Michael E Wechsler

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Bronchial thermoplasty for asthma: a critical review of a new therapy
    Michael E Wechsler
    Brigham and Women s Hospital, Partners Asthma Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Allergy Asthma Proc 29:365-70. 2008
  2. pmc Managing asthma in primary care: putting new guideline recommendations into context
    Michael E Wechsler
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mayo Clin Proc 84:707-17. 2009
  3. pmc Active albuterol or placebo, sham acupuncture, or no intervention in asthma
    Michael E Wechsler
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 365:119-26. 2011
  4. pmc Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial
    Michael E Wechsler
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 374:1754-64. 2009
  5. ncbi Managing asthma in the 21st century: role of pharmacogenetics
    Michael E Wechsler
    Asthma Research Center, Partners Asthma Center, Division of Pulmonary and Critical Care, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Ann 35:660-2, 664-9. 2006
  6. pmc Impact of race on asthma treatment failures in the asthma clinical research network
    Michael E Wechsler
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 184:1247-53. 2011
  7. ncbi Churg-strauss syndrome in patients treated with omalizumab
    Michael E Wechsler
    Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 136:507-18. 2009
  8. pmc Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 175:228-34. 2007
  9. pmc beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
  10. ncbi Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004

Detail Information

Publications40

  1. ncbi Bronchial thermoplasty for asthma: a critical review of a new therapy
    Michael E Wechsler
    Brigham and Women s Hospital, Partners Asthma Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    Allergy Asthma Proc 29:365-70. 2008
    ..While current trials are ongoing, BT holds promise as an exciting novel therapy in the management of patients with asthma...
  2. pmc Managing asthma in primary care: putting new guideline recommendations into context
    Michael E Wechsler
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Mayo Clin Proc 84:707-17. 2009
    ..This discussion is based primarily on the new guidelines and the references cited therein, supplemented by the author's own clinical experience...
  3. pmc Active albuterol or placebo, sham acupuncture, or no intervention in asthma
    Michael E Wechsler
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 365:119-26. 2011
    ..We compared the effects of a bronchodilator, two placebo interventions, and no intervention on outcomes in patients with asthma...
  4. pmc Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial
    Michael E Wechsler
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 374:1754-64. 2009
    ..We investigated whether there is a genotype-specific response to treatment with a longacting beta2 agonist in combination with inhaled corticosteroid...
  5. ncbi Managing asthma in the 21st century: role of pharmacogenetics
    Michael E Wechsler
    Asthma Research Center, Partners Asthma Center, Division of Pulmonary and Critical Care, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Pediatr Ann 35:660-2, 664-9. 2006
    ....
  6. pmc Impact of race on asthma treatment failures in the asthma clinical research network
    Michael E Wechsler
    Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 184:1247-53. 2011
    ..Recent studies suggest that people with asthma of different racial backgrounds may respond differently to various therapies...
  7. ncbi Churg-strauss syndrome in patients treated with omalizumab
    Michael E Wechsler
    Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis, MO, USA
    Chest 136:507-18. 2009
    ..Churg-Strauss syndrome (CSS) is a rare systemic vasculitis associated with asthma, eosinophilia, sinusitis, and pulmonary infiltrates. CSS has been reported in association with asthma therapies...
  8. pmc Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthma
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Respir Crit Care Med 175:228-34. 2007
    ..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
  9. pmc beta-Adrenergic receptor polymorphisms and response to salmeterol
    Michael E Wechsler
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
    Am J Respir Crit Care Med 173:519-26. 2006
    ..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
  10. ncbi Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trial
    Elliot Israel
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Lancet 364:1505-12. 2004
    ..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
  11. pmc Loss of salmeterol bronchoprotection against exercise in relation to ADRB2 Arg16Gly polymorphism and exhaled nitric oxide
    Matteo Bonini
    1 Asthma Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts and
    Am J Respir Crit Care Med 188:1407-12. 2013
    ..2-Agonists are the treatment of choice for exercise-induced bronchoconstriction (EIB) and act through specific receptors (ADRB2). Arg16Gly polymorphisms have been shown to affect responses to regular use of β2-agonists...
