Lucas D Ward

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Interpreting noncoding genetic variation in complex traits and human disease
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Biotechnol 30:1095-106. 2012
  2. pmc HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology and The Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA
    Nucleic Acids Res 40:D930-4. 2012
  3. ncbi request reprint Evidence of abundant purifying selection in humans for recently acquired regulatory functions
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 337:1675-8. 2012
  4. pmc Defining functional DNA elements in the human genome
    Manolis Kellis
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139
    Proc Natl Acad Sci U S A 111:6131-8. 2014
  5. ncbi request reprint Response to comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions"
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 340:682. 2013
  6. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
  7. pmc Mapping and analysis of chromatin state dynamics in nine human cell types
    Jason Ernst
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 473:43-9. 2011

Detail Information

Publications7

  1. pmc Interpreting noncoding genetic variation in complex traits and human disease
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Nat Biotechnol 30:1095-106. 2012
    ..Ultimately, advances in regulatory and systems genomics can help unleash the value of whole-genome sequencing for personalized genomic risk assessment, diagnosis and treatment...
  2. pmc HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology and The Broad Institute of MIT and Harvard, Cambridge, MA 02139, USA
    Nucleic Acids Res 40:D930-4. 2012
    ..HaploReg will be useful to researchers developing mechanistic hypotheses of the impact of non-coding variants on clinical phenotypes and normal variation. The HaploReg database is available at http://compbio.mit.edu/HaploReg...
  3. ncbi request reprint Evidence of abundant purifying selection in humans for recently acquired regulatory functions
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 337:1675-8. 2012
    ..Our results suggest continued turnover in regulatory regions, with at least an additional 4% of the human genome subject to lineage-specific constraint...
  4. pmc Defining functional DNA elements in the human genome
    Manolis Kellis
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139
    Proc Natl Acad Sci U S A 111:6131-8. 2014
    ..Our results reinforce the principle that each approach provides complementary information and that we need to use combinations of all three to elucidate genome function in human biology and disease. ..
  5. ncbi request reprint Response to comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions"
    Lucas D Ward
    Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 340:682. 2013
    ..We clarify that our estimate is dependent on the constrained and neutral references used, which can further increase the number of nucleotides involved, because a particularly stringent definition was initially used...
  6. pmc A high-resolution map of human evolutionary constraint using 29 mammals
    Kerstin Lindblad-Toh
    Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA
    Nature 478:476-82. 2011
    ..Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease...
  7. pmc Mapping and analysis of chromatin state dynamics in nine human cell types
    Jason Ernst
    Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA
    Nature 473:43-9. 2011
    ..Our study presents a general framework for deciphering cis-regulatory connections and their roles in disease...