M T Whary

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Detection, eradication, and research implications of Helicobacter infections in laboratory rodents
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16 825A, Cambridge, MA 02139, USA
    Lab Anim (NY) 35:25-7, 30-6. 2006
  2. pmc Verifying and quantifying Helicobacter pylori infection status of research mice
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Methods Mol Biol 921:143-56. 2012
  3. pmc Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora
    M T Whary
    Division of Comparative Medicine, Massachusette Institute of Technology, 77 Massachusetts Avenue, Bldg 16 825A, Cambridge, MA 02139, USA
    Infect Immun 74:6615-23. 2006
  4. ncbi request reprint Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825A, Cambridge, Massachusetts 02139, USA
    Cancer Epidemiol Biomarkers Prev 14:1464-9. 2005
  5. pmc Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-) ) mice
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Immunology 133:165-78. 2011
  6. pmc Chronic active hepatitis induced by Helicobacter hepaticus in the A/JCr mouse is associated with a Th1 cell-mediated immune response
    M T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 66:3142-8. 1998
  7. ncbi request reprint Th1-mediated pathology in mouse models of human disease is ameliorated by concurrent Th2 responses to parasite antigens
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825A, Cambridge, MA 02139, USA
    Curr Top Med Chem 4:531-8. 2004
  8. ncbi request reprint Cholangiohepatitis and inflammatory bowel disease induced by a novel urease-negative Helicobacter species in A/J and Tac:ICR:HascidfRF mice
    N H Shomer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Exp Biol Med (Maywood) 226:420-8. 2001
  9. pmc Experimental Helicobacter pylori infection induces antral gastritis and gastric mucosa-associated lymphoid tissue in guinea pigs
    N H Shomer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 66:2614-8. 1998
  10. pmc Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice
    Z Shen
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Infect Immun 77:2508-16. 2009

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Detection, eradication, and research implications of Helicobacter infections in laboratory rodents
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16 825A, Cambridge, MA 02139, USA
    Lab Anim (NY) 35:25-7, 30-6. 2006
    ..The authors discuss the impact of subclinical and clinical disease and offer recommendations for managing helicobacter-free rodent colonies...
  2. pmc Verifying and quantifying Helicobacter pylori infection status of research mice
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Methods Mol Biol 921:143-56. 2012
    ..pylori rRNA. In this chapter, we will summarize strategies to allow initiation of experiments with helicobacter-free mice and then focus on PCR and ELISA techniques to verify and quantify H. pylori infection of research mice...
  3. pmc Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora
    M T Whary
    Division of Comparative Medicine, Massachusette Institute of Technology, 77 Massachusetts Avenue, Bldg 16 825A, Cambridge, MA 02139, USA
    Infect Immun 74:6615-23. 2006
    ..trogontum (with or without H. rodentium) induces a rapid-onset, erosive to ulcerative typhlocolitis which impacts the normal anaerobic flora of the colon and increases the risk of sepsis...
  4. ncbi request reprint Intestinal helminthiasis in Colombian children promotes a Th2 response to Helicobacter pylori: possible implications for gastric carcinogenesis
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825A, Cambridge, Massachusetts 02139, USA
    Cancer Epidemiol Biomarkers Prev 14:1464-9. 2005
    ..Considering the risk for H. pylori disease seems affected by features of bacterial virulence and host polymorphisms, other poorly understood influences, such as concurrent helminthiasis, may also be important...
  5. pmc Lactobacillus reuteri promotes Helicobacter hepaticus-associated typhlocolitis in gnotobiotic B6.129P2-IL-10(tm1Cgn) (IL-10(-/-) ) mice
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, USA
    Immunology 133:165-78. 2011
    ..reuteri. Although the effects other microbiota may have on H. hepaticus virulence properties remain speculative, further investigations using this gnotobiotic model are now possible...
  6. pmc Chronic active hepatitis induced by Helicobacter hepaticus in the A/JCr mouse is associated with a Th1 cell-mediated immune response
    M T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 66:3142-8. 1998
    ..i. The characterization of a cell-mediated Th1 immune response to H. hepaticus infection in the A/JCr mouse should prove valuable as a model for experimental regimens which manipulate the host response to Helicobacter...
  7. ncbi request reprint Th1-mediated pathology in mouse models of human disease is ameliorated by concurrent Th2 responses to parasite antigens
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825A, Cambridge, MA 02139, USA
    Curr Top Med Chem 4:531-8. 2004
    ....
  8. ncbi request reprint Cholangiohepatitis and inflammatory bowel disease induced by a novel urease-negative Helicobacter species in A/J and Tac:ICR:HascidfRF mice
    N H Shomer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139, USA
    Exp Biol Med (Maywood) 226:420-8. 2001
    ..These results provide a new model of IBD and cholangio-hepatitis associated with a specific urease-negative, novel H. species...
