Sushrut S Waikar

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Biomarkers for the diagnosis of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Nephron Clin Pract 109:c192-7. 2008
  2. pmc Mortality after hospitalization with mild, moderate, and severe hyponatremia
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 122:857-65. 2009
  3. pmc Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Kidney Int 78:486-94. 2010
  4. pmc Mortality associated with low serum sodium concentration in maintenance hemodialysis
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 124:77-84. 2011
  5. ncbi request reprint Biomarkers for the diagnosis of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Nephrol Hypertens 16:557-64. 2007
  6. pmc Race and mortality after acute renal failure
    Sushrut S Waikar
    Department of Medicine, Brigham and Women s Hospital, MRB 4, 75 Francis Street, Boston, MA 02115, USA
    J Am Soc Nephrol 18:2740-8. 2007
  7. pmc Imperfect gold standards for kidney injury biomarker evaluation
    Sushrut S Waikar
    Brigham and Women s Hospital, Renal Division, 75 Francis Street, MRB 4, Boston, MA 02115, USA
    J Am Soc Nephrol 23:13-21. 2012
  8. pmc The incidence and prognostic significance of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Nephrol Hypertens 16:227-36. 2007
  9. ncbi request reprint Validity of International Classification of Diseases, Ninth Revision, Clinical Modification Codes for Acute Renal Failure
    Sushrut S Waikar
    Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1688-94. 2006
  10. ncbi request reprint Declining mortality in patients with acute renal failure, 1988 to 2002
    Sushrut S Waikar
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1143-50. 2006

