George R Washko

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi The role and potential of imaging in COPD
    George R Washko
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Med Clin North Am 96:729-43. 2012
  2. ncbi Computed tomographic-based quantification of emphysema and correlation to pulmonary function and mechanics
    George R Washko
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, Boston, Massachusetts 02115, USA
    COPD 5:177-86. 2008
  3. ncbi Physiological and computed tomographic predictors of outcome from lung volume reduction surgery
    George R Washko
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 181:494-500. 2010
  4. ncbi The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations
    George R Washko
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 177:164-9. 2008
  5. ncbi Airway wall attenuation: a biomarker of airway disease in subjects with COPD
    George R Washko
    Pulmonary and Critical Care Division, Dept of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Appl Physiol 107:185-91. 2009
  6. ncbi Kurtosis and skewness of density histograms on inspiratory and expiratory CT scans in smokers
    Tsuneo Yamashiro
    Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Boston, MA, USA
    COPD 8:13-20. 2011
  7. ncbi Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers
    Alejandro A Diaz
    Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 138:880-7. 2010
  8. ncbi Lung volumes and emphysema in smokers with interstitial lung abnormalities
    George R Washko
    Pulmonary and Critical Care Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 364:897-906. 2011
  9. ncbi Epidemiology, radiology, and genetics of nicotine dependence in COPD
    Deog Kyeom Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 12:9. 2011
  10. ncbi Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD
    Alejandro A Diaz
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Chest 141:736-44. 2012

Detail Information

Publications47

  1. ncbi The role and potential of imaging in COPD
    George R Washko
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Med Clin North Am 96:729-43. 2012
    ..Future clinical care and investigation will likely include some combination of these imaging modalities and more standard assessments of disease severity...
  2. ncbi Computed tomographic-based quantification of emphysema and correlation to pulmonary function and mechanics
    George R Washko
    Brigham and Women s Hospital, Division of Pulmonary and Critical Care Medicine, Boston, Massachusetts 02115, USA
    COPD 5:177-86. 2008
    ..The CT based quantification of emphysema may augment pulmonary function testing in the characterization of COPD by providing complementary phenotypic information...
  3. ncbi Physiological and computed tomographic predictors of outcome from lung volume reduction surgery
    George R Washko
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 181:494-500. 2010
    ..We therefore sought to examine radiographic and physiologic predictors of surgical outcomes in a large, multicenter clinical investigation, the National Emphysema Treatment Trial...
  4. ncbi The effect of lung volume reduction surgery on chronic obstructive pulmonary disease exacerbations
    George R Washko
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Crit Care Med 177:164-9. 2008
    ..The effect of LVRS on COPD exacerbations has not been as extensively studied, and whether improvement in postoperative lung function alters the risk of disease exacerbations is not known...
  5. ncbi Airway wall attenuation: a biomarker of airway disease in subjects with COPD
    George R Washko
    Pulmonary and Critical Care Division, Dept of Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    J Appl Physiol 107:185-91. 2009
    ..These latter findings suggest that the quantitative assessment of airway wall attenuation may offer complementary information to WA% in characterizing airway disease in subjects with COPD...
  6. ncbi Kurtosis and skewness of density histograms on inspiratory and expiratory CT scans in smokers
    Tsuneo Yamashiro
    Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Boston, MA, USA
    COPD 8:13-20. 2011
    ..Higher kurtosis or skewness on expiratory CT scan indicates more severe conditions in smokers...
  7. ncbi Airway count and emphysema assessed by chest CT imaging predicts clinical outcome in smokers
    Alejandro A Diaz
    Pulmonary and Critical Care Medicine Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 138:880-7. 2010
    ....
  8. ncbi Lung volumes and emphysema in smokers with interstitial lung abnormalities
    George R Washko
    Pulmonary and Critical Care Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    N Engl J Med 364:897-906. 2011
    ..Cigarette smoking is associated with emphysema and radiographic interstitial lung abnormalities. The degree to which interstitial lung abnormalities are associated with reduced total lung capacity and the extent of emphysema is not known...
