Elsa F Velazquez

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm
    Elsa F Velazquez
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02445, USA
    Am J Surg Pathol 32:974-9. 2008
  2. ncbi Desmoplastic/spindle cell squamous cell carcinoma of the skin. A diagnostically challenging tumor mimicking a scar: clinicopathologic and immunohistochemical study of 6 cases
    Elsa F Velazquez
    Departments of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Dermatopathol 32:333-9. 2010
  3. ncbi Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007)
    Elsa F Velazquez
    Pathology Department, Harvard Medical School, Boston, Massachusetts, USA
    Anal Quant Cytol Histol 29:185-98. 2007
  4. ncbi Clinical relevance of neutral endopeptidase (NEP/CD10) in melanoma
    Elsa F Velazquez
    Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA
    J Transl Med 5:2. 2007
  5. ncbi Positive resection margins in partial penectomies: sites of involvement and proposal of local routes of spread of penile squamous cell carcinoma
    Elsa F Velazquez
    New York University Medical Center, Department of Pathology, New York, NY 10016, USA
    Am J Surg Pathol 28:384-9. 2004
  6. ncbi Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: a report of 89 cases
    Elsa F Velazquez
    Department of Pathology, New York University Medical Center, New York, NY 10016, USA
    Mod Pathol 18:917-23. 2005
  7. ncbi Distinctive immunohistochemical profile of penile intraepithelial lesions: a study of 74 cases
    Alcides Chaux
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore MD, USA
    Am J Surg Pathol 35:553-62. 2011
  8. ncbi Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma
    Elsa F Velazquez
    New York University Medical Center, NY, USA
    Int J Surg Pathol 12:139-46. 2004
  9. ncbi Immunity to the melanoma inhibitor of apoptosis protein (ML-IAP; livin) in patients with malignant melanoma
    Jun Zhou
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Immunol Immunother 61:655-65. 2012
  10. ncbi Histologic classification of penile intraepithelial neoplasia
    Elsa F Velazquez
    Caris Life Sciences, Newton, Massachusetts, USA
    Semin Diagn Pathol 29:96-102. 2012