Research Grants

Detail Information

Publications44

  1. pmc Biomarkers for the diagnosis of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Nephron Clin Pract 109:c192-7. 2008
    ..Once adopted, more sensitive biomarkers of acute kidney injury hold the potential to transform the care of patients with renal disease...
  2. pmc Mortality after hospitalization with mild, moderate, and severe hyponatremia
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 122:857-65. 2009
    ..Hyponatremia is the most common electrolyte abnormality in hospitalized individuals...
  3. pmc Normalization of urinary biomarkers to creatinine during changes in glomerular filtration rate
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Kidney Int 78:486-94. 2010
    ..This ideal must be balanced, however, against practical considerations...
  4. pmc Mortality associated with low serum sodium concentration in maintenance hemodialysis
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Am J Med 124:77-84. 2011
    ....
  5. ncbi request reprint Biomarkers for the diagnosis of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Nephrol Hypertens 16:557-64. 2007
    ..This review summarizes clinical studies of newer biomarkers that may permit earlier and more accurate identification of acute kidney injury...
  6. pmc Race and mortality after acute renal failure
    Sushrut S Waikar
    Department of Medicine, Brigham and Women s Hospital, MRB 4, 75 Francis Street, Boston, MA 02115, USA
    J Am Soc Nephrol 18:2740-8. 2007
    ..In conclusion, in-hospital mortality is lower for black patients with acute renal failure than white patients. Future studies should assess the reasons for this difference...
  7. pmc Imperfect gold standards for kidney injury biomarker evaluation
    Sushrut S Waikar
    Brigham and Women s Hospital, Renal Division, 75 Francis Street, MRB 4, Boston, MA 02115, USA
    J Am Soc Nephrol 23:13-21. 2012
    ..The results of this study suggest that small changes in serum creatinine alone should not be used to define acute kidney injury in biomarker or interventional studies...
  8. pmc The incidence and prognostic significance of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Curr Opin Nephrol Hypertens 16:227-36. 2007
    ..This review summarizes the major epidemiologic studies that have informed our understanding of the incidence and prognostic significance of acute kidney injury...
  9. ncbi request reprint Validity of International Classification of Diseases, Ninth Revision, Clinical Modification Codes for Acute Renal Failure
    Sushrut S Waikar
    Renal Division and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1688-94. 2006
    ..The excellent performance characteristics of ICD-9-CM codes for ARF-D suggest that administrative data sets may be particularly well suited for research endeavors that involve patients with ARF-D...
  10. ncbi request reprint Declining mortality in patients with acute renal failure, 1988 to 2002
    Sushrut S Waikar
    Channing Laboratory, Brigham and Women s Hospital, 181 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:1143-50. 2006
    ..4% in 1988 to 26.6% in 2002 (P < 0.001). This study provides evidence from an administrative database that the incidence of ARF and ARF-D is rising. Despite an increase in the degree of comorbidity, in-hospital mortality has declined...
  11. pmc Creatinine kinetics and the definition of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 20:672-9. 2009
    ..We propose an alternative definition of AKI that incorporates absolute changes in SCr over a 24- to 48-h time period...
  12. pmc Fibrinogen excretion in the urine and immunoreactivity in the kidney serves as a translational biomarker for acute kidney injury
    Dana Hoffmann
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Pathol 181:818-28. 2012
    ..These results suggest that immunoreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early diagnostic translational biomarker for detection of AKI...
  13. pmc Imperfect gold standards for biomarker evaluation
    Sushrut S Waikar
    aRenal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Clin Trials 10:696-700. 2013
    ..Novel tubular injury biomarkers may revolutionize the diagnosis of AKI; however, even if a novel tubular injury biomarker is 100% sensitive and 100% specific, it may appear inaccurate when using serum creatinine as the gold standard...
  14. pmc Increased dietary sodium is independently associated with greater mortality among prevalent hemodialysis patients
    Finnian R Mc Causland
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Kidney Int 82:204-11. 2012
    ..Thus, higher reported dietary sodium intake is independently associated with greater mortality among prevalent hemodialysis patients. Randomized trials will be necessary to determine whether dietary sodium restriction improves survival...
  15. doi request reprint Diagnosis, epidemiology and outcomes of acute kidney injury
    Sushrut S Waikar
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Clin J Am Soc Nephrol 3:844-61. 2008
    ..This review summarizes the major epidemiologic studies of acute kidney injury and efforts to modernize the approach to its diagnosis...
  16. pmc Human miRNome profiling identifies microRNAs differentially present in the urine after kidney injury
    Krithika Ramachandran
    Renal Division, Department of Medicine, and
    Clin Chem 59:1742-52. 2013
    ....
  17. pmc Expression, circulation, and excretion profile of microRNA-21, -155, and -18a following acute kidney injury