  9. ncbi Epidemiology, radiology, and genetics of nicotine dependence in COPD
    Deog Kyeom Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 12:9. 2011
    ..This study was performed to elucidate the relationship between nicotine dependence, genetic susceptibility to nicotine dependence, and volumetric CT findings in smokers...
  10. ncbi Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD
    Alejandro A Diaz
    Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Chest 141:736-44. 2012
    ..Additionally, we compared clinical and CT scan features of subjects with (airway constrictors) and without a decrease in airway caliber...
  11. ncbi Intrathoracic tracheal volume and collapsibility on inspiratory and end-expiratory ct scans correlations with lung volume and pulmonary function in 85 smokers
    Tsuneo Yamashiro
    Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Acad Radiol 18:299-305. 2011
    ..To evaluate the correlations of tracheal volume and collapsibility on inspiratory and end-expiratory computed tomography (CT) with lung volume and with lung function in smokers...
  12. ncbi Quantitative assessment of bronchial wall attenuation with thin-section CT: An indicator of airflow limitation in chronic obstructive pulmonary disease
    Tsuneo Yamashiro
    Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Boston, MA, USA
    AJR Am J Roentgenol 195:363-9. 2010
    ..The purpose of this study was to evaluate the relation between bronchial wall attenuation on thin-section CT images and airflow limitation in persons with chronic obstructive pulmonary disease...
  13. ncbi Quantitative airway assessment on computed tomography in patients with alpha1-antitrypsin deficiency
    Tsuneo Yamashiro
    Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Boston, Massachusetts, USA
    COPD 6:468-77. 2009
    ..Emphysema of the lower lung is the predominant component; however, airway disease also has a significant impact on airflow limitation in AATD...
  14. ncbi Quantitative CT measurement of cross-sectional area of small pulmonary vessel in COPD: correlations with emphysema and airflow limitation
    Shin Matsuoka
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acad Radiol 17:93-9. 2010
    ....
  15. ncbi Automatic lung lobe segmentation using particles, thin plate splines, and maximum a posteriori estimation
    James C Ross
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Med Image Comput Comput Assist Interv 13:163-71. 2010
    ..Results indicate that our algorithm performs comparably to pulmonologist-generated lung lobe segmentations on a set of challenging cases...
  16. ncbi Interstitial lung abnormalities and reduced exercise capacity
    Tracy J Doyle
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Respir Crit Care Med 185:756-62. 2012
    ..The relationship between interstitial lung abnormalities (ILA) and exercise capacity has not been comprehensively evaluated...
  17. ncbi The relationship between small pulmonary vascular alteration and aortic atherosclerosis in chronic obstructive pulmonary disease: quantitative CT analysis
    Shin Matsuoka
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Acad Radiol 18:40-6. 2011
    ..We tested the hypothesis that the severity of thoracic aortic calcification measured by computed tomography (CT) would be associated with the total cross-sectional area of small pulmonary vessels (CSA) on CT images...
  18. ncbi Relationship of emphysema and airway disease assessed by CT to exercise capacity in COPD
    Alejandro A Diaz
    Pulmonary and Critical Care Medicine Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston MA, USA
    Respir Med 104:1145-51. 2010
    ..To assess the association of emphysema and airway disease assessed by volumetric computed tomography (CT) with exercise capacity in subjects with chronic obstructive pulmonary disease (COPD)...
  19. ncbi Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease
    Carlos H Martinez
    Division of Pulmonary and Critical Care Medicine, University of Michigan Health System, 3916 Taubman Center, Box 5360, 1500 E Medical Center Drive, Ann Arbor, MI 48109 5360, USA
    Thorax 67:399-406. 2012
    ..The authors hypothesised that QCT-defined emphysema and airway abnormalities relate to St George's Respiratory Questionnaire (SGRQ) and Body-Mass Index, Airflow Obstruction, Dyspnea and Exercise Capacity Index (BODE)...
  20. ncbi Identification of early interstitial lung disease in smokers from the COPDGene Study
    George R Washko
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acad Radiol 17:48-53. 2010
    ..The aim of this study is to compare two subjective methods for the identification of changes suggestive of early interstitial lung disease (ILD) on chest computed tomographic (CT) scans...