  12. ncbi Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroids
    Aaron Deykin
    Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    J Allergy Clin Immunol 115:720-7. 2005
    ..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
  13. ncbi Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial
    Mario Castro
    Washington University School of Medicine, St Louis, Missouri
    JAMA 311:2083-91. 2014
    ..In asthma and other diseases, vitamin D insufficiency is associated with adverse outcomes. It is not known if supplementing inhaled corticosteroids with oral vitamin D3 improves outcomes in patients with asthma and vitamin D insufficiency...
  14. ncbi Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndrome
    Sophia Kim
    Department of Pediatrics, Children s Hospital Boston, Boston, Mass, USA
    J Allergy Clin Immunol 125:1336-43. 2010
    ..Levels of IL-5, a cytokine regulating eosinophils, can be increased in patients with CSS. Mepolizumab, a humanized monoclonal anti-IL-5 antibody, decreases steroid requirements in patients with non-CSS hypereosinophilic syndromes...
  15. ncbi How pharmacogenomics will play a role in the management of asthma
    Michael E Wechsler
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 172:12-8. 2005
  16. pmc Cysteinyl leukotriene antagonism inhibits bronchoconstriction in response to hypertonic saline inhalation in asthma
    Shamsah Kazani
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, PBB Clinics 3, 75 Francis Street, Boston, MA 02115, USA
    Respir Med 105:667-73. 2011
    ..Whether polymorphisms in the leukotriene biosynthetic pathway affect the contribution of CysLTs to this response is also unknown...
  17. pmc Exhaled breath condensate eicosanoid levels associate with asthma and its severity
    Shamsah Kazani
    Pulmonary and Critical Care Division, Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 132:547-53. 2013
    ..The relationship between anti-inflammatory lipoxins and proinflammatory leukotrienes might be important in the pathobiology and severity of asthma...
  18. doi Do "placebo responders" exist?
    Ted J Kaptchuk
    Osher Research Center, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA
    Contemp Clin Trials 29:587-95. 2008
    ..Finally, this paper proposes one model to rigorously investigate the stability of placebo responses...
  19. pmc Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma
    Cindy Barnig
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Sci Transl Med 5:174ra26. 2013
    ..Because lipoxin A4 generation is decreased in severe asthma, these findings also implicate unrestrained ILC activation in asthma pathobiology...
  20. pmc The role of pharmacogenomics in improving the management of asthma
    Shamsah Kazani
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 125:295-302; quiz 303-4. 2010
    ..We explore the data developed from the early pharmacogenomic studies with the most common asthma therapies. Furthermore, we explore the potential use of pharmacogenomics, as well as caveats in interpreting such information...
  21. ncbi Case records of the Massachusetts General Hospital. Case 15-2007. A 20-year-old woman with asthma and cardiorespiratory arrest
    Michael E Wechsler
    Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women s Hospital, Boston, USA
    N Engl J Med 356:2083-91. 2007
  22. ncbi Pharmacogenetics of treatment with leukotriene modifiers
    Michael E Wechsler
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Allergy Clin Immunol 2:395-401. 2002
    ..This review highlights the importance of pharmacogenetic associations of an important class of asthma therapy, the leukotriene modifiers, and asthma...
  23. pmc Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial
    Mario Castro
    Washington University School of Medicine, Campus Box 8052, 660 S Euclid, St Louis, MO 63110 1093, USA
    Am J Respir Crit Care Med 181:116-24. 2010
    ..Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle...
  24. ncbi Sedation and analgesia in the intensive care unit: evaluating the role of dexmedetomidine
    Paul M Szumita
    Department of Pharmacy, Brigham and Women s Hospital BWH, Boston, MA 02115 6110, USA
    Am J Health Syst Pharm 64:37-44. 2007
    ..A review highlighting the application of sedatives and analgesics in the intensive care unit (ICU) setting, with a focus on the use of dexmedetomidine, is presented...
