Alexei Trofimov

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi Beam delivery sequencing for intensity modulated proton therapy
    Alexei Trofimov
    Northeast Proton Therapy Center Massachusetts General Hospital, Boston, MA 02114, USA
    Phys Med Biol 48:1321-31. 2003
  2. ncbi Optimization of beam parameters and treatment planning for intensity modulated proton therapy
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital, 30 Fruit Street, Boston, MA 02114, USA
    Technol Cancer Res Treat 2:437-44. 2003
  3. pmc Interfractional variations in the setup of pelvic bony anatomy and soft tissue, and their implications on the delivery of proton therapy for localized prostate cancer
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 80:928-37. 2011
  4. ncbi Temporo-spatial IMRT optimization: concepts, implementation and initial results
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 50:2779-98. 2005
  5. pmc Radiotherapy treatment of early-stage prostate cancer with IMRT and protons: a treatment planning comparison
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 69:444-53. 2007
  6. pmc Tumor trailing strategy for intensity-modulated radiation therapy of moving targets
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Med Phys 35:1718-33. 2008
  7. doi Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential
    Drosoula Giantsoudi
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 87:216-22. 2013
  8. doi Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No
    Herman Suit
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Radiother Oncol 86:148-53. 2008
  9. pmc Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions
    Chuan Zeng
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 40:051708. 2013
  10. pmc Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning
    Clemens Grassberger
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 80:1559-66. 2011

