A R Tzafriri

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint On the validity of the quasi-steady state approximation of bimolecular reactions in solution
    A Rami Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA 02139, USA
    J Theor Biol 233:343-50. 2005
  2. ncbi request reprint Michaelis-Menten kinetics at high enzyme concentrations
    A R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA 02139, USA
    Bull Math Biol 65:1111-29. 2003
  3. ncbi request reprint The total quasi-steady-state approximation is valid for reversible enzyme kinetics
    A R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA 02139, USA
    J Theor Biol 226:303-13. 2004
  4. ncbi request reprint Quasi-steady-state kinetics at enzyme and substrate concentrations in excess of the Michaelis-Menten constant
    A Rami Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA 02139, and Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
    J Theor Biol 245:737-48. 2007
  5. ncbi request reprint Analysis of compartmental models of ligand-induced endocytosis
    Abraham R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA, USA
    J Theor Biol 229:127-38. 2004
  6. ncbi request reprint Mathematical modeling and optimization of drug delivery from intratumorally injected microspheres
    Abraham Rami Tzafriri
    The Otto Loewi Minerva Center for Cellular and Molecular Neurobiology, Department of Neurobiology, The Hebrew University, Jerusalem, Israel
    Clin Cancer Res 11:826-34. 2005
  7. pmc Diffusion-limited binding explains binary dose response for local arterial and tumour drug delivery
    A R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell Prolif 42:348-63. 2009
  8. pmc Lesion complexity determines arterial drug distribution after local drug delivery
    Abraham R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Control Release 142:332-8. 2010
  9. ncbi request reprint Mathematical modeling of diffusion-mediated release from bulk degrading matrices
    A R Tzafriri
    Institute of Computer Science and Department of Neurobiology, The Hebrew University, Jerusalem, Israel
    J Control Release 63:69-79. 2000

Collaborators

Detail Information

Publications9

  1. ncbi request reprint On the validity of the quasi-steady state approximation of bimolecular reactions in solution
    A Rami Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA 02139, USA
    J Theor Biol 233:343-50. 2005
    ..This work underscores the need for exercising greater caution in invoking the QSSA...
  2. ncbi request reprint Michaelis-Menten kinetics at high enzyme concentrations
    A R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA 02139, USA
    Bull Math Biol 65:1111-29. 2003
    ..These approximations overlap and extend the domains of validity of the standard and reverse quasi-steady state approximations...
  3. ncbi request reprint The total quasi-steady-state approximation is valid for reversible enzyme kinetics
    A R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA 02139, USA
    J Theor Biol 226:303-13. 2004
    ..Using these simple analytical approximations, a sequential experimental-theoretical method is suggested for unambiguously estimating all the kinetic parameters of the reversible Michaelis-Menten scheme...
  4. ncbi request reprint Quasi-steady-state kinetics at enzyme and substrate concentrations in excess of the Michaelis-Menten constant
    A Rami Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA 02139, and Department of Medicine, Brigham and Women s Hospital, Boston 02115, USA
    J Theor Biol 245:737-48. 2007
    ....
  5. ncbi request reprint Analysis of compartmental models of ligand-induced endocytosis
    Abraham R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Room 16 343, Cambridge, MA, USA
    J Theor Biol 229:127-38. 2004
    ..This analysis also provides insight on the fast endocytosis and recycling limit of protocol III...
  6. ncbi request reprint Mathematical modeling and optimization of drug delivery from intratumorally injected microspheres
    Abraham Rami Tzafriri
    The Otto Loewi Minerva Center for Cellular and Molecular Neurobiology, Department of Neurobiology, The Hebrew University, Jerusalem, Israel
    Clin Cancer Res 11:826-34. 2005
    ..This study set out to rationally design such an optimal microsphere release mode based on mathematical modeling...
  7. pmc Diffusion-limited binding explains binary dose response for local arterial and tumour drug delivery
    A R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Cell Prolif 42:348-63. 2009
    ..Most therapies seek to prolong release, yet recent studies demonstrate sustained clinical benefit following local bolus endovascular delivery...
  8. pmc Lesion complexity determines arterial drug distribution after local drug delivery
    Abraham R Tzafriri
    Harvard MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    J Control Release 142:332-8. 2010
    ....
  9. ncbi request reprint Mathematical modeling of diffusion-mediated release from bulk degrading matrices
    A R Tzafriri
    Institute of Computer Science and Department of Neurobiology, The Hebrew University, Jerusalem, Israel
    J Control Release 63:69-79. 2000
    ..This analysis indicates that under ordinary mixing conditions the diffusion layer is not rate limiting and the release is very well approximated by the analytical result for perfect sink conditions...