W Walker

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response
    Nanda Nanthakumar
    Developmental Gastroenterology Laboratory, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17776. 2011
  2. ncbi request reprint State of pediatric gastroenterology, hepatology, and nutrition: 2006 and beyond
    W Allan Walker
    Harvard Medical School and Mucosal Immunology Laboratory, Massachusetts General Hospital for Children, 114 16th Street, Charlestown, MA 02129, USA
    Gastroenterology 132:434-6. 2007
  3. doi request reprint Mechanisms of action of probiotics
    W Allan Walker
    Division of Nutrition and Department of Pediatrics, Harvard Medical School, Boston, USA
    Clin Infect Dis 46:S87-91; discussion S144-51. 2008
  4. ncbi request reprint Opportunities in pediatric IBD research
    W Allan Walker
    Mucosal Immunology Laboratory, Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr Gastroenterol Nutr 40:S4. 2005
  5. pmc Commensal bacteria and epithelial cross talk in the developing intestine
    Samuli Rautava
    Mucosal Immunology Laboratory, Massachusetts General Hospital, 114 16th Street 114 3503, Charlestown, MA 02129 4404, USA
    Curr Gastroenterol Rep 9:385-92. 2007
  6. ncbi request reprint Bacterial-enterocyte crosstalk: cellular mechanisms in health and disease
    Henrik Kohler
    Mucosal Immunology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    J Pediatr Gastroenterol Nutr 36:175-85. 2003
  7. ncbi request reprint Protection of the neonate by the innate immune system of developing gut and of human milk
    David S Newburg
    Pediatric Gastroenterology and Nutrition Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Res 61:2-8. 2007
  8. doi request reprint The long-term health effects of neonatal microbial flora
    Michelle E Conroy
    Division of Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Opin Allergy Clin Immunol 9:197-201. 2009
  9. pmc Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation
    Erika C Claud
    Pediatric Gastroenterology Unit, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:7404-8. 2004
  10. pmc Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine
    Uzma Shah
    Mucosal Immunology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
    Pediatr Res 53:295-301. 2003

Collaborators

Detail Information

Publications57

  1. pmc The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response
    Nanda Nanthakumar
    Developmental Gastroenterology Laboratory, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e17776. 2011
    ..We conclude that the excessive inflammatory response of the immature intestine, a hallmark of NEC, is due to a developmental immaturity in innate immune response genes...
  2. ncbi request reprint State of pediatric gastroenterology, hepatology, and nutrition: 2006 and beyond
    W Allan Walker
    Harvard Medical School and Mucosal Immunology Laboratory, Massachusetts General Hospital for Children, 114 16th Street, Charlestown, MA 02129, USA
    Gastroenterology 132:434-6. 2007
  3. doi request reprint Mechanisms of action of probiotics
    W Allan Walker
    Division of Nutrition and Department of Pediatrics, Harvard Medical School, Boston, USA
    Clin Infect Dis 46:S87-91; discussion S144-51. 2008
    ....
  4. ncbi request reprint Opportunities in pediatric IBD research
    W Allan Walker
    Mucosal Immunology Laboratory, Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr Gastroenterol Nutr 40:S4. 2005
  5. pmc Commensal bacteria and epithelial cross talk in the developing intestine
    Samuli Rautava
    Mucosal Immunology Laboratory, Massachusetts General Hospital, 114 16th Street 114 3503, Charlestown, MA 02129 4404, USA
    Curr Gastroenterol Rep 9:385-92. 2007
    ..Cross talk between the host and commensal microbes is an essential component of gut homeostasis mechanisms also in later life. During recent years, innovative research has shed light on the molecular mechanisms of these interactions...
  6. ncbi request reprint Bacterial-enterocyte crosstalk: cellular mechanisms in health and disease
    Henrik Kohler
    Mucosal Immunology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, 114 16th Street, Charlestown, MA 02129, USA
    J Pediatr Gastroenterol Nutr 36:175-85. 2003
  7. ncbi request reprint Protection of the neonate by the innate immune system of developing gut and of human milk
    David S Newburg
    Pediatric Gastroenterology and Nutrition Unit, MassGeneral Hospital for Children and Harvard Medical School, Boston, Massachusetts, USA
    Pediatr Res 61:2-8. 2007
    ..Interactions between human milk glycans, intestinal microflora, and intestinal mucosa surface glycans underlie ontogeny of innate mucosal immunity, pathobiology of enteric infection, and inflammatory bowel diseases...
