Matthew G Vander Heiden

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
    Dimitrios Anastasiou
    Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Nat Chem Biol 8:839-47. 2012
  2. pmc Exploiting tumor metabolism: challenges for clinical translation
    Matthew G Vander Heiden
    Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 123:3648-51. 2013
  3. ncbi Metabolic pathway alterations that support cell proliferation
    M G Vander Heiden
    Massachusetts Institute of Technology, Koch Institute for Cancer Research and Department of Biology, Cambridge, Massachusetts 02139, USA
    Cold Spring Harb Symp Quant Biol 76:325-34. 2011
  4. doi Targeting cancer metabolism: a therapeutic window opens
    Matthew G Vander Heiden
    Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Rev Drug Discov 10:671-84. 2011
  5. pmc Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
    Sarah Maria Fendt
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Commun 4:2236. 2013
  6. ncbi Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of Mammalian cells
    Caroline A Lewis
    The Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 55:253-63. 2014
  7. pmc Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
    Sarah Maria Fendt
    Departments of Chemical Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA02139, USA
    Cancer Res 73:4429-38. 2013
  8. ncbi IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism
    Alexandra R Grassian
    Authors Affiliations Novartis Institutes for Biomedical Research Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts Departments of Bioengineering and Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, California
    Cancer Res 74:3317-31. 2014
  9. pmc PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
    William J Israelsen
    Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 155:397-409. 2013
  10. ncbi Allosteric regulation of PKM2 allows cellular adaptation to different physiological states
    Dan Y Gui
    Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Signal 6:pe7. 2013

Collaborators

  • Christian M Metallo
  • Shunqi Yan
  • Anne N Murphy
  • Hong Yin
  • Lenny Dang
  • Hua Yang
  • Yimin Yu
  • Wei Liu
  • Sarah Maria Fendt
  • Alfredo Csibi
  • Richard G Kibbey
  • Othon Iliopoulos
  • Laura N Burga
  • Jie Li
  • Fan Jiang
  • Gordon B Mills
  • Dolores Di Vizio
  • Gerburg M Wulf
  • Karsten Hiller
  • L C Cantley
  • Caroline A Lewis
  • Dan Y Gui
  • Shawn M Davidson
  • Brian P Fiske
  • William J Israelsen
  • Charles Kung
  • Sophia Y Lunt
  • Seth J Parker
  • Courtney R Green
  • Alexandra R Grassian
  • Benjamin A Olenchock
  • Dimitrios Anastasiou
  • Kaiko Kunii
  • Francesco G Salituro
  • Shengfang Jin
  • Fallon Lin
  • Douglas McCloskey
  • Adam M Feist
  • Joseph D Growney
  • Erika D Handly
  • Franklin Chung
  • Christopher Straub
  • Xiamei Zhang
  • Natalie I Vokes
  • Ajit S Divakaruni
  • Chad Vickers
  • Minying Pu
  • Raymond Pagliarini
  • Carol Joud-Caldwell
  • Kelly L Slocum
  • Gary Bellinger
  • Mika Sasaki
  • James W Horner
  • Tyler Jacks
  • Ronald A Depinho
  • Jianxin Xie
  • Michael J Jurczak
  • Aaron M Hosios
  • Talya L Dayton
  • Clary B Clish
  • Erin Murphy
  • Jeff Hixon
  • Douglas S Auld
  • Henrike Veith
  • Kevin Qian
  • Cheng Fang
  • Katharine Yen
  • Kevin Marks
  • Martin J Walsh
  • James Inglese
  • Gregory Stephanopoulos
  • William Leister
  • Shalini Sethumadhavan
  • Zachary R Johnson
  • Ed Driggers
  • Scott Malstrom
  • Noel Southall
  • Giovanni Cianchetta
  • Hee Won Park
  • Christopher P Austin
  • Sung Choe
  • Marian H Harris
  • Wentao Wei
  • Bum Soo Hong
  • Jeff Saunders
  • Yi Gao
  • Jian Kang Jiang
  • Shinsan M Su
  • Tahsin M Khan
  • Katherine R Mattaini

