Gordana Vunjak-Novakovic

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering
    G Vunjak-Novakovic
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biotechnol Prog 14:193-202. 1998
  2. ncbi request reprint Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage
    G Vunjak-Novakovic
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Orthop Res 17:130-8. 1999
  3. ncbi request reprint Bioreactor cultivation of osteochondral grafts
    G Vunjak-Novakovic
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Orthod Craniofac Res 8:209-18. 2005
  4. ncbi request reprint Tissue engineering of ligaments
    G Vunjak-Novakovic
    Massachusetts Institute of Technology, Harvard MIT Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biomed Eng 6:131-56. 2004
  5. ncbi request reprint Microgravity studies of cells and tissues
    Gordana Vunjak-Novakovic
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ann N Y Acad Sci 974:504-17. 2002
  6. ncbi request reprint Bioreactor studies of native and tissue engineered cartilage
    G Vunjak-Novakovic
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biorheology 39:259-68. 2002
  7. pmc Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors
    Alexander Augst
    Harvard MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J R Soc Interface 5:929-39. 2008
  8. ncbi request reprint Engineering cartilage-like tissue using human mesenchymal stem cells and silk protein scaffolds
    Lorenz Meinel
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, E25 330, 45 Carleton Street, Cambridge, Massachusetts 02139, USA
    Biotechnol Bioeng 88:379-91. 2004
  9. ncbi request reprint Mechanical properties and remodeling of hybrid cardiac constructs made from heart cells, fibrin, and biodegradable, elastomeric knitted fabric
    Jan Boublik
    Division of Health Sciences and Technology, Center for Space Research, and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Tissue Eng 11:1122-32. 2005
  10. ncbi request reprint Medium perfusion enables engineering of compact and contractile cardiac tissue
    Milica Radisic
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Am J Physiol Heart Circ Physiol 286:H507-16. 2004

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering
    G Vunjak-Novakovic
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biotechnol Prog 14:193-202. 1998
    ..The kinetics and possible mechanisms of cell seeding were related to the formation of cell aggregates by a simple mathematical model that can be used to optimize seeding conditions for cartilage tissue engineering...
  2. ncbi request reprint Bioreactor cultivation conditions modulate the composition and mechanical properties of tissue-engineered cartilage
    G Vunjak-Novakovic
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge 02139, USA
    J Orthop Res 17:130-8. 1999
    ..These findings suggest that the hydrodynamic conditions in tissue-culture bioreactors can modulate the composition, morphology, mechanical properties, and electromechanical function of engineered cartilage...
  3. ncbi request reprint Bioreactor cultivation of osteochondral grafts
    G Vunjak-Novakovic
    Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Orthod Craniofac Res 8:209-18. 2005
    ..Taken together, these studies provide a basis for the ongoing work on engineering osreochondral grafts for a variety of potential applications, including those in the craniofacial complex...
  4. ncbi request reprint Tissue engineering of ligaments
    G Vunjak-Novakovic
    Massachusetts Institute of Technology, Harvard MIT Division of Health Sciences and Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biomed Eng 6:131-56. 2004
    ..One representative tissue engineering system involving the integrated use of adult human stem cells, custom-designed scaffolds, and advanced bioreactors with dynamic loading is described...
  5. ncbi request reprint Microgravity studies of cells and tissues
    Gordana Vunjak-Novakovic
    Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Ann N Y Acad Sci 974:504-17. 2002
    ....
  6. ncbi request reprint Bioreactor studies of native and tissue engineered cartilage
    G Vunjak-Novakovic
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biorheology 39:259-68. 2002
    ....
  7. pmc Effects of chondrogenic and osteogenic regulatory factors on composite constructs grown using human mesenchymal stem cells, silk scaffolds and bioreactors
    Alexander Augst
    Harvard MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    J R Soc Interface 5:929-39. 2008
    ....
  8. ncbi request reprint Engineering cartilage-like tissue using human mesenchymal stem cells and silk protein scaffolds
    Lorenz Meinel
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, E25 330, 45 Carleton Street, Cambridge, Massachusetts 02139, USA
    Biotechnol Bioeng 88:379-91. 2004
    ..Taken together, these results suggest that silk scaffolds are particularly suitable for tissue engineering of cartilage starting from hMSC, presumably due to their high porosity, slow biodegradation, and structural integrity...