    Janani Saikumar
    Department of Medicine, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Toxicol Sci 129:256-67. 2012
    ..Taken together, these results suggest that miRNA-21 and -155 could potentially serve as translational biomarkers for detection of AKI and may play a critical role in the pathogenesis of kidney injury and tissue repair process...
  18. pmc Dialysate sodium, serum sodium and mortality in maintenance hemodialysis
    Finnian R Mc Causland
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Nephrol Dial Transplant 27:1613-8. 2012
    ....
  19. ncbi request reprint Acute renal failure after endovascular vs open repair of abdominal aortic aneurysm
    Ron Wald
    Division of Nephrology, Department of Medicine, Tufts New England Medical Center, Boston, Massachusetts 02111, USA
    J Vasc Surg 43:460-466; discussion 466. 2006
    ..The effect of EVAR on postprocedure acute renal failure has not been determined. We hypothesized that EVAR would be associated with a lower risk of acute renal failure and acute renal failure requiring hemodialysis...
  20. pmc Association of smoking with cardiovascular and infection-related morbidity and mortality in chronic hemodialysis
    Finnian R Mc Causland
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02116, USA
    Clin J Am Soc Nephrol 7:1827-35. 2012
    ..This study investigated the association of baseline smoking status with all-cause, cardiovascular, and infection-related morbidity and mortality in patients undergoing long-term hemodialysis...
  21. pmc Use of postoperative creatinine to predict sustained kidney injury in patients undergoing mesothelioma surgery
    K Annette Mizuguchi
    Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 7:1071-8. 2012
    ..The goal was to determine the best acute sCr measure predictive of sustained kidney injury defined as a 50% increase in sCr from baseline measured 2-4 weeks after surgery...
  22. pmc Variation in initial kidney replacement therapy for end-stage renal disease due to lupus nephritis in the United States
    Amy Devlin
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
    Arthritis Care Res (Hoboken) 63:1642-53. 2011
    ..We aimed to identify sociodemographic and clinical factors associated with variation in initial kidney replacement therapies among LN ESRD patients...
  23. doi request reprint Established and emerging markers of kidney function
    Michael A Ferguson
    Division of Nephrology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Clin Chem 58:680-9. 2012
    ..Several novel biomarkers of kidney injury and function are under investigation...
  24. pmc Preservation of blood pressure stability with hypertonic mannitol during hemodialysis initiation
    Finnian R Mc Causland
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02446, USA
    Am J Nephrol 36:168-74. 2012
    ..Prior studies and practice have suggested that administration of osmotically active drugs may ameliorate blood pressure decline during chronic hemodialysis...
  25. doi request reprint A risk prediction score for kidney failure or mortality in rhabdomyolysis
    Gearoid M McMahon
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts2Framingham Heart Study, National Heart, Lung, and Blood Institute, and Center for Population Studies, Framingham, Massachusetts
    JAMA Intern Med 173:1821-8. 2013
    ..Rhabdomyolysis ranges in severity from asymptomatic elevations in creatine phosphokinase levels to a life-threatening disorder characterized by severe acute kidney injury requiring hemodialysis or continuous renal replacement therapy (RRT)...
  26. pmc Relationship between the prognostic expectations of seriously ill patients undergoing hemodialysis and their nephrologists
    Melissa W Wachterman
    Division of General Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    JAMA Intern Med 173:1206-14. 2013
    ..Perceptions of prognosis and transplant candidacy may influence goals of care...
  27. pmc The relevance of dietary sodium in hemodialysis
    Finnian R Mc Causland
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA, USA
    Nephrol Dial Transplant 28:797-802. 2013
    ..Herein we examine the available evidence with respect to the effects of dietary sodium restriction on clinically relevant endpoints among hemodialysis patients...
  28. pmc Preoperative statin use and postoperative acute kidney injury
    Steven M Brunelli
    Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02120, USA
    Am J Med 125:1195-1204.e3. 2012
    ..The purpose of this study was to evaluate whether preoperative statin use is associated with a decreased risk of postoperative acute kidney injury...
  29. pmc Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury
    Aparna Krishnamoorthy
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 118:1934-42. 2011
    ..Given that kidney regeneration is a major determinant of outcome for patients with kidney damage, these results provide new opportunities for the use of Fg in diagnosis, prevention, and therapeutic interventions in kidney disease...
  30. pmc Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury
    Michael A Ferguson
    Division of Nephrology, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 77:708-14. 2010
    ..Our study shows that age-adjusted urinary L-FABP levels were significantly higher in patients with poor outcome, defined as the requirement for renal replacement therapy or the composite end point of death or renal replacement therapy...
