Vishal S Vaidya

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury
    Vishal S Vaidya
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, 4 Blackfan Circle, Harvard Institutes of Medicine, Rm 550, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 290:F517-29. 2006
  2. pmc Gene expression analysis reveals the cell cycle and kinetochore genes participating in ischemia reperfusion injury and early development in kidney
    Tae Min Kim
    Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25679. 2011
  3. pmc Heterozygosity for fibrinogen results in efficient resolution of kidney ischemia reperfusion injury
    Amrendra Kumar Ajay
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS ONE 7:e45628. 2012
  4. pmc A rapid urine test for early detection of kidney injury
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 76:108-14. 2009
  5. pmc Biomarkers of acute kidney injury
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Pharmacol Toxicol 48:463-93. 2008
  6. ncbi request reprint Mechanistic biomarkers for cytotoxic acute kidney injury
    Vishal S Vaidya
    Harvard Institutes of Medicine, Brigham and Women s Hospital, Harvard Medical School, Renal Division, Rm 550, 4 Blackfan Circle, Boston, MA 02115, USA
    Expert Opin Drug Metab Toxicol 2:697-713. 2006
  7. pmc Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 28:478-85. 2010
  8. pmc Fibrinogen excretion in the urine and immunoreactivity in the kidney serves as a translational biomarker for acute kidney injury
    Dana Hoffmann
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Pathol 181:818-28. 2012
  9. pmc A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury
    Amrendra Kumar Ajay
    Renal Division, Department of Medicine
    J Am Soc Nephrol 25:105-18. 2014
  10. pmc Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury
    Aparna Krishnamoorthy
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 118:1934-42. 2011

Research Grants

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Urinary kidney injury molecule-1: a sensitive quantitative biomarker for early detection of kidney tubular injury
    Vishal S Vaidya
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, 4 Blackfan Circle, Harvard Institutes of Medicine, Rm 550, Boston, MA 02115, USA
    Am J Physiol Renal Physiol 290:F517-29. 2006
    ....
  2. pmc Gene expression analysis reveals the cell cycle and kinetochore genes participating in ischemia reperfusion injury and early development in kidney
    Tae Min Kim
    Center for Biomedical Informatics, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e25679. 2011
    ..The molecular mechanisms that mediate the ischemia-reperfusion (I/R) injury in kidney are not completely understood. It is also largely unknown whether such mechanisms overlap with those governing the early development of kidney...
  3. pmc Heterozygosity for fibrinogen results in efficient resolution of kidney ischemia reperfusion injury
    Amrendra Kumar Ajay
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    PLoS ONE 7:e45628. 2012
    ..These data suggest that Fg heterozygosity allows maintenance of a critical balance of Fg that enables regression of initial injury and promotes faster resolution of kidney damage...
  4. pmc A rapid urine test for early detection of kidney injury
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 76:108-14. 2009
    ....
  5. pmc Biomarkers of acute kidney injury
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Annu Rev Pharmacol Toxicol 48:463-93. 2008
    ....
  6. ncbi request reprint Mechanistic biomarkers for cytotoxic acute kidney injury
    Vishal S Vaidya
    Harvard Institutes of Medicine, Brigham and Women s Hospital, Harvard Medical School, Renal Division, Rm 550, 4 Blackfan Circle, Boston, MA 02115, USA
    Expert Opin Drug Metab Toxicol 2:697-713. 2006
    ..This review presents the current status of sensitive and specific biomarkers to detect preclinical and clinical renal injury and summarises the techniques used to quantitate these biomarkers in biological fluids...
  7. pmc Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Biotechnol 28:478-85. 2010
    ..This should enable early identification and elimination of compounds that are potentially nephrotoxic...
  8. pmc Fibrinogen excretion in the urine and immunoreactivity in the kidney serves as a translational biomarker for acute kidney injury
    Dana Hoffmann
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Am J Pathol 181:818-28. 2012
    ..These results suggest that immunoreactivity of Fg in the kidney, as well as urinary excretion of Fg, serves as a sensitive and early diagnostic translational biomarker for detection of AKI...
