THOMAS J contact WANG

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study
    Nisha I Parikh
    Framingham Heart Study, Boston University School of Medicine, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702 5803, USA
    Eur Heart J 28:2644-52. 2007
  2. pmc Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
  3. pmc Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study
    Thomas J Wang
    Cardiology Division, GRB 800, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 126:1596-604. 2012
  4. pmc Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study
    Conall M O'Seaghdha
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue Suite 2, Framingham, MA, USA
    BMC Endocr Disord 12:3. 2012
  5. pmc Biomarkers and cardiovascular risk assessment for primary prevention: an update
    Lauren G Gilstrap
    Cardiology Division and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Chem 58:72-82. 2012
  6. pmc Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007
  7. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
  8. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
  9. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
  10. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007

Detail Information

Publications88

  1. ncbi request reprint Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study
    Nisha I Parikh
    Framingham Heart Study, Boston University School of Medicine, 73 Mount Wayte Avenue, Suite 2, Framingham, MA 01702 5803, USA
    Eur Heart J 28:2644-52. 2007
    ..We related plasma renin to incidence of CVD and mortality in 3408 individuals (mean age 59; 53% women) and in a hypertensive subset (n = 1413)...
  2. pmc Adiposity, cardiometabolic risk, and vitamin D status: the Framingham Heart Study
    Susan Cheng
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 59:242-8. 2010
    ..Few studies relating vitamin D deficiency to obesity have included direct measures of adiposity. Furthermore, the degree to which vitamin D is associated with metabolic traits after adjusting for adiposity measures is unclear...
  3. pmc Prognostic utility of novel biomarkers of cardiovascular stress: the Framingham Heart Study
    Thomas J Wang
    Cardiology Division, GRB 800, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Circulation 126:1596-604. 2012
    ..Biomarkers for predicting cardiovascular events in community-based populations have not consistently added information to standard risk factors. A limitation of many previously studied biomarkers is their lack of cardiovascular specificity...
  4. pmc Correlation of renin angiotensin and aldosterone system activity with subcutaneous and visceral adiposity: the framingham heart study
    Conall M O'Seaghdha
    National Heart, Lung and Blood Institute s Framingham Heart Study, 73 Mt, Wayte Avenue Suite 2, Framingham, MA, USA
    BMC Endocr Disord 12:3. 2012
    ..abstract:..
  5. pmc Biomarkers and cardiovascular risk assessment for primary prevention: an update
    Lauren G Gilstrap
    Cardiology Division and Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Chem 58:72-82. 2012
    ..This increase has been fueled by an improved understanding of cardiovascular pathophysiology, as well as novel technologies for biomarker identification...
  6. pmc Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study
    Christopher Newton-Cheh
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S7. 2007
    ..We report the results of a community-based genomewide association study of six ECG and HRV intermediate traits...
  7. pmc Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study
    Ramachandran S Vasan
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S2. 2007
    ..We conducted a genome-wide association study (GWAS) in the community-based Framingham Heart Study...
  8. pmc Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
    Martin G Larson
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S5. 2007
    ..Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. We report a community-based genome-wide association study of major CVD outcomes...
  9. pmc Genome-wide association with select biomarker traits in the Framingham Heart Study
    Emelia J Benjamin
    The National Heart Lung and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S11. 2007
    ..Genome-wide association studies (GWAS) provide mechanisms to investigate the genetic contributions to biomarker variability unconstrained by current knowledge of physiological relations...
  10. pmc Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness
    Daniel Levy
    The National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA, USA
    BMC Med Genet 8:S3. 2007
    ..Increased arterial stiffness is a key factor in the pathogenesis of systolic hypertension and cardiovascular disease. Substantial heritability of blood-pressure (BP) and arterial-stiffness suggests important genetic contributions...
  11. ncbi request reprint Multiple biomarkers for the prediction of first major cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    N Engl J Med 355:2631-9. 2006
    ..Few investigations have evaluated the incremental usefulness of multiple biomarkers from distinct biologic pathways for predicting the risk of cardiovascular events...