Detail Information

Publications14

  1. pmc Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
    Dimitrios Anastasiou
    Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Nat Chem Biol 8:839-47. 2012
    ..These data support the notion that small-molecule activation of PKM2 can interfere with anabolic metabolism...
  2. pmc Exploiting tumor metabolism: challenges for clinical translation
    Matthew G Vander Heiden
    Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 123:3648-51. 2013
    ..Emerging biomarker strategies to guide drug development are also highlighted. ..
  3. ncbi Metabolic pathway alterations that support cell proliferation
    M G Vander Heiden
    Massachusetts Institute of Technology, Koch Institute for Cancer Research and Department of Biology, Cambridge, Massachusetts 02139, USA
    Cold Spring Harb Symp Quant Biol 76:325-34. 2011
    ..Together, these findings argue that distinct metabolic phenotypes exist among proliferating cells, and both genetic and environmental factors influence how metabolism is regulated to support cell growth...
  4. doi Targeting cancer metabolism: a therapeutic window opens
    Matthew G Vander Heiden
    Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Rev Drug Discov 10:671-84. 2011
    ..Research into how changes in cell metabolism promote tumour growth has accelerated in recent years. This has refocused efforts to target metabolic dependencies of cancer cells as a selective anticancer strategy...
  5. pmc Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
    Sarah Maria Fendt
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Commun 4:2236. 2013
    ..Thus, targeting reductive glutamine conversion for a therapeutic benefit might require distinct modulations of metabolite concentrations rather than targeting the upstream signalling, which only indirectly affects the process. ..
  6. ncbi Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of Mammalian cells
    Caroline A Lewis
    The Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mol Cell 55:253-63. 2014
    ..Using this system we determine the direction of serine/glycine interconversion within the mitochondria and cytosol, highlighting the ability of this approach to resolve compartmentalized reactions in intact cells. ..
  7. pmc Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
    Sarah Maria Fendt
    Departments of Chemical Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA02139, USA
    Cancer Res 73:4429-38. 2013
    ..These data suggest that interfering with glutamine may synergize with metformin to improve outcomes in patients with prostate cancer...
  8. ncbi IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism
    Alexandra R Grassian
    Authors Affiliations Novartis Institutes for Biomedical Research Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts Departments of Bioengineering and Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, California
    Cancer Res 74:3317-31. 2014
    ..Lastly, IDH1-mutant cells also grew poorly as subcutaneous xenografts within a hypoxic in vivo microenvironment. Together, our results suggest therapeutic opportunities to exploit the metabolic vulnerabilities specific to IDH1 mutation...
  9. pmc PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
    William J Israelsen
    Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 155:397-409. 2013
    ..These data suggest that regulation of PKM2 activity supports the different metabolic requirements of proliferating and nonproliferating tumor cells...
  10. ncbi Allosteric regulation of PKM2 allows cellular adaptation to different physiological states
    Dan Y Gui
    Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Signal 6:pe7. 2013
    ..These findings add additional complexity to how PKM2 is regulated in cells and support the notion that modulating PKM2 activity enables cells to adapt their metabolic state to specific physiological contexts...
  11. doi Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    Sophia Y Lunt
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Cell Dev Biol 27:441-64. 2011
    ....
  12. pmc Small molecule activation of PKM2 in cancer cells induces serine auxotrophy
    Charles Kung
    Agios Pharmaceuticals, 38 Sidney Street, Cambridge, MA 02139, USA
    Chem Biol 19:1187-98. 2012
    ..These data support the hypothesis that PKM2 expression confers metabolic flexibility to cancer cells that allows adaptation to nutrient stress...
  13. pmc Pyruvate as a pivot point for oncogene-induced senescence
    Benjamin A Olenchock
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 153:1429-30. 2013
    ..A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically. ..
  14. pmc Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    Christian M Metallo
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 481:380-4. 2012
    ..These results identify a critical role for oxygen in regulating carbon use to produce AcCoA and support lipid synthesis in mammalian cells...