  9. pmc A bioinformatics approach identifies signal transducer and activator of transcription-3 and checkpoint kinase 1 as upstream regulators of kidney injury molecule-1 after kidney injury
    Amrendra Kumar Ajay
    Renal Division, Department of Medicine
    J Am Soc Nephrol 25:105-18. 2014
    ..These observations highlight Chk1 and STAT3 as critical upstream regulators of KIM-1 expression after AKI and may suggest novel approaches for therapeutic intervention. ..
  10. pmc Fibrinogen β-derived Bβ(15-42) peptide protects against kidney ischemia/reperfusion injury
    Aparna Krishnamoorthy
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 118:1934-42. 2011
    ..Given that kidney regeneration is a major determinant of outcome for patients with kidney damage, these results provide new opportunities for the use of Fg in diagnosis, prevention, and therapeutic interventions in kidney disease...
  11. pmc Expression, circulation, and excretion profile of microRNA-21, -155, and -18a following acute kidney injury
    Janani Saikumar
    Department of Medicine, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Toxicol Sci 129:256-67. 2012
    ..Taken together, these results suggest that miRNA-21 and -155 could potentially serve as translational biomarkers for detection of AKI and may play a critical role in the pathogenesis of kidney injury and tissue repair process...
  12. pmc Regression of microalbuminuria in type 1 diabetes is associated with lower levels of urinary tubular injury biomarkers, kidney injury molecule-1, and N-acetyl-β-D-glucosaminidase
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 79:464-70. 2011
    ..Hence, tubular dysfunction is a critical component of the early course of diabetic nephropathy...
  13. pmc Human miRNome profiling identifies microRNAs differentially present in the urine after kidney injury
    Krithika Ramachandran
    Renal Division, Department of Medicine, and
    Clin Chem 59:1742-52. 2013
    ....
  14. pmc Biomarkers of nephrotoxic acute kidney injury
    Michael A Ferguson
    Division of Nephrology, Children s Hospital Boston, Hunnewell 319, Boston, MA 02115, United States
    Toxicology 245:182-93. 2008
    ....
  15. pmc Urinary biomarkers for sensitive and specific detection of acute kidney injury in humans
    Vishal S Vaidya
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Clin Transl Sci 1:200-8. 2008
    ..Our results demonstrate the comparative value of multiple biomarkers in the diagnosis and prognosis of AKI...
  16. pmc TIM2 gene deletion results in susceptibility to cisplatin-induced kidney toxicity
    Aparna Krishnamoorthy
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Toxicol Sci 118:298-306. 2010
    ....
  17. pmc Impaired renal function and development in Belgrade rats
    Tania Veuthey
    Dept of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115
    Am J Physiol Renal Physiol 306:F333-43. 2014
    ..These results further implicate an important role for the transporter in kidney function not only in iron reabsorption but also in glomerular filtration of the serum protein. ..
  18. pmc Urinary biomarkers in the clinical prognosis and early detection of acute kidney injury
    Jay L Koyner
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, Illinois, USA
    Clin J Am Soc Nephrol 5:2154-65. 2010
    ..The diagnostic and prognostic utility of novel and traditional AKI biomarkers was evaluated during a prospective study of 123 adults undergoing cardiac surgery...
  19. pmc Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury
    Michael A Ferguson
    Division of Nephrology, Department of Medicine, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Kidney Int 77:708-14. 2010
    ..Our study shows that age-adjusted urinary L-FABP levels were significantly higher in patients with poor outcome, defined as the requirement for renal replacement therapy or the composite end point of death or renal replacement therapy...
  20. ncbi request reprint Urinary N-acetyl-beta-(D)-glucosaminidase activity and kidney injury molecule-1 level are associated with adverse outcomes in acute renal failure
    Orfeas Liangos
    Division of Nephrology, Caritas St Elizabeth s Medical Center, 736 Cambridge Street, Boston, MA 02135, USA
    J Am Soc Nephrol 18:904-12. 2007
    ..78 (95% CI 0.71 to 0.84) in predicting the composite outcome. Urinary markers of kidney injury such as NAG and KIM-1 can predict adverse clinical outcomes in patients with ARF...