  12. ncbi request reprint Multiple biomarkers and the risk of incident hypertension
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Hypertension 49:432-8. 2007
    ..These data support the premise that abnormalities in multiple biological pathways antedate the onset of overt hypertension...
  13. pmc Common genetic determinants of vitamin D insufficiency: a genome-wide association study
    Thomas J Wang
    Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Lancet 376:180-8. 2010
    ..We aimed to identify common genetic variants affecting vitamin D concentrations and risk of insufficiency...
  14. ncbi request reprint Association of plasma natriuretic peptide levels with metabolic risk factors in ambulatory individuals
    Thomas J Wang
    Cardiology Division, GRB 800, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02114, USA
    Circulation 115:1345-53. 2007
    ..Although it has been shown that obese individuals have reduced natriuretic peptide levels, conflicting data exist on the relation of natriuretic peptide levels to other metabolic risk factors...
  15. pmc Metabolite profiles and the risk of developing diabetes
    Thomas J Wang
    Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 17:448-53. 2011
    ..These findings underscore the potential key role of amino acid metabolism early in the pathogenesis of diabetes and suggest that amino acid profiles could aid in diabetes risk assessment...
  16. doi request reprint New cardiovascular risk factors exist, but are they clinically useful?
    Thomas J Wang
    Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Eur Heart J 29:441-4. 2008
    ....
  17. pmc Clinical and echocardiographic correlates of plasma procollagen type III amino-terminal peptide levels in the community
    Thomas J Wang
    Framingham Heart Study, Framingham, MA, USA
    Am Heart J 154:291-7. 2007
    ..Whether plasma PIIINP levels are a useful indicator of subclinical left ventricular abnormalities in ambulatory individuals has not been studied...
  18. pmc Vitamin D deficiency and risk of cardiovascular disease
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass, USA
    Circulation 117:503-11. 2008
    ..A growing body of evidence suggests that vitamin D deficiency may adversely affect the cardiovascular system, but data from longitudinal studies are lacking...
  19. ncbi request reprint Plasma natriuretic peptide levels and the risk of cardiovascular events and death
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    N Engl J Med 350:655-63. 2004
    ..The prognostic significance of plasma natriuretic peptide levels in apparently asymptomatic persons has not been established...
  20. pmc Multimarker approach to evaluate correlates of vascular stiffness: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, MA, USA
    Circulation 119:37-43. 2009
    ..Knowledge about the pathophysiological processes that determine arterial stiffness may help guide therapeutic approaches...
  21. pmc Association of parental obesity with concentrations of select systemic biomarkers in nonobese offspring: the Framingham Heart Study
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes 58:134-7. 2009
    ..Parental obesity is a risk factor for offspring obesity. It is unclear whether parental obesity also confers risk for obesity-associated conditions (e.g., a proinflammatory or prothrombotic state) in the absence of offspring obesity...
  22. pmc Cross-sectional relations of multiple biomarkers representing distinct biological pathways to plasma markers of collagen metabolism in the community
    Jacob Joseph
    Cardiology Section 111, VA Boston Healthcare System, Boston, Massachusetts, USA
    J Hypertens 27:1317-24. 2009
    ..Hence, we related a panel of biomarkers representing these pathways to plasma markers of collagen metabolism in a large community-based sample...
  23. ncbi request reprint Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study
    Erik Ingelsson
    Framingham Heart Study, Boston University School of Medicine, Framingham, MA 01702 5803, USA
    Circulation 116:984-92. 2007
    ..We evaluated the relative contributions of circulating biomarkers representing distinct biological pathways to the incidence of MetS and to longitudinal changes of its constituent risk factors...
  24. ncbi request reprint Plasma natriuretic peptides for community screening for left ventricular hypertrophy and systolic dysfunction: the Framingham heart study
    Ramachandran S Vasan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, MA 01702, USA
    JAMA 288:1252-9. 2002
    ..Prior studies were limited by small sample sizes and selection bias and none compared the diagnostic performance of these peptides in men and women...