  9. ncbi request reprint Mechanical properties and remodeling of hybrid cardiac constructs made from heart cells, fibrin, and biodegradable, elastomeric knitted fabric
    Jan Boublik
    Division of Health Sciences and Technology, Center for Space Research, and Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Tissue Eng 11:1122-32. 2005
    ..Together, the data showed that hybrid cardiac constructs initially exhibited supraphysiologic UTS, epsilon(f), and E, and remodeled in response to serum and stretch in vitro and in an ectopic in vivo model...
  10. ncbi request reprint Medium perfusion enables engineering of compact and contractile cardiac tissue
    Milica Radisic
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Am J Physiol Heart Circ Physiol 286:H507-16. 2004
    ....
  11. ncbi request reprint Bone and cartilage tissue constructs grown using human bone marrow stromal cells, silk scaffolds and rotating bioreactors
    Darja Marolt
    Harvard MIT Division of Health Sciences and Technology, Cambridge, MA, USA
    Biomaterials 27:6138-49. 2006
    ..Engineered bone constructs were large (8mm diameter x 2mm thick disks) and resembled trabecular bone with respect to structure and mineralized tissue volume fraction (12%)...
  12. ncbi request reprint Engineering bone-like tissue in vitro using human bone marrow stem cells and silk scaffolds
    Lorenz Meinel
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, E25 330, 45 Carleton Street, Cambridge, Massachusetts 02139, USA
    J Biomed Mater Res A 71:25-34. 2004
    ....
  13. ncbi request reprint Practical aspects of cardiac tissue engineering with electrical stimulation
    Christopher Cannizzaro
    Harvard MIT Division for Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, USA
    Methods Mol Med 140:291-307. 2007
    ....
  14. ncbi request reprint Microfluidic patterning for fabrication of contractile cardiac organoids
    Ali Khademhosseini
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomed Microdevices 9:149-57. 2007
    ..After 3 days in culture, the linearly aligned myocytes detached from the surface and formed contractile cardiac organoids. The procedure can be utilized to simply, rapidly and inexpensively create in vitro cardiac tissue models...
  15. pmc Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells
    Lino S Ferreira
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 28:2706-17. 2007
    ..Functionalized dextran-based hydrogels could thus enable derivation of vascular cells in large quantities, particularly endothelial cells, for potential application in tissue engineering and regenerative medicine...
  16. ncbi request reprint Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow
    Lorenz Meinel
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Ann Biomed Eng 32:112-22. 2004
    ..These results suggest that osteogenesis in cultured MSC can be modulated by scaffold properties and flow environment...
  17. pmc Pre-treatment of synthetic elastomeric scaffolds by cardiac fibroblasts improves engineered heart tissue
    Milica Radisic
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    J Biomed Mater Res A 86:713-24. 2008
    ..When implanted over the infarcted myocardium in a nude rat model, cell-free poly(glycerol sebacate) remained at the ventricular wall after 2 weeks of in vivo, and was vascularized...
  18. ncbi request reprint Perfusion improves tissue architecture of engineered cardiac muscle
    Rebecca L Carrier
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge 02139, USA
    Tissue Eng 8:175-88. 2002
    ..Medium perfusion could thus be utilized to better mimic the transport conditions within native cardiac muscle and enable in vitro engineering of cardiac constructs with clinically useful thicknesses...
  19. ncbi request reprint A novel composite scaffold for cardiac tissue engineering
    Hyoungshin Park
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    In Vitro Cell Dev Biol Anim 41:188-96. 2005
    ..Construct cellularity, presence of cardiac markers, and contractile properties were markedly improved in composite scaffolds as compared with both controls...
  20. ncbi request reprint Bioreactors mediate the effectiveness of tissue engineering scaffolds
    Ming Pei
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    FASEB J 16:1691-4. 2002
    ..The data imply that interactions between bioreactors and 3D tissue engineering scaffolds can be utilized to improve the structure, function, and molecular properties of in vitro-generated cartilage...