  21. ncbi Collapsibility of lung volume by paired inspiratory and expiratory CT scans: correlations with lung function and mean lung density
    Tsuneo Yamashiro
    Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Boston, MA, USA
    Acad Radiol 17:489-95. 2010
    ....
  22. ncbi Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation
    Jin Fu Xu
    Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Respir Crit Care Med 185:547-56. 2012
    ..The role of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in the development or progression of interstitial lung disease (ILD) is controversial...
  23. ncbi Lung deflation and oxygen pulse in COPD: results from the NETT randomized trial
    Carolyn E Come
    Pulmonary and Critical Care Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Med 106:109-19. 2012
    ..In COPD patients, hyperinflation impairs cardiac function. We examined whether lung deflation improves oxygen pulse, a surrogate marker of stroke volume...
  24. ncbi Clinical and radiographic correlates of hypoxemia and oxygen therapy in the COPDGene study
    Deog Kyeom Kim
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Respir Med 105:1211-21. 2011
    ..This study aimed to find the correlates of resting hypoxemia and the pattern of oxygen use in moderate to severe COPD patients...
  25. ncbi Family history is a risk factor for COPD
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA 02115, USA
    Chest 140:343-50. 2011
    ..Therefore, we sought to identify the effects of family history of smoking and family history of COPD on COPD susceptibility...
  26. ncbi Quantitative CT assessment of chronic obstructive pulmonary disease
    Shin Matsuoka
    Department of Radiology and Pulmonary and Critical Care Division, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Radiographics 30:55-66. 2010
    ..CT-based quantitative analyses can help differentiate the COPD phenotype (emphysema-predominant, airway-predominant, or mixed), which is crucial information for determining the appropriate management strategy...
  27. ncbi Perfusion scintigraphy and patient selection for lung volume reduction surgery
    Divay Chandra
    Division of Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Respir Crit Care Med 182:937-46. 2010
    ..It is unclear if lung perfusion can predict response to lung volume reduction surgery (LVRS)...
  28. ncbi Lung extraction, lobe segmentation and hierarchical region assessment for quantitative analysis on high resolution computed tomography images
    James C Ross
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Med Image Comput Comput Assist Interv 12:690-8. 2009
    ....
  29. ncbi Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD
    Craig P Hersh
    Channing Division of Network Medicine, Brigham and Women s Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA, 02115, USA
    Respir Res 14:42. 2013
    ..We sought to determine if measurements using paired inspiratory and expiratory CT scans may be better able to separate gas trapping due to emphysema from gas trapping due to small airway disease...
  30. ncbi Effect of emphysema on CT scan measures of airway dimensions in smokers
    Alejandro A Diaz
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Chest 143:687-93. 2013
    ..We aimed to first determine whether the stronger association of subsegmental vs segmental WA% with FEV1 % predicted is mitigated by emphysema and, second, to assess the relationships among emphysema, WA%, and total bronchial area (TBA)...
  31. ncbi Cluster analysis in severe emphysema subjects using phenotype and genotype data: an exploratory investigation
    Michael H Cho
    Channing Laboratory, Brigham and Women s Hospital, Boston, MA, USA
    Respir Res 11:30. 2010
    ..One reason may be heterogeneity in disease definition. Unsupervised learning approaches may assist in understanding disease heterogeneity...
  32. ncbi Interobserver variability in the determination of upper lobe-predominant emphysema
    Craig P Hersh
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Chest 131:424-31. 2007
    ..At many centers, radiologists and pulmonary physicians both review the images, but the agreement between readers from these specialties is not known...
  33. ncbi Volumetric expiratory HRCT of the lung: clinical applications
    Mizuki Nishino
    Department of Radiology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA
    Radiol Clin North Am 48:177-83. 2010
    ..It concludes that standardization of image acquisition and post-processing in CT examinations will be necessary for the real application of quantitative data derived from volumetric expiratory HRCT to daily clinical medical practice...
  34. ncbi Radiographic evaluation of the potential lung volume reduction surgery candidate
    George R Washko
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Proc Am Thorac Soc 5:421-6. 2008
    ..Heterogeneity and distribution can also be assessed by radionuclide ventilation perfusion scanning, but this modality adds little additional information to CT scanning...
