Kay M Tye

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. doi request reprint Optogenetic investigation of neural circuits underlying brain disease in animal models
    Kay M Tye
    Department of Bioengineering, Stanford University, 318 Campus Drive, Clark Center, Stanford, California 94305 5444, USA
    Nat Rev Neurosci 13:251-66. 2012
  2. doi request reprint Dopamine neurons modulate neural encoding and expression of depression-related behaviour
    Kay M Tye
    Picower Institute for Learning and Memory, Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 493:537-41. 2013
  3. doi request reprint Glutamate inputs to the nucleus accumbens: does source matter?
    Kay M Tye
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 76:671-3. 2012
  4. doi request reprint A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge
    Melissa R Warden
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 492:428-32. 2012
  5. doi request reprint Diverging neural pathways assemble a behavioural state from separable features in anxiety
    Sung Yon Kim
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 496:219-23. 2013
  6. doi request reprint Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins
    Joanna Mattis
    Department of Bioengineering, Stanford University, Stanford, California, USA
    Nat Methods 9:159-72. 2012
  7. ncbi request reprint Natural neural projection dynamics underlying social behavior
    Lisa A Gunaydin
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Cell 157:1535-51. 2014
  8. doi request reprint BLA to vHPC inputs modulate anxiety-related behaviors
    Ada C Felix-Ortiz
    The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 79:658-64. 2013
  9. ncbi request reprint Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors
    Edward H Nieh
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    Brain Res 1511:73-92. 2013
  10. pmc Input-specific control of reward and aversion in the ventral tegmental area
    Stephan Lammel
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA
    Nature 491:212-7. 2012

Collaborators

  • Soo Yeun Lee
  • Ilana B Witten
  • Ofer Yizhar
  • Patricia H Janak
  • Garret D Stuber
  • Karl Deisseroth
  • Ada C Felix-Ortiz
  • Sung Yon Kim
  • Anna Beyeler
  • Lisa A Gunaydin
  • Robert C Malenka
  • Avishek Adhikari
  • Stephan Lammel
  • Joanna Mattis
  • Melissa R Warden
  • Edward H Nieh
  • Lief E Fenno
  • Julie J Mirzabekov
  • Maisie Lo
  • Byung Kook Lim
  • Joel C Finkelstein
  • Kelly A Zalocusky
  • Raag D Airan
  • Logan Grosenick
  • Isaac V Kauvar
  • Polina Anikeeva
  • Christine A Eckhardt
  • Sally Pak
  • Craig P Wildes
  • Christina K Kim
  • Praneeth Namburi
  • Caitlin S Mallory
  • Changwoo Seo
  • Rachael Neve
  • James H Marshel
  • Christopher A Leppla
  • Emily A Ferenczi
  • Kee Wui Huang
  • Viviana Gradinaru
  • Chen Ran
  • Loren M Frank
  • Kimberly R Thompson
  • Charu Ramakrishnan
  • Aslihan Selimbeyoglu
  • Daniel J O'Shea
  • Michael J Betley
  • Rohit Prakash
  • Minsuk Hyun

Detail Information

Publications14

  1. doi request reprint Optogenetic investigation of neural circuits underlying brain disease in animal models
    Kay M Tye
    Department of Bioengineering, Stanford University, 318 Campus Drive, Clark Center, Stanford, California 94305 5444, USA
    Nat Rev Neurosci 13:251-66. 2012
    ....
  2. doi request reprint Dopamine neurons modulate neural encoding and expression of depression-related behaviour
    Kay M Tye
    Picower Institute for Learning and Memory, Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 493:537-41. 2013
    ....
  3. doi request reprint Glutamate inputs to the nucleus accumbens: does source matter?
    Kay M Tye
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 76:671-3. 2012
    ..2012) photostimulate glutamatergic axons from the amygdala, prefrontal cortex, and hippocampus in the nucleus accumbens, characterizing the functional role of each pathway both in vivo and ex vivo...
  4. doi request reprint A prefrontal cortex-brainstem neuronal projection that controls response to behavioural challenge
    Melissa R Warden
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 492:428-32. 2012
    ..These results may be of importance in understanding the neural circuitry underlying normal and pathological patterns of action selection and motivation in behaviour...
  5. doi request reprint Diverging neural pathways assemble a behavioural state from separable features in anxiety
    Sung Yon Kim
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 496:219-23. 2013
    ....
  6. doi request reprint Principles for applying optogenetic tools derived from direct comparative analysis of microbial opsins
    Joanna Mattis
    Department of Bioengineering, Stanford University, Stanford, California, USA
    Nat Methods 9:159-72. 2012
    ....
  7. ncbi request reprint Natural neural projection dynamics underlying social behavior
    Lisa A Gunaydin
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Cell 157:1535-51. 2014
    ..Direct observation of deep projection-specific activity in this way captures a fundamental and previously inaccessible dimension of mammalian circuit dynamics. ..
  8. doi request reprint BLA to vHPC inputs modulate anxiety-related behaviors
    Ada C Felix-Ortiz
    The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 79:658-64. 2013
    ..These data establish a role for BLA-vHPC synapses in bidirectionally controlling anxiety-related behaviors in an immediate, yet reversible, manner and a model for the local circuit mechanism of BLA inputs in the vHPC. ..
  9. ncbi request reprint Optogenetic dissection of neural circuits underlying emotional valence and motivated behaviors
    Edward H Nieh
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA
    Brain Res 1511:73-92. 2013
    ..In this review, we will present the body of optogenetic studies that has significantly enhanced our understanding of emotional valence and motivated behaviors. This article is part of a Special Issue entitled Optogenetics (7th BRES)...
  10. pmc Input-specific control of reward and aversion in the ventral tegmental area
    Stephan Lammel
    Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 265 Campus Drive, Stanford, California 94305, USA
    Nature 491:212-7. 2012
    ..These results establish that distinct VTA circuits generate reward and aversion, and thereby provide a new framework for understanding the circuit basis of adaptive and pathological motivated behaviours...
  11. pmc Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior
    Ada C Felix-Ortiz
    Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139
    J Neurosci 34:586-95. 2014
    ..These results indicate that BLA inputs to the vHPC are capable of modulating social behaviors in a bidirectional manner. ..
  12. pmc Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement
    Ilana B Witten
    Department of Bioengineering, Stanford University, Stanford, CA 94305, USA
    Neuron 72:721-33. 2011
    ..These studies complement existing targeting approaches by extending the generalizability of optogenetics to traditionally non-genetically-tractable but vital animal models...
  13. pmc Amygdala circuitry mediating reversible and bidirectional control of anxiety
    Kay M Tye
    Department of Bioengineering, Stanford University, Stanford, California 94305, USA
    Nature 471:358-62. 2011
    ....
  14. doi request reprint Deciphering memory function with optogenetics
    Anna Beyeler
    Department of Brain and Cognitive Sciences, Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Prog Mol Biol Transl Sci 122:341-90. 2014
    ..Recently, new light-sensitive molecules have been developed to control intracellular pathways or gene expression, which promise to enhance our understanding of the molecular mechanism of memory function. ..