George C Velmahos

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Does nephrectomy for trauma increase the risk of renal failure?
    George C Velmahos
    Department of Surgery, Division of Trauma and Critical Care, Los Angeles County and University of Southern California Medical Center, 1200 N State Street, Los Angeles, California 90033, USA
    World J Surg 29:1472-5. 2005
  2. doi request reprint Self-expanding hemostatic polymer for control of exsanguinating extremity bleeding
    George C Velmahos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Harvard Medical School, The Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Trauma 66:984-8. 2009
  3. pmc 2013 WSES guidelines for management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:3. 2013
  4. pmc Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:1. 2013
  5. pmc Bologna Guidelines for Diagnosis and Management of Adhesive Small Bowel Obstruction (ASBO): 2010 Evidence-Based Guidelines of the World Society of Emergency Surgery
    Fausto Catena
    Emergency Surgery Unit, Department of General and Multivisceral Transplant Surgery, S, Orsola Malpighi University Hospital, Bologna, Italy
    World J Emerg Surg 6:5. 2011
  6. pmc Penetrating abdominal injuries: management controversies
    Muhammad U Butt
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Scand J Trauma Resusc Emerg Med 17:19. 2009
  7. doi request reprint Management of the most severely injured spleen: a multicenter study of the Research Consortium of New England Centers for Trauma (ReCONECT)
    George C Velmahos
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02030, USA
    Arch Surg 145:456-60. 2010
  8. doi request reprint Pulmonary embolism and deep venous thrombosis in trauma: are they related?
    George C Velmahos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Ste 810, Boston, MA 02114, USA
    Arch Surg 144:928-32. 2009
  9. ncbi request reprint Electrostimulation for the prevention of deep venous thrombosis in patients with major trauma: a prospective randomized study
    George C Velmahos
    Department of Surgery, Division of Trauma and Critical Care, Los Angeles County and University of Southern California Medical Center, USA
    Surgery 137:493-8. 2005
  10. ncbi request reprint Abdominal insufflation for control of bleeding after severe splenic injury
    George C Velmahos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Surgery, The Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 63:285-8; discussion 288-90. 2007

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint Does nephrectomy for trauma increase the risk of renal failure?
    George C Velmahos
    Department of Surgery, Division of Trauma and Critical Care, Los Angeles County and University of Southern California Medical Center, 1200 N State Street, Los Angeles, California 90033, USA
    World J Surg 29:1472-5. 2005
    ..Given the increased operative complexity of nephrorrhaphy in comparison to nephrectomy and the frequent need to abbreviate the operation in patients with severe trauma, nephrectomy should not be avoided when appropriate...
  2. doi request reprint Self-expanding hemostatic polymer for control of exsanguinating extremity bleeding
    George C Velmahos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Harvard Medical School, The Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Trauma 66:984-8. 2009
    ..In contact with blood, the polymer absorbs the aqueous component of blood and exerts a tamponade effect by expanding against the walls of the wound cavity...
  3. pmc 2013 WSES guidelines for management of intra-abdominal infections
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:3. 2013
    ..The 2013 update of the World Society of Emergency Surgery (WSES) guidelines for the management of intra-abdominal infections contains evidence-based recommendations for management of patients with intra-abdominal infections...
  4. pmc Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)
    Massimo Sartelli
    Department of Surgery, Macerata Hospital, Macerata, Italy
    World J Emerg Surg 8:1. 2013
    ..7%) patients.The overall mortality rate was 10.1% (71/702). The final results of the CIAOW Study will be published following the conclusion of the study period in March 2013...
  5. pmc Bologna Guidelines for Diagnosis and Management of Adhesive Small Bowel Obstruction (ASBO): 2010 Evidence-Based Guidelines of the World Society of Emergency Surgery
    Fausto Catena
    Emergency Surgery Unit, Department of General and Multivisceral Transplant Surgery, S, Orsola Malpighi University Hospital, Bologna, Italy
    World J Emerg Surg 6:5. 2011
    ..abstract:..
  6. pmc Penetrating abdominal injuries: management controversies
    Muhammad U Butt
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Scand J Trauma Resusc Emerg Med 17:19. 2009
    ..We also discuss additional controversial issues, as related to antibiotic prophylaxis, management of asymptomatic thoracoabdominal injuries, and the use of colostomy vs. primary repair for colon injuries...
  7. doi request reprint Management of the most severely injured spleen: a multicenter study of the Research Consortium of New England Centers for Trauma (ReCONECT)
    George C Velmahos
    Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02030, USA
    Arch Surg 145:456-60. 2010
    ..To determine the rate and predictors of failure of nonoperative management (NOM) in grade IV and V blunt splenic injuries (BSI)...
  8. doi request reprint Pulmonary embolism and deep venous thrombosis in trauma: are they related?
    George C Velmahos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Ste 810, Boston, MA 02114, USA
    Arch Surg 144:928-32. 2009
    ..Pulmonary embolism (PE) and deep venous thrombosis (DVT) in trauma are related...