Detail Information

Publications23

  1. ncbi Beam delivery sequencing for intensity modulated proton therapy
    Alexei Trofimov
    Northeast Proton Therapy Center Massachusetts General Hospital, Boston, MA 02114, USA
    Phys Med Biol 48:1321-31. 2003
    ....
  2. ncbi Optimization of beam parameters and treatment planning for intensity modulated proton therapy
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital, 30 Fruit Street, Boston, MA 02114, USA
    Technol Cancer Res Treat 2:437-44. 2003
    ..Possibilities have been investigated for improving the proton dose conformity by optimizing the beam and scanning nozzle parameters, and by taking the specifics and limitations of the system into account in the treatment planning stage...
  3. pmc Interfractional variations in the setup of pelvic bony anatomy and soft tissue, and their implications on the delivery of proton therapy for localized prostate cancer
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 80:928-37. 2011
    ....
  4. ncbi Temporo-spatial IMRT optimization: concepts, implementation and initial results
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 50:2779-98. 2005
    ....
  5. pmc Radiotherapy treatment of early-stage prostate cancer with IMRT and protons: a treatment planning comparison
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 69:444-53. 2007
    ..To compare intensity-modulated photon radiotherapy (IMRT) with three-dimensional conformal proton therapy (3D-CPT) for early-stage prostate cancer, and explore the potential utility of intensity-modulated proton therapy (IMPT)...
  6. pmc Tumor trailing strategy for intensity-modulated radiation therapy of moving targets
    Alexei Trofimov
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Med Phys 35:1718-33. 2008
    ..g., peak-to-peak motion of less than 10 mm). The mechanical limitations of implementing tumor trailing are less rigorous than those of real-time tracking, and the same technology could be used for both...
  7. doi Linear energy transfer-guided optimization in intensity modulated proton therapy: feasibility study and clinical potential
    Drosoula Giantsoudi
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Int J Radiat Oncol Biol Phys 87:216-22. 2013
    ..To investigate the feasibility and potential clinical benefit of linear energy transfer (LET) guided plan optimization in intensity modulated proton therapy (IMPT)...
  8. doi Should positive phase III clinical trial data be required before proton beam therapy is more widely adopted? No
    Herman Suit
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Radiother Oncol 86:148-53. 2008
    ..Evaluate the rationale for the proposals that prior to a wider use of proton radiation therapy there must be supporting data from phase III clinical trials. That is, would less dose to normal tissues be an advantage to the patient?..
  9. pmc Maximizing the biological effect of proton dose delivered with scanned beams via inhomogeneous daily dose distributions
    Chuan Zeng
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Med Phys 40:051708. 2013
    ..The authors describe a method to construct inhomogeneous fractional dose (IFD) distributions, and evaluate the potential gain in the therapeutic effect from their delivery in proton therapy delivered by pencil beam scanning...
  10. pmc Variations in linear energy transfer within clinical proton therapy fields and the potential for biological treatment planning
    Clemens Grassberger
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 80:1559-66. 2011
    ..These distributions can be used to identify areas of elevated or diminished biological effect. The location of such areas might be influenced in intensity-modulated proton therapy (IMPT) optimization...
  11. doi Rectal dose-volume histogram parameters are associated with long-term patient-reported gastrointestinal quality of life after conventional and high-dose radiation for prostate cancer: a subgroup analysis of a randomized trial
    Paul L Nguyen
    Department of Radiation Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 78:1081-5. 2010
    ..2 GyE) or high-dose (79.2 GyE) radiation for prostate cancer...
  12. pmc Clinical controversies: proton therapy for prostate cancer
    Kent W Mouw
    Harvard Radiation Oncology Program, Boston, MA, USA
    Semin Radiat Oncol 23:109-14. 2013
    ..We review the available evidence and present the current state of proton beam therapy for prostate cancer...
  13. ncbi Proton beams to replace photon beams in radical dose treatments
    Herman Suit
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Acta Oncol 42:800-8. 2003
    ..5 provided there were to be no charge for the original facility and that there were sufficient patients for operating on an extended schedule (6-7 days of 14-16 h) with > or = two gantries and one fixed horizontal beam...
  14. doi Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 79:121-9. 2011
    ....
  15. pmc Hypofractionated proton therapy for prostate cancer: dose delivery uncertainty due to interfractional motion
    Yi Wang
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA
    Med Phys 40:071714. 2013
    ..The purpose of this study is to evaluate the impact of interfractional motion on treatment dose delivery within the likely range of the tumor α/β ratio...
  16. pmc Including robustness in multi-criteria optimization for intensity-modulated proton therapy
    Wei Chen
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Phys Med Biol 57:591-608. 2012
    ....
  17. doi Breathing interplay effects during proton beam scanning: simulation and statistical analysis
    Joao Seco
    Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA
    Phys Med Biol 54:N283-94. 2009
    ..5 x 8.5 x 10 cm(3). For smaller tumor volumes more repaintings will be required, while for larger volumes five repaintings should be sufficient to achieve the required dose accuracy...
  18. doi Proton vs carbon ion beams in the definitive radiation treatment of cancer patients
    Herman Suit
    Department of Radiation Oncology, Boston, MA, USA
    Radiother Oncol 95:3-22. 2010
    ..The principal differences are LET, low for (1)H and high for (12)C, and a narrower penumbra of (12)C beams. Were (12)C to yield a higher TCP for a defined NTCP than (1)H therapy, would LET, fractionation or penumbra width be the basis?..
  19. doi Early clinical outcomes using proton radiation for children with central nervous system atypical teratoid rhabdoid tumors
    Karen De Amorim Bernstein
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Int J Radiat Oncol Biol Phys 86:114-20. 2013
    ..Irradiation improves survival but has traditionally been avoided in patients under the age of 3 due to the increasing risk of neurocognitive side effects. We report the first cohort of AT/RT patients treated with proton therapy...
  20. ncbi Proton-beam vs intensity-modulated radiation therapy. Which is best for treating prostate cancer?
    Paul L Nguyen
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, MA 02114, USA
    Oncology (Williston Park) 22:748-54; discussion 754, 757. 2008
    ..In this article, we review the current status of the evidence supporting the use of protons in prostate cancer and discuss the active controversies that surround this modality...
  21. ncbi Proton radiotherapy for childhood ependymoma: initial clinical outcomes and dose comparisons
    Shannon M Macdonald
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 71:979-86. 2008
    ....
  22. ncbi MO-A-213AB-09: Hypofractionated Proton Therapy of the Prostate: The Impact of the Uncertainties in Dose Delivery and Alpha/Beta Ratio on Tumor Dose Escalation
    Yi Wang
    Francis H Burr Proton Therapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Med Phys 39:3860-1. 2012
    ..0 Gy, and is of minimal concern to hypofractionated proton therapy. This study was supported by the Federal Share of program income earned by Massachusetts General Hospital on C06-CA059267, Proton Therapy Research and Treatment Center...
  23. ncbi A unified approach for inversion problems in intensity-modulated radiation therapy
    Yair Censor
    Department of Mathematics, University of Haifa, Mt Carmel, Haifa 31905, Israel
    Phys Med Biol 51:2353-65. 2006
    ..We present computational results that demonstrate the validity of the model and the power of the proposed algorithmic scheme...