Research Topics

Genomes and Genes


George R Washko


Affiliation: Massachusetts General Hospital
Country: USA


  1. KLIMENT C, Araki T, Doyle T, Gao W, Dupuis J, Latourelle J, et al. A comparison of visual and quantitative methods to identify interstitial lung abnormalities. BMC Pulm Med. 2015;15:134 pubmed publisher
    ..Moreover, HAAs were not associated with MUC5B promoter genotype. ..
  2. Kalhan R, Dransfield M, Colangelo L, Cuttica M, Jacobs D, Thyagarajan B, et al. Respiratory Symptoms in Young Adults and Future Lung Disease: The CARDIA Lung Study. Am J Respir Crit Care Med. 2018;: pubmed publisher
    ..Persistent respiratory symptoms in young adults are associated with accelerated decline in lung function, incident obstructive and restrictive physiology, and greater odds of future radiographic emphysema. ..
  3. Copeland C, Nath H, Terry N, Wilson C, Kim Y, Lynch D, et al. Paratracheal Paraseptal Emphysema and Expiratory Central Airway Collapse in Smokers. Ann Am Thorac Soc. 2018;: pubmed publisher
    ..The identification of this risk factor on inspiratory scans should prompt further evaluation for ECAC. Clinical trial registered with (NCT00608764). ..
  4. Morrow J, Glass K, Cho M, Hersh C, Pinto Plata V, Celli B, et al. Human Lung DNA Methylation Quantitative Trait Loci Colocalize with COPD Genome-wide Association Loci. Am J Respir Crit Care Med. 2018;: pubmed publisher
    ..Colocalization of methylation QTL and GWAS loci provides regulatory characterization of significant and sub-threshold GWAS findings, supporting a role for genetic control of methylation in COPD pathogenesis. ..
  5. Kim W, Silverman E, Hoffman E, Criner G, Mosenifar Z, Sciurba F, et al. CT metrics of airway disease and emphysema in severe COPD. Chest. 2009;136:396-404 pubmed publisher
    ..The contribution of CT scan-assessed airway disease to objective measures of lung function and respiratory symptoms such as dyspnea in severe emphysema is less clear...
  6. Labaki W, Martinez C, Martinez F, Galban C, Ross B, Washko G, et al. The Role of Chest Computed Tomography in the Evaluation and Management of the Patient with COPD. Am J Respir Crit Care Med. 2017;: pubmed publisher
    ..Chest CT clearly has the potential to become a powerful tool in the quest to personalize medicine, but its value will ultimately depend on our ability to extract clinically important information that changes management. ..
  7. Gonzalez G, Ash S, Vegas Sanchez Ferrero G, Onieva Onieva J, Rahaghi F, Ross J, et al. Disease Staging and Prognosis in Smokers Using Deep Learning in Chest Computed Tomography. Am J Respir Crit Care Med. 2017;: pubmed publisher
    ..At a population level CNN analysis may be a powerful tool for risk assessment. ..