  31. doi request reprint Nonselective and cyclooxygenase-2-selective NSAIDs and acute kidney injury
    Wolfgang C Winkelmayer
    The Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02120, USA
    Am J Med 121:1092-8. 2008
    ..We undertook a large pharmacoepidemiologic analysis of the risk of acute kidney injury among older adults using nonselective NSAIDs or cyclooxygenase (COX)-2 inhibitors...
  32. pmc A rapid urine test for early detection of kidney injury
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 76:108-14. 2009
    ....
  33. pmc Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Transl Sci 1:200-8. 2008
    ..Our results demonstrate the comparative value of multiple biomarkers in the diagnosis and prognosis of AKI...
  34. pmc Incidence, outcomes, and comparisons across definitions of AKI in hospitalized individuals
    Xiaoxi Zeng
    Renal Division and, General Internal Medicine Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, Department of Nephrology, West China Hospital of Sichuan University, Sichuan, People s Republic of China, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts
    Clin J Am Soc Nephrol 9:12-20. 2014
    ..This study sought to characterize the epidemiology of AKI according to the most recent consensus definition proposed by the Kidney Disease Improving Global Outcomes (KDIGO) Work Group, and to compare it with three other definitions...
  35. ncbi request reprint Serum blood urea nitrogen as an independent marker of subsequent mortality among patients with acute coronary syndromes and normal to mildly reduced glomerular filtration rates
    Ajay J Kirtane
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts
    J Am Coll Cardiol 45:1781-6. 2005
    ..We hypothesized that elevated blood urea nitrogen (BUN) would be associated with adverse outcomes independent of serum creatinine (sCr)-based estimates of kidney function in patients with acute coronary syndromes (ACS)...
  36. pmc Outcome of critically ill patients with acute kidney injury using the Acute Kidney Injury Network criteria
    Tal Mandelbaum
    Department of Anesthesia, Critical Care and Pain Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Crit Care Med 39:2659-64. 2011
    ..Accurate urine output measurements as well as serum creatinine values from our database were used to detect patients with acute kidney injury and calculate their corresponding mortality risk and length of stay...
  37. pmc Plasma FGF23 levels increase rapidly after acute kidney injury
    Marta Christov
    1 Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA 2 Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Kidney Int 84:776-85. 2013
    ..Thus, circulating FGF23 levels rise rapidly during AKI in rodents and humans. In mice, this increase is independent of established modulators of FGF23 secretion. ..
  38. pmc Dialysis dose and intradialytic hypotension: results from the HEMO study
    Finnian R Mc Causland
    Renal Division, Brigham and Women s Hospital, Boston, Mass, USA
    Am J Nephrol 38:388-96. 2013
    ..A higher dialysis 'dose' may generate transient intradialytic osmotic gradients, predisposing to intracellular fluid shifts and resulting in hypotension...
  39. ncbi request reprint Association of serum sodium with morbidity and mortality in hospitalized patients undergoing major orthopedic surgery
    Finnian R Mc Causland
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts
    J Hosp Med 9:297-302. 2014
    ..Dysnatremia may predispose to falls and fractures, and serum sodium may influence bone health. Little is known of the association of perioperative dysnatremia and clinical outcomes in those undergoing major orthopedic surgery...
  40. ncbi request reprint Optimal dialysate sodium-what is the evidence?
    Finnian R Mc Causland
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts Harvard Medical School, Boston, Massachusetts
    Semin Dial 27:128-34. 2014
    ....
  41. doi request reprint Design of clinical trials in AKI: a report from an NIDDK workshop. Trials of patients with sepsis and in selected hospital settings
    Bruce A Molitoris
    Department of Medicine, Indiana University, Indianapolis, IN, USA
    Clin J Am Soc Nephrol 7:856-60. 2012
    ..The groups considered trial design issues and discussed advantages and disadvantages of several short- and long-term primary endpoints in these patients...
  42. pmc Evaluation of fluoroquinolones for the prevention of BK viremia after renal transplantation
    Steven Gabardi
    Department of Transplant Surgery, Center for for Clinical Investigation, Brigham and Women s Hospital, and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Clin J Am Soc Nephrol 5:1298-304. 2010
    ..Case reports have evaluated treatment options for BK virus, but no controlled studies have assessed prophylactic therapies. Fluoroquinolone antibiotics were studied for prevention of BK viremia after renal transplantation...
  43. doi request reprint Toward the promise of renal replacement therapy
    Glenn M Chertow
    J Am Soc Nephrol 19:839-40. 2008
  44. ncbi request reprint Can we rely on blood urea nitrogen as a biomarker to determine when to initiate dialysis?
    Sushrut S Waikar
    Clin J Am Soc Nephrol 1:903-4. 2006

Research Grants2

  1. Determinants of the Incidence and Outcome of Acute Renal Failure
    SUSHRUT WAIKAR; Fiscal Year: 2007
    ..At the completion of this career development award, Dr. Waikar will have a unique combination of skills and experience that will enable him to succeed as an independent clinical investigator. ..