Research Topics
| Adam WaxSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
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Detail Information
Publications
Cellular organization and substructure measured using angle-resolved low-coherence interferometryAdam Wax
G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge Massachusetts 02139, USA
Biophys J 82:2256-64. 2002..We also identify spatial correlations on a scale large compared with the size of a cell, indicating an overlying order within the monolayer...
Determination of particle size by using the angular distribution of backscattered light as measured with low-coherence interferometryAdam Wax
G R Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA
J Opt Soc Am A Opt Image Sci Vis 19:737-44. 2002..We also present various considerations for extending this technique to determining structural information in biological tissues, such as the effects of a distribution of particle sizes and the need to average out speckle contributions...- Tissue self-affinity and polarized light scattering in the born approximation: a new model for precancer detectionMartin Hunter
G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Phys Rev Lett 97:138102. 2006..Power law exponents used to fit dysplastic tissue site spectra are significantly smaller than those from normal sites, indicating that changes in tissue self-affinity can serve as a potential biomarker for precancer... - Harmonic phase-dispersion microscope with a Mach-Zehnder interferometerAndrew Ahn
G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Appl Opt 44:1188-90. 2005..We demonstrate quantitative phase-dispersion images of test structures and biological samples... - Quantitative phase imaging using actively stabilized phase-shifting low-coherence interferometryHidenao Iwai
G. R. Harrison Spectroscopy Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Opt Lett 29:2399-401. 2004..Depth gating via low-coherence light allows phase measurement from weakly reflecting biological samples. We demonstrate phase images from a test structure and living cells... - In situ detection of nuclear atypia in Barrett's esophagus by using angle-resolved low-coherence interferometryJohn W Pyhtila
Department of Biomedical Engineering and the Fitzpatrick Institute for Photonics, Duke University Medical Center, Durham, NC, USA
Gastrointest Endosc 65:487-91. 2007..Monitoring of patients with Barrett's esophagus (BE) for dysplasia, currently done by systematic biopsy, can be improved through increasing the proportion of at-risk tissue examined... - Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometryJohn W Pyhtila
Duke University, Department of Biomedical Engineering, Fitzpatrick Center for Photonics, Durham, North Carolina 27708
J Biomed Opt 11:34022. 2006..The a/LCI results show that the impact of coherent scattering on nuclear morphology measurements can be eliminated through data filtering... - Application of Mie theory to assess structure of spheroidal scattering in backscattering geometriesKevin J Chalut
Department of Biomedical Engineering, Fitzpatrick Institute for Photonics, Duke University, Durham, NC 27708, USA
J Opt Soc Am A Opt Image Sci Vis 25:1866-74. 2008..Over this wide range of parameters, our results indicate that this method provides a good estimate of spheroidal structure... - Fourier-domain low-coherence interferometry for light-scattering spectroscopyAdam Wax
Department of Biomedical Engineering and the Fitzpatrick Center for Photonics, Duke University, Durham, North Carolina 27708, USA
Opt Lett 28:1230-2. 2003..Application of the technique to probing the size of cell nuclei in living epithelial tissues is discussed... - Label-free, high-throughput measurements of dynamic changes in cell nuclei using angle-resolved low coherence interferometryKevin J Chalut
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Biophys J 94:4948-56. 2008..Given the high-throughput nature of the measurements, this deviation may be acceptable for many biological applications that seek to establish connections between morphology and function... - Label-free plasmonic detection of biomolecular binding by a single gold nanorodGreg J Nusz
Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA
Anal Chem 80:984-9. 2008..3 nm. Binding of streptavidin at 1 nM concentration induces a mean resonant wavelength shift of 0.59 nm suggesting that we are currently operating at close to the limit of detection of the system... - Temporal coherence and time-frequency distributions in spectroscopic optical coherence tomographyRobert N Graf
Department of Biomedical Engineering and the Fitzpatrick Institute for Photonics, Duke University, Durham, North Carolina 27708, USA
J Opt Soc Am A Opt Image Sci Vis 24:2186-95. 2007..The utility of time-frequency distributions is illustrated through analysis of calculated signals... - Application of Mie theory to determine the structure of spheroidal scatterers in biological materialsJustin D Keener
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Opt Lett 32:1326-8. 2007.... - Polarization effects on scatterer sizing accuracy analyzed with frequency-domain angle-resolved low-coherence interferometryJohn W Pyhtila
Department of Biomedical Engineering, Duke University, North Carolina 27708, USA
Appl Opt 46:1735-41. 2007.... - In situ detection of neoplastic transformation and chemopreventive effects in rat esophagus epithelium using angle-resolved low-coherence interferometryAdam Wax
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Cancer Res 63:3556-9. 2003..This technique also may provide a new screening tool for intraepithelial neoplasia... - In situ assessment of intraepithelial neoplasia in hamster trachea epithelium using angle-resolved low-coherence interferometryKevin J Chalut
Department of Biomedical Engineering, Duke University, Durham, North Carolina 27708, USA
Cancer Epidemiol Biomarkers Prev 16:223-7. 2007.... - Improved interferometric detection of scattered light with a 4f imaging systemJohn W Pyhtila
Department of Biomedical Engineering and the Fitzpatrick Center for Photonics, Duke University, Durham, North Carolina 27708, USA
Appl Opt 44:1785-91. 2005..Of the three systems analyzed, the 4f imaging system is determined to be most effective, because it accurately reproduces both the phase and the amplitude of the scattered field at the detector... - Label-free measurement of microbicidal gel thickness using low-coherence interferometryKelly E Braun
J Biomed Opt 11:020504. 2006..The impact of the new LCI-based design on in vivo measurements is discussed... - Fourier-domain angle-resolved low coherence interferometry through an endoscopic fiber bundle for light-scattering spectroscopyJohn W Pyhtila
Department of Biomedical Engineering and the Fitzpatrick Center for Photonics and Communication Systems, Duke University, Durham, North Carolina 27708, USA
Opt Lett 31:772-4. 2006..The data collected are processed in real time, producing a depth-resolved angular scattering distribution in 0.37 s. The data are used to determine the sizes of polystyrene microspheres with subwavelength precision and accuracy... - Prospective grading of neoplastic change in rat esophagus epithelium using angle-resolved low-coherence interferometryAdam Wax
Duke University, Department of Biomedical Engineering, Durham, North Carolina 27708, USA
J Biomed Opt 10:051604. 2005..We demonstrate that a/LCI is highly effective for monitoring neoplastic change and can be applied to assessing the efficacy of chemopreventive agents in the rat esophagus...