Corrine Welt

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi request reprint Mutations in eIF4ENIF1 Are Associated With Primary Ovarian Insufficiency
    Thushiga Kasippillai
    MD, Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 98:E1534-9. 2013
  2. pmc Fertility preservation in female classic galactosemia patients
    Britt van Erven
    Department of Pediatrics and Department of Genetic Metabolic Diseases Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands
    Orphanet J Rare Dis 8:107. 2013
  3. pmc Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry
    Corrine K Welt
    Reproductive Endocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1342-7. 2012
  4. ncbi request reprint Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5582-7. 2005
  5. ncbi request reprint Control of estradiol secretion in reproductive ageing
    C K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Hum Reprod 21:2189-93. 2006
  6. ncbi request reprint Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populations
    C K Welt
    Reproductive Endocrine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:4361-8. 2006
  7. ncbi request reprint Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features
    C K Welt
    Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:4842-8. 2006
  8. ncbi request reprint Will leptin become the treatment of choice for functional hypothalamic amenorrhea?
    Corrine K Welt
    Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Endocrinol Metab 3:556-7. 2007
  9. ncbi request reprint Primary ovarian insufficiency: a more accurate term for premature ovarian failure
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 68:499-509. 2008
  10. doi request reprint Autoimmune oophoritis in the adolescent
    Corrine K Welt
    Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Ann N Y Acad Sci 1135:118-22. 2008