  9. ncbi request reprint Electrostimulation for the prevention of deep venous thrombosis in patients with major trauma: a prospective randomized study
    George C Velmahos
    Department of Surgery, Division of Trauma and Critical Care, Los Angeles County and University of Southern California Medical Center, USA
    Surgery 137:493-8. 2005
    ..It has not been tested in multiple trauma patients...
  10. ncbi request reprint Abdominal insufflation for control of bleeding after severe splenic injury
    George C Velmahos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Surgery, The Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 63:285-8; discussion 288-90. 2007
    ..This model represents a clinically relevant scenario of continuous bleeding, which does not kill the patient immediately but may ultimately result in death if not managed early...
  11. ncbi request reprint Abdominal insufflation decreases blood loss without worsening the inflammatory response: implications for prehospital control of internal bleeding
    George C Velmahos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, The Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am Surg 74:297-301. 2008
    ..Our conclusion is that AI reduces blood loss from splenic injury without a measurable effect on the early inflammatory response in a clinically relevant animal model...
  12. ncbi request reprint Nephrectomy versus renal repair after trauma to the kidney: preserve or sacrifice?
    George C Velmahos
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California, Los Angeles, California, USA
    Int Surg 91:295-300. 2006
    ..Nephrectomy can be offered when necessary without concerns about increasing the likelihood of postoperative renal failure...
  13. doi request reprint Blunt pancreatoduodenal injury: a multicenter study of the Research Consortium of New England Centers for Trauma (ReCONECT)
    George C Velmahos
    Departments of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Arch Surg 144:413-9; discussion 419-20. 2009
    ..To evaluate the safety of nonoperative management (NOM), to examine the diagnostic sensitivity of computed tomography (CT), and to identify missed diagnoses and related outcomes in patients with blunt pancreatoduodenal injury (BPDI)...
  14. ncbi request reprint Falls from height: spine, spine, spine!
    George C Velmahos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Am Coll Surg 203:605-11. 2006
    ..Diagnostic evaluation of the spine is complex and debated. Our objective was to characterize spinal injury after falls from height and identify predictive factors of spinal injuries...
  15. ncbi request reprint Safety of repair for severe duodenal injuries
    George C Velmahos
    Division of Trauma and Critical Care, Department of Surgery, Los Angeles County and University of Southern California Medical Center, Los Angeles, California, USA
    World J Surg 32:7-12. 2008
    ..The objective of this study was to compare primary repair with pyloric exclusion to examine if primary repair can be safely used in SDIs...
  16. ncbi request reprint The concept of acute care surgery: a vision for the not-so-distant future
    George C Velmahos
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Surgery 141:288-90. 2007
  17. doi request reprint Surviving blood loss without blood transfusion in a swine poly-trauma model
    Hasan B Alam
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Surgery 146:325-33. 2009
    ..This study investigated whether VPA treatment would improve survival in a clinically relevant large animal model of poly-trauma/hemorrhagic shock, and whether the protective effects are executed through the Akt survival pathway...
  18. doi request reprint "Blush" on trauma computed tomography: not as bad as we think!
    Maria Michailidou
    Division of Trauma, Emergency Surgery, and Surgical Critical Care and the Department of Biostatistics and Epidemiology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Trauma Acute Care Surg 73:580-4; discussion 584-6. 2012
    ..The new-generation computed tomographic (CT) scanners identify IVCE with increasing frequency. We hypothesized that most IVCEs do not require an intervention...
  19. doi request reprint Putting life on hold-for how long? Profound hypothermic cardiopulmonary bypass in a Swine model of complex vascular injuries
    Hasan B Alam
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 64:912-22. 2008
    ..5 degrees C/min) for best results. However, the maximum duration of hypothermic arrest in a clinically relevant trauma model remains unknown...
  20. ncbi request reprint Hemodynamically "stable" patients with peritonitis after penetrating abdominal trauma: identifying those who are bleeding
    Carlos V R Brown
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California Keck School of Medicine, Los Angeles County University of Southern California Medical Center, 1200 N State Street, Los Angeles, CA 90033, USA
    Arch Surg 140:767-72. 2005
    ..Despite initial presentation, hemodynamically stable patients with penetrating abdominal trauma may have significant ongoing hemorrhage and major intra-abdominal injuries requiring emergent surgical intervention...
  21. doi request reprint Surviving lethal septic shock without fluid resuscitation in a rodent model
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    Surgery 148:246-54. 2010
    ..The purpose of the present study was to determine whether SAHA treatment would attenuate LPS-induced shock and improve survival when given postinsult in a rodent model...
  22. ncbi request reprint Pelvic fractures in pediatric and adult trauma patients: are they different injuries?
    Demetrios Demetriades
    Department of Surgery, University of Southern California, Los Angeles, USA
    J Trauma 54:1146-51; discussion 1151. 2003
    ....
  23. doi request reprint Development and testing of low-volume hyperoncotic, hyperosmotic spray-dried plasma for the treatment of trauma-associated coagulopathy
    Fahad Shuja
    Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    J Trauma 70:664-71. 2011
    ..To enhance the logistical advantage (lower volume and weight), we developed and tested a hyperoncotic, hyperosmotic spray-dried plasma (SDP) product in a multiple injuries/hemorrhagic shock swine model...
