Charles A Vacanti

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint The history of tissue engineering
    Charles A Vacanti
    Harvard Medical School, Department of Anesthesiology, Brigham and Womens Hospital, Boston, MA, USA
    J Cell Mol Med 10:569-76. 2006
  2. pmc Effect on ligament marker expression by direct-contact co-culture of mesenchymal stem cells and anterior cruciate ligament cells
    Jose A Canseco
    Department of Anesthesiology, Laboratory for Tissue Engineering and Regenerative Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Tissue Eng Part A 18:2549-58. 2012
  3. doi request reprint Engineering functional islets from cultured cells
    Shohta Kodama
    Tissue engineering and Regenerative Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Tissue Eng Part A 15:3321-9. 2009
  4. doi request reprint Bioengineered three-layered robust and elastic artery using hemodynamically-equivalent pulsatile bioreactor
    Kiyotaka Iwasaki
    Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School 75 Francis Street, Thorn 1327, Boston, MA 02115, USA
    Circulation 118:S52-7. 2008
  5. ncbi request reprint Bidirectional developmental potential in reprogrammed cells with acquired pluripotency
    Haruko Obokata
    1 Laboratory for Cellular Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan 2 Laboratory for Genomic Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan 3 Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 505:676-80. 2014
  6. ncbi request reprint Stimulus-triggered fate conversion of somatic cells into pluripotency
    Haruko Obokata
    1 Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA 2 Laboratory for Cellular Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan 3 Laboratory for Genomic Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 505:641-7. 2014
  7. ncbi request reprint In vitro culture of chondrocytes in a novel thermoreversible gelation polymer scaffold containing growth factors
    Ayuko Yasuda
    Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Tissue Eng 12:1237-45. 2006
  8. ncbi request reprint Tissue engineered cartilage "bioshell" protective layer for subcutaneous implants
    Angelo Monroy
    The Pediatric Otolaryngology Service, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Int J Pediatr Otorhinolaryngol 71:547-52. 2007
  9. doi request reprint Lidocaine inhibits NIH-3T3 cell multiplication by increasing the expression of cyclin-dependent kinase inhibitor 1A (p21)
    Sukumar P Desai
    Department of Anesthesiology, Perioperative and Pain Medicine, Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 107:1592-7. 2008
  10. doi request reprint Tissue engineering in the trachea
    Koji Kojima
    Laboratory for Tissue Engineering and Regenerative Medicine Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, 75 Francis St, Thorn 703, Boston, Massachusetts, 02115
    Anat Rec (Hoboken) 297:44-50. 2014

Collaborators

Detail Information

Publications35

  1. ncbi request reprint The history of tissue engineering
    Charles A Vacanti
    Harvard Medical School, Department of Anesthesiology, Brigham and Womens Hospital, Boston, MA, USA
    J Cell Mol Med 10:569-76. 2006
  2. pmc Effect on ligament marker expression by direct-contact co-culture of mesenchymal stem cells and anterior cruciate ligament cells
    Jose A Canseco
    Department of Anesthesiology, Laboratory for Tissue Engineering and Regenerative Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Tissue Eng Part A 18:2549-58. 2012
    ..Thus, we conclude that using a 50% co-culture of ACLcs and MSCs, instead of either cell population alone, may better maintain or even enhance ligament marker expression and improve healing...
  3. doi request reprint Engineering functional islets from cultured cells
    Shohta Kodama
    Tissue engineering and Regenerative Medicine, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Tissue Eng Part A 15:3321-9. 2009
    ..Tissue engineering islet cells in vitro that function when implanted in vivo provides a solution to this problem...
  4. doi request reprint Bioengineered three-layered robust and elastic artery using hemodynamically-equivalent pulsatile bioreactor
    Kiyotaka Iwasaki
    Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School 75 Francis Street, Thorn 1327, Boston, MA 02115, USA
    Circulation 118:S52-7. 2008
    ..We investigated the potential to engineer a three-layered robust and elastic artery using a novel hemodynamically-equivalent pulsatile bioreactor...
