Anand Vaidya

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. pmc Aldosterone dysregulation with aging predicts renal vascular function and cardiovascular risk
    Jenifer M Brown
    MMSc, Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, RFB, Boston, MA 02115
    Hypertension 63:1205-11. 2014
  2. pmc Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone
    Jenifer M Brown
    Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, RFB, Boston, MA 02115
    Hypertension 63:273-80. 2014
  3. pmc The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 62:539-47. 2013
  4. pmc Abnormal aldosterone physiology and cardiometabolic risk factors
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hypertension 61:886-93. 2013
  5. pmc Vitamin D3 therapy corrects the tissue sensitivity to angiotensin ii akin to the action of a converting enzyme inhibitor in obese hypertensives: an interventional study
    Anand Vaidya
    Brigham and Women s Hospital, Division of Endocrinology, Diabetes, and Hypertension, 221 Longwood Avenue, RFB, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 97:2456-65. 2012
  6. pmc The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Metabolism 61:450-8. 2012
  7. pmc The independent association between 25-hydroxyvitamin D and adiponectin and its relation with BMI in two large cohorts: the NHS and the HPFS
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:186-91. 2012
  8. pmc The association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-hydroxyvitamin D3 in human hypertension
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Endocrinol (Oxf) 74:294-9. 2011
  9. pmc Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertension
    A Vaidya
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Hum Hypertens 25:672-8. 2011
  10. pmc 25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, USA
    J Renin Angiotensin Aldosterone Syst 12:311-9. 2011

