Joel Voldman

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint Deformability-based microfluidic cell pairing and fusion
    Burak Dura
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 824, Cambridge, MA 02139, USA
    Lab Chip 14:2783-90. 2014
  2. pmc Microfluidic control of cell pairing and fusion
    Alison M Skelley
    Research Laboratory of Electronics, 50 Vassar Street, Massachusetts Institute of Technology MIT, Cambridge, Massachusetts 02139, USA
    Nat Methods 6:147-52. 2009
  3. doi request reprint Rapid dielectrophoretic characterization of single cells using the dielectrophoretic spring
    Hao Wei Su
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 824, Cambridge, MA 02139, USA
    Lab Chip 13:4109-17. 2013
  4. ncbi request reprint A microfabrication-based dynamic array cytometer
    Joel Voldman
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139, USA
    Anal Chem 74:3984-90. 2002
  5. ncbi request reprint Engineered systems for the physical manipulation of single cells
    Joel Voldman
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Room 36 824, Cambridge, MA 02139, USA
    Curr Opin Biotechnol 17:532-7. 2006
  6. ncbi request reprint Electrical forces for microscale cell manipulation
    Joel Voldman
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biomed Eng 8:425-54. 2006
  7. ncbi request reprint Quantitative modeling of dielectrophoretic traps
    Adam Rosenthal
    Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Lab Chip 6:508-15. 2006
  8. pmc Electrically addressable vesicles: tools for dielectrophoresis metrology
    Salil P Desai
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Langmuir 25:3867-75. 2009
  9. ncbi request reprint nDEP microwells for single-cell patterning in physiological media
    Nikhil Mittal
    Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Chip 7:1146-53. 2007
  10. pmc Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae
    Michael D Vahey
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Chip 13:2754-63. 2013

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Deformability-based microfluidic cell pairing and fusion
    Burak Dura
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 824, Cambridge, MA 02139, USA
    Lab Chip 14:2783-90. 2014
    ..Our design principles and cell trapping technique can readily be applied for different cell types and can be extended to trap and fuse multiple (>2) cell partners as demonstrated by our preliminary experiments. ..
  2. pmc Microfluidic control of cell pairing and fusion
    Alison M Skelley
    Research Laboratory of Electronics, 50 Vassar Street, Massachusetts Institute of Technology MIT, Cambridge, Massachusetts 02139, USA
    Nat Methods 6:147-52. 2009
    ....
  3. doi request reprint Rapid dielectrophoretic characterization of single cells using the dielectrophoretic spring
    Hao Wei Su
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 824, Cambridge, MA 02139, USA
    Lab Chip 13:4109-17. 2013
    ..We present characterization of the method with beads and cells as well as its application to rapidly find conditions that can discriminate neutrophils with different activation states. ..
  4. ncbi request reprint A microfabrication-based dynamic array cytometer
    Joel Voldman
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139, USA
    Anal Chem 74:3984-90. 2002
    ..Such a device has potential for use in investigating functional processes, as revealed by temporal behavior, in large numbers of single cells...
  5. ncbi request reprint Engineered systems for the physical manipulation of single cells
    Joel Voldman
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Room 36 824, Cambridge, MA 02139, USA
    Curr Opin Biotechnol 17:532-7. 2006
    ..In the realm of cell separation for screening, there has been significant progress in miniaturized flow-based optical sorters as well as in sorting following static microscopic observation...
  6. ncbi request reprint Electrical forces for microscale cell manipulation
    Joel Voldman
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Biomed Eng 8:425-54. 2006
    ..We first examine the forces and electrodes used to create them, then address potential impacts on cell health, followed by examples of devices for both separating cells and handling them...
  7. ncbi request reprint Quantitative modeling of dielectrophoretic traps
    Adam Rosenthal
    Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Lab Chip 6:508-15. 2006
    ..The software is freely available to the scientific community at: ...
