments (OR=1.55, p=0.01). Results suggest that these candidate SUD phenotypes may be useful for genetic studies of SUD... - New developments in the treatment of ADHDJoseph Biederman
Dept. of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
J Clin Psychiatry 67:148-59. 2006 - Does stimulant therapy of attention-deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literatureTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Pediatrics 111:179-85. 2003..We investigated all long-term studies in which pharmacologically treated and untreated youths with ADHD were examined for later SUD outcomes... - Cigarette smoking associated with attention deficit hyperactivity disorderTimothy E Wilens
Pediatric Psychopharmacology Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
J Pediatr 153:414-9. 2008..To evaluate the association between attention deficit hyperactivity disorder (ADHD) and severity of physical dependence on nicotine in a controlled study of adolescents and young adults with ADHD... - Overview and neurobiology of attention-deficit/hyperactivity disorderThomas J Spencer
Pediatric Psychopharmacology Unit, Psychiatry Service, Massachusetts General Hospital, Boston, USA
J Clin Psychiatry 63:3-9. 2002..Therefore, the treatment characteristics of newer, more selective treatments such as atomoxetine should continue to be explored in ADHD... - An open trial of bupropion for the treatment of adults with attention-deficit/hyperactivity disorder and bipolar disorderTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 54:9-16. 2003..Further controlled trials are warranted... - Effects of once-daily osmotic-release methylphenidate on blood pressure and heart rate in children with attention-deficit/hyperactivity disorder: results from a one-year follow-up studyTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Psychopharmacol 24:36-41. 2004..We evaluated the longer-term effects on vital signs of once-daily osmotic-release methylphenidate (MPH, Concerta) in children with ADHD... - Drug therapy for adults with attention-deficit hyperactivity disorderTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
Drugs 63:2395-411. 2003..Further studies are necessary to evaluate the long-term effectiveness and tolerability of various agents, functional and neuropsychological outcomes, and the use of various agents in specific subgroups of adults with ADHD... - Neuropsychological functioning in youth with bipolar disorderAlysa E Doyle
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 58:540-8. 2005..We compared neuropsychological and academic functioning of youth with and without DSM-IV BPD, controlling for effects of comorbid ADHD... - A naturalistic study of the effects of pharmacotherapy on substance use disorders among ADHD adultsStephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, NY 13210, USA
Psychol Med 37:1743-52. 2007.... - Influence of gender on attention deficit hyperactivity disorder in children referred to a psychiatric clinicJoseph Biederman
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 159:36-42. 2002..In this study the authors systematically examined the impact of gender on the clinical features of ADHD in a group of children referred to a clinic... - Substance use among ADHD adults: implications of late onset and subthreshold diagnosesStephen V Faraone
Department of Psychiatry, SUNY Upstate Medical University, Syracuse, New York 13210, USA
Am J Addict 16:24-32; quiz 33-4. 2007..In contrast, subthreshold ADHD seems to be a milder form of the disorder, or perhaps a heterogeneous group of true ADHD cases and false positives... - Atomoxetine treatment outcomes in adolescents and young adults with attention-deficit/hyperactivity disorder: results from a post hoc, pooled analysisLenard A Adler
Department of Psychiatry, New York University School of Medicine, New York, New York 10016, USA
Clin Ther 34:363-73. 2012..As a first step, we present the results of a post hoc, pooled analysis that compared the efficacy and safety profile of atomoxetine in these 2 patient populations... - Does stimulant treatment lead to substance use disorders?Stephen V Faraone
Harvard Medical School, and Massachusetts General Hospital, Boston 02114 3139, USA
J Clin Psychiatry 64:9-13. 2003..The implication of this finding is unquestionably one with enormous value both clinically and as a matter of public health... - ADHD: prevalence, diagnosis, and issues of comorbidityTimothy E Wilens
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
CNS Spectr 12:1-5. 2007 - Pharmacotherapy of ADHD in adultsTimothy E Wilens
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
CNS Spectr 13:11-3. 2008 - Psychiatric comorbidity and functioning in clinically referred preschool children and school-age youths with ADHDTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
