Ruth E Tuomala

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Antiretroviral therapy during pregnancy and the risk of an adverse outcome
    Ruth E Tuomala
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston 02115, USA
    N Engl J Med 346:1863-70. 2002
  2. ncbi Cell-associated genital tract virus and vertical transmission of human immunodeficiency virus type 1 in antiretroviral-experienced women
    Ruth E Tuomala
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 187:375-84. 2003
  3. ncbi Improved obstetric outcomes and few maternal toxicities are associated with antiretroviral therapy, including highly active antiretroviral therapy during pregnancy
    Ruth E Tuomala
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 38:449-73. 2005
  4. ncbi Polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, local midtrimester cytokine response to vaginal flora, and subsequent preterm birth
    Mehmet R Genc
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 191:1324-30. 2004
  5. ncbi Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy
    Roger Paredes
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    AIDS 24:45-53. 2010
  6. ncbi Increased risk of hepatotoxicity in HIV-infected pregnant women receiving antiretroviral therapy independent of nevirapine exposure
    David W Ouyang
    Division of Maternal Fetal Medicine, Brigham and Women s Hospital, USA
    AIDS 23:2425-30. 2009
  7. ncbi Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals
    David W Ouyang
    Division of Maternal Fetal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    AIDS 24:109-14. 2010
  8. ncbi A disproportionate increase in IL-1beta over IL-1ra in the cervicovaginal secretions of pregnant women with altered vaginal microflora correlates with preterm birth
    Mehmet R Genc
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Obstet Gynecol 190:1191-7. 2004
  9. ncbi Risk factors for in utero and intrapartum transmission of HIV
    Laurence S Magder
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 38:87-95. 2005
  10. ncbi High prevalence of primary lamivudine and nelfinavir resistance in HIV-1-infected pregnant women in the United States, 1998-2004
    Roger Paredes
    Section of Retroviral Therapeutics, Brigham and Women s Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, USA
    AIDS 21:2103-6. 2007