  25. ncbi request reprint Natural history of asymptomatic left ventricular systolic dysfunction in the community
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 108:977-82. 2003
    ..We sought to characterize the natural history of ALVD, by studying unselected individuals with this condition in the community...
  26. pmc Association of parental hypertension with concentrations of select biomarkers in nonhypertensive offspring
    Wolfgang Lieb
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Hypertension 52:381-6. 2008
    ..In conclusion, serum C-reactive protein concentrations are higher in nonhypertensive offspring of parents with hypertension. These data suggest that inflammation may partly mediate the familial influences on hypertension risk...
  27. pmc Resistin, adiponectin, and risk of heart failure the Framingham offspring study
    David S Frankel
    Department of Medicine, Massachusetts General Hospital, Boston, 02114, USA
    J Am Coll Cardiol 53:754-62. 2009
    ..We tested the association of the adipokines resistin and adiponectin with incident heart failure...
  28. pmc Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure
    Christopher Newton-Cheh
    Center for Human Genetic Research, Massachusetts General Hospital, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Genet 41:348-53. 2009
    ..85-0.95, P = 2 x 10(-4), respectively). Common genetic variants at the NPPA-NPPB locus found to be associated with circulating natriuretic peptide concentrations contribute to interindividual variation in blood pressure and hypertension...
  29. pmc Multimarker approach for the prediction of heart failure incidence in the community
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 122:1700-6. 2010
    ..There are no data, however, on the incremental utility of a parsimonious set of biomarkers (reflecting pathways implicated in HF) for predicting HF risk in the community...
  30. pmc Relations of biomarkers representing distinct biological pathways to left ventricular geometry
    Raghava S Velagaleti
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 118:2252-8, 5p following 2258. 2008
    ..Several biological pathways are activated concomitantly during left ventricular (LV) remodeling. However, the relative contribution of circulating biomarkers representing these distinct pathways to LV geometry is unclear...
  31. ncbi request reprint Associations of plasma natriuretic peptide, adrenomedullin, and homocysteine levels with alterations in arterial stiffness: the Framingham Heart Study
    Daniel Levy
    NHLBI Framingham Heart Study, Framingham, Mass, USA
    Circulation 115:3079-85. 2007
    ..Little is known about the relations of natriuretic peptides and homocysteine to arterial wall stiffness in the community...
  32. pmc Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data
    Ramachandran S Vasan
    Framingham Heart Study, 73 Mt Wayte Ave, Ste 2, Framingham, MA 01702 5827, USA
    JAMA 302:168-78. 2009
    ..Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease...
  33. ncbi request reprint Association of parental heart failure with risk of heart failure in offspring
    Douglas S Lee
    Framingham Heart Study of the National Heart, Lung, and Blood Institute, Framingham, Mass, USA
    N Engl J Med 355:138-47. 2006
    ..The association between heart failure in parents and the prevalence of left ventricular systolic dysfunction and the risk of heart failure in their offspring has not been investigated in a community-based setting...
  34. pmc Plasma leptin levels and incidence of heart failure, cardiovascular disease, and total mortality in elderly individuals
    Wolfgang Lieb
    Framingham Heart Study, Framingham, Massachusetts, USA
    Diabetes Care 32:612-6. 2009
    ..We tested the hypothesis that leptin levels are associated with greater risk of CHF, CVD, and mortality in elderly individuals...
  35. ncbi request reprint Heritability and genetic linkage of plasma natriuretic peptide levels
    Thomas J Wang
    Framingham Heart Study, MA 01702 5827, USA
    Circulation 108:13-6. 2003
    ..It is unknown to what extent genetic factors contribute to variation in plasma natriuretic peptide levels...
  36. ncbi request reprint Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, 73 Mt Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Circulation 107:2920-5. 2003
    ..Atrial fibrillation (AF) and congestive heart failure (CHF) frequently occur together, but there is limited information regarding their temporal relations and the combined influence of these conditions on mortality...
