Genomes and Genes
Affiliation: Massachusetts General Hospital
- Mechanical stretch and PI3K signaling link cell migration and proliferation to coordinate epithelial tubule morphogenesis in the zebrafish pronephrosAleksandr Vasilyev
Department of Pathology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
PLoS ONE 7:e39992. 2012....
- Fluid flow and guidance of collective cell migrationAleksandr Vasilyev
Pathology Department, Massachusetts General Hospital, Charlestown, MA, USA
Cell Adh Migr 4:353-7. 2010..Intratubular migration leads to significant changes in kidney morphology. This novel process provides a powerful in vivo model for further exploration of the mechanisms underlying mechanotransduction and collective migration...
- odd skipped related1 reveals a novel role for endoderm in regulating kidney versus vascular cell fateSudha P Mudumana
Nephrology Division, Massachusetts General Hospital, Charlestown, MA 02129, USA
Development 135:3355-67. 2008....
- The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formationSteve Mangos
Massachusetts General Hospital, Department of Medicine, Nephrology Division, and Harvard Medical School Department of Genetics, Charlestown, MA 02129, USA
Dis Model Mech 3:354-65. 2010..Our results suggest that pkd1a/b and pkd2 interact to regulate ECM secretion or assembly, and that altered matrix integrity may be a primary defect underlying ADPKD tissue pathologies...
- Collective cell migration drives morphogenesis of the kidney nephronAleksandr Vasilyev
Nephrology Division, Massachusetts General Hospital, Charlestown, Massachusetts, USA
PLoS Biol 7:e9. 2009..Our results establish intimate links between nephron function, fluid flow, and morphogenesis...
- Live imaging kidney development in zebrafishAleksandr Vasilyev
Nephrology Division and Department of Pathology, Charlestown, MA, USA
Methods Mol Biol 886:55-70. 2012..Here, we describe a simple procedure that can be used by laboratories to investigate the development of zebrafish kidney and other organs by time-lapse microscopy...