  21. ncbi request reprint A photolithographic method to create cellular micropatterns
    Jeffrey M Karp
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Biomaterials 27:4755-64. 2006
    ..Osteoblasts (SAOS-2) localized in the exposed glass regions (squares, triangles, or circles; 0.063-0.5mm(2)). They proliferated to confluence in 5 days, expressed alkaline phosphatase and produced a mineralized matrix...
  22. ncbi request reprint Vascular progenitor cells isolated from human embryonic stem cells give rise to endothelial and smooth muscle like cells and form vascular networks in vivo
    Lino S Ferreira
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Circ Res 101:286-94. 2007
    ....
  23. ncbi request reprint The inflammatory responses to silk films in vitro and in vivo
    Lorenz Meinel
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, E25 330, 45 Carleton Street, Cambridge, MA 02139, USA
    Biomaterials 26:147-55. 2005
    ..These data suggest that (a) purified degradable silk is biocompatible and (b) the in vitro cell culture model (hMSC seeded and cultured on biomaterial films) gave inflammatory responses that were comparable to those observed in vivo...
  24. ncbi request reprint High-density seeding of myocyte cells for cardiac tissue engineering
    Milica Radisic
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biotechnol Bioeng 82:403-14. 2003
    ..Direct perfusion can thus enable seeding of hypoxia-sensitive cells at physiologically high and spatially uniform initial densities and maintain cell viability and function...
  25. ncbi request reprint Development and remodeling of engineered cartilage-explant composites in vitro and in vivo
    Enrico Tognana
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Osteoarthritis Cartilage 13:896-905. 2005
    ..Development and remodeling of engineered cartilage-explant composites were studied in vitro and in vivo...
  26. pmc Functional assembly of engineered myocardium by electrical stimulation of cardiac myocytes cultured on scaffolds
    Milica Radisic
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, E25 342, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 101:18129-34. 2004
    ..Development of conductive and contractile properties of cardiac constructs was concurrent, with strong dependence on the initiation and duration of electrical stimulation...
  27. ncbi request reprint The fundamentals of tissue engineering: scaffolds and bioreactors
    Gordana Vunjak-Novakovic
    Massachusetts Institute of Technology, Harvard MIT Division of Health Sciences and Technology, Cambridge MA 02139, USA
    Novartis Found Symp 249:34-46; discussion 46-51, 170-4, 239-41. 2003
    ..Here we explore the paradigm of tissue-engineered cartilage repair that is based on the generation of immature but functional constructs in vitro, and the remodelling and maturation of these constructs in vivo...
  28. ncbi request reprint Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue
    Milica Radisic
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Biotechnol Bioeng 93:332-43. 2006
    ..Medium flow significantly increased oxygen concentration within the construct, correlating with the improved tissue properties observed for constructs cultured in convectively mixed bioreactors...
  29. ncbi request reprint Cell seeding of polymer scaffolds
    Gordana Vunjak-Novakovic
    Harvard MIT Division of Health Science and Technology, MIT, Cambridge, MA, USA
    Methods Mol Biol 238:131-46. 2004
  30. ncbi request reprint Advanced tools for tissue engineering: scaffolds, bioreactors, and signaling
    Lisa E Freed
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Tissue Eng 12:3285-305. 2006
    ....
  31. pmc Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells
    Sharon Gerecht
    Harvard Massachusetts Institute of Technology, Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:11298-303. 2007
    ..We therefore propose that HA hydrogels, with their developmentally relevant composition and tunable physical properties, provide a unique microenvironment for the self-renewal and differentiation of hESCs...
  32. pmc Effects of electrical stimulation in C2C12 muscle constructs
    Hyoungshin Park
    Health Science and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
    J Tissue Eng Regen Med 2:279-87. 2008
    ..Our data implicate that a specific electrical frequency may modulate type I collagen accumulation and a specific voltage may affect the differentiation of muscle sarcomeres in excitable cells...
  33. ncbi request reprint Cultivation in rotating bioreactors promotes maintenance of cardiac myocyte electrophysiology and molecular properties
    Nenad Bursac
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Tissue Eng 9:1243-53. 2003
    ....