  24. doi request reprint Alterations in gene expression after induction of profound hypothermia for the treatment of lethal hemorrhage
    Hasan B Alam
    Division of Trauma, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    J Trauma 68:1084-98. 2010
    ..However, the precise mechanisms have not been well defined. The aim of this high-throughput study was to investigate the impact of profound hypothermia on gene expression profiles...
  25. doi request reprint Successful selective nonoperative management of abdominal gunshot wounds despite low penetrating trauma volumes
    Karim Fikry
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Ste 810, Boston, MA 02114, USA
    Arch Surg 146:528-32. 2011
    ..To determine whether selective nonoperative management of abdominal gunshot wounds (AGSW) is safe in trauma centers with a low volume of penetrating trauma...
  26. doi request reprint Early treatment with lyophilized plasma protects the brain in a large animal model of combined traumatic brain injury and hemorrhagic shock
    Ayesha M Imam
    From the Division of Trauma, Emergency Surgery and Surgical Critical Care, A M I, G J, M S, M D, C H J, J O H, J L, M A D, G C V, H B A, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts and Department of Surgery G J, B L, H B A, University of Michigan Hospital, Ann Arbor, Michigan
    J Trauma Acute Care Surg 75:976-83. 2013
    ..However, FFP is a perishable product that is not well suited for use in the austere prehospital settings. In this study, we tested whether a shelf-stable, low-volume, lyophilized plasma (LSP) product was as effective as FFP...
  27. doi request reprint Does size matter? A prospective analysis of 28-32 versus 36-40 French chest tube size in trauma
    Kenji Inaba
    Division of Trauma and Surgical Critical Care, Los Angeles County and the University of Southern California Medical Center, USC Keck School of Medicine, Los Angeles, CA 90033, USA
    J Trauma Acute Care Surg 72:422-7. 2012
    ....
  28. doi request reprint Blunt pulmonary contusion: admission computed tomography scan predicts mechanical ventilation
    Marc A de Moya
    Division of Trauma Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 71:1543-7. 2011
    ..Admission computed tomography (CT) may offer accurate characterization of BPC and early prediction of the need for mechanical ventilation (MV)...
  29. pmc Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Surgery 150:442-51. 2011
    ..The present study was designed to confirm these findings and to test whether the pro-survival phenotype could be detected by an early alteration in serum biomarkers...
  30. doi request reprint Pharmacologic resuscitation: cell protective mechanisms of histone deacetylase inhibition in lethal hemorrhagic shock
    Muhammad U Butt
    Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 156:290-6. 2009
    ..This study investigated whether VPA treatment works through the c-Jun N-terminal kinase (JNK)/Caspase-3 survival pathways...
  31. doi request reprint Profound hypothermia decreases cardiac apoptosis through Akt survival pathway
    Fahad Shuja
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital, Boston, MA 02114, USA
    J Am Coll Surg 209:89-99. 2009
    ..Here we studied activation of Akt cell survival pathway in a rodent model of emergency preservation and delayed resuscitation...
  32. doi request reprint Pharmacologic resuscitation decreases circulating cytokine-induced neutrophil chemoattractant-1 levels and attenuates hemorrhage-induced acute lung injury
    Eugene Y Fukudome
    Department of Surgery, Division of Trauma, Emergency Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Surgery 152:254-61. 2012
    ..Herein, we have investigated the effects of HS and VPA treatment on ALI and circulating cytokines that may serve as biomarkers for the development of organ injury...
  33. ncbi request reprint Thromboprophylaxis does not protect severely injured patients against pulmonary embolism
    George C Velmahos
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California Keck School of Medicine, Los Angeles, California, USA
    Am Surg 70:893-6. 2004
    ..Practices from nontrauma populations have been erroneously extrapolated to the unique trauma population. To reduce the rate of PE after trauma, new methods of thromboprophylaxis should be considered...
  34. doi request reprint Fulminant Clostridium difficile colitis: patterns of care and predictors of mortality
    Elizabeth A Sailhamer
    Department of Surgery, Division of Trauma, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Arch Surg 144:433-9; discussion 439-40. 2009
    ..There exist predictors of mortality and the need for colectomy among patients with fulminant Clostridium difficile colitis...
  35. ncbi request reprint Abdominal computed tomographic scan for patients with gunshot wounds to the abdomen selected for nonoperative management
    George C Velmahos
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California Keck School of Medicine, Los Angeles County University of Southern California Medical Center, Los Angeles, California 90033, USA
    J Trauma 59:1155-60; discussion 1160-1. 2005
    ..Triple-contrast CT scanning (i.e., intravenous, oral, and rectal) has produced encouraging initial results. The exact role and usefulness of CT scanning with intravenous contrast only is unknown...
  36. doi request reprint Cell protective mechanism of valproic acid in lethal hemorrhagic shock
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Surgery 144:217-24. 2008
    ..This study investigated whether VPA treatment works through the beta-catenin survival pathways...
  37. ncbi request reprint White blood cell and platelet counts can be used to differentiate between infection and the normal response after splenectomy for trauma: prospective validation
    Janie Weng
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California and the Los Angeles County Medical Center, Los Angeles, California 90033, USA
    J Trauma 59:1076-80. 2005
    ..The current study intends to prospectively validate the WBC and PC/WBC ratio on postoperative day 5 as markers of infection after splenectomy for trauma...