  8. doi request reprint The long-term health effects of neonatal microbial flora
    Michelle E Conroy
    Division of Allergy and Immunology, Massachusetts General Hospital, Boston, MA 02114, USA
    Curr Opin Allergy Clin Immunol 9:197-201. 2009
    ..DNA-based detection techniques have allowed increased identification of specific microbes involved in this symbiosis...
  9. pmc Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation
    Erika C Claud
    Pediatric Gastroenterology Unit, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 101:7404-8. 2004
    ....
  10. pmc Distribution of the IgG Fc receptor, FcRn, in the human fetal intestine
    Uzma Shah
    Mucosal Immunology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, Massachusetts 02129 4404, USA
    Pediatr Res 53:295-301. 2003
    ....
  11. ncbi request reprint Probiotics and chronic disease
    Ilse J Broekaert
    Mucosal Immunology Laboratory, Massachusetts General Hospital for Children, Harvard Medical School, Boston, MA 02129, USA
    J Clin Gastroenterol 40:270-4. 2006
    ..In conclusion, probiotics act as an adjuvant in the prevention and treatment of a wide variety of chronic diseases...
  12. doi request reprint Intestinal immune health
    Michelle E Conroy
    Mucosal Immunology and Developmental Gastroenterology Laboratories, Massachusetts General Hospital for Children, Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Nestle Nutr Workshop Ser Pediatr Program 62:111-21; discussion 121-5. 2008
    ..Future research should explore these molecular interactions more closely for their potential therapeutic applications...
  13. pmc Butyrate regulates the expression of pathogen-triggered IL-8 in intestinal epithelia
    Meiqian Weng
    Department of Pediatrics, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Pediatr Res 62:542-6. 2007
    ..Our data suggest that the inflammatory modulation of butyrate in IBD is mediated by A20 and a short pulse rather than continuous administration of butyrate may provide a protective effect on IBD...
  14. pmc Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection
    Fu Chen Huang
    Mucosal Immunology Laboratory, Pediatric Gastroenterology and Nutrition Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, USA
    Infect Immun 72:5052-62. 2004
    ..These observations offer a mechanistic explanation for the involvement of these proteins in the pathogenesis of Salmonella-induced gastroenteritis...
  15. ncbi request reprint Secreted probiotic factors ameliorate enteropathogenic infection in zinc-deficient human Caco-2 and T84 cell lines
    Ilse J Broekaert
    Department of Pediatrics, Mucosal Immunology and Developmental Gastroenterology Laboratories, Massachusetts General Hospital for Children, Harvard Medical School, Boston, Massachusetts 02215, USA
    Pediatr Res 62:139-44. 2007
    ..Probiotic inhibitory factors are stable to treatment with proteases, deoxyribonucleases (DNAses), ribonucleases (RNAse), strong acid, and heat...
  16. ncbi request reprint Bacterial symbionts induce a FUT2-dependent fucosylated niche on colonic epithelium via ERK and JNK signaling
    Di Meng
    Developmental Gastroenterology Laboratory, Massachusetts General Hospital East, 114 16th St, Rm 3650, Charlestown, MA 02129, USA
    Am J Physiol Gastrointest Liver Physiol 293:G780-7. 2007
    ....
  17. doi request reprint Neonatal microbial flora and disease outcome
    Milo F Vassallo
    Mucosal Immunology and Developmental Gastroenterology Laboratories, Massachusetts General Hospital for Children, Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Nestle Nutr Workshop Ser Pediatr Program 61:211-24. 2008
    ..Intestinal microbes and hosts have co-evolved that, when in appropriate balance, they produce and propagate a life-long mutualism...
  18. ncbi request reprint Developmentally regulated intestinal expression of IFN-gamma and its target genes and the age-specific response to enteric Salmonella infection
    Sue J Rhee
    Mucosal Immunology Laboratory, Pediatric Gastroenterology and Nutrition Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 175:1127-36. 2005
    ..typhimurium infection resembled that of the wild-type pups. Our findings thus reveal a novel role for IFN-gamma in the developmental regulation of antimicrobial responses in the intestine...
