A A Tzika

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Multiparametric MR assessment of pediatric brain tumors
    A A Tzika
    NMR Surgical Laboratory, Massachusetts General Hospital and Shriners Burns Institute, Harvard Medical School, 51 Blossom Street, Room 261, Boston, MA 02114, USA
    Neuroradiology 45:1-10. 2003
  2. ncbi request reprint Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer 100:1246-56. 2004
  3. ncbi request reprint Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 21:825-32. 2008
  4. ncbi request reprint Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy
    A Aria Tzika
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, and Shriners Burns Institute, Boston, 02114, USA
    J Neurosurg 96:1023-31. 2002
  5. ncbi request reprint Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn
    A Aria Tzika
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 21:201-8. 2008
  6. ncbi request reprint Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment
    A A Tzika
    Department of Radiology, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Neuroradiology 43:169-77. 2001
  7. ncbi request reprint Magnetic resonance spectroscopy and magnetic resonance imaging findings in Krabbe's disease
    M K Zarifi
    Department of Radiology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Child Neurol 16:522-6. 2001
  8. ncbi request reprint MRI and 1H MRS findings in Smith-Lemli-Opitz syndrome
    P A Caruso
    Department of Radiology, Massachusetts Eye and Ear Infirmary, Boston, USA
    Neuroradiology 46:3-14. 2004
  9. ncbi request reprint Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult
    J S Soul
    Departments of Neurology, Children's Hospital, Boston, MA 02115, USA
    Pediatrics 108:1211-4. 2001
  10. ncbi request reprint Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 20:199-208. 2007

Research Grants

Collaborators

  • Leo Ling Cheng
  • R Gilberto Gonzalez
  • M B Irons
  • Karen J Marcus
  • J A J Martyn
  • Peter Black
  • Loukas G Astrakas
  • Qunhao Zhang
  • Katie E Padfield
  • Michael N Mindrinos
  • Ronald G Tompkins
  • Laurence G Rahme
  • Suresh Gopalan
  • Maria K Zarifi
  • Ovidiu C Andronesi
  • Dionyssios Mintzopoulos
  • L Astrakas
  • George Dai
  • P A Caruso
  • David Zurakowski
  • T Y Poussaint
  • L G Astrakas
  • M K Zarifi
  • J S Soul
  • Jochem Struppe
  • F Makedon
  • M Zarifi
  • John Schulz
  • Song Ye
  • Haihui Cao
  • Yong Ming Yu
  • Igor Goljer
  • Shingo Yasuhara
  • D Zurakowski
  • Umberto De Girolami
  • Douglas C Anthony
  • E R Elias
  • C Bay
  • Nancy J Tarbell
  • AdrĂ© du Plessis Ad
  • Tina Young Poussaint
  • A J du Plessis
  • B T Darras
  • J J Volpe
  • R L Robertson
  • D C Anthony