  21. pmc Novel technologies for the discovery and quantitation of biomarkers of toxicity
    Fitz B Collings
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Harvard Institutes of Medicine, Rm 550, 4 Blackfan Circle, Boston, MA 02115, United States
    Toxicology 245:167-74. 2008
    ..Novel technologies reviewed here have the potential to significantly reduce assay time and cost and improve the sensitivity of screening methods for candidate biomarkers of toxicity...
  22. ncbi request reprint Resolvin D series and protectin D1 mitigate acute kidney injury
    Jeremy S Duffield
    Renal Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 177:5902-11. 2006
    ..These data may also have therapeutic implications for potentiation of recovery from acute kidney injury...
  23. pmc Ischemic kidney injury and mechanisms of tissue repair
    Marwa El Sabbahy
    Laboratory of Kidney Toxicology and Regeneration, Renal Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA, USA
    Wiley Interdiscip Rev Syst Biol Med 3:606-18. 2011
    ..In this review, we attempt to analyze the mechanisms of ischemic injury and repair in acute and chronic kidney disease from the perspectives of both preclinical and human studies...
  24. ncbi request reprint Molecular mechanisms of renal tissue repair in survival from acute renal tubule necrosis: role of ERK1/2 pathway
    Vishal S Vaidya
    Department of Toxicology, School of Pharmacy, The University of Louisiana at Monroe, Louisiana 71209 0470, USA
    Toxicol Pathol 31:604-18. 2003
    ....
  25. ncbi request reprint Induction of kidney injury molecule-1 in homozygous Ren2 rats is attenuated by blockade of the renin-angiotensin system or p38 MAP kinase
    Martin H de Borst
    Dept of Pathology and Laboratory Medicine, Univ Medical Center Groningen and Univ of Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Physiol Renal Physiol 292:F313-20. 2007
    ..01). Kim-1 is associated with development of RAS-mediated renal damage. Antifibrotic treatment through RAS blockade or p38 MAP kinase inhibition reduced Kim-1 in the homozygous Ren2 model...
  26. pmc Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium
    Yuzhao Zhou
    Center for Devices and Radiological Health, U S Food and Drug Administration, White Oak Life Sciences Laboratory, Silver Spring, MD 20993, USA
    Toxicol Sci 101:159-70. 2008
    ..Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury following exposure to nephrotoxic chemicals and drugs...
  27. pmc High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    Transplantation 84:1625-30. 2007
    ..Urinary KIM-1 excretion has been quantified as biomarker of renal damage. We prospectively studied whether urinary KIM-1 predicts graft loss, independent of renal function and proteinuria...
  28. pmc Immunolocalization of Kim-1, RPA-1, and RPA-2 in kidney of gentamicin-, mercury-, or chromium-treated rats: relationship to renal distributions of iNOS and nitrotyrosine
    Jun Zhang
    Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, Maryland 20993, USA
    Toxicol Pathol 36:397-409. 2008
    ..It is possible that iNOS activation with nitrotyrosine production in injured nephron segments may be involved in the induction of Kim-1, RPA-1, and RPA-2 following exposure to nephrotoxicants...
  29. ncbi request reprint Upregulated promitogenic signaling via cytokines and growth factors: potential mechanism of robust liver tissue repair in calorie-restricted rats upon toxic challenge
    Udayan M Apte
    Department of Toxicology, College of Pharmacy, The University of Louisiana at Monroe, 700 University Avenue, Sugar Hall 306B, Monroe, LA 71209 0495, USA
    Toxicol Sci 69:448-59. 2002
    ..It appears that the physiological effects of DR make the liver cells vigilant and prime the liver tissue promptly for liver regeneration through promitogenic signaling upon toxic challenge...

Research Grants2