Research Topics
| Joel VoldmanSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
Research Grants
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Detail Information
Publications
Electrokinetic confinement of axonal growth for dynamically configurable neural networksThibault Honegger
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 36 824, Cambridge, MA 02139, USA
Lab Chip 13:589-98. 2013..AC electrokinetic confinement of axonal growth has potential for creating configurable, directional neural networks...
A microfabrication-based dynamic array cytometerJoel Voldman
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge 02139, USA
Anal Chem 74:3984-90. 2002..Such a device has potential for use in investigating functional processes, as revealed by temporal behavior, in large numbers of single cells...- Engineered systems for the physical manipulation of single cellsJoel Voldman
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Room 36 824, Cambridge, MA 02139, USA
Curr Opin Biotechnol 17:532-7. 2006..In the realm of cell separation for screening, there has been significant progress in miniaturized flow-based optical sorters as well as in sorting following static microscopic observation... - Electrical forces for microscale cell manipulationJoel Voldman
Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Annu Rev Biomed Eng 8:425-54. 2006..We first examine the forces and electrodes used to create them, then address potential impacts on cell health, followed by examples of devices for both separating cells and handling them... - Quantitative modeling of dielectrophoretic trapsAdam Rosenthal
Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
Lab Chip 6:508-15. 2006..The software is freely available to the scientific community at: ... - nDEP microwells for single-cell patterning in physiological mediaNikhil Mittal
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Lab Chip 7:1146-53. 2007..We calculate the temperatures and transmembrane potential that cells in the device experience and compare them to physiologically acceptable levels described in previous studies... - Electrically addressable vesicles: tools for dielectrophoresis metrologySalil P Desai
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Langmuir 25:3867-75. 2009..This combined with the ability to encode information about the properties of the vesicle in its fluorescence signature forms the first steps toward the development of EAV populations as metrology tools for any DEP-based microsystem... 
Spatially organized in vitro models instruct asymmetric stem cell differentiationYi Chin Toh
Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
Integr Biol (Camb) 3:1179-87. 2011....- Emergent behavior in particle-laden microfluidic systems informs strategies for improving cell and particle separationsMichael D Vahey
Department of Electrical Engineering and Computer Science, 77 Massachusetts Avenue, Building 36 824, Cambridge, Massachusetts 02139, USA
Lab Chip 11:2071-80. 2011..Finally, we present a simple analytic model based on hydrodynamic coupling that captures important features of strongly interacting particle suspensions... - Optimizing micromixer design for enhancing dielectrophoretic microconcentrator performanceHsu Yi Lee
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 50 Vassar Street, Room 36 824, Cambridge, Massachusetts 02139, USA
Anal Chem 79:1833-9. 2007..Finally, we used these analyses to illustrate the design principles of mixers for DEP-based concentrators... - A practical guide to microfluidic perfusion culture of adherent mammalian cellsLily Kim
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Rm 36 824, Cambridge, MA 02139, USA
Lab Chip 7:681-94. 2007.... - Assembly of metal nanoparticles into nanogapsRobert J Barsotti
Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Small 3:488-99. 2007..Assembly of fewer than 10 isolated particles in a gap is demonstrated. Preliminary electrical characterization reveals that stable conductance of the assembled particles can be achieved... - Advancing stem cell research with microtechnologies: opportunities and challengesYi Chin Toh
Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
Integr Biol (Camb) 2:305-25. 2010..By appropriately applying micro-scale engineering principles to stem cell research, we believe that significant breakthroughs can be made in stem cell research... - Nonmitogenic survival-enhancing autocrine factors including cyclophilin A contribute to density-dependent mouse embryonic stem cell growthNikhil Mittal
Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Stem Cell Res 6:168-76. 2011..Additionally, inhibition of the cyclophilin A receptor CD147 decreases the growth rate of mESCs. These findings identify cyclophilin A as a novel survival-enhancing autocrine factor in mouse ESC cultures... - Cell patterning chip for controlling the stem cell microenvironmentAdam Rosenthal
Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Biomaterials 28:3208-16. 2007..Thus, by allowing exquisite control of the cellular microenvironment, we provide a technology that enables new applications in tissue engineering and regenerative medicine... - Dielectrophoretic traps for single-particle patterningAdam Rosenthal
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Biophys J 88:2193-205. 2005..We provide the foundations for an enabling technology that can be used to pattern cells in unique ways, allowing us to do novel cell biology experiments at the microscale... - Plastic masters-rigid templates for soft lithographySalil P Desai
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02139, USA
Lab Chip 9:1631-7. 2009..PMs provide an easy technique for the fabrication of microfluidic devices and a simple route for the scaling-up of fabrication of robust masters for soft lithography... - Flexible split-ring electrode for insect flight biasing using multisite neural stimulationWei Mong Tsang
Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
IEEE Trans Biomed Eng 57:1757-64. 2010..Finally, in loosely tethered flight, we have used stimulation through the flexible microelectrodes to alter the abdominal angle, thus causing the flying moth to deviate to the left or right of its intended path... - Isodielectric separation and analysis of cellsMichael D Vahey
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA
Methods Mol Biol 853:53-63. 2012.... - Microfluidic perfusion for regulating diffusible signaling in stem cellsKatarina Blagović
Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America