  38. ncbi request reprint A prospective study on the safety and efficacy of angiographic embolization for pelvic and visceral injuries
    George C Velmahos
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California, and the Los Angeles County and University of Southern California Medical Center, Los Angeles, California 90033, USA
    J Trauma 53:303-8; discussion 308. 2002
    ..Angiographic embolization (AE) is used with increasing frequency as an alternative to surgery for control of intraperitoneal and retroperitoneal bleeding. There are no prospective studies on its efficacy, safety, and indications...
  39. ncbi request reprint Wound management after colon injury: open or closed? A prospective randomized trial
    George C Velmahos
    Department of Surgery, University of Southern California and the Los Angeles County and University of Southern California Medical Center, 90033, USA
    Am Surg 68:795-801. 2002
    ..Because of the complexity of evaluating the real clinical significance of superficial wound infection larger studies on trauma patients are required...
  40. ncbi request reprint Nonoperative treatment of blunt injury to solid abdominal organs: a prospective study
    George C Velmahos
    Department of Surgery, University of Southern California, Los Angeles, California 90033, USA
    Arch Surg 138:844-51. 2003
    ..Patients in whom NOM is likely to fail can be identified by specific criteria...
  41. doi request reprint Treatment with histone deacetylase inhibitor attenuates MAP kinase mediated liver injury in a lethal model of septic shock
    Robert A Finkelstein
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 163:146-54. 2010
    ..The purpose of this study was to assess the effect of SAHA treatment on MAP kinases and associated inflammatory markers in murine liver after LPS-induced injury...
  42. ncbi request reprint High success with nonoperative management of blunt hepatic trauma: the liver is a sturdy organ
    George C Velmahos
    Division of Trauma and Critical Care, Department of Surgery, University of Southern California and the Los Angeles County USC Healthcare Network, Los Angeles 90033, USA
    Arch Surg 138:475-80; discussion 480-1. 2003
    ..Nonoperative management of liver injuries (NOMLI) is highly successful and rarely leads to adverse events...
  43. doi request reprint Presenting blood pressure in traumatic brain injury: a bimodal distribution of death
    Syed Nabeel Zafar
    Harvard School of Public Health, Boston Massachusetts, USA
    J Trauma 71:1179-84. 2011
    ..This work has not included traumatic brain injury (TBI). We aimed to evaluate the relationship of the initial emergency department systolic blood pressure (EDSBP) with outcome...
  44. doi request reprint Hypoxic "second hit" in leukocytes from trauma patients: Modulation of the immune response by histone deacetylase inhibition
    Elizabeth A Sailhamer
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Cytokine 49:303-11. 2010
    ..The current experiments were designed to study the effects of HDACI after hemorrhage and severe hypoxia...
  45. ncbi request reprint Normal electrocardiography and serum troponin I levels preclude the presence of clinically significant blunt cardiac injury
    George C Velmahos
    Department of Surgery, University of Southern California, and the Los Angeles County and University of Southern California LAC USC Medical Center, Los Angeles, CA 90033, USA
    J Trauma 54:45-50; discussion 50-1. 2003
    ..The purpose of this study was to examine whether the combination of two simple tests, electrocardiography (ECG) and serum troponin I (TnI) level, may serve as reliable predictors of BCI or the absence of it...
  46. doi request reprint Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury
    Guang Jin
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, USA
    J Trauma Acute Care Surg 73:1461-70. 2012
    ..This study was performed to determine whether addition of VPA to Hex would decrease the lesion size in a clinically relevant large animal model of TBI + HS...
  47. pmc Histone deacetylase inhibitor suberoylanilide hydroxamic acid attenuates Toll-like receptor 4 signaling in lipopolysaccharide-stimulated mouse macrophages
    Wei Chong
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 178:851-9. 2012
    ..This study was designed to assess whether SAHA affects LPS/Toll-like receptor 4 signaling through acetylation of heat shock protein 90 (HSP90) and degradation of its client protein interleukin-1 receptor-associated kinase 1 (IRAK1)...
  48. doi request reprint Traumatic brain injury and hemorrhagic shock: evaluation of different resuscitation strategies in a large animal model of combined insults
    Guang Jin
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Shock 38:49-56. 2012
    ..Early administration of FFP reduces the size of brain lesion and associated swelling in a large animal model of TBI + HS. In contrast, artificial colloid (Hex) decreases swelling without reducing the actual size of the brain lesion...
  49. doi request reprint Pain as an indication for rib fixation: a bi-institutional pilot study
    Marc de Moya
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Trauma 71:1750-4. 2011
    ..Further, we hypothesized that improved pain control would result in fewer pulmonary complications and decreased length of stay...
  50. doi request reprint Diagnosis and treatment of blunt thoracic aortic injuries: changing perspectives
    Demetrios Demetriades
    AAST Multi institutional Thoracic Aortic Injury Study Group, Los Angeles, California, USA
    J Trauma 64:1415-8; discussion 1418-9. 2008
    ..The present study compares clinical practices and results between an earlier prospective multicenter study by the American Association for the Surgery of Trauma completed in 1997 (AAST1) and a new similar study completed in 2007 (AAST2)...