  5. ncbi request reprint Bidirectional developmental potential in reprogrammed cells with acquired pluripotency
    Haruko Obokata
    1 Laboratory for Cellular Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan 2 Laboratory for Genomic Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan 3 Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 505:676-80. 2014
    ..Taken together, the developmental potential of STAP cells, shown by chimaera formation and in vitro cell conversion, indicates that they represent a unique state of pluripotency. ..
  6. ncbi request reprint Stimulus-triggered fate conversion of somatic cells into pluripotency
    Haruko Obokata
    1 Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA 2 Laboratory for Cellular Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan 3 Laboratory for Genomic Reprogramming, RIKEN Center for Developmental Biology, Kobe 650 0047, Japan
    Nature 505:641-7. 2014
    ..Thus, our findings indicate that epigenetic fate determination of mammalian cells can be markedly converted in a context-dependent manner by strong environmental cues. ..
  7. ncbi request reprint In vitro culture of chondrocytes in a novel thermoreversible gelation polymer scaffold containing growth factors
    Ayuko Yasuda
    Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Tissue Eng 12:1237-45. 2006
    ..We have concluded that TGP has potential as a scaffold material in the generation of tissue-engineered cartilage in vitro...
  8. ncbi request reprint Tissue engineered cartilage "bioshell" protective layer for subcutaneous implants
    Angelo Monroy
    The Pediatric Otolaryngology Service, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Int J Pediatr Otorhinolaryngol 71:547-52. 2007
    ..We hypothesized that if subjected to intentional exposure, a bioshell coating over an implant would provide enhanced wound healing...
  9. doi request reprint Lidocaine inhibits NIH-3T3 cell multiplication by increasing the expression of cyclin-dependent kinase inhibitor 1A (p21)
    Sukumar P Desai
    Department of Anesthesiology, Perioperative and Pain Medicine, Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Anesth Analg 107:1592-7. 2008
    ..Their effects on wound healing are controversial. We examined the effects and novel mechanisms by which lidocaine affects in vitro multiplication of the murine fibroblast cell line NIH-3T3...
  10. doi request reprint Tissue engineering in the trachea
    Koji Kojima
    Laboratory for Tissue Engineering and Regenerative Medicine Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, 75 Francis St, Thorn 703, Boston, Massachusetts, 02115
    Anat Rec (Hoboken) 297:44-50. 2014
    ..Nevertheless, we believe that the field of tissue engineering has great potential for surmounting these obstacles and allowing us to generate functional tracheal replacements in the near future...
  11. ncbi request reprint Tissue engineering: where are we headed?
    Charles A Vacanti
    Department of Anesthesiology, Brigham and Women s Hospital, Boston, MA 02115, USA tners org
    J Am Coll Surg 206:1095-6. 2008
  12. ncbi request reprint The potential of stem cells in adult tissues representative of the three germ layers
    Haruko Obokata
    Department of Anesthesiology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    Tissue Eng Part A 17:607-15. 2011
    ..Such cells could potentially be as useful as embryonic stem cells in tissue engineering and regenerative medicine...
  13. pmc Isoflurane decreases self-renewal capacity of rat cultured neural stem cells
    Deborah J Culley
    Department of Anesthesia, Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Anesthesiology 115:754-63. 2011
    ..In models, isoflurane produces neural and behavioral deficits in vitro and in vivo. This study tested the hypothesis that neural stem cells are adversely affected by isoflurane such that it inhibits proliferation and kills these cells...
  14. ncbi request reprint History of tissue engineering and a glimpse into its future
    Charles A Vacanti
    Harvard Medical School, Department of Anesthesiology, Brigham and Womens Hospital, Boston, Massachusetts, USA
    Tissue Eng 12:1137-42. 2006
  15. ncbi request reprint Novel technique for peripheral nerve reconstruction in the absence of an artificial conduit
    Takatsugu Komiyama
    Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Neurosci Methods 134:133-40. 2004
    ....