  9. pmc Experimental Helicobacter pylori infection induces antral gastritis and gastric mucosa-associated lymphoid tissue in guinea pigs
    N H Shomer
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 66:2614-8. 1998
    ..pylori-infected humans. The H. pylori-infected guinea pig should prove useful in modeling the interaction of helicobacter and vitamin C in gastric carcinogenesis...
  10. pmc Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice
    Z Shen
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Infect Immun 77:2508-16. 2009
    ..These results indicate that WT(Hc) can be used to model inflammatory bowel disease in IL-10(-/-) mice and that CDT contributes to the virulence of H. cinaedi...
  11. pmc Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticus
    Z Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 39:2598-602. 2001
    ..hepaticus DNA. Therefore, this assay can be used with high sensitivity and specificity to quantify H. hepaticus in experimentally infected mouse models as well as in naturally infected mice...
  12. ncbi request reprint Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology Cambridge, Massachusetts 02139, USA
    Nat Med 6:536-42. 2000
    ..Thus, concurrent enteric helminth infection can attenuate gastric atrophy, a premalignant lesion...
  13. ncbi request reprint Long-term colonization levels of Helicobacter hepaticus in the cecum of hepatitis-prone A/JCr mice are significantly lower than those in hepatitis-resistant C57BL/6 mice
    M T Whary
    Massachusetts Institute of Technology, Cambridge 02139, USA
    Comp Med 51:413-7. 2001
    ..hepaticus in the cecum, compared with those of hepatitis-resistant C57BL/6 mice. Host responses of A/JCr mice that limit cecal colonization with H. hepaticus may have important roles in the pathogenesis of hepatic lesions...
  14. ncbi request reprint Mice carrying a truncated Apc gene have diminished gastric epithelial proliferation, gastric inflammation, and humoral immunity in response to Helicobacter felis infection
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02138, USA
    Cancer Res 57:3972-8. 1997
    ....
  15. doi request reprint Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer
    J G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Mucosal Immunol 4:22-30. 2011
    ..hepaticus pathogenesis. Delineating targets of H. hepaticus virulence factors could facilitate novel approaches to treating microbially induced lower bowel inflammatory diseases...
  16. ncbi request reprint Helicobacter bilis-associated hepatitis in outbred mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Comp Med 54:571-7. 2004
    ..bilis-infected mice of group III seroconverted to H. bilis outer membrane antigen. Helicobacter bilis infection is associated with hepatitis in SW mice and can confound experimental results...
  17. ncbi request reprint Protective role of 17 beta -estradiol against the development of Helicobacter pylori-induced gastric cancer in INS-GAS mice
    Masahiro Ohtani
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 16 825C, Cambridge, MA 02139, USA
    Carcinogenesis 28:2597-604. 2007
    ..These results demonstrate a protective effect of E2 in H.pylori-induced gastric cancer in a mouse model...
  18. pmc Accelerated progression of gastritis to dysplasia in the pyloric antrum of TFF2 -/- C57BL6 x Sv129 Helicobacter pylori-infected mice
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Am J Pathol 171:1520-8. 2007
    ..pylori-infected mice at 19 months pi. These data support a protective role for TFF2 in part by modulating levels of gastric interferon-gamma in the development of H. pylori-associated premalignancy of the distal stomach...
  19. pmc Vitamin C supplementation does not protect L-gulono-gamma-lactone oxidase-deficient mice from Helicobacter pylori-induced gastritis and gastric premalignancy
    Chung Wei Lee
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Int J Cancer 122:1068-76. 2008
    ..pylori-induced premalignant gastric lesions. In addition, less severe gastric lesions in H.pylori infected gulo(-/-) mice supplemented with low vitamin C correlated with an attenuated Th1 inflammatory response...
  20. doi request reprint Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Microb Pathog 45:18-24. 2008
    ..These results indicate that H. hepaticus urease activity plays a crucial role in hepatic disease but is not required for cecal colonization by H. hepaticus...
  21. pmc Helicobacter hepaticus HHGI1 is a pathogenicity island associated with typhlocolitis in B6.129-IL10 tm1Cgn mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Microbes Infect 10:726-33. 2008
    ..05) at 13 WPI. These results demonstrate that genes in the HHGI1 contribute to the pathogenicity of H. hepaticus, at least in part via up-regulation of proinflammatory mediators IFN-gamma, TNF-alpha and IL-17a...
  22. ncbi request reprint Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cancer Res 63:942-50. 2003
    ..This study highlights the importance of using both genders to investigate the pathogenesis of H. pylori...
  23. ncbi request reprint Germ-line p53-targeted disruption inhibits helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Cancer Res 62:696-702. 2002
    ....