  51. ncbi request reprint Routine repeat head CT for minimal head injury is unnecessary
    George C Velmahos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Neurosurgery, and Biostatistics Center DJD, Massachusetts General Hospital, Harvard School of Medicine, Boston, MA 02114, USA
    J Trauma 60:494-9; discussion 499-501. 2006
    ..RRHCT is ordered based on the premise that significant injury progression may take place in the absence of clinical deterioration...
  52. doi request reprint Predictors of bleeding from stable pelvic fractures
    Athanasios Bramos
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Arch Surg 146:407-11. 2011
    ..Our hypothesis is that simple indicators, easily detectable at the bedside, can alert the clinician about the likelihood of bleeding and the need for closer monitoring or early intervention in patients with SPFs...
  53. ncbi request reprint Can we rely on computed tomographic scanning to diagnose pulmonary embolism in critically ill surgical patients?
    George C Velmahos
    Department of Surgery, University of Southern California, Los Angeles 90033, USA
    J Trauma 56:518-25; discussion 525-6. 2004
    ..Hemodynamic and respiratory issues of critical illness may interfere with CTPA's diagnostic accuracy. The objective of this study was to compare CTPA with PA for the diagnosis of PE in critically ill surgical patients...
  54. ncbi request reprint The impact of obesity on the outcomes of 1,153 critically injured blunt trauma patients
    Carlos V R Brown
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California and the Los Angeles County Medical Center, Los Angeles, California 90033, USA
    J Trauma 59:1048-51; discussion 1051. 2005
    ..The purpose of the present study was to evaluate a large cohort of critically injured patients to better understand the influence of obesity on the outcomes of patients after severe blunt trauma...
  55. doi request reprint Excessively long hospital stays after trauma are not related to the severity of illness: let's aim to the right target!
    John O Hwabejire
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston
    JAMA Surg 148:956-61. 2013
    ..However, many existing approaches are flawed because the assumptions of what cause excessive length of stay are incorrect; we methodically identified the right targets in this study...
  56. doi request reprint Successful nonoperative management of the most severe blunt renal injuries: a multicenter study of the research consortium of New England Centers for Trauma
    Gwendolyn M van der Wilden
    Department of Surgery, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts
    JAMA Surg 148:924-31. 2013
    ..Severe renal injuries after blunt trauma cause diagnostic and therapeutic challenges for the treating clinicians. The need for an operative vs a nonoperative approach is debated...
  57. doi request reprint Novel pharmacologic treatment attenuates septic shock and improves long-term survival
    Ting Zhao
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Surgery 154:206-13. 2013
    ..The goal of this study was to investigate the impact of SAHA on survival in a more clinically relevant model of cecal ligation and puncture (CLP)-induced septic shock and to elucidate changes in cytokine responses and organ injury...
  58. doi request reprint Implementation of 24/7 intensivist presence in the SICU: effect on processes of care
    Gwendolyn M van der Wilden
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02141, USA
    J Trauma Acute Care Surg 74:563-7. 2013
    ..We hypothesized that 24/7 attending intensivist staffing in the SICU would improve outcomes and processes of care...
  59. pmc Histone deacetylase inhibitor treatment attenuates MAP kinase pathway activation and pulmonary inflammation following hemorrhagic shock in a rodent model
    Ashley R Kochanek
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 176:185-94. 2012
    ..The aim of the current study was to examine whether these protective effects were due to attenuation of mitogen activated protein kinase (MAPK) signaling pathways, which are known to promote inflammation and apoptosis...
  60. pmc Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion
    Kyuseok Kim
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Resuscitation 83:243-8. 2012
    ..The purpose of this study was to investigate whether VPA could affect survival and development of ALI in a rat model of intestinal I/R...
  61. doi request reprint Histone deacetylase inhibitors prevent apoptosis following lethal hemorrhagic shock in rodent kidney cells
    Nikolaos Zacharias
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Resuscitation 82:105-9. 2011
    ..These agents are known to acetylate insulin receptor substrate-I (IRS-I), which in turn activates the Akt survival pathway. This study investigated whether HDACI exert their beneficial effects through the Akt survival pathway...
  62. doi request reprint Bedside placement of removable vena cava filters guided by intravascular ultrasound in the critically injured
    Konstantinos Spaniolas
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge Street, Suite 810, Boston, MA 02114, USA
    World J Surg 32:1438-43. 2008
    ..Intravascular ultrasound (IVUS) eliminates such problems. The objective of the present study was to analyze the safety and feasibility of IVUS-guided bedside RVCF placement in critically injured patients...
  63. ncbi request reprint Does routine serial computed tomography of the head influence management of traumatic brain injury? A prospective evaluation
    Carlos V R Brown
    Department of Surgery, Division of Trauma and Critical Care, Los Angeles County and University of Southern California Medical Center, Los Angeles, California, USA
    J Trauma 57:939-43. 2004
    ..Recent retrospective reviews have challenged the need for serial head CT after traumatic brain injury (TBI). This study intends to prospectively examine the value of routine serial head CT after TBI...