  34. ncbi request reprint Mathematical model of oxygen distribution in engineered cardiac tissue with parallel channel array perfused with culture medium containing oxygen carriers
    Milica Radisic
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Am J Physiol Heart Circ Physiol 288:H1278-89. 2005
    ..5 cm). In future work, the model can be utilized as a tool for optimization of scaffold geometry and flow conditions...
  35. ncbi request reprint Spaceflight bioreactor studies of cells and tissues
    Lisa E Freed
    Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, USA
    Adv Space Biol Med 8:177-95. 2002
    ..The increasing scientific and medical relevance of this work is evidenced by the growing number of publications in which advanced bioreactors are used for in vitro studies in physiologically relevant cell and tissue models...
  36. ncbi request reprint Nanofabrication and microfabrication of functional materials for tissue engineering
    Hyoungshin Park
    Division of Health Sciences and Technology, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Tissue Eng 13:1867-77. 2007
    ..It is our opinion that these novel materials and technologies will bring engineered tissues one step closer to practical application in the clinic. This review discusses their application to cardiac, liver, and nerve tissue engineering...
  37. ncbi request reprint Effects of oxygen on engineered cardiac muscle
    Rebecca L Carrier
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Biotechnol Bioeng 78:617-25. 2002
    ..Experiments of this kind can form a basis for controlled studies of the effects of oxygen on the in vitro development of engineered tissues...
  38. ncbi request reprint Differential effects of growth factors on tissue-engineered cartilage
    Torsten Blunk
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Tissue Eng 8:73-84. 2002
    ..Different regulatory factors thus elicit significantly different chondrogenic responses and can be used to selectively control the growth rate and improve the composition of engineered cartilage...
  39. pmc Engineering tissue with BioMEMS
    Jeffrey T Borenstein
    Biomedical Engineering Center, Draper Laboratory, Cambridge, Massachusetts, USA
    IEEE Pulse 2:28-34. 2011
    ....
  40. pmc Engineering custom-designed osteochondral tissue grafts
    Warren L Grayson
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Trends Biotechnol 26:181-9. 2008
    ....
  41. ncbi request reprint It takes a village to grow a tissue
    David L Kaplan
    Nat Biotechnol 23:1237-9. 2005
  42. ncbi request reprint Cell differentiation by mechanical stress
    Gregory H Altman
    Department of Chemical and Biological Engineering, Bioengineering Center, Tufts University, Medford, Massachusetts 02155, USA
    FASEB J 16:270-2. 2002
    ..At the same time, no up-regulation of bone or cartilage-specific cell markers was observed...
  43. ncbi request reprint Non-invasive time-lapsed monitoring and quantification of engineered bone-like tissue
    Henri Hagenm├╝ller
    Institute for Biomechanics, ETH Zurich, 8093, Zurich, Switzerland
    Ann Biomed Eng 35:1657-67. 2007
    ..Our data demonstrate the feasibility of qualitatively and quantitatively detailing the spatial and temporal mineralization of bone-like tissue formation in tissue engineering...
  44. ncbi request reprint Advanced bioreactor with controlled application of multi-dimensional strain for tissue engineering
    Gregory H Altman
    Tufts University, Department of Chemical and Biological Engineering, Bioengineering Center, 4 Colby Street, Medford, MA 02155, USA
    J Biomech Eng 124:742-9. 2002
    ..5%) over 14 days in culture. The system supported cell spreading and growth on the silk fiber matrices based on SEM characterization, as well as the differentiation of the cells into ligament-like cells and tissue (Altman et al., 2001)...
  45. pmc Engineering cartilage and bone using human mesenchymal stem cells
    Pen Hsiu Grace Chao
    Department of Biomedical Engineering, Columbia University, 363G Engineering Terrace, New York, NY 10027, USA
    J Orthop Sci 12:398-404. 2007
  46. pmc Silk fibroin microtubes for blood vessel engineering
    Michael Lovett
    Department of Biomedical Engineering, Tufts University, 4 Colby St, Medford, MA 02155, USA
    Biomaterials 28:5271-9. 2007
    ..When combined with the biocompatible and suturability features of silk fibroin, these results suggest that silk microtubes, either implanted directly or preseeded with cells, are an attractive biomaterial for microvascular grafts...