  16. ncbi request reprint Role for interleukin 1alpha in the inhibition of chondrogenesis in autologous implants using polyglycolic acid-polylactic acid scaffolds
    Nicole Rotter
    Center for Tissue Engineering, University of Massachusetts Medical Center, Worcester, Massachusetts, USA
    Tissue Eng 11:192-200. 2005
    ..These results suggest that inflammatory reactions against scaffold materials and serum components lead to the production of cytokines such as IL-1alpha that may inhibit cartilage tissue formation in autologous transplant models...
  17. ncbi request reprint Age dependence of biochemical and biomechanical properties of tissue-engineered human septal cartilage
    Nicole Rotter
    Center for Tissue Engineering, University of Massachusetts Medical School, Worcester 01655, USA
    Biomaterials 23:3087-94. 2002
    ..Together, the results of this study suggest that the process of extracellular matrix assembly by chondrocytes on three-dimensional scaffolds may be independent of in vivo conditions experienced by the tissue prior to harvest...
  18. ncbi request reprint Fibroblasts regulate contractile force independent of MMP activity in 3D-collagen
    Jonathan A Phillips
    Department of Cell Biology, Center of Tissue Engineering, Graduate School of Biomedical Sciences, University of Massachusetts, Worcester, MA, USA
    Biochem Biophys Res Commun 312:725-32. 2003
    ..These results suggest cellular controls of contractile forces are independent of MMP activity. Our results also raise the possibility that the material properties of the matrix dynamically change during remodeling...
  19. ncbi request reprint Comparison of tracheal and nasal chondrocytes for tissue engineering of the trachea
    Koji Kojima
    Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Thorac Surg 76:1884-8. 2003
    ..We also tested sheep tracheal and nasal septum for cell yield and quality of the engineered cartilage each produced...
  20. ncbi request reprint Tissue engineering of autologous cartilage for craniofacial reconstruction by injection molding
    Sophia C N Chang
    Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, USA
    Plast Reconstr Surg 112:793-9; discussion 800-1. 2003
    ..The equilibrium modulus and the hydraulic permeability were 74 and 105 percent of those of native sheep auricular cartilage, respectively...
  21. ncbi request reprint A composite tissue-engineered trachea using sheep nasal chondrocyte and epithelial cells
    Koji Kojima
    Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    FASEB J 17:823-8. 2003
    ..This has the potential to facilitate an autologous repair of segmental tracheal defects...
  22. ncbi request reprint A novel technique to isolate adult Schwann cells for an artificial nerve conduit
    Takatsugu Komiyama
    Center for Tissue Engineering, University of Massachusetts Medical School, 55 Lake Ave, North, Worcester, MA 01655, USA
    J Neurosci Methods 122:195-200. 2003
    ..The combination of this technique and the altered medium promoted the migration and proliferation of SCs selectively by utilizing the supporting cells of SCs instead of discarding them by changing the culture dishes and media...
  23. ncbi request reprint In vitro tissue engineering to generate a human-sized auricle and nasal tip
    Syed H Kamil
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Laryngoscope 113:90-4. 2003
    ..We hypothesized that a human-sized cartilaginous structure could be generated completely in vitro as a complementary or an alternative technique...
  24. ncbi request reprint Autologous tissue-engineered trachea with sheep nasal chondrocytes
    Koji Kojima
    Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, 01603 3122, USA
    J Thorac Cardiovasc Surg 123:1177-84. 2002
    ..This study was designed to evaluate the ability of autologous tissue-engineered trachea shaped in a helix to form the structural component of a functional tracheal replacement...
  25. ncbi request reprint Microtia chondrocytes as a donor source for tissue-engineered cartilage
    Syed H Kamil
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, U S A
    Laryngoscope 114:2187-90. 2004
    ..The authors wished to evaluate the biological potential of chondrocytes isolated from microtia cartilage as compared with normal auricular cartilage as a source of tissue-engineered cartilage...