J Am Acad Child Adolesc Psychiatry 41:262-8. 2002..We evaluated the clinical characteristics, psychiatric comorbidity, and functioning of preschool children and school-age youths with ADHD referred to a pediatric psychiatric clinic for evaluation... - Can adults with attention-deficit/hyperactivity disorder be distinguished from those with comorbid bipolar disorder? Findings from a sample of clinically referred adultsTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Biol Psychiatry 54:1-8. 2003..We now evaluate the clinical characteristics of referred adults with (n = 24) and without BPD (n = 27)... - A family study of the high-risk children of opioid- and alcohol-dependent parentsTimothy E Wilens
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Boston 02114, USA
Am J Addict 11:41-51. 2002..With a growing consensus that certain risk factors for later SUD start in childhood with potentially treatable childhood-onset disorders, new preventive approaches for individuals at risk may be developed targeting childhood precursors of.. - Bupropion SR for the treatment of substance-abusing outpatient adolescents with attention-deficit/hyperactivity disorder and mood disordersRamon Solhkhah
Pediatric Psychopharmacology Unit, Division of Child and Adolescent Psychiatry, Massachusetts General Hospital and Harvard Medical School, USA
J Child Adolesc Psychopharmacol 15:777-86. 2005..The ratings were completed at baseline, at month 3, and at the 6-month endpoint. Bupropion SR was initiated at 100 mg once-daily and titrated naturalistically to a maximum dose of 400 mg/day... - Adult psychiatric outcomes of girls with attention deficit hyperactivity disorder: 11-year follow-up in a longitudinal case-control studyJoseph Biederman
Clinical and Research Programs in Pediatric Psychopharmacology, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Psychiatry 167:409-17. 2010..Few follow-up studies have been conducted of girls with ADHD, and none have followed girls into adulthood. The authors sought to estimate the prevalence of psychopathology in girls with and without ADHD followed into young adulthood... - Psychopathology in females with attention-deficit/hyperactivity disorder: a controlled, five-year prospective studyJoseph Biederman
Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, 32 Fruit Street, Boston, MA 02114, USA
Biol Psychiatry 60:1098-105. 2006..This study estimated the lifetime burden of comorbid psychopathology in a large sample of girls with and without ADHD followed up over five years... - Family-based genome-wide association scan of attention-deficit/hyperactivity disorderEric Mick
Massachusetts General Hospital, 55 Fruit Street Warren 705, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 49:898-905.e3. 2010..We have conducted a third, independent, multisite GWAS of DSM-IV-TR ADHD... - Young adult outcome of attention deficit hyperactivity disorder: a controlled 10-year follow-up studyJoseph Biederman
Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
Psychol Med 36:167-79. 2006..Our objective was to estimate the lifetime prevalence of psychopathology in a sample of youth with and without attention deficit hyperactivity disorder (ADHD) through young adulthood using contemporaneous diagnostic and analytic techniques... - Efficacy and safety of mixed amphetamine salts extended release (Adderall XR) in the management of attention-deficit/hyperactivity disorder in adolescent patients: a 4-week, randomized, double-blind, placebo-controlled, parallel-group studyThomas J Spencer
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
Clin Ther 28:266-79. 2006..The ability to recognize and diagnose attention-deficit/hyperactivity disorder (ADHD) has increased in recent years. The persistence of ADHD symptoms puts adolescents with ADHD at risk for long-term adverse psychosocial outcomes... - Assessing cannabis use in adolescents and young adults: what do urine screen and parental report tell you?Martin Gignac
Pediatric Psychopharmacology Unit of the Psychiatry Department, Massachusetts General Hospital, Boston, MA, USA
J Child Adolesc Psychopharmacol 15:742-50. 2005..Our analysis compares three approaches to detect the most common drug abused in early adulthood, cannabis: (1) report on direct structured interview; (2) indirect parental report; and (3) urine toxicology screen... - Treatment of ADHD with stimulant medications: response to Nissen perspective in the New England Journal of MedicineJoseph Biederman
Clinical Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Am Acad Child Adolesc Psychiatry 45:1147-50. 2006 - The familial association between cigarette smoking and ADHD: a study of clinically referred girls with and without ADHD, and their familiesMichael C Monuteaux
Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA
Nicotine Tob Res 10:1549-58. 2008..These findings support the hypothesis that the combination of ADHD and smoking comprises an etiologically distinct familial subtype of ADHD in girls... - Cognitive-behavioral therapy for ADHD in medication-treated adults with continued symptomsSteven A Safren
Massachusetts General Hospital, MGH Psychiatry, Harvard Medical School, WACC 815, 15 Parkman Street, Boston, MA 02114, USA
Behav Res Ther 43:831-42. 2005..02). These data support the hypothesis that CBT for adults with ADHD with residual symptoms is a feasible, acceptable, and potentially efficacious next-step treatment approach, worthy of further testing... - Does social class predict substance problems in young adults with ADHD?Michael C Monuteaux
