Research Topics
| A ViswanathanSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Cerebral amyloid angiopathy in the elderlyAnand Viswanathan
Department of Neurology and Clinical Trials Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Ann Neurol 70:871-80. 2011..This review will discuss the pathophysiology of CAA and focus on new imaging modalities and laboratory biomarkers that may aid in the clinical diagnosis of individuals with the disease...
Tissue microstructural changes are independently associated with cognitive impairment in cerebral amyloid angiopathyAnand Viswanathan
Hemorrhagic Stroke Research Program, Massachusetts General Hospital, Stroke Research Center, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
Stroke 39:1988-92. 2008..We hypothesized that higher global mean apparent diffusion coefficient (mean ADC), reflecting a higher amount of chronic tissue disruption caused by CAA, would be independently associated with CAA-related cognitive impairment...
Plasma Abeta, homocysteine, and cognition: the Vitamin Intervention for Stroke Prevention (VISP) trialA Viswanathan
Hemorrhagic Stroke Research Program, Massachusetts General Hospital Stroke Research Center, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
Neurology 72:268-72. 2009....
Warfarin-related intraventricular hemorrhage: imaging and outcomeA Biffi
Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA
Neurology 77:1840-6. 2011..We investigated whether OAT also influences risk of development of intraventricular hemorrhage (IVH), the volume of IVH and IVH expansion, and whether IVH is a substantive mediator of the overall effect of OAT on ICH outcome...
Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathyW T Kimberly
Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neurology 72:1230-5. 2009..We examined the prevalence and associated risk factors for infarcts detected by diffusion-weighted imaging (DWI)...
Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathyA Biffi
Department of Neurology and Hemorrhagic Stroke Research Program, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, 175 Cambridge Street, Suite 300, Boston, MA 02114, USA
Neurology 75:693-8. 2010..To identify and compare clinical and neuroimaging predictors of primary lobar intracerebral hemorrhage (ICH) recurrence, assessing their relative contributions to recurrent ICH...
MR imaging detection of cerebral microbleeds: effect of susceptibility-weighted imaging, section thickness, and field strengthR N K Nandigam
Hemorrhagic Stroke Research Program, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
AJNR Am J Neuroradiol 30:338-43. 2009....
Statin use and outcome after intracerebral hemorrhage: case-control study and meta-analysisA Biffi
Center for Human Genetic Research, Massachusetts General Hospital, 185 Cambridge Street, CPZN 6818, Boston, MA 02114, USA
Neurology 76:1581-8. 2011..We therefore performed a meta-analysis of all available evidence, including unpublished data from our own institution, to determine whether statin exposure is protective for patients who develop ICH...
Microbleeds versus macrobleeds: evidence for distinct entitiesSteven M Greenberg
MGH Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA
Stroke 40:2382-6. 2009..It is unclear whether microbleeds and macrobleeds represent arbitrary categories within a single continuum versus truly distinct events with separate pathophysiologies...
Cerebral microbleeds: a guide to detection and interpretationSteven M Greenberg
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Lancet Neurol 8:165-74. 2009..We propose a procedural guide for identification of CMBs and suggest possible future approaches for elucidating the role of these common lesions as markers for, and contributors to, small-vessel brain disease...
Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound BSteven M Greenberg
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Ann Neurol 64:587-91. 2008..These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions...
Spatial relation between microbleeds and amyloid deposits in amyloid angiopathyGregory A Dierksen
Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Ann Neurol 68:545-8. 2010..0001). These findings indicate that microbleeds occur preferentially in local regions of concentrated amyloid and support therapeutic strategies aimed at reducing vascular amyloid deposition...
Association of subdural hematoma with increased mortality in lobar intracerebral hemorrhagePratik V Patel
Hemorrhagic Stroke Research Program, Department of Neurology, Massachusetts General Hospital, 175 Cambridge St, Ste 300, Boston, MA 02114, USA
Arch Neurol 66:79-84. 2009..To determine the prevalence of subdural hematoma (SDH) in patients presenting with primary nontraumatic lobar intracerebral hemorrhage (ICH) and characteristics associated with the presence of SDH...