Research Grants

Collaborators

Detail Information

Publications26

  1. doi request reprint Mutations in eIF4ENIF1 Are Associated With Primary Ovarian Insufficiency
    Thushiga Kasippillai
    MD, Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114
    J Clin Endocrinol Metab 98:E1534-9. 2013
    ..Conclusion: Data demonstrate a new gene associated with dominantly inherited POI. These results highlight the importance of translation initiation factors and their regulators in ovarian function. ..
  2. pmc Fertility preservation in female classic galactosemia patients
    Britt van Erven
    Department of Pediatrics and Department of Genetic Metabolic Diseases Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands
    Orphanet J Rare Dis 8:107. 2013
    ..We propose that fertility preservation should only be offered with appropriate institutional research ethics approval to classic galactosemia girls at a young prepubertal age. ..
  3. pmc Variants in DENND1A are associated with polycystic ovary syndrome in women of European ancestry
    Corrine K Welt
    Reproductive Endocrine Unit, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 97:E1342-7. 2012
    ..Replication is necessary to determine whether the same variants confer risk for PCOS in women of European ancestry...
  4. ncbi request reprint Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:5582-7. 2005
    ..Previous studies suggest that inhibin subunit expression is decreased in granulosa cells of women with polycystic ovary syndrome (PCOS)...
  5. ncbi request reprint Control of estradiol secretion in reproductive ageing
    C K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Hum Reprod 21:2189-93. 2006
    ..We hypothesized that increased aromatase activity accounts for E(2) preservation in older women...
  6. ncbi request reprint Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populations
    C K Welt
    Reproductive Endocrine, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:4361-8. 2006
    ..The phenotype of women with polycystic ovary syndrome (PCOS) is variable, depending on the ethnic background...
  7. ncbi request reprint Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features
    C K Welt
    Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 91:4842-8. 2006
    ..The Rotterdam criteria for polycystic ovary syndrome (PCOS) defines discrete subgroups whose phenotypes are not yet clear...
  8. ncbi request reprint Will leptin become the treatment of choice for functional hypothalamic amenorrhea?
    Corrine K Welt
    Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, Boston, MA 02114, USA
    Nat Clin Pract Endocrinol Metab 3:556-7. 2007
  9. ncbi request reprint Primary ovarian insufficiency: a more accurate term for premature ovarian failure
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin Endocrinol (Oxf) 68:499-509. 2008
    ..Management should be directed at symptom resolution and bone protection, but most importantly should include psychosocial support for women facing this devastating diagnosis...
  10. doi request reprint Autoimmune oophoritis in the adolescent
    Corrine K Welt
    Reproductive Endocrine Unit, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Ann N Y Acad Sci 1135:118-22. 2008
    ..Granulosa cells are spared, and inhibin A and B levels are normal to high. Treatment is aimed at symptom relief with further investigation needed to assess treatment options such as immunosuppression...
  11. ncbi request reprint Selective theca cell dysfunction in autoimmune oophoritis results in multifollicular development, decreased estradiol, and elevated inhibin B levels
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:3069-76. 2005
    ..In addition, the normal inhibin A and inhibin B production in the absence of estradiol precursors and estradiol provide insight into the selective dysfunction of the theca cells in autoimmune oophoritis...
  12. ncbi request reprint Relationship of estradiol and inhibin to the follicle-stimulating hormone variability in hypergonadotropic hypogonadism or premature ovarian failure
    Corrine K Welt
    Reproductive Endocrine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 90:826-30. 2005
    ..These data also demonstrate the variability in FSH levels as a function of underlying follicular development in women with POF...
  13. ncbi request reprint Differential regulation of inhibin A and inhibin B by luteinizing hormone, follicle-stimulating hormone, and stage of follicle development
    C K Welt
    Reproductive Endocrine Unit, Reproductive Endocrine Sciences Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:2531-7. 2001
    ..Thus, both differential secretion of LH and FSH and the stage of follicle development determine the patterns of inhibin A and inhibin B secretion in the normal menstrual cycle...
  14. ncbi request reprint The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction
    Corrine K Welt
    Reproductive Endocrine Unit, Reproductive Endocrine Sciences Center and National Center for Infertility Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Obstet Gynecol 14:317-23. 2002
    ..Thus, the mechanism of inhibin action and its role in normal and abnormal ovarian function continues to emerge...
  15. ncbi request reprint Control of follicle-stimulating hormone by estradiol and the inhibins: critical role of estradiol at the hypothalamus during the luteal-follicular transition
    Corrine K Welt
    Reproductive Endocrine Unit and National Center for Infertility Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 88:1766-71. 2003
    ..In contrast, inhibin A and/or B plays a more critical role as the follicular phase progresses. In addition, these studies support a primary if not exclusive hypothalamic site of estrogen-negative feedback in the early follicular phase...
  16. pmc Leptin and soluble leptin receptor in follicular fluid
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Assist Reprod Genet 20:495-501. 2003
    ..The relationship between intrafollicular leptin and the soluble leptin receptor, ovarian hormones, and oocyte quality was examined to determine potential factors contributing to this finding...
  17. ncbi request reprint Differential regulation of inhibin B and inhibin a by follicle-stimulating hormone and local growth factors in human granulosa cells from small antral follicles
    C K Welt
    Reproductive Endocrine Unit, Reproductive Endocrine Sciences Center, National Center for Infertility Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 86:330-6. 2001
    ..However, additional growth factors or increasing granulosa cell number may contribute to the preferential serum inhibin B increase across the luteal-follicular transition in the menstrual cycle...
  18. ncbi request reprint Evidence of early ovarian aging in fragile X premutation carriers
    C K Welt
    Reproductive Endocrine, BHX 511, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:4569-74. 2004
    ..Early ovarian aging in fragile X premutation carriers likely results from decreased follicle number and function, as reflected by lower inhibin B, inhibin A, and P4 levels...
  19. ncbi request reprint Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium
    Corrine Welt
    Reproductive Endocrine Unit and Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA
    Exp Biol Med (Maywood) 227:724-52. 2002
    ..As technology and model systems become more sophisticated in the next few years, it should become possible to test this concept directly to more clearly define the role of activin, inhibin, and FS in reproductive physiology...
  20. ncbi request reprint Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism
    Felecia Cerrato
    Reproductive Endocrine Unit, Massachusetts General Hospital BHX 504, Fruit Street, Boston, Massachusetts 02114, USA
    Eur J Endocrinol 155:S3-S10. 2006
    ....
  21. ncbi request reprint Regulation and function of inhibins in the normal menstrual cycle
    Corrine K Welt
    Reproductive Endocrine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Semin Reprod Med 22:187-93. 2004
    ..Future work will be necessary to define further the relative role of the inhibins, estradiol, and other autocrine-paracrine factors in these important reproductive functions...
  22. ncbi request reprint Serum inhibin B in polycystic ovary syndrome: regulation by insulin and luteinizing hormone
    Corrine K Welt
    Reproductive Endocrine Unit and the National Center for Infertility Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:5559-65. 2002
    ..These findings suggest that both increased LH and insulin may account for the relative suppression of inhibin B in patients with PCOS...
  23. ncbi request reprint Recombinant human leptin in women with hypothalamic amenorrhea
    Corrine K Welt
    Reproductive Endocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    N Engl J Med 351:987-97. 2004
    ..We hypothesized that exogenous recombinant leptin replacement would improve reproductive and neuroendocrine function in women with hypothalamic amenorrhea...
  24. pmc The adult galactosemic phenotype
    Susan E Waisbren
    Children s Hospital Boston, Boston, MA, USA
    J Inherit Metab Dis 35:279-86. 2012
    ..Data on how individuals with galactosemia fare as adults will improve our ability to predict disease progression...
  25. pmc Effects of recombinant human prolactin on breast milk composition
    Camille E Powe
    Harvard Medical School, Harvard University, Boston, Massachusetts 02114, USA
    Pediatrics 127:e359-66. 2011
    ..The objective of this study was to determine the impact of recombinant human prolactin (r-hPRL) on the nutritional and immunologic composition of breast milk...
  26. ncbi request reprint The FMR1 premutation and reproduction
    Michael D Wittenberger
    Intramural Research Program, Section on Women s Health Research, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 1103, USA
    Fertil Steril 87:456-65. 2007
    ..It is now recognized that this was incorrect, specifically with respect to female reproduction...

Research Grants4

  1. Phase 2 Trial of Recombinant Human Prolactin for Lactation Insufficiency
    Corrine Welt; Fiscal Year: 2005
    ..The studies may thus provide data that lead to the first FDA approved treatment for lactation insufficiency. In addition, these studies may further define the physiological role of prolactin in lactation. ..
  2. The Genetics of Polycystic Ovary Syndrom
    Corrine K Welt; Fiscal Year: 2010
    ..Discovering the variants and/or gene(s) that predispose to PCOS will determine an etiology and will provide a novel target to develop new treatments for the 1 in 10 reproductive age women it affects. ..