  64. ncbi request reprint Abdominal insufflation for prevention of exsanguination
    Jack Sava
    Department of Surgery, Division of Trauma and Critical Care, University of Southern California Keck School of Medicine, USA
    J Trauma 54:590-4. 2003
    ..Currently, traumatic intra-abdominal hemorrhage continues unchecked during transport and triage, and a simple technique of prehospital hemostasis might improve outcomes. The hemostatic effect of abdominal hypertension has not been studied...
  65. ncbi request reprint Intubation after cervical spinal cord injury: to be done selectively or routinely?
    George C Velmahos
    Department of Surgery, University of Southern California, Los Angeles, California 90033, USA
    Am Surg 69:891-4. 2003
    ..The majority of patients with CSCI require intubation. In patients with CSCI above C5 and complete quadriplegia, intubation should be offered routinely and early because delays may cause preventable morbidity...
  66. ncbi request reprint Is upper extremity deep venous thrombosis underdiagnosed in trauma patients?
    Konstantinos Spaniolas
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am Surg 74:124-8. 2008
    ..UEDVT is an uncommon event with unclear significance in trauma. Aggressive screening did not result in a higher rate of UEDVT diagnosis, nor an opportunity to prevent PE...
  67. ncbi request reprint Obesity is an independent risk factor of mortality in severely injured blunt trauma patients
    Angela L Neville
    Department of Surgery, Division of Trauma and Critical Care, Los Angeles County, University of Southern California Medical Center, Los Angeles 90033, USA
    Arch Surg 139:983-7. 2004
    ..Obesity is associated with increased morbidity and mortality in critically injured blunt trauma patients...
  68. ncbi request reprint Influence of flail chest on outcome among patients with severe thoracic cage trauma
    George C Velmahos
    Division of Trauma and Critical Care, Department of Surgery, University of Southern California, Los Angeles, California, USA
    Int Surg 87:240-4. 2002
    ..In the presence of associated injuries, intubation is unavoidable and should be done under controlled conditions early after arrival to avoid morbidity related to sudden respiratory decompensation...
  69. doi request reprint Protective effect of suberoylanilide hydroxamic acid against LPS-induced septic shock in rodents
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Shock 32:517-23. 2009
    ..We report for the first time that administration of SAHA (50 mg/kg) significantly attenuates a variety of inflammatory markers and improves long-term survival after a lethal LPS insult...
  70. ncbi request reprint Profound hypothermic cardiopulmonary bypass facilitates survival without a high complication rate in a swine model of complex vascular, splenic, and colon injuries
    Elizabeth A Sailhamer
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    J Am Coll Surg 204:642-53. 2007
    ....
  71. doi request reprint Missed opportunities for primary repair in complicated acute diverticulitis
    Malek Tabbara
    Harvard Medical School, Boston, MA, USA
    Surgery 148:919-24. 2010
    ..We aim to identify patient characteristics predicting successful PR and explore if patients are managed by FD despite the presence of such characteristics...
  72. doi request reprint Factors associated with survival following blunt chest trauma in older patients: results from a large regional trauma cooperative
    David T Harrington
    Department of Surgery, Rhode Island Hospital, Warren Alpert Medical School, Brown University, Providence, RI 02903, USA
    Arch Surg 145:432-7. 2010
    ..We hypothesized that patient factors, injury patterns, and therapeutic interventions influence outcomes among older patients incurring traumatic chest injuries...
  73. ncbi request reprint Mortality prediction of head Abbreviated Injury Score and Glasgow Coma Scale: analysis of 7,764 head injuries
    Demetrios Demetriades
    Division of Trauma and SICU, Department of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    J Am Coll Surg 199:216-22. 2004
    ..We assessed the prognostic value and limitations of Glasgow Coma Scale (GCS) and head Abbreviated Injury Score (AIS) and correlated head AIS with GCS...
  74. pmc Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-regulated kinase 1/2
    Eugene Y Fukudome
    Department of Surgery, Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    J Surg Res 163:118-26. 2010
    ..Here we have investigated the effects of VPA treatment on extracellular signal-regulated kinase 1/2 (ERK) activation, as ERK is well known to modulate cell death, gene expression, and inflammation...
  75. ncbi request reprint A prospective study of post-traumatic biliary and pancreatic fistuli. The role of expectant management
    Pantelis Vassiliu
    Department of Surgery, Division of Trauma and Critical Care at Los Angeles County and University of Southern California Medical Center, Los Angeles, CA 90033, USA
    Injury 35:223-7. 2004
    ..The objective of this prospective study is to evaluate the clinical course and efficacy of non-operative treatment of biliary fistuli (BF) and pancreatic fistuli (PF) post-traumatic fistulae...
  76. doi request reprint Adhesional small bowel obstruction in the absence of previous operations: management and outcomes
    Muhammad U Butt
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Suite 810, Boston, MA 02114, USA
    World J Surg 33:2368-71. 2009
    ..Our objective was to describe the management, findings, and outcomes of unexplained adhesional SBO (UA-SBO) and examine whether preoperative diagnostic uncertainty leads to delays in therapy and complications...