Antiplatelet use after intracerebral hemorrhageA Viswanathan
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 66:206-9. 2006..3, p = 0.88). CONCLUSION: Antiplatelet agent use is relatively common following intracerebral hemorrhage but did not appear to be associated with a large increased risk of intracerebral hemorrhage recurrence in this observational study...
Unsuspected coagulopathy rarely prevents IV thrombolysis in acute ischemic strokeN S Rost
Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
Neurology 73:1957-62. 2009..We sought to identify how often blood clotting abnormalities were responsible for withholding IV tPA at our institution...
Acute and chronic graft-versus-host disease after allogeneic peripheral-blood stem-cell and bone marrow transplantation: a meta-analysisC Cutler
Division of Hematologic Oncology, Dana Farber Cancer Institute, and Harvard School of Public Health, Boston, MA 02115, USA
J Clin Oncol 19:3685-91. 2001..We performed a meta-analysis of all trials comparing the incidence of acute and chronic GVHD after PBSCT and BMT reported as of June, 2000. Secondary analyses examined relapse rates after the two procedures...
Blood pressure and haemoglobin A1c are associated with microhaemorrhage in CADASIL: a two-centre cohort studyAnand Viswanathan
Department of Neurology, , , Paris, France
Brain 129:2375-83. 2006..These lesions have a potential clinical impact in CADASIL. These findings further suggest that modulation of blood pressure and glucose levels might influence the course of the disease...
Cortical changes in cerebral small vessel diseases: a 3D MRI study of cortical morphology in CADASILEric Jouvent
Department of Neurology, INSERM UMR 740 and Université Paris VII, France
Brain 131:2201-8. 2008..These results suggest that the examination of cortical morphology may be of high clinical relevance in SVDB...
Multiple simultaneous cerebral infarctions in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathyClaire Gobron
Department of Neurology, , , Paris, France
Cerebrovasc Dis 22:445-6. 2006
Brain atrophy is related to lacunar lesions and tissue microstructural changes in CADASILEric Jouvent
Department of Neurology, CHU Lariboisière, Assistance Publique des Hopitaux de Paris, and Université Paris VII, Paris, France
Stroke 38:1786-90. 2007..The contribution of subcortical cerebral lesions in this process remains undetermined. The aim of this study was to investigate the relationships between cerebral volume and different types of subcortical MRI lesions in CADASIL...
Diagnostic criteria of vascular dementia in CADASILSarah Benisty
Department of Geriatric Medicine, University Paris 7, 2 rue Ambroise Pare, 75010 Paris, France
Stroke 39:838-44. 2008..Application of these criteria in CADASIL, a genetic model of SIVD, may help to better assess their significance. The aim of this study was to compare different sets of diagnostic criteria of VaD in a population of CADASIL patients...
Effect of statins on intracerebral hemorrhage outcome and recurrenceEmilie FitzMaurice
Stroke 39:2151-4. 2008..82, 95% CI 0.34 to 1.99, P=0.66). CONCLUSIONS: Pre-ICH statin use is not associated with improved ICH functional outcome or mortality. Post-ICH statin use is not associated with an increased risk of ICH recurrence...
Cerebral microhemorrhageAnand Viswanathan
Department of Neurology, , , France
Stroke 37:550-5. 2006..Further studies to characterize the associated risks of cerebral microhemorrhages in different stroke populations are needed to use this new imaging marker in therapeutic decisions...
Navigation with electromagnetic tracking for interventional radiology procedures: a feasibility studyBradford J Wood
Diagnostic Radiology Department, National Institutes of Health Clinical Center, Building 10, Room 1C 660, Bethesda, Maryland 20892, USA
J Vasc Interv Radiol 16:493-505. 2005..To assess the feasibility of the use of preprocedural imaging for guide wire, catheter, and needle navigation with electromagnetic tracking in phantom and animal models...