  24. pmc Wild-type and interleukin-10-deficient regulatory T cells reduce effector T-cell-mediated gastroduodenitis in Rag2-/- mice, but only wild-type regulatory T cells suppress Helicobacter pylori gastritis
    Chung Wei Lee
    Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Infect Immun 75:2699-707. 2007
    ..pylori-mediated inflammation and in regulatory effects between wt T(R) and IL-10(-/-) T(R) cells suggest that IL-10 expression by wt T(R) cells is important to regulatory suppression of gastric inflammation...
  25. pmc Trefoil family factor 2 is expressed in murine gastric and immune cells and controls both gastrointestinal inflammation and systemic immune responses
    Evelyn A Kurt-Jones
    Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Lazare Research Building Rm 226, Worcester, MA 01605, USA
    Infect Immun 75:471-80. 2007
    ..Our studies suggest that TFF2 not only controls gastrointestinal repair but also regulates mononuclear cell inflammatory responses...
  26. pmc Gastric helicobacter infection induces a Th2 phenotype but does not elevate serum cholesterol in mice lacking inducible nitric oxide synthase
    Melanie Ihrig
    Division of Comparative Medicine, Massachusetts Institute of Technology, 77 Massachusetts Ave, Bldg 16, Rm 825C, Cambridge, MA 02139, USA
    Infect Immun 73:1664-70. 2005
    ..H. felis colonization was significantly greater in the iNOS-deficient mice. These findings are indicative of an impaired Th1 component of the H. felis-induced inflammatory response when the influence of iNOS is removed...
  27. pmc Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice
    Zhongming Ge
    Division of Comparative Medicine, Massachusetts Institute of Technology, 16 873, 77 Massachusetts Avenue, Cambridge, MA 02131, USA
    Infect Immun 73:3559-67. 2005
    ..hepaticus in cecum, colon, and jejunum but only transient colonization of H. hepaticus in the ileum of female mice; (iv) H. hepaticus colonization was associated with down-regulation of colonic IL-10 production...
  28. ncbi request reprint Progression of chronic hepatitis and preneoplasia in Helicobacter hepaticus-infected A/JCr mice
    Arlin B Rogers
    Comparative Pathology Laboratory 16 849, Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Toxicol Pathol 32:668-77. 2004
    ..Continued study of chronic hepatitis progression may reveal therapeutic targets to reduce the risk of hepatocellular carcinoma...
  29. ncbi request reprint Natural and experimental Helicobacter infections
    Mark T Whary
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Comp Med 54:128-58. 2004
    ..Current recommendations for deriving and managing helicobacter-free animal colonies for research are provided...
  30. ncbi request reprint p27kip1 deficiency confers susceptibility to gastric carcinogenesis in Helicobacter pylori-infected mice
    Noriyoshi Kuzushita
    Division of Gastroenterology, Department of Medicine, Rhode Island Hospital Brown University, Providence, Rhode Island 02903, USA
    Gastroenterology 129:1544-56. 2005
    ..We therefore evaluated p27-deficient mice as a model for H pylori-associated gastric cancer...
  31. ncbi request reprint Helicobacter pylori but not high salt induces gastric intraepithelial neoplasia in B6129 mice
    Arlin B Rogers
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cancer Res 65:10709-15. 2005
    ..In summary, we report for the first time H. pylori-induced gastric intraepithelial neoplasia in a wild-type mouse model and show no additive effect of high-salt ingestion on tumor progression...
  32. pmc Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains
    James G Fox
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Infect Immun 72:1116-25. 2004
    ..jejuni to escape immune surveillance. NF-kappaB-deficient mice should be a useful model to further study the role of CDT and other aspects of C. jejuni pathogenesis...
  33. pmc Comparison of diagnostic techniques for Helicobacter cetorum infection in wild Atlantic bottlenose dolphins (Tursiops truncatus)
    Claudia G Harper
    Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Microbiol 41:2842-8. 2003
    ..cetorum, and results indicate there is at least a 50% prevalence of H. cetorum infection in these dolphins...
  34. ncbi request reprint Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer
    Shigeo Takaishi
    Division of Digestive and Liver Disease, Department of Medicine, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Gastroenterology 128:1965-83. 2005
    ..We used this model to examine the role of cholecystokinin 2 (CCK2)/gastrin receptor and histamine H2-receptor signaling in the development of gastric atrophy and cancer...
  35. pmc Cross-reactivity between immune responses to Helicobacter bilis and Helicobacter pylori in a population in Thailand at high risk of developing cholangiocarcinoma
    Paola Pisani
    Descriptive Epidemiology Group, International Agency for Research on Cancer, 150 cours Albert Thomas, 69372 Lyon Cedex 03, France
    Clin Vaccine Immunol 15:1363-8. 2008
    ..We found high cross-reactivity between the immune responses to H. pylori and H. bilis antigens. More-specific H. bilis antigens need to be isolated to develop serologic tests suitable for epidemiological studies...