Matthew G Vander Heiden

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. pmc Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
    Dimitrios Anastasiou
    Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Nat Chem Biol 8:839-47. 2012
  2. pmc Exploiting tumor metabolism: challenges for clinical translation
    Matthew G Vander Heiden
    Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 123:3648-51. 2013
  3. ncbi Metabolic pathway alterations that support cell proliferation
    M G Vander Heiden
    Massachusetts Institute of Technology, Koch Institute for Cancer Research and Department of Biology, Cambridge, Massachusetts 02139, USA
    Cold Spring Harb Symp Quant Biol 76:325-34. 2011
  4. doi Targeting cancer metabolism: a therapeutic window opens
    Matthew G Vander Heiden
    Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Rev Drug Discov 10:671-84. 2011
  5. pmc Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
    Sarah Maria Fendt
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Commun 4:2236. 2013
  6. pmc Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
    Sarah Maria Fendt
    Departments of Chemical Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA02139, USA
    Cancer Res 73:4429-38. 2013
  7. pmc PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
    William J Israelsen
    Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 155:397-409. 2013
  8. ncbi Allosteric regulation of PKM2 allows cellular adaptation to different physiological states
    Dan Y Gui
    Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Signal 6:pe7. 2013
  9. doi Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    Sophia Y Lunt
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Cell Dev Biol 27:441-64. 2011
  10. pmc Small molecule activation of PKM2 in cancer cells induces serine auxotrophy
    Charles Kung
    Agios Pharmaceuticals, 38 Sidney Street, Cambridge, MA 02139, USA
    Chem Biol 19:1187-98. 2012

Collaborators

  • Wei Liu
  • Yimin Yu
  • Hua Yang
  • Lenny Dang
  • Shunqi Yan
  • Alfredo Csibi
  • Richard G Kibbey
  • Sarah Maria Fendt
  • Othon Iliopoulos
  • Laura N Burga
  • Christian M Metallo
  • Jie Li
  • Fan Jiang
  • Gordon B Mills
  • Dolores Di Vizio
  • Gerburg M Wulf
  • Karsten Hiller
  • L C Cantley
  • William J Israelsen
  • Charles Kung
  • Sophia Y Lunt
  • Benjamin A Olenchock
  • Dan Y Gui
  • Brian P Fiske
  • Shawn M Davidson
  • Dimitrios Anastasiou
  • Kaiko Kunii
  • Francesco G Salituro
  • Shengfang Jin
  • Gary Bellinger
  • Mika Sasaki
  • James W Horner
  • Michael J Jurczak
  • Aaron M Hosios
  • Talya L Dayton
  • Clary B Clish
  • Tyler Jacks
  • Caroline A Lewis
  • Ronald A Depinho
  • Jianxin Xie
  • Erin Murphy
  • Jian Kang Jiang
  • Shinsan M Su
  • Jeff Hixon
  • Tahsin M Khan
  • Katherine R Mattaini
  • Kyle R Brimacombe
  • Douglas S Auld
  • Henrike Veith
  • Kevin Qian
  • Byron DeLaBarre
  • Cheng Fang
  • Katharine Yen
  • Kevin Marks
  • Abhishek Jha
  • Martin J Walsh
  • Svetoslav Dimov
  • James Inglese
  • Gregory Stephanopoulos
  • Shaohui Wang
  • William Leister
  • Wolfram Tempel
  • Shalini Sethumadhavan
  • Kevin D Courtney
  • Zachary R Johnson
  • Ed Driggers
  • Stuart Murray
  • Scott Malstrom
  • Hin Koon Woo
  • Heather R Christofk
  • Noel Southall
  • Giovanni Cianchetta
  • Hee Won Park
  • Min Shen
  • Christopher P Austin
  • Stefan Gross
  • Craig J Thomas
  • John M Asara
  • Matthew B Boxer
  • Sung Choe
  • Marian H Harris
  • Xiling Wang
  • Amanda P Skoumbourdis
  • Wentao Wei
  • Bum Soo Hong
  • Jeff Saunders
  • Yi Gao
  • Katharine E Yen

Detail Information

Publications12

  1. pmc Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
    Dimitrios Anastasiou
    Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Nat Chem Biol 8:839-47. 2012
    ..These data support the notion that small-molecule activation of PKM2 can interfere with anabolic metabolism...
  2. pmc Exploiting tumor metabolism: challenges for clinical translation
    Matthew G Vander Heiden
    Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Clin Invest 123:3648-51. 2013
    ..Emerging biomarker strategies to guide drug development are also highlighted. ..
  3. ncbi Metabolic pathway alterations that support cell proliferation
    M G Vander Heiden
    Massachusetts Institute of Technology, Koch Institute for Cancer Research and Department of Biology, Cambridge, Massachusetts 02139, USA
    Cold Spring Harb Symp Quant Biol 76:325-34. 2011
    ..Together, these findings argue that distinct metabolic phenotypes exist among proliferating cells, and both genetic and environmental factors influence how metabolism is regulated to support cell growth...
  4. doi Targeting cancer metabolism: a therapeutic window opens
    Matthew G Vander Heiden
    Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Rev Drug Discov 10:671-84. 2011
    ..Research into how changes in cell metabolism promote tumour growth has accelerated in recent years. This has refocused efforts to target metabolic dependencies of cancer cells as a selective anticancer strategy...
  5. pmc Reductive glutamine metabolism is a function of the α-ketoglutarate to citrate ratio in cells
    Sarah Maria Fendt
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Nat Commun 4:2236. 2013
    ..Thus, targeting reductive glutamine conversion for a therapeutic benefit might require distinct modulations of metabolite concentrations rather than targeting the upstream signalling, which only indirectly affects the process. ..
  6. pmc Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism
    Sarah Maria Fendt
    Departments of Chemical Engineering and Biology, Massachusetts Institute of Technology, Cambridge, MA02139, USA
    Cancer Res 73:4429-38. 2013
    ..These data suggest that interfering with glutamine may synergize with metformin to improve outcomes in patients with prostate cancer...
  7. pmc PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells
    William J Israelsen
    Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 155:397-409. 2013
    ..These data suggest that regulation of PKM2 activity supports the different metabolic requirements of proliferating and nonproliferating tumor cells...
  8. ncbi Allosteric regulation of PKM2 allows cellular adaptation to different physiological states
    Dan Y Gui
    Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Sci Signal 6:pe7. 2013
    ..These findings add additional complexity to how PKM2 is regulated in cells and support the notion that modulating PKM2 activity enables cells to adapt their metabolic state to specific physiological contexts...
  9. doi Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    Sophia Y Lunt
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Annu Rev Cell Dev Biol 27:441-64. 2011
    ....
  10. pmc Small molecule activation of PKM2 in cancer cells induces serine auxotrophy
    Charles Kung
    Agios Pharmaceuticals, 38 Sidney Street, Cambridge, MA 02139, USA
    Chem Biol 19:1187-98. 2012
    ..These data support the hypothesis that PKM2 expression confers metabolic flexibility to cancer cells that allows adaptation to nutrient stress...
  11. pmc Pyruvate as a pivot point for oncogene-induced senescence
    Benjamin A Olenchock
    Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 153:1429-30. 2013
    ..A new report in the journal Nature by Kaplon et al. suggests that driving pyruvate oxidation can thwart tumor growth in BRAF-driven melanoma by inducing oncogene-induced senescence, a finding that might be exploited therapeutically. ..
  12. pmc Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
    Christian M Metallo
    Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 481:380-4. 2012
    ..These results identify a critical role for oxygen in regulating carbon use to produce AcCoA and support lipid synthesis in mammalian cells...