  37. ncbi request reprint Low-grade albuminuria and the risks of hypertension and blood pressure progression
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 111:1370-6. 2005
    ....
  38. ncbi request reprint Cross-sectional relations of electrocardiographic QRS duration to left ventricular dimensions: the Framingham Heart Study
    Ravi Dhingra
    Framingham Heart Study, Framingham, Massachusetts Veterans Affairs Boston Healthcare System, Boston, Massachusetts, USA
    J Am Coll Cardiol 45:685-9. 2005
    ..The goal of this study was to assess the relations of electrocardiographic QRS duration to left ventricular (LV) measurements in individuals without heart failure (HF) or prior myocardial infarction (MI)...
  39. pmc Relations of matrix remodeling biomarkers to blood pressure progression and incidence of hypertension in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass, USA
    Circulation 119:1101-7. 2009
    ..Biomarkers of extracellular matrix remodeling are associated with prevalent hypertension in cross-sectional studies, but their relations to longitudinal changes in blood pressure (BP) and hypertension incidence are unknown...
  40. ncbi request reprint Increasing trends in incidence of overweight and obesity over 5 decades
    Nisha I Parikh
    Framingham Heart Study, Framingham, Mass 01702 5803, USA
    Am J Med 120:242-50. 2007
    ..We evaluated trends in the incidence of overweight and obesity over the past 50 years...
  41. ncbi request reprint Impact of obesity on plasma natriuretic peptide levels
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702, USA
    Circulation 109:594-600. 2004
    ..The natriuretic peptides are important regulators of sodium homeostasis and neurohormonal activation, raising the possibility that obese individuals have an impaired natriuretic peptide response...
  42. ncbi request reprint A risk score for predicting near-term incidence of hypertension: the Framingham Heart Study
    Nisha I Parikh
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    Ann Intern Med 148:102-10. 2008
    ..Risk stratification may facilitate cost-effective approaches to management...
  43. pmc Metabolic signatures of exercise in human plasma
    Gregory D Lewis
    Cardiology Division and Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    Sci Transl Med 2:33ra37. 2010
    ..Plasma metabolic profiles obtained during exercise provide signatures of exercise performance and cardiovascular disease susceptibility, in addition to highlighting molecular pathways that may modulate the salutary effects of exercise...
  44. ncbi request reprint Evaluating the role of biomarkers for cardiovascular risk prediction: focus on CRP, BNP and urinary microalbumin
    Abigail May
    Massachusetts General Hospital, Department of Internal Medicine Harvard Medical School, Boston, MA 02114, USA
    Expert Rev Mol Diagn 7:793-804. 2007
    ..New developments in molecular biology and genetics may allow the identification of additional biomarkers, likely acting via different pathways, to achieve this goal...
  45. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  46. pmc Relation of QRS width in healthy persons to risk of future permanent pacemaker implantation
    Susan Cheng
    Framingham Heart Study, Massachusetts, USA
    Am J Cardiol 106:668-72. 2010
    ..In conclusion, subjects with prolonged QRS durations, even without bundle branch block, are at increased risk for future pacemaker implantation. Such individuals may warrant monitoring for progressive conduction disease...
  47. pmc Association of colony-forming units with coronary artery and abdominal aortic calcification
    Susan Cheng
    Cardiology Division, GRB 800, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Circulation 122:1176-82. 2010
    ..Experimental data suggest that depletion of these angiogenic cell populations may promote atherogenesis, but limited data are available on their relation to subclinical atherosclerotic cardiovascular disease in humans...
  48. ncbi request reprint Biomarkers for cardiovascular disease: challenges and future directions
    Abigail May
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Trends Mol Med 14:261-7. 2008
    ..This review highlights recent developments in the field of cardiovascular biomarkers and describes the use of new technologies for the identification of biomarkers...
