Antonio Valencia

Summary

Affiliation: Massachusetts General Hospital
Location: Boston, USA
Publications:
1.
Reagents that block neuronal death from Huntingtons disease also curb oxidative stress.
Valencia A, Sapp E, Reeves PB, Alexander J, Masso N, Li X, Kegel KB, DiFiglia M.
Neuroreport. 2012 Jan 4;23(1):10-5.
PMID: [PubMed - in process]
Related citations

2.
Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors.
Kegel KB, Sapp E, Alexander J, Reeves P, Bleckmann D, Sobin L, Masso N, Valencia A, Jeong H, Krainc D, Palacino J, Curtis D, Kuhn R, Betschart C, Sena-Esteves M, Aronin N, Paganetti P, Difiglia M.
Mol Neurodegener. 2010 Dec 14;5:58.
PMID: [PubMed] Free PMC Article
Related citations

3.
Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntingtons disease.
Li X, Valencia A, Sapp E, Masso N, Alexander J, Reeves P, Kegel KB, Aronin N, Difiglia M.
J Neurosci. 2010 Mar 31;30(13):4552-61.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations

4.
Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity.
Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, DiFiglia M.
Mol Cell Biol. 2009 Nov;29(22):6106-16. Epub 2009 Sep 14.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Related citations

5.
Disruption of Rab11 activity in a knock-in mouse model of Huntingtons disease.
Li X, Sapp E, Chase K, Comer-Tierney LA, Masso N, Alexander J, Reeves P, Kegel KB, Valencia A, Esteves M, Aronin N, Difiglia M.
Neurobiol Dis. 2009 Nov;36(2):374-83. Epub 2009 Aug 20.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Related citations

6.
Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntingtons disease.
Valencia A, Reeves PB, Sapp E, Li X, Alexander J, Kegel KB, Chase K, Aronin N, DiFiglia M.
J Neurosci Res. 2010 Jan;88(1):179-90.
PMID: [PubMed - indexed for MEDLINE]
Related citations

7.
Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
Kegel KB, Sapp E, Alexander J, Valencia A, Reeves P, Li X, Masso N, Sobin L, Aronin N, DiFiglia M.
J Neurochem. 2009 Sep;110(5):1585-97. Epub 2009 Jun 29.
PMID: [PubMed - indexed for MEDLINE]
Related citations

8.
A function of huntingtin in guanine nucleotide exchange on Rab11.
Li X, Sapp E, Valencia A, Kegel KB, Qin ZH, Alexander J, Masso N, Reeves P, Ritch JJ, Zeitlin S, Aronin N, Difiglia M.
Neuroreport. 2008 Oct 29;19(16):1643-7.
PMID: [PubMed - indexed for MEDLINE]
Related citations

9.
Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons.
Coyoy A, Valencia A, Guemez-Gamboa A, Morán J.
Free Radic Biol Med. 2008 Oct 15;45(8):1056-64. Epub 2008 Jul 2.
PMID: [PubMed - indexed for MEDLINE]
Related citations

10.
Nox1-based NADPH oxidase is the major source of UVA-induced reactive oxygen species in human keratinocytes.
Valencia A, Kochevar IE.
J Invest Dermatol. 2008 Jan;128(1):214-22. Epub 2007 Jul 5.
PMID: [PubMed - indexed for MEDLINE] Free Article
Related citations

11.
7-Dehydrocholesterol enhances ultraviolet A-induced oxidative stress in keratinocytes: roles of NADPH oxidase, mitochondria, and lipid rafts.
Valencia A, Rajadurai A, Carle AB, Kochevar IE.
Free Radic Biol Med. 2006 Dec 1;41(11):1704-18. Epub 2006 Sep 9.
PMID: [PubMed - indexed for MEDLINE] Free PMC Article
Related citations

12.
Ultraviolet A induces apoptosis via reactive oxygen species in a model for Smith-Lemli-Opitz syndrome.
Valencia A, Kochevar IE.
Free Radic Biol Med. 2006 Feb 15;40(4):641-50. Epub 2005 Oct 25.
PMID: [PubMed - indexed for MEDLINE]
Related citations

13.
Reactive oxygen species induce different cell death mechanisms in cultured neurons.
Valencia A, Morán J.
Free Radic Biol Med. 2004 May 1;36(9):1112-25.
PMID: [PubMed - indexed for MEDLINE]
Related citations

