Aaron Waxman

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. doi Pulmonary arterial hypertension: new insights into the optimal role of current and emerging prostacyclin therapies
    Aaron B Waxman
    Department of Medicine, Harvard Medical School, and Pulmonary Vascular Disease Program, Pulmonary and Critical Care Medicine, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 111:1A-16A; quiz 17A-19A. 2013
  2. doi Exercise physiology and pulmonary arterial hypertension
    Aaron B Waxman
    Pulmonary Vascular Disease Program, Dyspnea and Exercise Intolerance Center, Pulmonary Critical Care Medicine, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Prog Cardiovasc Dis 55:172-9. 2012
  3. pmc IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins
    Aaron B Waxman
    Pulmonary Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA
    Am J Respir Cell Mol Biol 41:385-96. 2009
  4. ncbi Interleukin-11 and interleukin-6 protect cultured human endothelial cells from H2O2-induced cell death
    Aaron B Waxman
    Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148 Boston, MA 02114
    Am J Respir Cell Mol Biol 29:513-22. 2003
  5. pmc A review of sitaxsentan sodium in patients with pulmonary arterial hypertension
    Aaron B Waxman
    Department of Internal Medicine, Pulmonary Critical Care Unit, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114 2621, USA
    Vasc Health Risk Manag 3:151-7. 2007
  6. pmc Roundtable debate: Controversies in the management of the septic patient--desperately seeking consensus
    Aaron B Waxman
    Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Crit Care 9:E1. 2005
  7. pmc Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury
    Chuan Hua He
    Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 115:1039-48. 2005
  8. pmc Noninvasive assessment of murine pulmonary arterial pressure: validation and application to models of pulmonary hypertension
    Helene B Thibault
    Cardiac Ultrasound Laboratory, Cardiology Division of Department of Medicine, Cardiovascular Research Center, Anesthesia Center for Critical Care Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Circ Cardiovasc Imaging 3:157-63. 2010
  9. doi The role of IL-6 and IL-11 in hyperoxic injury in developing lung
    Anne Chetty
    Department of Pediatrics, Floating Hospital for Children, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Pediatr Pulmonol 43:297-304. 2008
  10. ncbi Impaired systemic oxygen extraction at maximum exercise in pulmonary hypertension
    James Tolle
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Med Sci Sports Exerc 40:3-8. 2008