  49. pmc Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample
    Erik Ingelsson
    The Framingham Study, Boston University School of Medicine, Framingham, Massachusetts 01702 5803, USA
    J Clin Endocrinol Metab 93:3149-57. 2008
    ..The conjoint effects and relative importance of ghrelin, leptin, and soluble leptin receptor (sOB-R), adipokines involved in appetite control and energy expenditure in mediating cardiometabolic risk, is unknown...
  50. pmc Serum gamma-glutamyl transferase and risk of heart failure in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Arterioscler Thromb Vasc Biol 30:1855-60. 2010
    ..To examine the association of serum gamma-glutamyltransferase (GGT) with incident heart failure...
  51. pmc Exercise blood pressure and the risk of incident cardiovascular disease (from the Framingham Heart Study)
    Gregory D Lewis
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Cardiol 101:1614-20. 2008
    ..Our findings support the concept that dynamic BP provides incremental information to BP at rest and suggest that exercise diastolic BP may be a better predictor than exercise systolic BP in this age group...
  52. ncbi request reprint Plasma brain natriuretic peptide levels and blood pressure tracking in the Framingham Heart Study
    Michael H Freitag
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, Mass 01702 5827, USA
    Hypertension 41:978-83. 2003
    ..Additional investigations are warranted to confirm these findings and elucidate the basis for these gender-related differences...
  53. ncbi request reprint Obesity and the risk of new-onset atrial fibrillation
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    JAMA 292:2471-7. 2004
    ..Obesity is associated with atrial enlargement and ventricular diastolic dysfunction, both known predictors of atrial fibrillation (AF). However, it is unclear whether obesity is a risk factor for AF...
  54. ncbi request reprint Screening for ventricular remodeling
    Douglas S Lee
    Framingham Heart Study, MA 01702, USA
    Curr Heart Fail Rep 3:5-13. 2006
    ..Additional studies are warranted to confirm these findings...
  55. ncbi request reprint Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample
    Christopher Newton-Cheh
    Framingham Heart Study of the National Heart Lung and Blood Institute and Boston University School of Medicine, Framingham, MA 01702 5827, USA
    Hypertension 49:846-56. 2007
    ..16; 95% CI: 1.00 to 1.33). ARR is a heritable trait influenced by clinical and genetic factors. There is a continuous gradient of increasing risk of BP progression across ARR levels in nonhypertensive individuals...
  56. ncbi request reprint Heritability, linkage, and genetic associations of exercise treadmill test responses
    Erik Ingelsson
    Framingham Study, Framingham, Mass, USA
    Circulation 115:2917-24. 2007
    ..The blood pressure (BP) and heart rate responses to exercise treadmill testing predict incidence of cardiovascular disease, but the genetic determinants of hemodynamic and chronotropic responses to exercise are largely unknown...
  57. ncbi request reprint A utilization management intervention to reduce unnecessary testing in the coronary care unit
    Thomas J Wang
    Massachusetts General Hospital, Wang Ambulatory Care Center 478, 15 Parkman St, Boston, MA 02114, USA
    Arch Intern Med 162:1885-90. 2002
    ..There have been no studies of interventions to reduce test utilization in the coronary care unit...
  58. ncbi request reprint Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community
    Ravi Dhingra
    Framingham Heart Study, 73 Mount Wayte Ave, Suite 2, Framingham, MA 01702 5803, USA
    Circulation 116:480-8. 2007
    ..Consumption of soft drinks has been linked to obesity in children and adolescents, but it is unclear whether it increases metabolic risk in middle-aged individuals...
  59. ncbi request reprint The search for new cardiovascular biomarkers
    Robert E Gerszten
    Massachusetts General Hospital, Cardiology Division, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nature 451:949-52. 2008
    ..Thus, new biomarkers are needed to augment the information obtained from traditional indicators and to illuminate disease mechanisms...
  60. ncbi request reprint Carotid intima-media thickness is associated with premature parental coronary heart disease: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Circulation 108:572-6. 2003
    ..We hypothesized that an important mediator of the familial predisposition to CHD is subclinical atherosclerosis, which is detectable by noninvasive imaging...