  19. ncbi request reprint Development of the intestinal mucosal barrier
    W Allan Walker
    Combined Program in Pediatric Gastroenterology and Nutrition at Harvard Medical School, Massachusetts General Hospital, Charlestown 02129, USA
    J Pediatr Gastroenterol Nutr 34:S33-9. 2002
  20. doi request reprint Probiotics: role in pathophysiology and prevention in necrotizing enterocolitis
    Camilia R Martin
    Department of Pediatrics, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Semin Perinatol 32:127-37. 2008
    ....
  21. pmc Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis
    Meiqian Weng
    Mucosal Immunology Laboratory, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 179:4721-31. 2007
    ....
  22. ncbi request reprint Probiotics as flourishing benefactors for the human body
    Ilse J Broekaert
    Mucosal Immunology Laboratory, Massachusetts General Hospital for Children, Boston, 02129, USA
    Gastroenterol Nurs 29:26-34. 2006
    ..In the presence of prebiotics, which are nondigestible food ingredients favorable for probiotic growth, their survival in the intestine is ameliorated...
  23. ncbi request reprint Glucocorticoid responsiveness in developing human intestine: possible role in prevention of necrotizing enterocolitis
    N Nanda Nanthakumar
    Developmental Gastroenterology Laboratory, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Physiol Gastrointest Liver Physiol 288:G85-92. 2005
    ..Therefore, accelerating intestinal maturation by glucocorticoids within the responsive period by accelerating functional and inflammatory maturation may provide an effective preventive therapy for NEC...
  24. ncbi request reprint Innate immunity of the gut: mucosal defense in health and disease
    Qian Yuan
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Pediatr Gastroenterol Nutr 38:463-73. 2004
    ..This review updates our current understanding of innate immunity of the gastrointestinal tract...
  25. pmc Academy of Breastfeeding Medicine founder's lecture 2008: breastfeeding--an extrauterine link between mother and child
    Samuli Rautava
    Developmental Gastroenterology Laboratory, Division of Pediatric Gastroenterology, Massachusetts General Hospital for Children, Charlestown, Massachusetts, USA
    Breastfeed Med 4:3-10. 2009
    ..The body of scientific data regarding the role of transforming growth factor-beta in breastmilk in enhancing healthy immune maturation and reducing the risk of disease is reviewed in this article...
  26. ncbi request reprint The dynamic effects of breastfeeding on intestinal development and host defense
    W Allan Walker
    Departments of Nutrition and Pediatrics, Harvard Medical School, Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Adv Exp Med Biol 554:155-70. 2004
    ..Additional studies of human immature gut function along with translational and clinical studies are necessary to provide further objective evidence in support of breastfeeding for all neonates, particularly premature neonates...
  27. ncbi request reprint Intestinal immune defences and the inflammatory response in necrotising enterocolitis
    Camilia R Martin
    Harvard Medical School, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Rose 318, Boston, MA 02215, USA
    Semin Fetal Neonatal Med 11:369-77. 2006
    ..Here, we review intestinal immunity and the specific inflammatory mediators involved in this disease process...
  28. pmc Hydrocortisone modulates cholera toxin endocytosis by regulating immature enterocyte plasma membrane phospholipids
    Lei Lu
    Developmental Gastroenterology Laboratory, Massachusetts General Hospital for Children, Boston, Massachusetts, USA
    Gastroenterology 135:185-193.e1. 2008
    ..Our aim was to characterize the developmental difference in cholera toxin (CT)-GM1-mediated endocytosis...
  29. ncbi request reprint Endocytosis of cholera toxin by human enterocytes is developmentally regulated
    Lei Lu
    Developmental Gastroenterology Laboratory, Massachusetts General Hospital, 114 16th St 114 3503, Charlestown, MA 02129 4404, USA
    Am J Physiol Gastrointest Liver Physiol 289:G332-41. 2005
    ..We also present evidence that this clathrin pathway is developmentally regulated as demonstrated by its response to corticosteroids, a known maturation factor that causes a decreased CT endocytosis by this pathway...
  30. pmc Attenuated inflammatory responses in hemochromatosis reveal a role for iron in the regulation of macrophage cytokine translation
    Lijian Wang
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Immunol 181:2723-31. 2008
    ..Our results provide molecular insight into immune function in type I hemochromatosis and other disorders of iron homeostasis, and reveal a novel role for iron in the regulation of the inflammatory response...