Collaborators

Detail Information

Publications21

  1. pmc Aldosterone dysregulation with aging predicts renal vascular function and cardiovascular risk
    Jenifer M Brown
    MMSc, Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, RFB, Boston, MA 02115
    Hypertension 63:1205-11. 2014
    ....
  2. pmc Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone
    Jenifer M Brown
    Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, RFB, Boston, MA 02115
    Hypertension 63:273-80. 2014
    ..Future studies to evaluate the impact of RAAS inhibitors in treating PTH-mediated disorders are warranted. ..
  3. pmc The influence of sodium- and calcium-regulatory hormone interventions on adipocytokines in obesity and diabetes
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 62:539-47. 2013
    ..We evaluated human interventional study protocols to investigate whether controlled modulations of these calcium- and sodium-regulatory hormones could influence adipocytokines and inflammation in obesity and diabetes...
  4. pmc Abnormal aldosterone physiology and cardiometabolic risk factors
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    Hypertension 61:886-93. 2013
    ..Assessing the physiological range of aldosterone responses may provide greater insights into adrenal pathophysiology. Dysregulated aldosterone physiology may contribute to, or result from, early cardiometabolic abnormalities...
  5. pmc Vitamin D3 therapy corrects the tissue sensitivity to angiotensin ii akin to the action of a converting enzyme inhibitor in obese hypertensives: an interventional study
    Anand Vaidya
    Brigham and Women s Hospital, Division of Endocrinology, Diabetes, and Hypertension, 221 Longwood Avenue, RFB, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 97:2456-65. 2012
    ..Vitamin D deficiency and obesity are associated with increased tissue renin-angiotensin system (RAS) activity...
  6. pmc The relationship between vitamin D and the renin-angiotensin system in the pathophysiology of hypertension, kidney disease, and diabetes
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Metabolism 61:450-8. 2012
    ..There is a need for more well-designed prospective interventional studies to validate this hypothesis in human clinical outcomes...
  7. pmc The independent association between 25-hydroxyvitamin D and adiponectin and its relation with BMI in two large cohorts: the NHS and the HPFS
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 20:186-91. 2012
    ..Since lower levels of 25(OH)D and adiponectin are associated with higher cardio-metabolic risk, assessing the effect of vitamin D supplementation on adiponectin levels is warranted...
  8. pmc The association of plasma resistin with dietary sodium manipulation, the renin-angiotensin-aldosterone system, and 25-hydroxyvitamin D3 in human hypertension
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Endocrinol (Oxf) 74:294-9. 2011
    ..Both resistin and vitamin D have been associated with the renin-angiotensin-aldosterone system (RAAS). We investigated the association between resistin and the RAAS, and resistin and vitamin D under controlled dietary sodium conditions...
  9. pmc Vitamin D and the vascular sensitivity to angiotensin II in obese Caucasians with hypertension
    A Vaidya
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Hum Hypertens 25:672-8. 2011
    ..Future studies to evaluate the effect of vitamin D supplementation on vascular RAS activity in obesity are needed...
  10. pmc 25-Hydroxyvitamin D is associated with plasma renin activity and the pressor response to dietary sodium intake in Caucasians
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital and Harvard Medical School, USA
    J Renin Angiotensin Aldosterone Syst 12:311-9. 2011
    ..We investigated the association between PRA and 25-hydroxyvitamin D (25OHD), the most clinically relevant vitamin D metabolite, and whether 25OHD associates with SS of BP in renin phenotypes of hypertension...
  11. pmc The influence of body mass index and renin-angiotensin-aldosterone system activity on the relationship between 25-hydroxyvitamin D and adiponectin in Caucasian men
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, 221 Longwood Avenue, RFB 386, Boston, Massachusetts 02115, USA
    Eur J Endocrinol 164:995-1002. 2011
    ..We evaluated the association between adiponectin and 25-hydroxyvitamin D (25(OH)D) after controlling RAAS activity with dietary sodium equilibration and also evaluated whether this relationship was influenced by BMI...
  12. pmc The Fok1 vitamin D receptor gene polymorphism is associated with plasma renin activity in Caucasians
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Clin Endocrinol (Oxf) 74:783-90. 2011
    ....
  13. pmc Dietary sodium alters the prevalence of electrocardiogram determined left ventricular hypertrophy in hypertension
    Anand Vaidya
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Am J Hypertens 22:669-73. 2009
    ..Dietary sodium and HTN are both associated with unfavorable alterations in left ventricular mass, however, to what extent their interplay affects ECG screening for LVH is unclear...
  14. pmc Glycation of the complement regulatory protein CD59 is a novel biomarker for glucose handling in humans
    Pamela Ghosh
    Division of Hematology P G, R S, M C, J A H, Department of Medicine, and Division of Endocrinology, Diabetes, and Hypertension A V, Brigham and Women s Hospital, Harvard Medical School, and Crimson Biospecimen Core N H, L B, Partners HealthCare System, Boston, Massachusetts 02115 and Joslin Diabetes Center A G, Harvard Medical School, Boston, Massachusetts 02115
    J Clin Endocrinol Metab 99:E999-E1006. 2014
    ..Human CD59, an inhibitor of the membrane attack complex of complement, is inactivated by glycation. Glycation inactivation of CD59 enhances complement-mediated injury in target organs of diabetes complications...
  15. pmc Nonmodulation as the mechanism for salt sensitivity of blood pressure in individuals with hypertension and type 2 diabetes mellitus
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, RFB 386, Boston, Massachusetts 02115, USA
    J Clin Endocrinol Metab 97:3775-82. 2012
    ..However, studies supporting these assumptions may have been confounded by participant inclusion criteria, and study results may reflect target organ damage...
  16. pmc Replication and meta-analysis of the gene-environment interaction between body mass index and the interleukin-6 promoter polymorphism with higher insulin resistance
    Patricia C Underwood
    Division of Endocrinology, Diabetes, and HTN, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Metabolism 61:667-71. 2012
    ..05 × 10(-6)). This rare replication of a gene-environment interaction extends the generalizability of the results to hypertension while highlighting this polymorphism as a marker of IR in obese individuals...
  17. doi request reprint Vitamin D and vascular disease: the current and future status of vitamin D therapy in hypertension and kidney disease
    Anand Vaidya
    Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Curr Hypertens Rep 14:111-9. 2012
    ..These studies are reviewed, with special emphasis on recent findings. Definitive studies are warranted to elucidate the effects of vitamin D supplementation on mechanisms of hypertension and kidney disease...
  18. pmc Influence of dietary sodium modulation on electrocardiographic voltage criteria for left ventricular hypertrophy in normotensive individuals
    Carol Larson
    Division of Endocrinology, Diabetes, and Hypertension, Departmentof Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Investig Med 60:39-43. 2012
    ..We evaluated the influence of dietary sodium intake on ECG voltage and ECG criteria for LVH in normotensive individuals...
  19. pmc Improving the management of diabetes in hospitalized patients: the results of a computer-based house staff training program
    Anand Vaidya
    Division of Endocrinology, Diabetes and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Technol Ther 14:610-8. 2012
    ..We hypothesized that computer-based diabetes training could improve house staff knowledge and comfort for the management of diabetes in a large tertiary-care hospital...
  20. ncbi request reprint Interactions between adrenal-regulatory and calcium-regulatory hormones in human health
    Jenifer M Brown
    Center for Adrenal Disorders, Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Endocrinol Diabetes Obes 21:193-201. 2014
    ..To summarize the evidence characterizing the interactions between adrenal-regulating and calcium-regulating hormones, and the relevance of these interactions to human cardiovascular and skeletal health...
  21. pmc A specific and sensitive assay for blood levels of glycated CD59: a novel biomarker for diabetes
    Pamela Ghosh
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Am J Hematol 88:670-6. 2013
    ..Because GCD59 likely contributes to the pathogenesis of diabetes complications, measurement of blood levels of GCD59 may be useful in the diagnosis and management of diabetes...