Collaborators

Detail Information

Publications25

  1. ncbi Histologic grade and perineural invasion are more important than tumor thickness as predictor of nodal metastasis in penile squamous cell carcinoma invading 5 to 10 mm
    Elsa F Velazquez
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02445, USA
    Am J Surg Pathol 32:974-9. 2008
    ..The probability of inguinal node metastasis in patients with grade 1 tumors without perineural invasion is almost nonexistent whereas for high-grade tumors associated with perineural invasion is near 80%...
  2. ncbi Desmoplastic/spindle cell squamous cell carcinoma of the skin. A diagnostically challenging tumor mimicking a scar: clinicopathologic and immunohistochemical study of 6 cases
    Elsa F Velazquez
    Departments of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Am J Dermatopathol 32:333-9. 2010
    ..Careful search for atypical features and squamous differentiation, immunohistochemical studies, and, in some cases, deeper sections are required to establish the diagnosis...
  3. ncbi Penile squamous cell carcinoma: anatomic, pathologic and viral studies in Paraguay (1993-2007)
    Elsa F Velazquez
    Pathology Department, Harvard Medical School, Boston, Massachusetts, USA
    Anal Quant Cytol Histol 29:185-98. 2007
    ..Probable precursor lesions of penile carcinoma include squamous hyperplasia, low and high grade squamous intraepithelial neoplasia and lichen sclerosus...
  4. ncbi Clinical relevance of neutral endopeptidase (NEP/CD10) in melanoma
    Elsa F Velazquez
    Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA
    J Transl Med 5:2. 2007
    ..We investigated the role of NEP expression in the clinical progression of cutaneous melanoma...
  5. ncbi Positive resection margins in partial penectomies: sites of involvement and proposal of local routes of spread of penile squamous cell carcinoma
    Elsa F Velazquez
    New York University Medical Center, Department of Pathology, New York, NY 10016, USA
    Am J Surg Pathol 28:384-9. 2004
    ....
  6. ncbi Epithelial abnormalities and precancerous lesions of anterior urethra in patients with penile carcinoma: a report of 89 cases
    Elsa F Velazquez
    Department of Pathology, New York University Medical Center, New York, NY 10016, USA
    Mod Pathol 18:917-23. 2005
    ..Keratinizing and hyperplastic squamous metaplasias may be important in the pathogenesis of special types of penile carcinomas such as verrucous carcinoma...
  7. ncbi Distinctive immunohistochemical profile of penile intraepithelial lesions: a study of 74 cases
    Alcides Chaux
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore MD, USA
    Am J Surg Pathol 35:553-62. 2011
    ..The use of a triple p16/p53/Ki-67 immunohistochemical panel was found to be helpful in the classification, differential diagnosis, and morphologic standardization of penile intraepithelial lesions...
  8. ncbi Limitations in the interpretation of biopsies in patients with penile squamous cell carcinoma
    Elsa F Velazquez
    New York University Medical Center, NY, USA
    Int J Surg Pathol 12:139-46. 2004
    ....
  9. ncbi Immunity to the melanoma inhibitor of apoptosis protein (ML-IAP; livin) in patients with malignant melanoma
    Jun Zhou
    Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA
    Cancer Immunol Immunother 61:655-65. 2012
    ..High frequency immune responses in melanoma patients, associations with favorable treatment outcomes, and its essential role in melanoma pathogenesis support the development of ML-IAP as a disease marker and therapeutic target...
  10. ncbi Histologic classification of penile intraepithelial neoplasia
    Elsa F Velazquez
    Caris Life Sciences, Newton, Massachusetts, USA
    Semin Diagn Pathol 29:96-102. 2012
    ..It takes into account the similarities between vulvar and penile pathology and the hypothesis of a bimodal pathway of penile cancer progression...
  11. ncbi Expression of the cancer/testis antigen NY-ESO-1 in primary and metastatic malignant melanoma (MM)--correlation with prognostic factors
    Elsa F Velazquez
    Ronald O Perelman Department of Dermatology, New York University School of Medicine, New York, NY 10016, USA
    Cancer Immun 7:11. 2007
    ..Our study suggests that patients with metastatic MM who express NY-ESO-1 may benefit from NY-ESO-1-based immunotherapy...
  12. ncbi Sarcomatoid carcinoma of the penis: a clinicopathologic study of 15 cases
    Elsa F Velazquez
    Department of Dermatology, New York University Medical Center, New York, NY 10016, USA
    Am J Surg Pathol 29:1152-8. 2005
    ..Diffuse immunoreactivity for p53, compared with a more basal and focal reactivity in differentiated squamous cell carcinoma, may be indicative of a late mutation in the natural progression of the disease...
  13. ncbi New pathologic entities in penile carcinomas: an update of the 2004 world health organization classification
    Alcides Chaux
    Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Semin Diagn Pathol 29:59-66. 2012
    ..In this review special emphasis is given to the differential diagnosis of these special variants with a discussion of the possible implications for clinical management...