  25. ncbi Using the high-dose corticotropin test to diagnose relative adrenal insufficiency in vasopressor-dependent septic shock
    Paul M Szumita
    Department of Pharmacy, Brigham and Women s Hospital, Boston, MA 02115 6110, USA
    Am J Health Syst Pharm 63:466-71. 2006
  26. ncbi Vasopressin for vasopressor-dependent septic shock
    Paul M Szumita
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Health Syst Pharm 62:1931-6. 2005
  27. pmc Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma
    Yvonne J Huang
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Calif, USA
    J Allergy Clin Immunol 127:372-381.e1-3. 2011
    ..However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present...
  28. ncbi Asthma therapies and Churg-Strauss syndrome
    Craig M Lilly
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Allergy Clin Immunol 109:S1-19. 2002
    ..Early recognition and immunosuppressive therapy are the keystones of successful treatment of this rare disorder...
  29. ncbi The placebo effect in asthma
    Stefanie Dutile
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Curr Allergy Asthma Rep 14:456. 2014
    ....
  30. ncbi Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levels
    Karin Storm van's Gravesande
    Division of Pulmonary and Critical Care Medicine, Tower 4B, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 168:228-31. 2003
    ....
  31. pmc Novel targeted therapies for eosinophilic disorders
    Michael E Wechsler
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Allergy Clin Immunol 130:563-71. 2012
    ....
  32. ncbi Daily versus as-needed corticosteroids for mild persistent asthma
    Homer A Boushey
    University of California at San Francisco, San Francisco, USA
    N Engl J Med 352:1519-28. 2005
    ....
  33. doi Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthma
    Timothy J Craig
    Division of Pulmonary Care, Pennsylvania State University College of Medicine, Hershey, PA 17033 0853, USA
    J Allergy Clin Immunol 121:671-7. 2008
    ..Aeroallergen sensitization in adult asthmatic patients from a wide geographic area has not been correlated with patients' characteristics, markers of airways inflammation, and lung function...
  34. ncbi Asthma drug use and the development of Churg-Strauss syndrome (CSS)
    Leslie R Harrold
    Meyers Primary Care Institute, University of Massachusetts Medical School, Fallon Clinic and Fallon Community Health Plan, Worcester, MA 01655, USA
    Pharmacoepidemiol Drug Saf 16:620-6. 2007
    ..Using pooled data from two nested case-control studies, we examined the association between asthma drug use and the development of CSS...
  35. pmc Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthma
    Stephen C Lazarus
    University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
    Am J Respir Crit Care Med 175:783-90. 2007
    ..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
  36. pmc The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trial
    Richard J Martin
    National Jewish Medical and Research Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 119:73-80. 2007
    ..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
  37. ncbi beta-adrenergic receptor genotype and response to salmeterol
    Michael E Wechsler
    J Allergy Clin Immunol 120:218-9; author reply 219-20. 2007
  38. ncbi Discussing the COSTS of asthma: controlling outcomes, symptoms, and treatment strategies
    Donald A Bukstein
    8201 West McNab Road Tamarac, FL 33321, USA
    Am J Manag Care 11:S318-S336; quiz S337-S339. 2005
    ..This article explores current treatment therapies for asthma, the challenges of managing asthma effectively, and strategies for improving outcomes in patients with asthma...
  39. ncbi Incidence of Churg-Strauss syndrome in asthma drug users: a population-based perspective
    Leslie R Harrold
    Meyers Primary Care Institute, University of Massachusetts Medical School and Fallon Foundation, Worcester, MA 01655, USA
    J Rheumatol 32:1076-80. 2005
    ..To estimate the incidence of Churg-Strauss syndrome (CSS) among a large population of asthma drug users...
  40. ncbi Approaches to the treatment of hypereosinophilic syndromes: a workshop summary report
    Amy D Klion
    Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Allergy Clin Immunol 117:1292-302. 2006
    ..Furthermore, the need for newer therapeutic strategies and novel drugs, as well as multicenter trials to assess all treatment modalities, was emphasized...