  31. ncbi request reprint Development of microbial-human enterocyte interaction: cholera toxin
    Lei Lu
    Combined Program in Pediatric Gastroenterology and Nutrition, Harvard Medical School, Director, Developmental Gastroenterology Laboratory, Massachusetts General Hospital, 114 16th Street 114 3503, Charlestown, MA 02129 4404, U S A
    Pediatr Res 54:212-8. 2003
    ..Nonetheless, this approach to determining the role of development in the pathophysiology of cholera in infants may help in strategies to prevent and treat this condition and other age-related intestinal infectious diseases...
  32. ncbi request reprint The role of indigenous microflora in the development of murine intestinal fucosyl- and sialyltransferases
    N Nanda Nanthakumar
    Developmental Gastroenterology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02129, USA
    FASEB J 17:44-6. 2003
    ..These findings may help explain the regional specificity of commensal bacteria and of enteric pathogens and may also relate age-related changes in microflora to susceptibility to enteropathogens...
  33. ncbi request reprint Protective nutrients and functional foods for the gastrointestinal tract
    Christopher Duggan
    Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital Boston, Massachusetts General Hospital, and Division of Nutrition, Harvard Medical School, Boston, MA, USA
    Am J Clin Nutr 75:789-808. 2002
    ..Regulatory changes in the way in which health claims can be made for dietary supplements should also be encouraged...
  34. ncbi request reprint Regulation of intestinal ontogeny: effect of glucocorticoids and luminal microbes on galactosyltransferase and trehalase induction in mice
    N Nanda Nanthakumar
    Developmental Gastroenterology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Glycobiology 15:221-32. 2005
    ....
  35. ncbi request reprint Bacterial colonization, probiotics, and necrotizing enterocolitis
    Erika C Claud
    Department of Pediatrics, University of Chicago, Chicago, IL, USA
    J Clin Gastroenterol 42:S46-52. 2008
    ..Although concerns remain and further study is necessary, probiotics are a plausible means of optimizing intestinal colonization and influencing outcome of these vulnerable infants...
  36. ncbi request reprint Recommendations for probiotic use--2008
    Martin H Floch
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06520 8019, USA
    J Clin Gastroenterol 42:S104-8. 2008
    ..Many reports in the "C" recommendations were significant but fell short of receiving stronger ratings because of the size of reported patient studies, and also the factors that limited categories to the "B" rating...
  37. ncbi request reprint Probiotics and prebiotics: role in clinical disease states
    Chien Chang Chen
    Chang Gung University and Chang Gung Children s Hospital, Taoyuan, Taiwan
    Adv Pediatr 52:77-113. 2005
    ..With additional multicenter clinical trial confirmations, these substances may become routine in the care of infants and young children...
  38. ncbi request reprint The role of gut-associated lymphoid tissues and mucosal defence
    Maria Luisa Forchielli
    Department of Pediatrics, University of Bologna, Italy
    Br J Nutr 93:S41-8. 2005
    ..If this can be demonstrated, then prebiotics can be used as a dietary supplement to stimulate a balanced and an appropriately effective mucosal immune system in newborns and infants...
  39. ncbi request reprint Immunology
    Ian R Sanderson
    Curr Opin Gastroenterol 21:684-6. 2005
  40. ncbi request reprint Preinoculation with the probiotic Lactobacillus acidophilus early in life effectively inhibits murine Citrobacter rodentium colitis
    Chien Chang Chen
    Chang Gung Children s Hospital and Chang Gung University, Taoyuan, Taiwan
    Pediatr Res 58:1185-91. 2005
    ..This study may have ramifications for prevention of infectious diarrhea in human infants and children, particularly in developing countries...
  41. ncbi request reprint The development of pediatric gastroenterology: a historical overview
    John Walker-Smith
    The Wellcome Trust Centre for the History of Medicine, University of College London, England
    Pediatr Res 53:706-15. 2003
  42. ncbi request reprint Nutritional impact of pre- and probiotics as protective gastrointestinal organisms
    Jonathan E Teitelbaum
    MCP Hahnemann School of Medicine, Pediatric Gastroenterology and Nutrition, Monmouth Medical Center, Long Branch, New Jersey 07740, USA
    Annu Rev Nutr 22:107-38. 2002
    ..Specific attention is turned to their effects on immunomodulation, lipid metabolism, cancer prevention, diarrhea, Helicobacter pylori, necrotizing enterocolitis, allergy, and inflammatory bowel disease...