Detail Information

Publications21

  1. ncbi request reprint Multiparametric MR assessment of pediatric brain tumors
    A A Tzika
    NMR Surgical Laboratory, Massachusetts General Hospital and Shriners Burns Institute, Harvard Medical School, 51 Blossom Street, Room 261, Boston, MA 02114, USA
    Neuroradiology 45:1-10. 2003
    ....
  2. ncbi request reprint Spectroscopic and perfusion magnetic resonance imaging predictors of progression in pediatric brain tumors
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Cancer 100:1246-56. 2004
    ....
  3. ncbi request reprint Murine intramyocellular lipids quantified by NMR act as metabolic biomarkers in burn trauma
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 21:825-32. 2008
    ..We believe that IMCLs may therefore be useful biomarkers in predicting the therapeutic effectiveness of hypolipidemic agents for patients with severe burns...
  4. ncbi request reprint Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy
    A Aria Tzika
    Department of Radiology, Massachusetts General Hospital, Harvard Medical School, and Shriners Burns Institute, Boston, 02114, USA
    J Neurosurg 96:1023-31. 2002
    ..Their hypothesis was that ex vivo MR spectroscopy provides a link between in vivo MR spectroscopy and neuropathological analysis...
  5. ncbi request reprint Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn
    A Aria Tzika
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 21:201-8. 2008
    ..That PGC-1beta is a highly inducible factor in most tissues and responds to common calcium and cyclic adenosine monophosphate (cAMP) signaling pathways strongly suggests that it may be possible to develop drugs that can induce PGC-1beta...
  6. ncbi request reprint Proton magnetic spectroscopic imaging of the child's brain: the response of tumors to treatment
    A A Tzika
    Department of Radiology, Children s Hospital and Harvard Medical School, Boston, MA, USA
    Neuroradiology 43:169-77. 2001
    ..The only significant independent predictor of active tumor growth was tCr (P < 0.01). We suggest that tCr is useful in assessing response of brain tumors to treatment...
  7. ncbi request reprint Magnetic resonance spectroscopy and magnetic resonance imaging findings in Krabbe's disease
    M K Zarifi
    Department of Radiology, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Child Neurol 16:522-6. 2001
    ..In conjunction with brain MRI, these magnetic resonance spectroscopy findings may alert clinicians to the possibility of leukodystrophy in children with progressive encephalopathy...
  8. ncbi request reprint MRI and 1H MRS findings in Smith-Lemli-Opitz syndrome
    P A Caruso
    Department of Radiology, Massachusetts Eye and Ear Infirmary, Boston, USA
    Neuroradiology 46:3-14. 2004
    ..The use of MRI and 1H MRS is an effective way to demonstrate brain structural abnormalities in patients with SLOS and may prove to be an effective method for the assessment of the effects of cholesterol replacement therapy in the brain...
  9. ncbi request reprint Time course of changes in diffusion-weighted magnetic resonance imaging in a case of neonatal encephalopathy with defined onset and duration of hypoxic-ischemic insult
    J S Soul
    Departments of Neurology, Children's Hospital, Boston, MA 02115, USA
    Pediatrics 108:1211-4. 2001
    ..hypoxia-ischemia, newborn brain, perinatal asphyxia, diffusion-weighted imaging, proton magnetic resonance spectroscopy...
  10. ncbi request reprint Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 20:199-208. 2007
    ....
  11. ncbi request reprint Predicting survival of children with CNS tumors using proton magnetic resonance spectroscopic imaging biomarkers
    Karen J Marcus
    Department of Radiation Oncology, Children s Hospital Boston, 51 Blossom Street, Boston, MA 02114, USA
    Int J Oncol 30:651-7. 2007
    ..More accurate prediction using this non-invasive technique represents an important advance and may suggest more appropriate therapy, especially when diagnostic biopsy is not feasible...
  12. ncbi request reprint Uncoupling protein 3 expression and intramyocellular lipid accumulation by NMR following local burn trauma
    Qunhao Zhang
    Department of Surgery, Massachusetts General Hospital, Shriners Burn Institute and Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 18:1223-9. 2006
    ....
  13. ncbi request reprint Local and distant burn injury alter immuno-inflammatory gene expression in skeletal muscle
    Katie E Padfield
    Department of Surgery, Massachusetts General Hospital, Shriners Burns, Institute and Harvard Medical School, Boston, Massachusetts 02114, USA
    J Trauma 61:280-92. 2006
    ..We are investigating the immuno-inflammatory response by characterizing gene expression changes in skeletal muscle after local and distant burn injury...
  14. ncbi request reprint Proton NMR spectroscopy shows lipids accumulate in skeletal muscle in response to burn trauma-induced apoptosis
    Loukas G Astrakas
    Department of Surgery, Massachusetts General Hospital, Shriners Burns Institute and Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 19:1431-40. 2005
    ..Together, our results provide new insight into the local physiological changes that occur in skeletal muscle after severe burn trauma...
  15. pmc Burn injury causes mitochondrial dysfunction in skeletal muscle
    Katie E Padfield
    Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 102:5368-73. 2005
    ....
  16. ncbi request reprint Noninvasive magnetic resonance spectroscopic imaging biomarkers to predict the clinical grade of pediatric brain tumors
    Loukas G Astrakas
    Nuclear Magnetic Resonance Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Shriners Burns Institute, Harvard Medical School, Boston, Massachusetts 02114, USA
    Clin Cancer Res 10:8220-8. 2004
    ..Proton magnetic resonance spectroscopic imaging, although not a proxy for histology, provides noninvasive, in vivo biomarkers for predicting clinical grades of pediatric brain tumors...
  17. ncbi request reprint Prediction of adverse outcome with cerebral lactate level and apparent diffusion coefficient in infants with perinatal asphyxia
    Maria K Zarifi
    Departments of Radiology, Children s Hospital, Harvard Medical School, Boston, Mass 02114, USA
    Radiology 225:859-70. 2002
    ..To compare the predictive value for adverse outcome of quantitative cerebral lactate level and of apparent diffusion coefficient (ADC) in infants with perinatal asphyxia in the early postnatal period...
  18. ncbi request reprint Neuroimaging in pediatric brain tumors: Gd-DTPA-enhanced, hemodynamic, and diffusion MR imaging compared with MR spectroscopic imaging
    A Aria Tzika
    Department of Radiology, Children s Hospital, Harvard Medical School, Boston, MA 02114, USA
    AJNR Am J Neuroradiol 23:322-33. 2002
    ..Our aim was to improve conventional neuroimaging of pediatric brain tumors with hemodynamic, diffusion, and spectroscopic MR imaging...
  19. ncbi request reprint The clinical perspective of large scale projects: a case study of multiparametric MR imaging of pediatric brain tumors
    L Astrakas
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital, Harvard Medical School, 51 Blossom Street, Boston, MA 02114, USA
    Oncol Rep 15:1065-9. 2006
    ..At present, efforts to organize medical data locally and between different sites is limited by diversity, interoperability, security, and accountability difficulties...
  20. ncbi request reprint Proton magnetic resonance spectroscopic imaging as a cancer biomarker for pediatric brain tumors (Review)
    A Aria Tzika
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner s Burn Institute, Harvard Medical School, Boston, MA 02114, USA
    Int J Oncol 32:517-26. 2008
    ..We further focus on applying the MRS technology to pediatric brain tumors, the leading cause of pediatric cancer mortality...
  21. doi request reprint Solid-state NMR adiabatic TOBSY sequences provide enhanced sensitivity for multidimensional high-resolution magic-angle-spinning 1H MR spectroscopy
    Ovidiu C Andronesi
    NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner s Burn Institute, Harvard Medical School, 51 Blossom Street, Room 261, Boston, MA 02114, USA
    J Magn Reson 193:251-8. 2008
    ..This is the first demonstration of such a concept for HRMAS metabolic profiling of disease processes, including cancer, from biopsies requiring reduced sample degradation for further genomic analysis...

Research Grants1