Detail Information

Publications18

  1. ncbi Antiretroviral therapy during pregnancy and the risk of an adverse outcome
    Ruth E Tuomala
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston 02115, USA
    N Engl J Med 346:1863-70. 2002
    ..Some studies suggest that combination antiretroviral therapy in pregnant women with human immunodeficiency virus type 1 (HIV-1) infection increases the risk of premature birth and other adverse outcomes of pregnancy...
  2. ncbi Cell-associated genital tract virus and vertical transmission of human immunodeficiency virus type 1 in antiretroviral-experienced women
    Ruth E Tuomala
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Infect Dis 187:375-84. 2003
    ..28; 95% CI, 1.09-4.78; P=.03). The cell-associated genital tract compartment is important in the pathophysiology and prevention of vertical HIV-1 transmission...
  3. ncbi Improved obstetric outcomes and few maternal toxicities are associated with antiretroviral therapy, including highly active antiretroviral therapy during pregnancy
    Ruth E Tuomala
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 38:449-73. 2005
    ..3, 95% CI: 0.2-0.7). Benefits of ART continue to outweigh observed risks...
  4. ncbi Polymorphism in intron 2 of the interleukin-1 receptor antagonist gene, local midtrimester cytokine response to vaginal flora, and subsequent preterm birth
    Mehmet R Genc
    Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 191:1324-30. 2004
    ....
  5. ncbi Postpartum antiretroviral drug resistance in HIV-1-infected women receiving pregnancy-limited antiretroviral therapy
    Roger Paredes
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    AIDS 24:45-53. 2010
    ..Pregnancy-limited antiretroviral therapy (PLAT) drastically reduces HIV-1 transmission to the newborn, but may select for antiretroviral drug resistance mutations in mothers...
  6. ncbi Increased risk of hepatotoxicity in HIV-infected pregnant women receiving antiretroviral therapy independent of nevirapine exposure
    David W Ouyang
    Division of Maternal Fetal Medicine, Brigham and Women s Hospital, USA
    AIDS 23:2425-30. 2009
    ..To estimate whether the association between nevirapine (NVP) and hepatotoxicity differs according to pregnancy status in HIV-infected women...
  7. ncbi Lack of increased hepatotoxicity in HIV-infected pregnant women receiving nevirapine compared with other antiretrovirals
    David W Ouyang
    Division of Maternal Fetal Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    AIDS 24:109-14. 2010
    ..To estimate whether HIV-infected pregnant women were at an increased risk of hepatotoxicity when taking nevirapine (NVP)-containing regimens compared with HIV-infected pregnant women taking antiretroviral therapy (ART) not containing NVP...
  8. ncbi A disproportionate increase in IL-1beta over IL-1ra in the cervicovaginal secretions of pregnant women with altered vaginal microflora correlates with preterm birth
    Mehmet R Genc
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Am J Obstet Gynecol 190:1191-7. 2004
    ..Study design Vaginal samples collected at 18 to 22 weeks' gestation from 207 women were analyzed to study qualitative and quantitative microbiologic aspects of vaginal microflora and IL-1beta and IL-1ra concentrations...
  9. ncbi Risk factors for in utero and intrapartum transmission of HIV
    Laurence S Magder
    Department of Epidemiology and Preventive Medicine, University of Maryland, Baltimore, MD, USA
    J Acquir Immune Defic Syndr 38:87-95. 2005
    ..To identify predictors of in utero and intrapartum HIV-1 transmission in infants born in the Women and Infants Transmission Study between 1990 and 2000...
  10. ncbi High prevalence of primary lamivudine and nelfinavir resistance in HIV-1-infected pregnant women in the United States, 1998-2004
    Roger Paredes
    Section of Retroviral Therapeutics, Brigham and Women s Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts, USA
    AIDS 21:2103-6. 2007
    ....
  11. ncbi No association between antepartum serologic and genital tract evidence of herpes simplex virus-2 coinfection and perinatal HIV-1 transmission
    Katherine T Chen
    Department of Obstetrics and Gynecology and Epidemiology, Columbia University, New York, NY 10032, USA
    Am J Obstet Gynecol 198:399.e1-5. 2008
    ..The purpose of this study was to assess the risk of perinatal HIV-1 transmission in women who are coinfected with herpes simplex virus-2 (HSV-2)...
  12. ncbi Mode of delivery and postpartum HIV-1 disease progression: the Women and Infants Transmission Study
    Elena L Navas-Nacher
    Children's Memorial Medical Center, Chicago, Illinois, USA
    AIDS 20:429-36. 2006
    ..66 years. CONCLUSIONS: The present results suggest that, among HIV-1-infected women in North America, mode of delivery is not associated with subsequent HIV-1 disease progression...
  13. ncbi Pharmacokinetics and safety of indinavir in human immunodeficiency virus-infected pregnant women
    Jashvant D Unadkat
    Department of Pharmaceutics, University of Washington, Box 357610, Seattle, WA 98195, USA
    Antimicrob Agents Chemother 51:783-6. 2007
    ..Indinavir area under the plasma concentration-time curve was 68% lower antepartum versus postpartum, suggesting increased intestinal and/or hepatic CYP3A activity during pregnancy...
  14. ncbi Adherence to antiretrovirals among US women during and after pregnancy
    Arlene D Bardeguez
    Department of Obstetrics, Gynecology and Women s Health, University of Medicine and Dentistry of New Jersey New Jersey Medical School, Newark, NJ 07103 1709, USA
    J Acquir Immune Defic Syndr 48:408-17. 2008
    ..Antiretrovirals (ARVs) are recommended for maternal health and to reduce HIV-1 mother-to-child transmission, but suboptimal adherence can counteract its benefits...
  15. ncbi Protease inhibitor use during pregnancy: is there an obstetrical risk?
    Ruth E Tuomala
    J Infect Dis 193:1191-4. 2006
  16. ncbi Quantitative microbiologic models for preterm delivery
    Andrew B Onderdonk
    Channing Laboratory, Departments of Pathology and Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Microbiol 41:1073-9. 2003
    ..91 (CI, 0.79 to 1). It may be possible to predict PTD by using microbiologic risk factors measured once the gestation period has reached the 20-week time point...
  17. ncbi Herpes simplex virus hepatitis causing acute liver dysfunction and thrombocytopenia in pregnancy
    Rebecca H Allen
    Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Obstet Gynecol 106:1187-9. 2005
    ..Herpes simplex virus (HSV) hepatitis in pregnant women is a rare condition. We report a case confirmed by liver biopsy and successfully treated with empiric intravenous acyclovir...
  18. ncbi Predictors of repeat pregnancy among HIV-1-infected women
    Allison S Bryant
    University of California, San Francisco, San Francisco, CA 94143, USA
    J Acquir Immune Defic Syndr 44:87-92. 2007
    ..We examined predictors of repeat pregnancy among HIV-1-infected women enrolled in the Women and Infants Transmission Study (WITS)...