  43. ncbi request reprint Physiologic and pathologic interactions of bacteria with gastrointestinal epithelium
    Marko A Kalliomäki
    Department of Pediatrics, Turku University Hospital and University of Turku, Kiinamyllykatu 4 8, FIN 20521, Turku, Finland
    Gastroenterol Clin North Am 34:383-99, vii. 2005
  44. ncbi request reprint Presentation of the 2003 NASPGHAN Distinguished Service Award to Dr. Joseph Fitzgerald
    W Allan Walker
    J Pediatr Gastroenterol Nutr 38:119-20. 2004
  45. ncbi request reprint Region-specific ontogeny of alpha-2,6-sialyltransferase during normal and cortisone-induced maturation in mouse intestine
    Dingwei Dai
    Shanghai Institute for Pediatric Research, Xinhua Hospital and Shanghai Second Medical University, Shanghai, People s Republic of China 200092
    Am J Physiol Gastrointest Liver Physiol 282:G480-90. 2002
    ..globlet cells. These age-dependent and region-specific differences in sialyl alpha-2,6 glycoconjugates may be mediated in part by altered alpha-2,6-ST gene expression regulated by trophic factors such as glucocorticoids...
  46. ncbi request reprint Public access to NIH biomedical research
    W Allan Walker
    J Pediatr Gastroenterol Nutr 40:115. 2005
  47. ncbi request reprint Nutritional factors contributing to the development of cholestasis during total parenteral nutrition
    Maria Luisa Forchielli
    Department of Pediatrics, University of Bologna, Bologna, Italy
    Adv Pediatr 50:245-67. 2003
    ..It is hoped that a better understanding of factors affecting hepatocyte secretion and bile formation and flow will help to prevent this life-threatening complication of TPN...
  48. doi request reprint Advances in clinical use of probiotics
    Martin H Floch
    Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Gastroenterol 42:S45. 2008
  49. pmc Concurrent infection with an intestinal helminth parasite impairs host resistance to enteric Citrobacter rodentium and enhances Citrobacter-induced colitis in mice
    Chien Chang Chen
    Chang Gung University and Chang Gung Children s Hospital, Taoyuan, Taiwan
    Infect Immun 73:5468-81. 2005
    ..We conclude that H. polygyrus coinfection can promote C. rodentium-associated disease and colitis through a STAT 6-mediated immune mechanism...
  50. ncbi request reprint Lipopolysaccharide-induced human enterocyte tolerance to cytokine-mediated interleukin-8 production may occur independently of TLR-4/MD-2 signaling
    Tor C Savidge
    Developmental Gastroenterology Laboratory, MA General Hospital and Harvard Medical School, Charlestown 02129, USA
    Pediatr Res 59:89-95. 2006
    ....
  51. ncbi request reprint The effect of protective nutrients on mucosal defense in the immature intestine
    Maria L Forchielli
    Department of Pediatrics, University of Bologna, Bologna, Italy
    Acta Paediatr Suppl 94:74-83. 2005
    ..This paper emphasizes how some nutrients may beneficially affect the gastrointestinal immune system's maturation in both term and especially premature neonates...
  52. ncbi request reprint The role of TIM-4 in food allergy
    Hai Ning Shi
    Gastroenterology 133:1723-6. 2007
  53. ncbi request reprint Recommendations for probiotic use
    Martin H Floch
    Yale University School of Medicine, New Haven, CT 06520 8019, USA
    J Clin Gastroenterol 40:275-8. 2006
    ..Clearly, larger and better-designed studies of probiotics are necessary, including comparative and dose-ranging trials...
  54. pmc TLRs in the Gut I. The role of TLRs/Nods in intestinal development and homeostasis
    Ian R Sanderson
    Centre for Gastroenterology, Institute of Cell and Molecular Science, Barts and The London, Turner St, London E1 2AD, UK
    Am J Physiol Gastrointest Liver Physiol 292:G6-10. 2007
    ..The class II transactivator regulates major histocompatibility complex class II expression. In the intestine, it is developmentally regulated, and its expression depends on weaning and, independently, on age...