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
Am J Addict 16:403-9. 2007..No significant association was found in controls. These findings indicate that substance use risk in ADHD subjects is especially vulnerable to social class... - Familial risk analyses of attention deficit hyperactivity disorder and substance use disordersJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit St, Warren 705, Boston, MA 02114, USA
Am J Psychiatry 165:107-15. 2008..A robust and bidirectional comorbidity between attention deficit hyperactivity disorder (ADHD) and psychoactive substance use disorder (alcohol or drug abuse or dependence) has been consistently reported in the extant literature... - Is cigarette smoking a gateway to alcohol and illicit drug use disorders? A study of youths with and without attention deficit hyperactivity disorderJoseph Biederman
Department of Psychiatry, Harvard Medical School, USA
Biol Psychiatry 59:258-64. 2006.... - Impact of executive function deficits and attention-deficit/hyperactivity disorder (ADHD) on academic outcomes in childrenJoseph Biederman
Pediatric Psychopharmacology Unit, Psychiatry Department, Massachusetts General Hospital, Boston, MA 02114, USA
J Consult Clin Psychol 72:757-66. 2004..Children and adolescents with ADHD and EFDs were found to be at high risk for significant impairments in academic functioning. These results support screening children with ADHD for EFDs to prevent academic failure... - Long-term safety and effectiveness of mixed amphetamine salts extended release in adults with ADHDJoseph Biederman
Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
CNS Spectr 10:16-25. 2005..Assess the long-term safety and effectiveness of mixed amphetamine salts extended release (MAS XR) in adults with attention-deficit/hyperactivity disorder (ADHD) combined subtype... - Examination of concordance between maternal and youth reports in the diagnosis of pediatric bipolar disorderJoseph Biederman
Clinical and Research Program in Pediatric Psychopharmacology, Massachusetts General Hospital, 55 Fruit Street, Warren 705, Boston, MA 02114, USA
Bipolar Disord 11:298-306. 2009..To this end we compared discordant (mother positive and youth negative) and concordant (mother and youth positive) cases... - Do stimulants protect against psychiatric disorders in youth with ADHD? A 10-year follow-up studyJoseph Biederman
Psychiatry Department, Massachusetts General Hospital, Clinical and Research Programs in PediatricPsychopharmacology and Adult ADHD, Boston, Massachusetts 02114, USA
Pediatrics 124:71-8. 2009..We tested the association between stimulant treatment and the subsequent development of psychiatric comorbidity in a longitudinal sample of patients with ADHD... - Nonstimulant treatment of adult attention-deficit/hyperactivity disorderThomas Spencer
Pediatric Psychopharmacology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
Psychiatr Clin North Am 27:373-83. 2004..Such developments have the promise of improving the quality of life of the millions of affected patients and their families worldwide... - Long-term cardiovascular effects of mixed amphetamine salts extended release in adults with ADHDRichard H Weisler
Duke University Medical Center, University of North Carilina, Chapel Hill, Raleigh 27609, USA
CNS Spectr 10:35-43. 2005..To assess long-term cardiovascular effects of mixed amphetamine salts extended release (MAS XR) in adults with attention-deficit/hyperactivity disorder (ADHD) combined subtype... - Short- and long-term cardiovascular effects of mixed amphetamine salts extended release in childrenRobert L Findling
University Hospitals of Cleveland, Cleveland, Ohio 44106 5080, USA
J Pediatr 147:348-54. 2005....
Research Grants
- Substance Abuse in ADHD GirlsTimothy Wilens; Fiscal Year: 2006..Thus, the research, approach, and goals of this R01 application are consistent with those underscored in the PA and by the Institute of Medicine as being of the highest research priority. ..
- Atomoxetine in Adolescents with ADHD and SUDTimothy Wilens; Fiscal Year: 2007..In this manner, the candidate will satisfy overall career development and mentoring objectives of the K24 award. ..
- Juvenile Bipolar Disorder and Substance AbuseTimothy Wilens; Fiscal Year: 2007..Since BPD is identifiable and treatable, findings from the four-year follow-up will provide valuable information to formulate prevention and early intervention strategies. ..
- Juvenile Bipolar Disorder and Substance AbuseTimothy Wilens; Fiscal Year: 2009..Since BPD is identifiable and treatable, findings from the four-year follow-up will provide valuable information to formulate prevention and early intervention strategies. ..
- LONG TERM DRUG ABUSE IN ADHDTimothy Wilens; Fiscal Year: 2002..abstract_text> ..
- Juvenile Bipolar Disorder and Substance AbuseTimothy E Wilens; Fiscal Year: 2010..Since BPD is identifiable and treatable, findings from the four-year follow-up will provide valuable information to formulate prevention and early intervention strategies. ..