14.
Role of ionic fluxes in the apoptotic cell death of cultured cerebellar granule neurons.
Franco-Cea A, Valencia A, Sánchez-Armass S, Domínguez G, Morán J.
Neurochem Res. 2004 Jan;29(1):227-38.
PMID: [PubMed - indexed for MEDLINE]
Related citations

15.
Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule neurons.
Valencia A, Morán J.
J Neurosci Res. 2001 May 1;64(3):284-97.
PMID: [PubMed - indexed for MEDLINE]
Related citations

16.
Effect of NMDA antagonists on the activity of glutaminase and aspartate aminotransferase in the developing rat cerebellum.
Moran J, Alavez S, Rivera-Gaxiola M, Valencia A, Hurtado S.
Int J Dev Neurosci. 1999 Feb;17(1):57-65.
PMID: [PubMed - indexed for MEDLINE]
Related citations

Publications

  1. ncbi request reprint Effect of NMDA antagonists on the activity of glutaminase and aspartate aminotransferase in the developing rat cerebellum
    J Moran
    Institute of Cell Physiology, National University of Mexico, Mexico DF
    Int J Dev Neurosci 17:57-65. 1999
  2. pmc Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
    Kimberly B Kegel
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Neurodegener 5:58. 2010
  3. pmc Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease
    Xueyi Li
    Cellular Neurobiology Laboratory and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 30:4552-61. 2010
  4. pmc Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity
    Xueyi Li
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 29:6106-16. 2009
  5. pmc Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease
    Xueyi Li
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neurobiol Dis 36:374-83. 2009
  6. doi request reprint Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease
    Antonio Valencia
    Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Neurosci Res 88:179-90. 2010
  7. doi request reprint Polyglutamine expansion in huntingtin alters its interaction with phospholipids
    Kimberly B Kegel
    Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, 11416th Street, Room 2150, Charlestown, MA 02129, USA
    J Neurochem 110:1585-97. 2009
  8. doi request reprint A function of huntingtin in guanine nucleotide exchange on Rab11
    Xueyi Li
    Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Neuroreport 19:1643-7. 2008
  9. doi request reprint Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons
    Angélica Coyoy
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, 04510 Mexico, DF, Mexico
    Free Radic Biol Med 45:1056-64. 2008
  10. ncbi request reprint Nox1-based NADPH oxidase is the major source of UVA-induced reactive oxygen species in human keratinocytes
    Antonio Valencia
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Invest Dermatol 128:214-22. 2008