  14. ncbi CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNS
    F Stephen Hodi
    Melanoma Program, Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Nat Clin Pract Oncol 5:557-61. 2008
    ..MRI of the spine and brain revealed multiple metastases. The patient received ipilimumab and after 3 months experienced intermittent confusion and focal seizures...
  15. ncbi Histopathologic spectrum of psoriasiform skin reactions associated with tumor necrosis factor-α inhibitor therapy. A study of 16 biopsies
    Alvaro C Laga
    Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Dermatopathol 32:568-73. 2010
    ..Because the different histopathologic findings may be subtle, clinical correlation is crucial to make the diagnosis...
  16. ncbi Lichen sclerosus in 68 patients with squamous cell carcinoma of the penis: frequent atypias and correlation with special carcinoma variants suggests a precancerous role
    Elsa F Velazquez
    Department of Pathology, New York University Medical Center, New York, USA
    Am J Surg Pathol 27:1448-53. 2003
    ..These findings suggest that lichen sclerosus may represent preneoplastic condition for at least some types of penile cancers, in particular those not related to human papillomavirus...
  17. ncbi Expression of the embryonic stem cell transcription factor SOX2 in human skin: relevance to melanocyte and merkel cell biology
    Alvaro C Laga
    Department of Pathology, Program in Dermatopathology, Boston, MA 02115, USA
    Am J Pathol 176:903-13. 2010
    ..In aggregate, these findings suggest that SOX2 is a novel biomarker for subpopulations of normal skin cells that reside in established stem cell niches and that might relate to Merkel cell and melanocyte ontogeny and tumorigenesis...
  18. ncbi Infectious granulomatous dermatitis associated with Rothia mucilaginosa bacteremia: A case report
    Elizabeth A Morgan
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Dermatopathol 32:175-9. 2010
    ..mucilaginosa bacteremia and raises awareness of this unusual histopathological presentation in the setting of a bacterial infection affecting the skin...
  19. ncbi Major response to imatinib mesylate in KIT-mutated melanoma
    F Stephen Hodi
    The Melanoma Program, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA
    J Clin Oncol 26:2046-51. 2008
  20. ncbi Preputial variability and preferential association of long phimotic foreskins with penile cancer: an anatomic comparative study of types of foreskin in a general population and cancer patients
    Elsa F Velazquez
    Department of Pathology, New York University Medical Center, New York, NY 10016, USA
    Am J Surg Pathol 27:994-8. 2003
    ..For these reasons we support preventive circumcision in patients with long and phimotic foreskins living in high-risk areas. Cancers not related to long foreskins and phimosis may be causally different...
  21. ncbi Aluminum granuloma after administration of the quadrivalent human papillomavirus vaccine. Report of a case
    Derek K Marsee
    Department of Pathology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Am J Dermatopathol 30:622-4. 2008
    ..Aluminum granulomas should be included in the differential diagnosis of deep granulomatous reaction in young women, due to the high frequency of vaccination in this population...
  22. ncbi Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells
    Marcus O Butler
    Department of Medical Oncology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA
    Sci Transl Med 3:80ra34. 2011
    ..Therefore, this approach may broaden the availability of adoptive cell therapy to patients both alone and in combination with other therapeutic modalities...
  23. ncbi Carcinoma cuniculatum: a distinctive variant of penile squamous cell carcinoma: report of 7 cases
    Jose E Barreto
    Instituto de Patologia e Investigacion and Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Asuncion, Paraguay
    Am J Surg Pathol 31:71-5. 2007
    ..Unlike most subtypes of penile SCCs and despite the deep invasion, none of the tumors showed groin or systemic dissemination at time of diagnosis...
  24. ncbi Epithelial lesions associated with invasive penile squamous cell carcinoma: a pathologic study of 288 cases
    Antonio L Cubilla
    Instituto de Patologia e Investigacion, Facultad de Ciencias Medicas, Universidad Nacional de Asuncion, Paraguay
    Int J Surg Pathol 12:351-64. 2004
    ..The association and histologic similarities between high-grade SIL of the basaloid, warty, or mixed forms with their invasive counterparts indicate these lesions are their likely precursors...
  25. ncbi Pseudohyperplastic squamous cell carcinoma of the penis associated with lichen sclerosus. An extremely well-differentiated, nonverruciform neoplasm that preferentially affects the foreskin and is frequently misdiagnosed: a report of 10 cases of a distinct
    Antonio L Cubilla
    , Asuncion, Paraguay
    Am J Surg Pathol 28:895-900. 2004
    ..Because it was present in all cases, lichen sclerosus may play a precancerous role...