  55. ncbi request reprint New therapies and preventive approaches for necrotizing enterocolitis: report of a research planning workshop
    Gilman D Grave
    Endocrinology, Nutrition and Growth Branch, National Institute of Child Health and Development National Institutes of Health, Bethesda, Maryland 20892, USA
    Pediatr Res 62:510-4. 2007
    ....
  56. ncbi request reprint Immunology
    W Allan Walker
    Curr Opin Gastroenterol 22:641-3. 2006
  57. ncbi request reprint Immunology
    W Allan Walker
    Curr Opin Gastroenterol 23:644-6. 2007

Research Grants25

  1. ONTOGENY OF THE INTESTINAL MUCOSAL BARRIER AND NEC
    W Walker; Fiscal Year: 2007
    ..Based on these studies, we should be able to consider future clinical trials using protective nutrients to prevent this devastating disease. ..
  2. ONTOGENY OF THE INTESTINAL MUCOSAL BARRIER AND NEC
    W Walker; Fiscal Year: 2006
    ..Based on these studies, we should be able to consider future clinical trials using protective nutrients to prevent this devastating disease. ..
  3. BUTYRATE REGULATION OF IMMUNE FUNCTIONS OF ENTEROCYTES
    W Walker; Fiscal Year: 2001
    ..The luminal milieu is a major factor in the development of necrotizing enterocolitis. A study of how luminal molecules regulate intestinal immune function will help our understanding of the pathogenesis of this condition. ..
  4. BUTYRATE REGULATION OF IMMUNE FUNCTIONS OF ENTEROCYTES
    W Walker; Fiscal Year: 2000
    ..The luminal milieu is a major factor in the development of necrotizing enterocolitis. A study of how luminal molecules regulate intestinal immune function will help our understanding of the pathogenesis of this condition. ..
  5. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Walker; Fiscal Year: 1993
    ....
  6. ONTOGENY OF THE INTESTINAL MUCOSAL BARRIER AND NEC
    W Walker; Fiscal Year: 2009
    ..Based on these studies, we should be able to consider future clinical trials using protective nutrients to prevent this devastating disease. ..
  7. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Allan Walker; Fiscal Year: 2010
    ..We will determine how breastfeeding prevents age-related neonatal inflammatory diseases ..
  8. ONTOGENY OF THE INTESTINAL MUCOSAL BARRIER AND NEC
    W Walker; Fiscal Year: 2002
    ..The final aim is designed to use human in vitro intestinal models to study mechanisms for strategies to prevent pathologic bacterial colonization. ..
  9. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Walker; Fiscal Year: 2009
    ..We will determine how breastfeeding prevents age-related neonatal inflammatory diseases ..
  10. ONTOGENY OF THE INTESTINAL MUCOSAL BARRIER AND NEC
    W Walker; Fiscal Year: 2003
    ..The final aim is designed to use human in vitro intestinal models to study mechanisms for strategies to prevent pathologic bacterial colonization. ..
  11. ONTOGENY OF THE INTESTINAL MUCOSAL BARRIER AND NEC
    W Walker; Fiscal Year: 2001
    ..The final aim is designed to use human in vitro intestinal models to study mechanisms for strategies to prevent pathologic bacterial colonization. ..
  12. ONTOGENY OF THE INTESTINAL MUCOSAL BARRIER AND NEC
    W Walker; Fiscal Year: 2000
    ..The final aim is designed to use human in vitro intestinal models to study mechanisms for strategies to prevent pathologic bacterial colonization. ..
  13. BUTYRATE REGULATION OF IMMUNE FUNCTIONS OF ENTEROCYTES
    W Walker; Fiscal Year: 1999
    ..The luminal milieu is a major factor in the development of necrotizing enterocolitis. A study of how luminal molecules regulate intestinal immune function will help our understanding of the pathogenesis of this condition. ..
  14. ONTOGENY OF THE INTESTINAL MUCOSAL BARRIER AND NEC
    W Walker; Fiscal Year: 1999
    ..The final aim is designed to use human in vitro intestinal models to study mechanisms for strategies to prevent pathologic bacterial colonization. ..
  15. EFFECT OF COLOSTRUM ON GUT MATURATION AND HOST DEFENSE
    W Allan Walker; Fiscal Year: 2010
    ..We will determine how breastfeeding prevents age-related neonatal inflammatory diseases ..