BENJAMIN VAKOC

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video)
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Gastrointest Endosc 65:898-905. 2007
  2. pmc Statistical properties of phase-decorrelation in phase-resolved Doppler optical coherence tomography
    Benjamin J Vakoc
    Wellman Center, for Photomedicine, Massachusetts General Hospital and Harvard Medical, School, Boston, MA 02114, USA
    IEEE Trans Med Imaging 28:814-21. 2009
  3. pmc Elimination of depth degeneracy in optical frequency-domain imaging through polarization-based optical demodulation
    B J Vakoc
    Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston 02114, USA
    Opt Lett 31:362-4. 2006
  4. ncbi request reprint Real-time microscopic visualization of tissue response to laser thermal therapy
    Benjamin J Vakoc
    Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:020501. 2007
  5. pmc Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine
    Melissa J Suter
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 71:346-53. 2010
  6. pmc Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 15:1219-23. 2009
  7. pmc Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging
    Guillermo J Tearney
    Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02114, USA
    JACC Cardiovasc Imaging 1:752-61. 2008
  8. ncbi request reprint Spectral- and frequency-encoded fluorescence imaging
    Jason T Motz
    Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Opt Lett 30:2760-2. 2005
  9. pmc Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging
    Melissa J Suter
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital Boston, Massachusetts 02114, USA
    Gastrointest Endosc 68:745-53. 2008
  10. pmc Comprehensive volumetric optical microscopy in vivo
    Seok H Yun
    Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 12:1429-33. 2006