  8. pmc Electrically addressable vesicles: tools for dielectrophoresis metrology
    Salil P Desai
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Langmuir 25:3867-75. 2009
    ..This combined with the ability to encode information about the properties of the vesicle in its fluorescence signature forms the first steps toward the development of EAV populations as metrology tools for any DEP-based microsystem...
  9. ncbi request reprint nDEP microwells for single-cell patterning in physiological media
    Nikhil Mittal
    Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Chip 7:1146-53. 2007
    ..We calculate the temperatures and transmembrane potential that cells in the device experience and compare them to physiologically acceptable levels described in previous studies...
  10. pmc Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae
    Michael D Vahey
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Chip 13:2754-63. 2013
    ..The screening approach demonstrated here and the attendant results are immediately applicable to the intrinsic separations community...
  11. doi request reprint Spatially organized in vitro models instruct asymmetric stem cell differentiation
    Yi Chin Toh
    Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Integr Biol (Camb) 3:1179-87. 2011
    ....
  12. ncbi request reprint Optimizing micromixer design for enhancing dielectrophoretic microconcentrator performance
    Hsu Yi Lee
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 50 Vassar Street, Room 36 824, Cambridge, Massachusetts 02139, USA
    Anal Chem 79:1833-9. 2007
    ..Finally, we used these analyses to illustrate the design principles of mixers for DEP-based concentrators...
  13. doi request reprint Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separations
    Michael D Vahey
    Department of Electrical Engineering and Computer Science, 77 Massachusetts Avenue, Building 36 824, Cambridge, Massachusetts 02139, USA
    Lab Chip 11:2071-80. 2011
    ..Finally, we present a simple analytic model based on hydrodynamic coupling that captures important features of strongly interacting particle suspensions...
  14. ncbi request reprint A practical guide to microfluidic perfusion culture of adherent mammalian cells
    Lily Kim
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Rm 36 824, Cambridge, MA 02139, USA
    Lab Chip 7:681-94. 2007
    ....
  15. pmc Dielectrophoretic traps for single-particle patterning
    Adam Rosenthal
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Biophys J 88:2193-205. 2005
    ..We provide the foundations for an enabling technology that can be used to pattern cells in unique ways, allowing us to do novel cell biology experiments at the microscale...
  16. pmc Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3
    Laralynne M Przybyla
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Stem Cells 31:1097-106. 2013
    ..These results uncover a new role for feeder cells in maintaining self-renewal and show that mESCs normally produce sufficient levels of autocrine-acting pro-self-renewal ligands...
  17. ncbi request reprint Assembly of metal nanoparticles into nanogaps
    Robert J Barsotti
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Small 3:488-99. 2007
    ..Assembly of fewer than 10 isolated particles in a gap is demonstrated. Preliminary electrical characterization reveals that stable conductance of the assembled particles can be achieved...
  18. doi request reprint Advancing stem cell research with microtechnologies: opportunities and challenges
    Yi Chin Toh
    Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Integr Biol (Camb) 2:305-25. 2010
    ..By appropriately applying micro-scale engineering principles to stem cell research, we believe that significant breakthroughs can be made in stem cell research...
  19. pmc Cell patterning chip for controlling the stem cell microenvironment
    Adam Rosenthal
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Biomaterials 28:3208-16. 2007
    ..Thus, by allowing exquisite control of the cellular microenvironment, we provide a technology that enables new applications in tissue engineering and regenerative medicine...
  20. doi request reprint Plastic masters-rigid templates for soft lithography
    Salil P Desai
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
    Lab Chip 9:1631-7. 2009
    ..PMs provide an easy technique for the fabrication of microfluidic devices and a simple route for the scaling-up of fabrication of robust masters for soft lithography...