PLoS ONE 6:e22892. 2011..A new approach explored in this work is to leverage transport phenomena at cellular resolution to downregulate overall diffusible signaling through the physical removal of cell-secreted ligands... - Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transductionYi Chin Toh
Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
FASEB J 25:1208-17. 2011..This study demonstrates that self-renewing mESCs possess the molecular machinery to sense shear stress and provides quantitative shear application benchmarks for future scalable stem cell culture systems... - Cell-based sensors for quantifying the physiological impact of microsystemsSalil P Desai
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Integr Biol (Camb) 3:48-56. 2011..Combined voltage and frequency sweeps enable the generation of complex maps of physiological state... - A scalable addressable positive-dielectrophoretic cell-sorting arrayBrian M Taff
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 36-854, Cambridge, Massachusetts 02139, USA
Anal Chem 77:7976-83. 2005..We demonstrate capture, holding, and release operations with both beads and cells in small arrays of this new architecture... - Microfluidic control of cell pairing and fusionAlison M Skelley
Research Laboratory of Electronics, 50 Vassar Street, Massachusetts Institute of Technology MIT, Cambridge, Massachusetts 02139, USA
Nat Methods 6:147-52. 2009.... - An active bubble trap and debubbler for microfluidic systemsAlison M Skelley
Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Lab Chip 8:1733-7. 2008..We present a range of trap sizes, from 2 to 10 mm diameter, and can trap and remove bubbles up to 25 microL in under 3 h... - Microfluidic arrays for logarithmically perfused embryonic stem cell cultureLily Kim
Massachusetts Institute of Technology, 77 Massachusetts Avenue, Rm 36-824, Cambridge, MA 02139, USA
Lab Chip 6:394-406. 2006..We have also demonstrated logarithmically scaled continuous perfusion culture of 3T3 fibroblasts for 3 days, with proliferation at all flow rates except the slowest rate... - High-throughput positive-dielectrophoretic bioparticle microconcentratorNitzan Gadish
Department of Electrical and Computer Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Building 36-854, Cambridge, Massachusetts 02139, USA
Anal Chem 78:7870-6. 2006..The resulting microconcentrator is sufficiently high throughput to serve as an interface between macroscale sample collectors and micro- or nanoscale detectors... - Probing embryonic stem cell autocrine and paracrine signaling using microfluidicsLaralynne Przybyla
Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Annu Rev Anal Chem (Palo Alto Calif) 5:293-315. 2012..Here we review how such techniques have begun to be adapted for use with embryonic stem cells, and we illustrate how many remaining questions in embryonic stem cell biology could be addressed using microfluidic technologies... - Attenuation of extrinsic signaling reveals the importance of matrix remodeling on maintenance of embryonic stem cell self-renewalLaralynne M Przybyla
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 109:835-40. 2012.... - Insect-machine interface: a carbon nanotube-enhanced flexible neural probeW M Tsang
Electrical Engineering and Computer Science, Massachusetts Institute of Technology, USA
J Neurosci Methods 204:355-65. 2012..Together, these FNPs present a potent new platform for manipulating and measuring the neural circuitry of insects, and for other nerves in humans and other animals with similar dimensions as the ventral nerve cord of the moth... - A photopatternable silicone for biological applicationsSalil P Desai
Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Langmuir 24:575-81. 2008..The key material properties and integration capabilities explored in this work should present new avenues for exploring silicone microstructures for the design and implementation of increasingly complex bioMEMS architectures... - Dielectrophoretic registration of living cells to a microelectrode arrayDarren S Gray
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
Biosens Bioelectron 19:1765-74. 2004..By allowing the placement of desired numbers of cells at specified locations, this approach addresses many needs to manipulate and register cells to the surfaces of biosensors and other devices with high precision and fidelity... - Characterization of electrical stimulation electrodes for cardiac tissue engineeringNina Tandon
Department of Biomedical Engineering, Columbia University, 1210 Amsterdam Avenue, 353 Engineering Terrace, New York, NY 10027, USA
Conf Proc IEEE Eng Med Biol Soc 1:845-8. 2006.... - Dielectrophoretic registration of living cells to a microelectrode arrayDarren S Gray
Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Baltimore, MD 21205, USA
Biosens Bioelectron 19:771-80. 2004..By allowing the placement of desired numbers of cells at specified locations, this approach addresses many needs to manipulate and register cells to the surfaces of biosensors and other devices with high precision and fidelity... - BioMEMS: Building with cellsJoel Voldman
Nat Mater 2:433-4. 2003
Research Grants
- A microscale sorting cytometer for cell-based screensJoel Voldman; Fiscal Year: 2007..abstract_text> ..
- Microscale control of stem cell signaling using cell patterning and perfusionJoel Voldman; Fiscal Year: 2010..Our technology provides a new window into stem cell biology that will help determine new ways to control their behavior. ..
- Microscale control of stem cell signaling using cell patterning and perfusionJoel Voldman; Fiscal Year: 2009..Our technology provides a new window into stem cell biology that will help determine new ways to control their behavior. ..
- Microscale control of stem cell signaling using cell patterning and perfusionJoel Voldman; Fiscal Year: 2007..Our technology provides a new window into stem cell biology that will help determine new ways to control their behavior. ..
- Continuous cell screening using iso-dielectric separationJoel Voldman; Fiscal Year: 2006..This has the potential to both increase the class of biomolecules available as well as more efficiently find & produce them. ..
- Multiplex system for stem cell culture and in situ assayJoel Voldman; Fiscal Year: 2004..abstract_text> ..
- Cell-based sensors for measuring impact of microsystems on cell physiologyJoel Voldman; Fiscal Year: 2010..We are proposing to develop cell "sensors" that would glow colors if they are subjected to stresses from microsystems. ..