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Effect of NMDA antagonists on the activity of glutaminase and aspartate aminotransferase in the developing rat cerebellum
    J Moran
    Institute of Cell Physiology, National University of Mexico, Mexico DF
    Int J Dev Neurosci 17:57-65. 1999
    ..These results support the suggestion that presynaptic influences, particularly from glutamatergic neurons, are critical to promote cerebellar granule neurons differentiation during critical periods of the cerebellar development...
  2. pmc Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors
    Kimberly B Kegel
    Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Mol Neurodegener 5:58. 2010
    ..abstract:..
  3. pmc Aberrant Rab11-dependent trafficking of the neuronal glutamate transporter EAAC1 causes oxidative stress and cell death in Huntington's disease
    Xueyi Li
    Cellular Neurobiology Laboratory and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Neurosci 30:4552-61. 2010
    ..Our data support a novel mechanism for oxidative stress in HD: Rab11 dysfunction slows trafficking of EAAC1 to the cell surface and impairs cysteine uptake, thereby leading to deficient synthesis of glutathione...
  4. pmc Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity
    Xueyi Li
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    Mol Cell Biol 29:6106-16. 2009
    ..We propose a novel mechanism for cellular dysfunction by the HD mutation arising from the inhibition of Rab11 activity and a deficit in vesicle formation at recycling endosomes...
  5. pmc Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease
    Xueyi Li
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Neurobiol Dis 36:374-83. 2009
    ..Partial rescue from glutamate-induced cell death occurred in HD neurons expressing dominant active Rab11. We propose a novel mechanism of HD pathogenesis arising from diminished Rab11 activity at recycling endosomes...
  6. doi request reprint Mutant huntingtin and glycogen synthase kinase 3-beta accumulate in neuronal lipid rafts of a presymptomatic knock-in mouse model of Huntington's disease
    Antonio Valencia
    Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    J Neurosci Res 88:179-90. 2010
    ..We speculate that accumulation of mutant huntingtin and glycogen synthase kinase 3-beta in lipid rafts of presymptomatic Huntington's disease mouse neurons contributes to neurodegeneration in Huntington's disease...
  7. doi request reprint Polyglutamine expansion in huntingtin alters its interaction with phospholipids
    Kimberly B Kegel
    Laboratory of Cellular Neurobiology, Department of Neurology, Massachusetts General Hospital, 11416th Street, Room 2150, Charlestown, MA 02129, USA
    J Neurochem 110:1585-97. 2009
    ..These data suggest that huntingtin interacts with membranes through specific phospholipid associations and that mutant huntingtin may disrupt membrane trafficking and signaling at membranes...
  8. doi request reprint A function of huntingtin in guanine nucleotide exchange on Rab11
    Xueyi Li
    Laboratory of Cellular Neurobiology and Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Neuroreport 19:1643-7. 2008
    ..These data suggest a role for huntingtin in a complex that activates Rab11...
  9. doi request reprint Role of NADPH oxidase in the apoptotic death of cultured cerebellar granule neurons
    Angélica Coyoy
    Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, 04510 Mexico, DF, Mexico
    Free Radic Biol Med 45:1056-64. 2008
    ..We conclude that ROS could be an early signal of apoptotic neuronal death and that NADPH oxidase, including NOX1, 2, and/or 4, could have a central role in apoptotic death induced by different conditions in these neurons...
  10. ncbi request reprint Nox1-based NADPH oxidase is the major source of UVA-induced reactive oxygen species in human keratinocytes
    Antonio Valencia
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Invest Dermatol 128:214-22. 2008
    ..These results indicate that UVA activates Nox1-based NADPH oxidase to produce ROS that stimulate PGE2 synthesis, and that Nox1 may be an appropriate target for agents designed to block UVA-induced skin injury...
  11. pmc 7-Dehydrocholesterol enhances ultraviolet A-induced oxidative stress in keratinocytes: roles of NADPH oxidase, mitochondria, and lipid rafts
    Antonio Valencia
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Thier 224, 55 Fruit Street, Boston, MA 02114, USA
    Free Radic Biol Med 41:1704-18. 2006
    ..These results indicate that 7-DHC enhances rapid UVA-induced ROS and PGE(2) formation by enhancing free radical-mediated membrane lipid oxidation and suggests that this mechanism might underlie the UVA photosensitivity in SLOS...
  12. ncbi request reprint Ultraviolet A induces apoptosis via reactive oxygen species in a model for Smith-Lemli-Opitz syndrome
    Antonio Valencia
    Wellman Center for Photomedicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Free Radic Biol Med 40:641-50. 2006
    ..These results support a ROS-mediated apoptotic mechanism for the enhanced UVA-induced inflammation in SLO-S patients...
  13. ncbi request reprint Reactive oxygen species induce different cell death mechanisms in cultured neurons
    Antonio Valencia
    Department of Neuroscience, Institute of Cell Physiology, National University of Mexico, Mexico City, Mexico
    Free Radic Biol Med 36:1112-25. 2004
    ..These results suggest that formation of specific ROS can lead to different molecular cell death mechanisms (necrosis and apoptosis) and that ROS formed under different conditions could act as initiators or executioners on neuronal death...
  14. ncbi request reprint Role of ionic fluxes in the apoptotic cell death of cultured cerebellar granule neurons
    A Franco-Cea
    Department of Neuroscience, Institute of Cell Physiology, National University of Mexico, Mexico City, Mexico
    Neurochem Res 29:227-38. 2004
    ..These findings suggest that pH is a condition that could contribute to the modulation of cell death induced by some stimuli and that other ions, such as potassium, could have a role in the initial phase of apoptotic death of CGC...
  15. ncbi request reprint Role of oxidative stress in the apoptotic cell death of cultured cerebellar granule neurons
    A Valencia
    Department of Neurosciences, Institute of Cell Physiology, National University of Mexico, Mexico City, Mexico
    J Neurosci Res 64:284-97. 2001
    ....
  16. doi request reprint Reagents that block neuronal death from Huntington's disease also curb oxidative stress
    Antonio Valencia
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA
    Neuroreport 23:10-5. 2012
    ..These results suggest that reducing the levels of reactive oxygen species may be necessary to protect neurons with the Huntington's disease mutation from cell death...