  61. ncbi request reprint Low-grade albuminuria and incidence of cardiovascular disease events in nonhypertensive and nondiabetic individuals: the Framingham Heart Study
    Johan Arnlov
    Framingham Heart Study, National Heart, Lung and Blood Institute, Bethesda, MD, USA
    Circulation 112:969-75. 2005
    ..Data are limited with regard to the relations of low-grade albuminuria (below the microalbuminuria threshold) and incidence of cardiovascular disease (CVD) events in nondiabetic, nonhypertensive individuals...
  62. pmc Genome-wide association study of blood pressure and hypertension
    Daniel Levy
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Nat Genet 41:677-87. 2009
    ..Identifying genes associated with blood pressure advances our understanding of blood pressure regulation and highlights potential drug targets for the prevention or treatment of hypertension...
  63. ncbi request reprint Association of C-reactive protein with carotid atherosclerosis in men and women: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, Mass 01702 5827, USA
    Arterioscler Thromb Vasc Biol 22:1662-7. 2002
    ..The objective of this study was to examine the relationship between C-reactive protein (CRP) and carotid atherosclerosis...
  64. ncbi request reprint Obstructive sleep apnea and plasma natriuretic peptide levels in a community-based sample
    Anjali A Patwardhan
    Boston University School of Medicine, Boston, MA, USA
    Sleep 29:1301-6. 2006
    ..We examined the association of OSAH with natriuretic peptides in a community-based sample...
  65. pmc Long-term trends in the incidence of heart failure after myocardial infarction
    Raghava S Velagaleti
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Circulation 118:2057-62. 2008
    ....
  66. pmc Lack of association between serum magnesium and the risks of hypertension and cardiovascular disease
    Abigail May Khan
    Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Am Heart J 160:715-20. 2010
    ..Prior clinical studies have yielded conflicting results but were limited by the use of self-reported magnesium intake or short follow-up periods...
  67. pmc Cardiac natriuretic peptides, obesity, and insulin resistance: evidence from two community-based studies
    Abigail May Khan
    Cardiology Division, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 96:3242-9. 2011
    ..It has been suggested that obesity promotes a relative natriuretic peptide deficiency, but this has been a variable finding in prior studies and the cause is unknown...
  68. ncbi request reprint Antecedent blood pressure, body mass index, and the risk of incident heart failure in later life
    Douglas S Lee
    Institute for Clinical Evaluative Sciences and University Health Network, University of Toronto, Toronto, Canada
    Hypertension 50:869-76. 2007
    ..Higher blood pressure and BMI in midlife are harbingers of increased risk of heart failure in later life. Early risk factor modification may decrease heart failure burden...
  69. ncbi request reprint Parental cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults: a prospective study of parents and offspring
    Donald M Lloyd-Jones
    Department of Preventive Medicine and Division of Cardiology, Feinberg School of Medicine, Northwestern University, Chicago, Ill, USA
    JAMA 291:2204-11. 2004
    ..Whether parental cardiovascular disease confers increased risk independent of other risk factors remains controversial. Prior studies relied on offspring report, without complete validation of parental events...
  70. ncbi request reprint Lifetime risk for development of atrial fibrillation: the Framingham Heart Study
    Donald M Lloyd-Jones
    Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University Feinberg School of Medicine, 680 N Lake Shore Drive, Suite 1102, Chicago, IL, 60611, USA
    Circulation 110:1042-6. 2004
    ..Atrial fibrillation (AF) is the most common cardiac dysrhythmia and a source of considerable morbidity and mortality, but lifetime risk for AF has not been estimated...
  71. ncbi request reprint Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study)
    Avni H Thakore
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Massachusetts, USA
    Am J Cardiol 99:1598-602. 2007
    ..In conclusion, there were modest associations of inflammatory markers, particularly IL-6, with carotid atherosclerosis. This association appears more pronounced in current smokers than in former smokers and nonsmokers...