Research Grants

Detail Information

Publications17

  1. pmc Comprehensive esophageal microscopy by using optical frequency-domain imaging (with video)
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Massachusetts General Hospital, Harvard MIT Division of Health Sciences and Technology, Boston, Massachusetts, USA
    Gastrointest Endosc 65:898-905. 2007
    ..However, the relatively slow image-acquisition rate of the present OCT systems inhibits wide-field imaging and limits the clinical utility of OCT for diagnostic imaging in patients with Barrett's esophagus...
  2. pmc Statistical properties of phase-decorrelation in phase-resolved Doppler optical coherence tomography
    Benjamin J Vakoc
    Wellman Center, for Photomedicine, Massachusetts General Hospital and Harvard Medical, School, Boston, MA 02114, USA
    IEEE Trans Med Imaging 28:814-21. 2009
    ..Expressions for the noise distribution and the noise variance as a function of relevant imaging system parameters are given, and the implications of these results on both system and algorithm design are discussed...
  3. pmc Elimination of depth degeneracy in optical frequency-domain imaging through polarization-based optical demodulation
    B J Vakoc
    Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston 02114, USA
    Opt Lett 31:362-4. 2006
    ..Our system design is compatible with dual-balanced and polarization-diverse detection, important techniques in the practical biomedical application of optical frequency-domain imaging...
  4. ncbi request reprint Real-time microscopic visualization of tissue response to laser thermal therapy
    Benjamin J Vakoc
    Harvard Medical School and Massachusetts General Hospital, Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:020501. 2007
    ..Using porcine esophageal specimens ex vivo, we demonstrate that the extent and evolution of laser thermal damage can be assessed in real time...
  5. pmc Image-guided biopsy in the esophagus through comprehensive optical frequency domain imaging and laser marking: a study in living swine
    Melissa J Suter
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Gastrointest Endosc 71:346-53. 2010
    ..When deployed through a balloon-centering catheter, OFDI can automatically image the entire distal esophagus (6.0 cm length) in approximately 2 minutes...
  6. pmc Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging
    Benjamin J Vakoc
    Wellman Center for Photomedicine, Department of Dermatology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 15:1219-23. 2009
    ....
  7. pmc Three-dimensional coronary artery microscopy by intracoronary optical frequency domain imaging
    Guillermo J Tearney
    Wellman Center for Photomedicine, Massachusetts General Hospital, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02114, USA
    JACC Cardiovasc Imaging 1:752-61. 2008
    ..We present the first clinical experience with intracoronary optical frequency domain imaging (OFDI) in human patients...
  8. ncbi request reprint Spectral- and frequency-encoded fluorescence imaging
    Jason T Motz
    Harvard Medical School and the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Opt Lett 30:2760-2. 2005
    ..This method is applicable for developing submillimeter diameter endoscopes. The principles of the technique are validated by imaging indocyanine green fluorescence in microfluidic channels...
  9. pmc Comprehensive microscopy of the esophagus in human patients with optical frequency domain imaging
    Melissa J Suter
    Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital Boston, Massachusetts 02114, USA
    Gastrointest Endosc 68:745-53. 2008
    ..The clinical utility of OCT has been limited, however, by its inability to acquire images over large areas...
  10. pmc Comprehensive volumetric optical microscopy in vivo
    Seok H Yun
    Wellman Center for Photomedicine, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Nat Med 12:1429-33. 2006
    ..Our pilot study results suggest that this technology may be a useful clinical tool for comprehensive diagnostic imaging for epithelial disease and for evaluating coronary pathology and iatrogenic effects...
  11. pmc Backscattering spectroscopic contrast with angle-resolved optical coherence tomography
    Adrien E Desjardins
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, Boston 02114, USA
    Opt Lett 32:3158-60. 2007
    ..High levels of speckle noise reduction achieved by angular compounding increased the spatial resolution at which backscattering spectra could be accurately differentiated...
  12. pmc Performance of reduced bit-depth acquisition for optical frequency domain imaging
    BRIAN D GOLDBERG
    Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom St, Boston, MA 02114, USA
    Opt Express 17:16957-68. 2009
    ..Images of a human coronary artery acquired in vivo at 8-bit depth are presented and compared with images at higher bit-depth acquisition...
  13. pmc Principal-component-analysis-based estimation of blood flow velocities using optical coherence tomography intensity signals
    Nishant Mohan
    Wellman Center for Photomedicine, Harvard Medical School and Massachusetts General Hospital, 40 Blossom Street, Boston, Massachusetts 02114, USA
    Opt Lett 36:2068-70. 2011
    ..We demonstrate this technique in simulation, phantom and in vivo blood flow measurements, and highlight its potential to enable three-dimensional wide-field mapping of blood flow using OCT...
  14. pmc Fourier-domain optical coherence tomography: recent advances toward clinical utility
    Brett E Bouma
    Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Harvard MIT Division of Health Sciences and Technology, Boston, MA 02114, USA
    Curr Opin Biotechnol 20:111-8. 2009
    ....
  15. pmc Multimodality optical imaging of embryonic heart microstructure
    Ronit Yelin
    Massachusetts General Hospital, Harvard Medical School and the Wellman Center for Photomedicine, 55 Fruit Street, BAR 703, Boston, Massachusetts 02114, USA
    J Biomed Opt 12:064021. 2007
    ..Microstructural abnormalities associated with high levels of ethanol exposure are observed, including compromised heart looping and loss of ventricular trabecular mass...
  16. pmc Real-time FPGA processing for high-speed optical frequency domain imaging
    Adrien E Desjardins
    Harvard Biophysics Program, Boston, MA 02115, USA
    IEEE Trans Med Imaging 28:1468-72. 2009
    ..When implemented in FPGAs, the algorithm allowed for real-time processing of interferograms acquired with a high-speed OFDI system at 54 kHz and a sampling rate of 100 MS/s...
  17. pmc >400 kHz repetition rate wavelength-swept laser and application to high-speed optical frequency domain imaging
    Wang Yuhl Oh
    Harvard Medical School and Wellman Center for Photomedicine, Massachusetts General Hospital, 50 Blossom Street, BAR 704, Boston, Massachusetts 02114, USA
    Opt Lett 35:2919-21. 2010
    ..Optical frequency domain imaging of the human skin in vivo is presented using this laser, and the system shows sensitivity of higher than 98 dB with single-side ranging depth of 1.7 mm over 4 dB sensitivity roll-off...

Research Grants2

  1. Image-Guided Laser Therapy for Barrett's Esophagus
    BENJAMIN VAKOC; Fiscal Year: 2007
    ..Since esophageal adenocarcinoma is a prevalent disease associated with high morbidity and dismal survival, an improved therapeutic approach that addresses the shortcomings of currently available therapies will make a significant impact. ..