  21. pmc Nonmitogenic survival-enhancing autocrine factors including cyclophilin A contribute to density-dependent mouse embryonic stem cell growth
    Nikhil Mittal
    Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Stem Cell Res 6:168-76. 2011
    ..Additionally, inhibition of the cyclophilin A receptor CD147 decreases the growth rate of mESCs. These findings identify cyclophilin A as a novel survival-enhancing autocrine factor in mouse ESC cultures...
  22. ncbi request reprint Flexible split-ring electrode for insect flight biasing using multisite neural stimulation
    Wei Mong Tsang
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    IEEE Trans Biomed Eng 57:1757-64. 2010
    ..Finally, in loosely tethered flight, we have used stimulation through the flexible microelectrodes to alter the abdominal angle, thus causing the flying moth to deviate to the left or right of its intended path...
  23. pmc Microfluidic perfusion for regulating diffusible signaling in stem cells
    Katarina Blagović
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
    PLoS ONE 6:e22892. 2011
    ..A new approach explored in this work is to leverage transport phenomena at cellular resolution to downregulate overall diffusible signaling through the physical removal of cell-secreted ligands...
  24. ncbi request reprint A scalable addressable positive-dielectrophoretic cell-sorting array
    Brian M Taff
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 36 854, Cambridge, Massachusetts 02139, USA
    Anal Chem 77:7976-83. 2005
    ..We demonstrate capture, holding, and release operations with both beads and cells in small arrays of this new architecture...
  25. ncbi request reprint Microfluidic arrays for logarithmically perfused embryonic stem cell culture
    Lily Kim
    Massachusetts Institute of Technology, 77 Massachusetts Avenue, Rm 36 824, Cambridge, MA 02139, USA
    Lab Chip 6:394-406. 2006
    ..We have also demonstrated logarithmically scaled continuous perfusion culture of 3T3 fibroblasts for 3 days, with proliferation at all flow rates except the slowest rate...
  26. doi request reprint Isodielectric separation and analysis of cells
    Michael D Vahey
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
    Methods Mol Biol 853:53-63. 2012
    ....
  27. pmc Cell-based sensors for quantifying the physiological impact of microsystems
    Salil P Desai
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Integr Biol (Camb) 3:48-56. 2011
    ..Combined voltage and frequency sweeps enable the generation of complex maps of physiological state...
  28. pmc Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction
    Yi Chin Toh
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    FASEB J 25:1208-17. 2011
    ..This study demonstrates that self-renewing mESCs possess the molecular machinery to sense shear stress and provides quantitative shear application benchmarks for future scalable stem cell culture systems...
  29. ncbi request reprint High-throughput positive-dielectrophoretic bioparticle microconcentrator
    Nitzan Gadish
    Department of Electrical and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 36 854, Cambridge, Massachusetts 02139, USA
    Anal Chem 78:7870-6. 2006
    ..The resulting microconcentrator is sufficiently high throughput to serve as an interface between macroscale sample collectors and micro- or nanoscale detectors...
  30. doi request reprint An active bubble trap and debubbler for microfluidic systems
    Alison M Skelley
    Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Lab Chip 8:1733-7. 2008
    ..We present a range of trap sizes, from 2 to 10 mm diameter, and can trap and remove bubbles up to 25 microL in under 3 h...
  31. ncbi request reprint Probing embryonic stem cell autocrine and paracrine signaling using microfluidics
    Laralynne Przybyla
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Anal Chem (Palo Alto Calif) 5:293-315. 2012
    ..Here we review how such techniques have begun to be adapted for use with embryonic stem cells, and we illustrate how many remaining questions in embryonic stem cell biology could be addressed using microfluidic technologies...
  32. pmc Attenuation of extrinsic signaling reveals the importance of matrix remodeling on maintenance of embryonic stem cell self-renewal
    Laralynne M Przybyla
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 109:835-40. 2012
    ....
  33. pmc Electrokinetic confinement of axonal growth for dynamically configurable neural networks
    Thibault Honegger
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 824, Cambridge, MA 02139, USA
    Lab Chip 13:589-98. 2013
    ..AC electrokinetic confinement of axonal growth has potential for creating configurable, directional neural networks...