  72. ncbi request reprint Impact of age and sex on plasma natriuretic peptide levels in healthy adults
    Thomas J Wang
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Massachusetts 01702, USA
    Am J Cardiol 90:254-8. 2002
    ..The reference limits derived from this large, healthy community-based sample will aid in the identification of elevated natriuretic peptide levels in clinical practice...
  73. ncbi request reprint Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community
    Ravi Dhingra
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5803, USA
    Arch Intern Med 167:879-85. 2007
    ..However, it is unknown if serum phosphorus levels influence vascular risk in individuals without CKD or CVD...
  74. ncbi request reprint Prevalence and prognostic impact of subclinical cardiovascular disease in individuals with the metabolic syndrome and diabetes
    Erik Ingelsson
    National Heart, Lung, and Blood Institute s Framingham Study, Framingham, Massachusetts 01702 5803, USA
    Diabetes 56:1718-26. 2007
    ..93 [1.15-3.24]). In our community-based sample, individuals with MetS have a high prevalence of subclinical atherosclerosis that likely contributes to the increased risk of overt CVD associated with the condition...
  75. pmc Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
    Oded Shaham
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Syst Biol 4:214. 2008
    ..Our findings lay the groundwork for using metabolic profiling to define an individual's 'insulin response profile', which could have value in predicting diabetes, its complications, and in guiding therapy...
  76. ncbi request reprint Electrocardiographic QRS duration and the risk of congestive heart failure: the Framingham Heart Study
    Ravi Dhingra
    Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA, USA
    Hypertension 47:861-7. 2006
    ..In our community-based sample, longer electrocardiographic QRS was associated with increased CHF risk, consistent with the hypothesis that depolarization delay may increase CHF risk...
  77. pmc Interindividual variation in serum sodium and longitudinal blood pressure tracking in the Framingham Heart Study
    Rodrigo M Lago
    Framingham Heart Study, Framingham, Massachusetts 01702 5803, USA
    J Hypertens 26:2121-5. 2008
    ..Recent cross-sectional studies have suggested that higher serum sodium levels may be a marker of elevated blood pressure. It is unclear whether serum sodium levels are related to the risk of developing hypertension in the community...
  78. ncbi request reprint Endogenous sex hormones and cardiovascular disease incidence in men
    Johan Arnlov
    National Heart, Lung, and Blood Institute s Framingham Heart Study, National Institutes of Health, Bethesda, Maryland, USA
    Ann Intern Med 145:176-84. 2006
    ..Yet, prospective studies relating sex hormones to CVD incidence in men have yielded inconsistent results...
  79. ncbi request reprint Pulse pressure and risk of new-onset atrial fibrillation
    Gary F Mitchell
    Cardiovascular Engineering Inc, Waltham, Mass 02453, USA
    JAMA 297:709-15. 2007
    ..Increased pulse pressure, a reflection of aortic stiffness, increases cardiac load and may increase AF risk...
  80. ncbi request reprint Gamma glutamyl transferase and metabolic syndrome, cardiovascular disease, and mortality risk: the Framingham Heart Study
    Douglas S Lee
    Institute for Clinical Evaluative Sciences, Division of Cardiology, University Health Network, University of Toronto, Rm G 106, 2075 Bayview Ave, Toronto, Ontario, M4N 3M5 Canada
    Arterioscler Thromb Vasc Biol 27:127-33. 2007
    ..To determine whether serum gamma-glutamyl transferase (GGT) predicts cardiovascular disease (CVD) morbidity and mortality, accounting for temporal changes in known CVD risk factors and C-reactive protein (CRP)...
  81. ncbi request reprint Burden and prognostic importance of subclinical cardiovascular disease in overweight and obese individuals
    Erik Ingelsson
    Framingham Heart Study, 73 Mount Wayte Ave, Framingham, MA 01702 5803, USA
    Circulation 116:375-84. 2007
    ..The burden and prognostic importance of subclinical cardiovascular disease (CVD) in obesity has not been investigated systematically...