  77. doi request reprint Clinical clearance of the cervical spine in blunt trauma patients younger than 3 years: a multi-center study of the american association for the surgery of trauma
    Rafael Pieretti-Vanmarcke
    Department of Pediatric Surgery, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Trauma 67:543-9; discussion 549-50. 2009
    ..We examined whether simple clinical criteria can be used to safely rule out CSI in patients younger than 3 years...
  78. ncbi request reprint [Technology of the future applied to the present: Life Support for Trauma and Transport (LSTAT)]
    Patrizio Petrone
    Division of Trauma Surgery and Critical Care, Department of Surgery, University of Southern California Keck School of Medicine, LAC USC Medical Center, Los Angeles, USA
    Cir Esp 78:198-201. 2005
    ....
  79. pmc Histone deacetylase inhibitors enhance endothelial cell sprouting angiogenesis in vitro
    Guang Jin
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Surgery 150:429-35. 2011
    ..Because HDACi can modulate expression of various genes involved in angiogenic activity, we investigated the effect of these agents on capillary-like sprout formation in this study...
  80. doi request reprint Diagnosis of necrotizing soft tissue infections by computed tomography
    Nikos Zacharias
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, 165 Cambridge St, Ste 810, Boston, MA 02114, USA
    Arch Surg 145:452-5. 2010
    ..In contrast to previous beliefs, we hypothesize that computed tomography (CT) scanning is sensitive and specific for the diagnosis of necrotizing soft tissue infections (NSTIs)...
  81. ncbi request reprint Outcome and prognostic factors in head injuries with an admission Glasgow Coma Scale score of 3
    Demetrios Demetriades
    Division of Trauma, Surgical Intensive Care Unit, Los Angeles County, and University of Southern California Medical Center, Los Angeles, CA 90033, USA
    Arch Surg 139:1066-8. 2004
    ..To identify significant risk factors associated with mortality in patients with a Glasgow Coma Scale score of 3...
  82. ncbi request reprint Computed tomography for evaluation of mild to moderate pediatric trauma: are we overusing it?
    Anurag Jindal
    Division of Trauma and Critical Care, Department of Surgery, University of Southern California and LAC USC Medical Center, 1200 North State Street, Room 9900, Los Angeles, CA 90033, USA
    World J Surg 26:13-6. 2002
    ..It was concluded that a liberal policy of CT scanning for pediatric patients with a low ISS leads to increased resource consumption with no obvious diagnostic or treatment benefit...
  83. ncbi request reprint Day for night: should we staff a trauma center like a nightclub?
    Ian C Carmody
    Division of Trauma and Critical Care, Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Am Surg 68:1048-51. 2002
    ..None of the six comparisons showed a significant difference in mortality. There was no significant difference in ISS-matched mortality related to fixed trauma call staffing...
  84. doi request reprint Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition
    Yongqing Li
    Department of Surgery, Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 64:863-70; discussion 870-1. 2008
    ..In the present study, neurons were subjected to severe hypoxic condition in vitro to test whether VPA would prevent hypoxia-induced apoptosis, and to explore the possible mechanisms...
  85. doi request reprint Colovesical fistula repair: is early Foley catheter removal safe?
    Marc A de Moya
    Division of Trauma, Emergency Surgery and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Surg Res 156:274-7. 2009
    ..late removal of the Foley catheter after CVF repair secondary to diverticulitis. Our hypothesis was that early Foley catheter removal is not associated with increased complications, and postoperative cystogram is of low value...
  86. doi request reprint Two routine blood tests-mean corpuscular volume and aspartate aminotransferase-as predictors of delirium tremens in trauma patients
    John K Findley
    Division of Trauma, Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 69:199-201. 2010
    ..This study examines the predictive ability of these two readily available biological markers...
  87. ncbi request reprint Impact of resuscitation strategies on the acetylation status of cardiac histones in a swine model of hemorrhage
    Hasan B Alam
    Trauma Research and Readiness Institute for Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, United States
    Resuscitation 76:299-310. 2008
    ....
  88. ncbi request reprint Handsewn versus stapled anastomosis in penetrating colon injuries requiring resection: a multicenter study
    Demetrios Demetriades
    Los Angeles County and University of Southern California Trauma Center, Los Angeles, California, USA
    J Trauma 52:117-21. 2002
    ..The purpose of this study was to compare stapled with handsewn colonic anastomosis following penetrating trauma...
  89. doi request reprint Difficulties in managing the surgical patient who is morbidly obese
    David R King
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Crit Care Med 38:S478-82. 2010
    ..Where good data exist, however, one should consider carefully and individually deviation from the evidence-based approach...
  90. doi request reprint The effect of cumulative length of hospital stay on the antifungal resistance of Candida strains isolated from critically ill surgical patients
    Themistoklis K Kourkoumpetis
    Department of Medicine, Infectious Disease Division, Massachusetts General Hospital, Harvard Medical School, Gray Jackson 504, 55 Fruit St, Boston, MA 02114, USA
    Mycopathologia 171:85-91. 2011
    ..Clinicians should consider the duration of previous hospital stay when deciding on empiric antifungal therapy...