  26. pmc Tissue-engineered endothelial and epithelial implants differentially and synergistically regulate airway repair
    Brett G Zani
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 105:7046-51. 2008
    ....
  27. ncbi request reprint Biomechanical and biochemical characterization of composite tissue-engineered intervertebral discs
    Hirokazu Mizuno
    Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, MA, USA
    Biomaterials 27:362-70. 2006
    ..These studies document the feasibility of creating composite tissue-engineered intevertebral disc implants with similar composition and mechanical properties to native tissue...
  28. ncbi request reprint Tissue-engineered cartilage as a graft source for laryngotracheal reconstruction: a pig model
    Syed H Kamil
    Department of Otolaryngology, Pediatric Otolaryngology Service, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Arch Otolaryngol Head Neck Surg 130:1048-51. 2004
    ..To evaluate the feasibility of using tissue-engineered cartilage for laryngotracheal reconstruction in the pig model...
  29. ncbi request reprint Tissue-engineered lung: an in vivo and in vitro comparison of polyglycolic acid and pluronic F-127 hydrogel/somatic lung progenitor cell constructs to support tissue growth
    Joaquin Cortiella
    Laboratory of Tissue Engineering and Regenerative Medicine, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Tissue Eng 12:1213-25. 2006
    ..These data suggest that the therapeutic use of engineered tissues requires both the use of specific cell phenotypes, as well as the careful selection of synthetic polymers, to facilitate the assembly of functional tissue...
  30. ncbi request reprint A novel approach to regenerating periodontal tissue by grafting autologous cultured periosteum
    Hirokazu Mizuno
    Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Tissue Eng 12:1227-335. 2006
    ..These results show that our novel treatment is effective in regenerating alveolar bone for the treatment of periodontal disease...
  31. ncbi request reprint Tissue-engineered trachea from sheep marrow stromal cells with transforming growth factor beta2 released from biodegradable microspheres in a nude rat recipient
    Koji Kojima
    Laboratory for Tissue Engineering and Regenerative Medicine, Brigham and Women s Hospital, Harvard Medical School, Worcester, MA 02115, USA
    J Thorac Cardiovasc Surg 128:147-53. 2004
    ..We also explored the potential benefit of local delivery of transforming growth factor beta 2 with biodegradable gelatin microspheres...
  32. ncbi request reprint Tissue-engineered composites of anulus fibrosus and nucleus pulposus for intervertebral disc replacement
    Hirokazu Mizuno
    Center for Tissue Engineering, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Spine (Phila Pa 1976) 29:1290-7; discussion 1297-8. 2004
    ..By the technique of tissue engineering, composite intervertebral disc implants were fabricated as novel materials for disc replacement, implanted into athymic mice, and removed at times up to 12 weeks...
  33. ncbi request reprint Generation of a tissue-engineered tracheal equivalent
    Koji Kojima
    Laboratory for Tissue Engineering and Regenerative Medicine, Department of Anesthesiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Biotechnol Appl Biochem 39:257-62. 2004
    ..In addition to utilizing the angiogenic qualities of cytokines, we hope to exploit the growth potentials of stromal cells derived from bone marrow for the production of a clinically practical, bioengineered trachea...
  34. ncbi request reprint Nanofabrication and microfabrication of functional materials for tissue engineering
    Hyoungshin Park
    Division of Health Sciences and Technology, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Tissue Eng 13:1867-77. 2007
    ..It is our opinion that these novel materials and technologies will bring engineered tissues one step closer to practical application in the clinic. This review discusses their application to cardiac, liver, and nerve tissue engineering...
  35. ncbi request reprint Age-related changes in the composition and mechanical properties of human nasal cartilage
    Nicole Rotter
    Center for Tissue Engineering, Department of Anesthesiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0333, USA
    Arch Biochem Biophys 403:132-40. 2002
    ..This suggests that changes in matrix organization may accompany changes in tissue composition...