  82. ncbi request reprint The epidemiology of "asymptomatic" left ventricular systolic dysfunction: implications for screening
    Thomas J Wang
    National Heart, Lung, and Blood Institute s Framingham Heart Study, 73 Mt Wayte Avenue, Suite 2, Framingham, Massachusetts 01702 5827, USA
    Ann Intern Med 138:907-16. 2003
    ..Given the increasing prevalence of heart failure, additional studies are needed to develop effective strategies to detect and optimally manage individuals with asymptomatic left ventricular dysfunction in the community...
  83. ncbi request reprint A risk score for predicting stroke or death in individuals with new-onset atrial fibrillation in the community: the Framingham Heart Study
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702 5827, USA
    JAMA 290:1049-56. 2003
    ....
  84. ncbi request reprint Epidemiology of uncontrolled hypertension in the United States
    Thomas J Wang
    Framingham Heart Study, Framingham, MA 01702, USA
    Circulation 112:1651-62. 2005
  85. ncbi request reprint Sibling cardiovascular disease as a risk factor for cardiovascular disease in middle-aged adults
    Joanne M Murabito
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, Mass 01702, USA
    JAMA 294:3117-23. 2005
    ..While parental cardiovascular disease (CVD) doubles the risk for CVD in offspring, the extent of increased risk associated with sibling CVD is unclear...
  86. ncbi request reprint Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function
    Sekar Kathiresan
    National Heart, Lung, and Blood Institute s Framingham Heart Study, Framingham, MA 01702 5827, USA
    Circulation 113:938-45. 2006
    ..We evaluated the relative contributions of distinct biological pathways to interindividual variation in endothelial function by relating prototype biomarkers (representing these pathways) to brachial artery vasodilator function...
  87. ncbi request reprint Algorithms for assessing cardiovascular risk in women
    Thomas J Wang
    JAMA 298:176; author reply 177-8. 2007
  88. pmc Challenges in translating plasma proteomics from bench to bedside: update from the NHLBI Clinical Proteomics Programs
    Robert E Gerszten
    Cardiology Division and Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA
    Am J Physiol Lung Cell Mol Physiol 295:L16-22. 2008
    ..Strategies to overcome these challenges are discussed...

Research Grants10

  1. Endothelial Progenitor Cells: Clinical Prognosis
    Thomas Wang; Fiscal Year: 2006
    ....
  2. Physiologic effects of natriuretic peptide genetic variation
    THOMAS J contact WANG; Fiscal Year: 2010
    ....
  3. Nutriuretic Peptides, the Renin-Angiotensin System, and Metabolic Risk in Obesity
    Thomas Wang; Fiscal Year: 2009
    ..Assessment ofbiochemial markers of these pathways may identify obese individuals at higher risk of developing cardiovascular risk factors and may suggest novel therapeutic targets. ..
  4. Endothelial Progenitor Cells: Clinical Correlates and Prognosis in the Community
    Thomas Wang; Fiscal Year: 2009
    ..abstract_text> ..
  5. Nutriuretic Peptides, the Renin-Angiotensin System, and Metabolic Risk in Obesity
    Thomas Wang; Fiscal Year: 2007
    ..Assessment ofbiochemial markers of these pathways may identify obese individuals at higher risk of developing cardiovascular risk factors and may suggest novel therapeutic targets. ..
  6. Natriuretic Peptides, Genes, and Diastolic Heart Failure
    Thomas Wang; Fiscal Year: 2007
    ..Each of these skills will be critical to the candidate's long-term goal of becoming an independent clinical investigator with a focus on heart failure. ..
  7. Endothelial Progenitor Cells: Clinical Correlates and Prognosis in the Community
    Thomas Wang; Fiscal Year: 2007
    ....
  8. Nutriuretic Peptides, the Renin-Angiotensin System, and Metabolic Risk in Obesity
    Thomas J Wang; Fiscal Year: 2010
    ..Assessment ofbiochemial markers of these pathways may identify obese individuals at higher risk of developing cardiovascular risk factors and may suggest novel therapeutic targets. ..