  47. pmc Cardiac tissue engineering using perfusion bioreactor systems
    Milica Radisic
    Department of Chemical Engineering and Applied Chemistry, Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada
    Nat Protoc 3:719-38. 2008
    ..This model is well suited for a wide range of cardiac tissue engineering applications, including the use of human stem cells, and high-fidelity models for biological research...
  48. ncbi request reprint Effect of scaffold design on bone morphology in vitro
    Lorenz Uebersax
    Institute for Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    Tissue Eng 12:3417-29. 2006
    ..The ability to direct bone morphology via scaffold design suggests new options in the use of biodegradable scaffolds to control in vitro engineered bone tissue outcomes...
  49. pmc Engineering complex tissues
    Antonios G Mikos
    Department of Bioengineering, Rice University, Houston, Texas, USA
    Tissue Eng 12:3307-39. 2006
    ..Anthony Atala offered a clinician's perspective for functional tissue regeneration, and discussed new biomaterials that can be used to develop new regenerative technologies...
  50. ncbi request reprint Micro-bioreactor array for controlling cellular microenvironments
    Elisa Figallo
    Department of Chemical Engineering, University of Padova, Italy
    Lab Chip 7:710-9. 2007
    ..To illustrate the utility of the MBA for controlled studies of hESCs, we established correlations between the expression of smooth muscle actin and cell density for three different flow configurations...
  51. ncbi request reprint Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: comparison of adenovirus mediated gene transfer and protein delivery of BMP-2
    Lorenz Meinel
    Department of Chemistry and Applied Biosciences, ETH Zuerich, Wolfgang Pauli Str 10, 8093 Zuerich, Switzerland
    Biomaterials 27:4993-5002. 2006
    ..These findings suggest additional options to control differentiation where exogenous additions of growth factors or morphogens can be replaced with transfected MSCs...
  52. ncbi request reprint Control of in vitro tissue-engineered bone-like structures using human mesenchymal stem cells and porous silk scaffolds
    Sandra Hofmann
    Institute of Pharmaceutical Sciences, HCI J 392, Wolfgang Pauli Strasse 10, ETH Zurich, 8093 Zurich, Switzerland
    Biomaterials 28:1152-62. 2007
    ..Micro-computed tomography (microCT) detailed the pore structures of the newly formed tissue and suggested that the structure of tissue-engineered bone was controlled by the underlying scaffold geometry...
  53. ncbi request reprint Influence of macroporous protein scaffolds on bone tissue engineering from bone marrow stem cells
    Hyeon Joo Kim
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, Medford, MA 02155, USA
    Biomaterials 26:4442-52. 2005
    ..These data illustrate the importance of materials processing on biological outcomes, as the same protein, silk fibroin, was used in both preparations...
  54. ncbi request reprint Porous silk fibroin 3-D scaffolds for delivery of bone morphogenetic protein-2 in vitro and in vivo
    Vassilis Karageorgiou
    Department of Biomedical Engineering Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, Massachusetts 02155, USA
    J Biomed Mater Res A 78:324-34. 2006
    ....
  55. ncbi request reprint Stem cell-based tissue engineering with silk biomaterials
    Yongzhong Wang
    Department of Chemical and Biological Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Biomaterials 27:6064-82. 2006
    ....
  56. ncbi request reprint Silk implants for the healing of critical size bone defects
    Lorenz Meinel
    Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    Bone 37:688-98. 2005
    ..These results demonstrate the feasibility of silk-based implants with engineered bone for the (re-)generation of bone tissues and expand the class of protein-based bone-implant materials with a mechanically stable and durable option...
  57. ncbi request reprint Cartilage-like tissue engineering using silk scaffolds and mesenchymal stem cells
    Sandra Hofmann
    Institute of Pharmaceutical Sciences, ETH Zurich, Zurich, Switzerland
    Tissue Eng 12:2729-38. 2006
    ....