  34. doi request reprint Insect-machine interface: a carbon nanotube-enhanced flexible neural probe
    W M Tsang
    Electrical Engineering and Computer Science, Massachusetts Institute of Technology, USA
    J Neurosci Methods 204:355-65. 2012
    ..Together, these FNPs present a potent new platform for manipulating and measuring the neural circuitry of insects, and for other nerves in humans and other animals with similar dimensions as the ventral nerve cord of the moth...
  35. ncbi request reprint A photopatternable silicone for biological applications
    Salil P Desai
    Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Langmuir 24:575-81. 2008
    ..The key material properties and integration capabilities explored in this work should present new avenues for exploring silicone microstructures for the design and implementation of increasingly complex bioMEMS architectures...
  36. ncbi request reprint Characterization of electrical stimulation electrodes for cardiac tissue engineering
    Nina Tandon
    Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, 353 Engineering Terrace, New York, NY 10027, USA
    Conf Proc IEEE Eng Med Biol Soc 1:845-8. 2006
    ....
  37. ncbi request reprint Dielectrophoretic registration of living cells to a microelectrode array
    Darren S Gray
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Biosens Bioelectron 19:1765-74. 2004
    ..By allowing the placement of desired numbers of cells at specified locations, this approach addresses many needs to manipulate and register cells to the surfaces of biosensors and other devices with high precision and fidelity...
  38. ncbi request reprint Dielectrophoretic registration of living cells to a microelectrode array
    Darren S Gray
    Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Biosens Bioelectron 19:771-80. 2004
    ..By allowing the placement of desired numbers of cells at specified locations, this approach addresses many needs to manipulate and register cells to the surfaces of biosensors and other devices with high precision and fidelity...
  39. ncbi request reprint BioMEMS: Building with cells
    Joel Voldman
    Nat Mater 2:433-4. 2003

Research Grants14

  1. A microscale sorting cytometer for cell-based screens
    Joel Voldman; Fiscal Year: 2007
    ..abstract_text> ..
  2. Multiplex system for stem cell culture and in situ assay
    Joel Voldman; Fiscal Year: 2003
    ..abstract_text> ..
  3. Microscale control of stem cell signaling using cell patterning and perfusion
    Joel Voldman; Fiscal Year: 2010
    ..Our technology provides a new window into stem cell biology that will help determine new ways to control their behavior. ..
  4. Microscale control of stem cell signaling using cell patterning and perfusion
    Joel Voldman; Fiscal Year: 2009
    ..Our technology provides a new window into stem cell biology that will help determine new ways to control their behavior. ..
  5. Microscale control of stem cell signaling using cell patterning and perfusion
    Joel Voldman; Fiscal Year: 2007
    ..Our technology provides a new window into stem cell biology that will help determine new ways to control their behavior. ..
  6. Continuous cell screening using iso-dielectric separation
    Joel Voldman; Fiscal Year: 2006
    ..This has the potential to both increase the class of biomolecules available as well as more efficiently find & produce them. ..
  7. A microscale sorting cytometer for cell-based screens
    Joel Voldman; Fiscal Year: 2006
    ..abstract_text> ..
  8. A microscale sorting cytometer for cell-based screens
    Joel Voldman; Fiscal Year: 2005
    ..abstract_text> ..
  9. Multiplex system for stem cell culture and in situ assay
    Joel Voldman; Fiscal Year: 2004
    ..abstract_text> ..
  10. A microscale sorting cytometer for cell-based screens
    Joel Voldman; Fiscal Year: 2004
    ..abstract_text> ..
  11. Cell-based sensors for measuring impact of microsystems on cell physiology
    Joel Voldman; Fiscal Year: 2010
    ..We are proposing to develop cell "sensors" that would glow colors if they are subjected to stresses from microsystems. ..