Research Topics
Species | Michael E WechslerSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Bronchial thermoplasty for asthma: a critical review of a new therapyMichael E Wechsler
Brigham and Women s Hospital, Partners Asthma Center, Harvard Medical School, Boston, Massachusetts 02115, USA
Allergy Asthma Proc 29:365-70. 2008..While current trials are ongoing, BT holds promise as an exciting novel therapy in the management of patients with asthma...
Managing asthma in the 21st century: role of pharmacogeneticsMichael E Wechsler
Asthma Research Center, Partners Asthma Center, Division of Pulmonary and Critical Care, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Pediatr Ann 35:660-2, 664-9. 2006....
Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trialMichael E Wechsler
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Lancet 374:1754-64. 2009..We investigated whether there is a genotype-specific response to treatment with a longacting beta2 agonist in combination with inhaled corticosteroid...- Active albuterol or placebo, sham acupuncture, or no intervention in asthmaMichael E Wechsler
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 365:119-26. 2011..We compared the effects of a bronchodilator, two placebo interventions, and no intervention on outcomes in patients with asthma... - Managing asthma in primary care: putting new guideline recommendations into contextMichael E Wechsler
Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Mayo Clin Proc 84:707-17. 2009..This discussion is based primarily on the new guidelines and the references cited therein, supplemented by the author's own clinical experience... - Impact of race on asthma treatment failures in the asthma clinical research networkMichael E Wechsler
Brigham and Women s Hospital, Boston, MA 02115, USA
Am J Respir Crit Care Med 184:1247-53. 2011..Recent studies suggest that people with asthma of different racial backgrounds may respond differently to various therapies... - Churg-strauss syndrome in patients treated with omalizumabMichael E Wechsler
Division of Allergy and Pulmonary Medicine, Washington University School of Medicine, St Louis, MO, USA
Chest 136:507-18. 2009..Churg-Strauss syndrome (CSS) is a rare systemic vasculitis associated with asthma, eosinophilia, sinusitis, and pulmonary infiltrates. CSS has been reported in association with asthma therapies... - Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthmaAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 175:228-34. 2007..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well... - beta-Adrenergic receptor polymorphisms and response to salmeterolMichael E Wechsler
Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
Am J Respir Crit Care Med 173:519-26. 2006..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists... - Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trialElliot Israel
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Lancet 364:1505-12. 2004..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial... - Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroidsAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Allergy Clin Immunol 115:720-7. 2005..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued... - Mepolizumab as a steroid-sparing treatment option in patients with Churg-Strauss syndromeSophia Kim
Department of Pediatrics, Children s Hospital Boston, Boston, Mass, USA
J Allergy Clin Immunol 125:1336-43. 2010..Levels of IL-5, a cytokine regulating eosinophils, can be increased in patients with CSS. Mepolizumab, a humanized monoclonal anti-IL-5 antibody, decreases steroid requirements in patients with non-CSS hypereosinophilic syndromes... - How pharmacogenomics will play a role in the management of asthmaMichael E Wechsler
Pulmonary and Critical Care Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 172:12-8. 2005 - Cysteinyl leukotriene antagonism inhibits bronchoconstriction in response to hypertonic saline inhalation in asthmaShamsah Kazani
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, PBB Clinics 3, 75 Francis Street, Boston, MA 02115, USA
Respir Med 105:667-73. 2011..Whether polymorphisms in the leukotriene biosynthetic pathway affect the contribution of CysLTs to this response is also unknown... - Do "placebo responders" exist?Ted J Kaptchuk
Osher Research Center, Harvard Medical School, 401 Park Drive, Boston, MA 02215, USA
Contemp Clin Trials 29:587-95. 2008..Finally, this paper proposes one model to rigorously investigate the stability of placebo responses... - Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trialMario Castro
Washington University School of Medicine, Campus Box 8052, 660 S Euclid, St Louis, MO 63110 1093, USA
Am J Respir Crit Care Med 181:116-24. 2010..Bronchial thermoplasty (BT) is a bronchoscopic procedure in which controlled thermal energy is applied to the airway wall to decrease smooth muscle... - Pharmacogenetics of treatment with leukotriene modifiersMichael E Wechsler
Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Curr Opin Allergy Clin Immunol 2:395-401. 2002.... - The role of pharmacogenomics in improving the management of asthmaShamsah Kazani
Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Allergy Clin Immunol 125:295-302; quiz 303-4. 2010..We explore the data developed from the early pharmacogenomic studies with the most common asthma therapies. Furthermore, we explore the potential use of pharmacogenomics, as well as caveats in interpreting such information... - Case records of the Massachusetts General Hospital. Case 15-2007. A 20-year-old woman with asthma and cardiorespiratory arrestMichael E Wechsler
Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women's Hospital, Boston, USA
N Engl J Med 356:2083-91. 2007 - Using the high-dose corticotropin test to diagnose relative adrenal insufficiency in vasopressor-dependent septic shockPaul M Szumita
Department of Pharmacy, Brigham and Women's Hospital, Boston, MA 02115-6110, USA
Am J Health Syst Pharm 63:466-71. 2006 - Sedation and analgesia in the intensive care unit: evaluating the role of dexmedetomidinePaul M Szumita
Department of Pharmacy, Brigham and Women s Hospital BWH, Boston, MA 02115 6110, USA
Am J Health Syst Pharm 64:37-44. 2007..A review highlighting the application of sedatives and analgesics in the intensive care unit (ICU) setting, with a focus on the use of dexmedetomidine, is presented... - Vasopressin for vasopressor-dependent septic shockPaul M Szumita
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA
Am J Health Syst Pharm 62:1931-6. 2005 - Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthmaCindy Barnig
Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Sci Transl Med 5:174ra26. 2013..Because lipoxin A4 generation is decreased in severe asthma, these findings also implicate unrestrained ILC activation in asthma pathobiology... - Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthmaYvonne J Huang
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, San Francisco, Calif, USA
J Allergy Clin Immunol 127:372-381.e1-3. 2011..However, the airway might be populated by a more diverse microbiota, and clinical features of asthma might be associated with characteristics of the airway microbiota present... - Asthma therapies and Churg-Strauss syndromeCraig M Lilly
Pulmonary and Critical Care Division, Brigham and Women's Hospital, Boston, MA 02115, USA
J Allergy Clin Immunol 109:S1-19. 2002..Early recognition and immunosuppressive therapy are the keystones of successful treatment of this rare disorder... - Association of a missense mutation in the NOS3 gene with exhaled nitric oxide levelsKarin Storm van's Gravesande
Division of Pulmonary and Critical Care Medicine, Tower 4B, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
Am J Respir Crit Care Med 168:228-31. 2003.... - Novel targeted therapies for eosinophilic disordersMichael E Wechsler
Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
J Allergy Clin Immunol 130:563-71. 2012.... - Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthmaTimothy J Craig
Division of Pulmonary Care, Pennsylvania State University College of Medicine, Hershey, PA 17033 0853, USA
J Allergy Clin Immunol 121:671-7. 2008..Aeroallergen sensitization in adult asthmatic patients from a wide geographic area has not been correlated with patients' characteristics, markers of airways inflammation, and lung function... - Daily versus as-needed corticosteroids for mild persistent asthmaHomer A Boushey
University of California at San Francisco, San Francisco, USA
N Engl J Med 352:1519-28. 2005..Further studies are required to determine whether this novel approach to treatment should be recommended... - The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trialRichard J Martin
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:73-80. 2007..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids... - Asthma drug use and the development of Churg-Strauss syndrome (CSS)Leslie R Harrold
Meyers Primary Care Institute, University of Massachusetts Medical School, Fallon Clinic and Fallon Community Health Plan, Worcester, MA 01655, USA
Pharmacoepidemiol Drug Saf 16:620-6. 2007..Using pooled data from two nested case-control studies, we examined the association between asthma drug use and the development of CSS... - Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthmaStephen C Lazarus
University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
Am J Respir Crit Care Med 175:783-90. 2007..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control... - beta-adrenergic receptor genotype and response to salmeterolMichael E Wechsler
J Allergy Clin Immunol 120:218-9; author reply 219-20. 2007 - Approaches to the treatment of hypereosinophilic syndromes: a workshop summary reportAmy D Klion
Laboratory of Parasitic Diseases, National Institutes of Health, Bethesda, MD 20892, USA
J Allergy Clin Immunol 117:1292-302. 2006..Furthermore, the need for newer therapeutic strategies and novel drugs, as well as multicenter trials to assess all treatment modalities, was emphasized... - Incidence of Churg-Strauss syndrome in asthma drug users: a population-based perspectiveLeslie R Harrold
Meyers Primary Care Institute, University of Massachusetts Medical School and Fallon Foundation, Worcester, MA 01655, USA
J Rheumatol 32:1076-80. 2005..To estimate the incidence of Churg-Strauss syndrome (CSS) among a large population of asthma drug users... - Discussing the COSTS of asthma: controlling outcomes, symptoms, and treatment strategiesDonald A Bukstein
8201 West McNab Road; Tamarac, FL 33321, USA
Am J Manag Care 11:S318-S336; quiz S337-S339. 2005..This article explores current treatment therapies for asthma, the challenges of managing asthma effectively, and strategies for improving outcomes in patients with asthma...