Research Grants

Collaborators

Detail Information

Publications22

  1. doi Pulmonary arterial hypertension: new insights into the optimal role of current and emerging prostacyclin therapies
    Aaron B Waxman
    Department of Medicine, Harvard Medical School, and Pulmonary Vascular Disease Program, Pulmonary and Critical Care Medicine, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Am J Cardiol 111:1A-16A; quiz 17A-19A. 2013
    ....
  2. doi Exercise physiology and pulmonary arterial hypertension
    Aaron B Waxman
    Pulmonary Vascular Disease Program, Dyspnea and Exercise Intolerance Center, Pulmonary Critical Care Medicine, Cardiovascular Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Prog Cardiovasc Dis 55:172-9. 2012
    ..Study of the pressure-flow relationships in the pulmonary vascular bed will provide an improved appreciation of the pathophysiology of pulmonary hypertension...
  3. pmc IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins
    Aaron B Waxman
    Pulmonary Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA
    Am J Respir Cell Mol Biol 41:385-96. 2009
    ..Taken together, our results suggest that IL-6 induces Bcl-2 expression to perform cytoprotective functions in response to oxygen toxicity, and that this effect is mediated by alterations in the interactions between Bak and Mfns...
  4. ncbi Interleukin-11 and interleukin-6 protect cultured human endothelial cells from H2O2-induced cell death
    Aaron B Waxman
    Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148 Boston, MA 02114
    Am J Respir Cell Mol Biol 29:513-22. 2003
    ..They also demonstrate that this protection is mediated, at least in part, by a STAT3 and MEK-1-dependent specific signal transduction pathway(s)...
  5. pmc A review of sitaxsentan sodium in patients with pulmonary arterial hypertension
    Aaron B Waxman
    Department of Internal Medicine, Pulmonary Critical Care Unit, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114 2621, USA
    Vasc Health Risk Manag 3:151-7. 2007
    ..Sitaxsentan has been shown to be safe, well tolerated, and associated with a lower incidence of liver toxicity than other approved ETRAs...
  6. pmc Roundtable debate: Controversies in the management of the septic patient--desperately seeking consensus
    Aaron B Waxman
    Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Crit Care 9:E1. 2005
    ..This presentation is intended to show how experienced intensivists apply clinical science to their practice of critical care medicine...
  7. pmc Bcl-2-related protein A1 is an endogenous and cytokine-stimulated mediator of cytoprotection in hyperoxic acute lung injury
    Chuan Hua He
    Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8057, USA
    J Clin Invest 115:1039-48. 2005
    ..A1 is an important regulator of oxidant-induced lung injury, apoptosis, necrosis, and Bcl-2 and Bcl-xl gene expression and a critical mediator of IL-11- and VEGF-induced cytoprotection...
  8. pmc Noninvasive assessment of murine pulmonary arterial pressure: validation and application to models of pulmonary hypertension
    Helene B Thibault
    Cardiac Ultrasound Laboratory, Cardiology Division of Department of Medicine, Cardiovascular Research Center, Anesthesia Center for Critical Care Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Circ Cardiovasc Imaging 3:157-63. 2010
    ..However, it is a terminal procedure and does not allow for serial measurements. Our objective was to validate a noninvasive technique to assess RVSP in mice...
  9. doi The role of IL-6 and IL-11 in hyperoxic injury in developing lung
    Anne Chetty
    Department of Pediatrics, Floating Hospital for Children, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    Pediatr Pulmonol 43:297-304. 2008
    ..IL-11 and IL-6 provide protective effects against oxidant-mediated injury in fetal type II cells and IL-11 provides protection in vivo by down-regulation of caspase-mediated cell death...
  10. ncbi Impaired systemic oxygen extraction at maximum exercise in pulmonary hypertension
    James Tolle
    Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Med Sci Sports Exerc 40:3-8. 2008
    ..To determine the relative contributions of the Fick principle variables to impaired exercise tolerance in pulmonary arterial hypertension compared with pulmonary venous hypertension...
  11. ncbi Plasma gelsolin is a marker and therapeutic agent in animal sepsis
    Po Shun Lee
    Pulmonary and Critical Care Division Brigham and Women s Hospital, Boston, MA, USA
    Crit Care Med 35:849-55. 2007
    ..Depletion of plasma gelsolin in systemic inflammation may contribute to adverse outcomes. We examined the role of plasma gelsolin in animal models of sepsis...
  12. ncbi Conversion to bosentan from prostacyclin infusion therapy in pulmonary arterial hypertension: a pilot study
    M Kathryn Steiner
    Tufts New England Medical Center, Boston, MA, USA
    Chest 130:1471-80. 2006
    ..We assessed the efficacy of bosentan in transitioning from prostacyclin infusions in patients with pulmonary arterial hypertension (PAH)...
  13. pmc DNA damage induced by hyperoxia: quantitation and correlation with lung injury
    George F Barker
    Pulmonary and Critical Care Unit, Department of Medicine, Harvard Medical School, Massachusetts General Hospital, Bulfinch 148, 55 Fruit St, Boston, Massachusetts 02114, USA
    Am J Respir Cell Mol Biol 35:277-88. 2006
    ..Analysis of purified alveolar type 2 preparations from hyperoxic mice indicated that strand breaks preferentially affected this cell type...
  14. pmc IL-6 cytoprotection in hyperoxic acute lung injury occurs via PI3K/Akt-mediated Bax phosphorylation
    Narasaiah Kolliputi
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Physiol Lung Cell Mol Physiol 297:L6-16. 2009
    ..Thus IL-6 functions in a cytoprotective manner, in part, by suppressing Bax translocation and dimerization through PI3K/Akt-mediated Bax phosphorylation...
  15. pmc Plasma gelsolin depletion and circulating actin in sepsis: a pilot study
    Po Shun Lee
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA, USA
    PLoS ONE 3:e3712. 2008
    ..We hypothesized that the extent of pGSN reduction correlates with outcomes of septic patients and that circulating actin is a manifestation of sepsis...
  16. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 14-2003. A 73-year-old woman with pneumonia and progressive respiratory failure
    Aaron B Waxman
    Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, USA
    N Engl J Med 348:1902-12. 2003
  17. pmc IL-6 cytoprotection in hyperoxic acute lung injury occurs via suppressor of cytokine signaling-1-induced apoptosis signal-regulating kinase-1 degradation
    Narasaiah Kolliputi
    Pulmonary Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148, Boston, MA 02114, USA
    Am J Respir Cell Mol Biol 40:314-24. 2009
    ..Furthermore, the interaction between SOCS-1 and ASK-1 promotes ubiquitin-mediated degradation both in vivo and in vitro. These studies demonstrate that SOCS-1 is an important regulator in IL-6-induced cytoprotection against HALI...
  18. ncbi Pulmonary arterial hypertension: evaluation and management
    Anne V LaRaia
    Pulmonary Critical Care Unit and the Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    South Med J 100:393-9. 2007
    ..Ongoing research promises to lead to a more comprehensive understanding of the genetics, etiology, and pathogenesis of pulmonary arterial hypertension, which may ultimately translate into more effective therapeutic options...
  19. pmc The inflammasome mediates hyperoxia-induced alveolar cell permeability
    Narasaiah Kolliputi
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 184:5819-26. 2010
    ..These events would affect the permeability of the alveolar epithelium and ultimately lead to epithelial barrier dysfunction and cell death...
  20. ncbi Pulmonary hypertension: work in progress
    Paul D Boyce
    Pulmonary Division, Brigham and Women s Hospital, Boston, MA, USA
    J Nucl Cardiol 10:413-23. 2003
    ..Ongoing research in the nuclear medicine field holds great promise for understanding the pathophysiologic pathways for this condition, as well as the monitoring of the continually evolving therapeutic options...
  21. pmc Exercise-induced pulmonary arterial hypertension
    James J Tolle
    Pulmonary and Critical Care Unit, BUL 1 148, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 118:2183-9. 2008
    ..Using invasive cardiopulmonary exercise testing, we hypothesized that exercise-induced PAH represents a symptomatic stage of PAH, physiologically intermediate between resting pulmonary arterial hypertension and normal...
  22. ncbi Modulation of IGF-binding protein-2 and -3 in hyperoxic injury in developing rat lung
    Anne Chetty
    Floating Hospital for Children, New England Medical Center and Tufts Medical School, Boston, Massachusetts 02111, USA
    Pediatr Res 58:222-8. 2005
    ..We speculate that RA protects against O(2)-induced neonatal lung injury through modulation of the IGFBPs...

Research Grants4

  1. Il-6 type cytokine protection from hyperoxic lung injury
    Aaron Waxman; Fiscal Year: 2007
    ..abstract_text> ..