  58. ncbi request reprint Space Station Biological Research Project (SSBRP) Cell Culture Unit (CCU) and incubator for International Space Station (ISS) cell culture experiments
    Donald Vandendriesche
    NASA Ames Research Center, Moffett Field, CA 94035, USA
    J Gravit Physiol 11:93-103. 2004
    ....
  59. ncbi request reprint Gene transfer of a human insulin-like growth factor I cDNA enhances tissue engineering of cartilage
    Henning Madry
    Department of Orthopedic Surgery, Harvard Medical School, Massachusetts General Hospital, Boston 02114, USA
    Hum Gene Ther 13:1621-30. 2002
    ....
  60. pmc Engineering of functional cartilage tissue using stem cells from synovial lining: a preliminary study
    Ming Pei
    Tissue Engineering Laboratory, Department of Orthopaedics, West Virginia University, 3943 Health Sciences Center South, PO Box 9196, Morgantown, WV 26506 9196, USA
    Clin Orthop Relat Res 466:1880-9. 2008
    ..We thus propose functional cartilage constructs could be engineered in vitro through the use of negatively isolated SDSCs...
  61. doi request reprint Tissue engineering by self-assembly of cells printed into topologically defined structures
    Karoly Jakab
    Department of Physics, University of Missouri, Columbia, Missouri 65211, USA
    Tissue Eng Part A 14:413-21. 2008
    ..The postprinting self-assembly of bio-ink particles resulted in synchronously beating solid tissue blocks, showing signs of early vascularization, with the endothelial cells organized into vessel-like conduits...
  62. ncbi request reprint Characterization of electrical stimulation electrodes for cardiac tissue engineering
    Nina Tandon
    Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, 353 Engineering Terrace, New York, NY 10027, USA
    Conf Proc IEEE Eng Med Biol Soc 1:845-8. 2006
    ....
  63. ncbi request reprint Growth factor induced fibroblast differentiation from human bone marrow stromal cells in vitro
    Jodie E Moreau
    Department of Biomedical Engineering, Bioengineering Center, Tufts University, 4 Colby Street, Medford, MA 02155, USA
    J Orthop Res 23:164-74. 2005
    ....
  64. ncbi request reprint Tissue-engineered composites for the repair of large osteochondral defects
    Dirk Schaefer
    University of Basel, Basel, Switzerland
    Arthritis Rheum 46:2524-34. 2002
    ....
  65. pmc The effect of actin disrupting agents on contact guidance of human embryonic stem cells
    Sharon Gerecht
    Harvard M I T Division of Health Sciences and Technology, USA
    Biomaterials 28:4068-77. 2007
    ..These findings further demonstrate the importance of interplay between cytoskeleton and substrate interactions as a key modulator of morphological and proliferative cellular response in hESCs on nanotopography...
  66. ncbi request reprint Osteogenic differentiation of human bone marrow stromal cells on partially demineralized bone scaffolds in vitro
    Joshua R Mauney
    Department of Chemical and Biological Engineering, Biotechnology Center, Tufts University, Medford, Massachusetts, USA
    Tissue Eng 10:81-92. 2004
    ..This osseous biomaterial may offer new potential benefits as a tool for clinical bone replacement...
  67. ncbi request reprint Synthetic oxygen carriers in cardiac tissue engineering
    Rohin K Iyer
    University of Toronto, IBBME, Department of Chemical Engineering and Applied Chemistry, Toronto, Ontario, Canada
    Artif Cells Blood Substit Immobil Biotechnol 35:135-48. 2007
    ..The presence of PFC enhanced the transport of oxygen, increased oxygen concentrations, and yielded constructs that displayed stronger cardiac-like phenotype...
  68. ncbi request reprint Tissue engineering: the next generation
    Gordana Vunjak-Novakovic
    Department of Biomedical Engineering, Columbia University, New York, NY 10027, USA
    Tissue Eng 12:3261-3. 2006
  69. ncbi request reprint Translation from research to applications
    Ernst Hunziker
    ITI Research Institute for Dental and Skeletal Biology, University of Bern, Bern, Switzerland
    Tissue Eng 12:3341-64. 2006
    ....