Research Topics
Genomes and GenesSpecies | Corrine WeltSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestryCorrine K Welt
Reproductive Endocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 97:E1342-7. 2012..Replication is necessary to determine whether the same variants confer risk for PCOS in women of European ancestry...
Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levelsCorrine K Welt
Reproductive Endocrine Unit, Department of Medicine, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 90:3069-76. 2005..In addition, the normal inhibin A and inhibin B production in the absence of estradiol precursors and estradiol provide insight into the selective dysfunction of the theca cells in autoimmune oophoritis...- Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesisCorrine K Welt
Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 90:5582-7. 2005..Previous studies suggest that inhibin subunit expression is decreased in granulosa cells of women with polycystic ovary syndrome (PCOS)... - Control of estradiol secretion in reproductive ageingC K Welt
Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Hum Reprod 21:2189-93. 2006..We hypothesized that increased aromatase activity accounts for E(2) preservation in older women... - Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populationsC K Welt
Reproductive Endocrine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 91:4361-8. 2006..The phenotype of women with polycystic ovary syndrome (PCOS) is variable, depending on the ethnic background... - Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic featuresC K Welt
Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 91:4842-8. 2006..The Rotterdam criteria for polycystic ovary syndrome (PCOS) defines discrete subgroups whose phenotypes are not yet clear... - Will leptin become the treatment of choice for functional hypothalamic amenorrhea?Corrine K Welt
Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, Boston, MA 02114, USA
Nat Clin Pract Endocrinol Metab 3:556-7. 2007 - Primary ovarian insufficiency: a more accurate term for premature ovarian failureCorrine K Welt
Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
Clin Endocrinol (Oxf) 68:499-509. 2008..Management should be directed at symptom resolution and bone protection, but most importantly should include psychosocial support for women facing this devastating diagnosis... 
Autoimmune oophoritis in the adolescentCorrine K Welt
Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Ann N Y Acad Sci 1135:118-22. 2008..Granulosa cells are spared, and inhibin A and B levels are normal to high. Treatment is aimed at symptom relief with further investigation needed to assess treatment options such as immunosuppression...- Relationship of estradiol and inhibin to the follicle-stimulating hormone variability in hypergonadotropic hypogonadism or premature ovarian failureCorrine K Welt
Reproductive Endocrine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 90:826-30. 2005..These data also demonstrate the variability in FSH levels as a function of underlying follicular development in women with POF... - Evidence of early ovarian aging in fragile X premutation carriersC K Welt
Reproductive Endocrine, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 89:4569-74. 2004..Early ovarian aging in fragile X premutation carriers likely results from decreased follicle number and function, as reflected by lower inhibin B, inhibin A, and P4 levels... - Differential regulation of inhibin A and inhibin B by luteinizing hormone, follicle-stimulating hormone, and stage of follicle developmentC K Welt
Reproductive Endocrine Unit, Reproductive Endocrine Sciences Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 86:2531-7. 2001..Thus, both differential secretion of LH and FSH and the stage of follicle development determine the patterns of inhibin A and inhibin B secretion in the normal menstrual cycle... - The physiology and pathophysiology of inhibin, activin and follistatin in female reproductionCorrine K Welt
Reproductive Endocrine Unit, Reproductive Endocrine Sciences Center and National Center for Infertility Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Curr Opin Obstet Gynecol 14:317-23. 2002..Thus, the mechanism of inhibin action and its role in normal and abnormal ovarian function continues to emerge... - Differential regulation of inhibin B and inhibin a by follicle-stimulating hormone and local growth factors in human granulosa cells from small antral folliclesC K Welt
Reproductive Endocrine Unit, Reproductive Endocrine Sciences Center, National Center for Infertility Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 86:330-6. 2001..However, additional growth factors or increasing granulosa cell number may contribute to the preferential serum inhibin B increase across the luteal-follicular transition in the menstrual cycle... - Control of follicle-stimulating hormone by estradiol and the inhibins: critical role of estradiol at the hypothalamus during the luteal-follicular transitionCorrine K Welt
Reproductive Endocrine Unit and National Center for Infertility Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 88:1766-71. 2003..In contrast, inhibin A and/or B plays a more critical role as the follicular phase progresses. In addition, these studies support a primary if not exclusive hypothalamic site of estrogen-negative feedback in the early follicular phase... - Leptin and soluble leptin receptor in follicular fluidCorrine K Welt
Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Assist Reprod Genet 20:495-501. 2003..The relationship between intrafollicular leptin and the soluble leptin receptor, ovarian hormones, and oocyte quality was examined to determine potential factors contributing to this finding... - Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millenniumCorrine Welt
Reproductive Endocrine Unit and Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA
Exp Biol Med (Maywood) 227:724-52. 2002..As technology and model systems become more sophisticated in the next few years, it should become possible to test this concept directly to more clearly define the role of activin, inhibin, and FS in reproductive physiology... - Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadismFelecia Cerrato
Reproductive Endocrine Unit, Massachusetts General Hospital BHX 504, Fruit Street, Boston, Massachusetts 02114, USA
Eur J Endocrinol 155:S3-S10. 2006..Twenty-four rare variants were identified in GNRHR (within 15 probands) and seven rare variants in GPR54 (within five probands). CONCLUSIONS: Rare variants in GNRHR are more common than GPR54 in a nIHH population... - Serum inhibin B in polycystic ovary syndrome: regulation by insulin and luteinizing hormoneCorrine K Welt
Reproductive Endocrine Unit and the National Center for Infertility Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Clin Endocrinol Metab 87:5559-65. 2002..These findings suggest that both increased LH and insulin may account for the relative suppression of inhibin B in patients with PCOS... - Regulation and function of inhibins in the normal menstrual cycleCorrine K Welt
Reproductive Endocrine, Massachusetts General Hospital, Boston, Massachusetts, USA
Semin Reprod Med 22:187-93. 2004..Future work will be necessary to define further the relative role of the inhibins, estradiol, and other autocrine-paracrine factors in these important reproductive functions... - Recombinant human leptin in women with hypothalamic amenorrheaCorrine K Welt
Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
N Engl J Med 351:987-97. 2004.... - The adult galactosemic phenotypeSusan E Waisbren
Children s Hospital Boston, Boston, MA, USA
J Inherit Metab Dis 35:279-86. 2012..Data on how individuals with galactosemia fare as adults will improve our ability to predict disease progression... - Effects of recombinant human prolactin on breast milk compositionCamille E Powe
Harvard Medical School, Harvard University, Boston, Massachusetts 02114, USA
Pediatrics 127:e359-66. 2011..The objective of this study was to determine the impact of recombinant human prolactin (r-hPRL) on the nutritional and immunologic composition of breast milk... - The FMR1 premutation and reproductionMichael D Wittenberger
Intramural Research Program, Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
Fertil Steril 87:456-65. 2007..It is now recognized that this was incorrect, specifically with respect to female reproduction...
Research Grants
- Phase 2 Trial of Recombinant Human Prolactin for Lactation InsufficiencyCorrine Welt; Fiscal Year: 2005..The studies may thus provide data that lead to the first FDA approved treatment for lactation insufficiency. In addition, these studies may further define the physiological role of prolactin in lactation. ..
- The Genetics of Polycystic Ovary SyndromCorrine K Welt; Fiscal Year: 2010..Discovering the variants and/or gene(s) that predispose to PCOS will determine an etiology and will provide a novel target to develop new treatments for the 1 in 10 reproductive age women it affects. ..