  91. ncbi request reprint Nonoperative management of blunt renal trauma: a prospective study
    Konstantinos G Toutouzas
    Division of Trauma and Critical Care, Department of Surgery, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA
    Am Surg 68:1097-103. 2002
    ..Predictors of failure may exist on the basis of injury severity, fluid and blood requirements, and abdominal ultrasonographic findings and need validation by a larger sample size...
  92. ncbi request reprint Diagnostic peritoneal aspiration--the foster child of DPL: a prospective observational study
    Eric J Kuncir
    Division of Trauma and Critical Care, Department of Surgery, University of Southern California, Los Angeles County and University of Southern California Medical Center, Los Angeles, CA, USA
    Int J Surg 5:167-71. 2007
    ..We hypothesized that Diagnostic Peritoneal Aspiration (DPA), without a full lavage, accurately detects intraperitoneal blood if present in sufficient volume to cause hypotension and warrant emergent operation...
  93. ncbi request reprint Is contrast as bad as we think? Renal function after angiographic embolization of injured patients
    Pantelis Vassiliu
    Division of Trauma and Critical Care, Keck School of Medicine, University of Southern California, Los Angeles, USA
    J Am Coll Surg 194:142-6. 2002
    ..Angiographic embolization (AE) is increasingly used to control bleeding after severe trauma. Serious concerns have been raised about the safety of high-volume i.v. contrast in hypotensive, hypovolemic patients...
  94. doi request reprint Development and testing of freeze-dried plasma for the treatment of trauma-associated coagulopathy
    Fahad Shuja
    Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    J Trauma 65:975-85. 2008
    ..Development of shelf-stable, easy to use, low volume, lyophilized, Freeze-Dried Plasma (FDP) can overcome the logistical limitations. We hereby report the development and testing of such a product...
  95. ncbi request reprint Bullets and biliptysis
    John J Nigro
    Department of Cardiothoracic Surgery, Keck School of Medicine, University of Southern California, Los Angeles County University of Southern California Medical Center, 90033, USA
    Ann Thorac Surg 73:1645-7. 2002
    ..We report a bronchial biliary fistula resulting from penetrating thoracoabdominal trauma and the use of positive-pressure ventilation to obtain initial fistula control prior to definitive surgical repair...
  96. ncbi request reprint Severe trauma is not an excuse for prolonged antibiotic prophylaxis
    George C Velmahos
    Division of Trauma and Critical Care, Department of Surgery, University of Southern California and Los Angeles County USC Medical Center, 1200 N State St, Room 9900, Los Angeles, CA 90033, USA
    Arch Surg 137:537-41; discussion 541-2. 2002
    ..For critically injured patients, a limited course of antibiotics is as effective as a prolonged course in preventing sepsis and organ failures...
  97. ncbi request reprint Leukocytosis after posttraumatic splenectomy: a physiologic event or sign of sepsis?
    Konstantinos G Toutouzas
    Department of Surgery, University of Southern California, Keck School of Medicine, Los Angeles, USA
    Arch Surg 137:924-8; discussion 928-9. 2002
    ..Although elevations in white blood cell count (WBC) and platelet count (PC) after splenectomy for trauma constitute a physiologic event, certain WBC and PC patterns help differentiate patients with from those without sepsis...
  98. ncbi request reprint Imipenem levels are not predictable in the critically ill patient
    Howard Belzberg
    Department of Surgery, Los Angeles County and University of Southern California Medical Center, 90033, USA
    J Trauma 56:111-7. 2004
    ..Critically ill patients often demonstrate extremely unusual volumes of distribution (Vd) and half-lives (t1/2) of drugs. Imipenem is a widely used antibiotic in critically ill patients...
  99. ncbi request reprint Early discharge after nonoperative management for splenic injuries: increased patient risk caused by late failure?
    Robert S Crawford
    Division of Trauma, Emergency Surgery, and Surgical Critical Care, Department of Surgery, Harvard Medical School, Boston, MA 02114, USA
    Surgery 142:337-42. 2007
    ..To evaluate if blunt trauma patients managed by NOMSI can be safely discharged early, because failure after the third day from injury occurs infrequently and is not associated with added morbidity...
  100. ncbi request reprint Angiographic embolization for pelvic fractures in older patients
    Brian J Kimbrell
    Division of Trauma and Surgical Critical Care, University of Southern California and the Los Angeles County and University of Southern California Medical Center, Los Angeles, Calif 90033, USA
    Arch Surg 139:728-32; discussion 732-3. 2004
    ..Old age predicts reliably the presence of pelvic bleeding, requiring angiographic embolization (AE) among blunt trauma patients with major pelvic fractures...
  101. ncbi request reprint All patients with truncal gunshot wounds deserve trauma team activation
    Jack Sava
    Division of Trauma and Critical Care, Department of Surgery, University of Southern California Keck School of Medicine and the Los Angeles County University of Southern California Medical Center, Los Angeles, California 90033, USA
    J Trauma 52:276-9. 2002
    ..To validate this suggestion, we reviewed records of patients with GSWT to see if patients not meeting standard TTA criteria had serious injuries that would benefit from TTA...