  35. ncbi Three-dimensional airway measurements and algorithms
    Raul San Jose Estepar
    Laboratory of Mathematics in Imaging, Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, 5 Floor, Boston, MA 02215, USA
    Proc Am Thorac Soc 5:905-9. 2008
    ..We also offer a comprehensive view of the analysis pipeline for three-dimensional airway trees and a validation framework that is needed to compare different techniques...
  36. ncbi Pulmonary function and emphysema in Williams-Beuren syndrome
    Emily S Wan
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Med Genet A 152:653-6. 2010
    ..Further investigation may elucidate the pathogenesis of non-smoking-related emphysema...
  37. ncbi Randomized trial of zileuton for treatment of COPD exacerbations requiring hospitalization
    Prescott G Woodruff
    Division of Pulmonary and Critical Care Medicine, University of California, San Francisco, San Francisco, California, USA
    COPD 8:21-9. 2011
    ..Leukotrienes have been implicated in the pathogenesis of acute exacerbations of COPD, but leukotriene modifiers have not been studied as a possible therapy for exacerbations...
  38. ncbi Probabilistic elastography: estimating lung elasticity
    Petter Risholm
    Surgical Planning Lab, Department of Radiology, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts USA
    Inf Process Med Imaging 22:699-710. 2011
    ....
  39. ncbi Diagnostic imaging in COPD
    George R Washko
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, Massachusetts
    Semin Respir Crit Care Med 31:276-85. 2010
    ..Given the more limited availability of these techniques, they will be viewed here as adjuncts to computed tomographic imaging...
  40. ncbi TLR4 deficiency promotes autophagy during cigarette smoke-induced pulmonary emphysema
    Chang Hyeok An
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Physiol Lung Cell Mol Physiol 303:L748-57. 2012
    ..The expression of cleaved caspase-3 was markedly increased in Tlr4-deficient mice exposed to CS. We describe a protective regulatory function of TLR4 against emphysematous changes of the lung in response to CS...
  41. ncbi Quantitative pulmonary imaging using computed tomography and magnetic resonance imaging
    George R Washko
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Respirology 17:432-44. 2012
    ..Following a brief introduction of each method, we detail some of the most recent work being done to characterize smoking-related lung disease and the clinical applications of such knowledge...
  42. ncbi Volume-related and volume-independent effects of posture on esophageal and transpulmonary pressures in healthy subjects
    George R Washko
    Department of Anesthesia and Critical Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Appl Physiol 100:753-8. 2006
    ..We conclude that postural differences in estimated transpulmonary pressure at a given lung volume are small compared with the substantial range of PLrel in patients with acute lung injury...
  43. ncbi Aorta segmentation with a 3D level set approach and quantification of aortic calcifications in non-contrast chest CT
    Sila Kurugol
    Dept of Pulmonary and Critical Care, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:2343-6. 2012
    ..52 ± 0.10 mm between the manually and automatically segmented surfaces. The true positive detection rate of calcification algorithm was 0.96 over all CT scans...
  44. ncbi Volumetric expiratory HRCT of the lung: clinical applications
    Mizuki Nishino
    Department of Radiology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02215, USA
    Thorac Surg Clin 20:121-7, viii-ix. 2010
    ..It concludes that standardization of image acquisition and post-processing in CT examinations will be necessary for the real application of quantitative data derived from volumetric expiratory HRCT to daily clinical medical practice...
  45. ncbi CT and physiologic determinants of dyspnea and exercise capacity during the six-minute walk test in mild COPD
    Alejandro A Diaz
    Division of Pulmonary and Critical Care, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Respir Med 107:570-9. 2013
    ....
  46. ncbi Assessment of pulmonary hypertension what CT and MRI can provide
    Yuka Okajima
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acad Radiol 18:437-53. 2011
    ..With the accumulated technological advancement, CT and MRI may provide practical tools for not only morphologic but also functional assessment of patients with PH...
  47. ncbi Gender differences in the severity of CT emphysema in COPD
    Mark T Dransfield
    University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Chest 132:464-70. 2007
    ..We aimed to determine if there are gender differences in the severity of CT emphysema among COPD patients...