Susumu Tonegawa

Summary

Affiliation: Massachusetts Institute of Technology
Country: USA

Publications

  1. ncbi request reprint That great time in Basel
    Susumu Tonegawa
    The Picower Center for Learning and Memory, E17 353, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Cell 116:S99-101, 1 p following S106. 2004
  2. ncbi request reprint The ins and outs of hippocampal circuits
    Susumu Tonegawa
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 57:175-7. 2008
  3. pmc Genetic neuroscience of mammalian learning and memory
    Susumu Tonegawa
    Picower Center for Learning and Memory, Howard Hughes Medical Institute, and RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 358:787-95. 2003
  4. ncbi request reprint Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
  5. pmc Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory
    Toshiaki Nakashiba
    The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 62:781-7. 2009
  6. ncbi request reprint Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience
    Kazu Nakazawa
    Howard Hughes Medical Institute, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 38:305-15. 2003
  7. ncbi request reprint Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice
    Mansuo L Hayashi
    The Picower Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Neuron 42:773-87. 2004
  8. pmc CA3 NMDA receptors are required for the rapid formation of a salient contextual representation
    Thomas J McHugh
    The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Hippocampus 19:1153-8. 2009
  9. pmc Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits
    Keigo Kohara
    1 RIKEN MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA 2
    Nat Neurosci 17:269-79. 2014
  10. ncbi request reprint Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
    Toshiaki Nakashiba
    Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 319:1260-4. 2008

Research Grants

Collaborators

Detail Information

Publications52

  1. ncbi request reprint That great time in Basel
    Susumu Tonegawa
    The Picower Center for Learning and Memory, E17 353, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Cell 116:S99-101, 1 p following S106. 2004
  2. ncbi request reprint The ins and outs of hippocampal circuits
    Susumu Tonegawa
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 57:175-7. 2008
    ....
  3. pmc Genetic neuroscience of mammalian learning and memory
    Susumu Tonegawa
    Picower Center for Learning and Memory, Howard Hughes Medical Institute, and RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 358:787-95. 2003
    ....
  4. ncbi request reprint Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network
    Thomas J McHugh
    Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 317:94-9. 2007
    ..These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation...
  5. pmc Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memory
    Toshiaki Nakashiba
    The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 62:781-7. 2009
    ..Collectively, these results suggest that the posttraining integrity of the trisynaptic pathway and the ripple-associated reactivation of hippocampal memory engram are crucial for memory consolidation...
  6. ncbi request reprint Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experience
    Kazu Nakazawa
    Howard Hughes Medical Institute, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 38:305-15. 2003
    ..These results suggest that CA3 NRs play a crucial role in rapid hippocampal encoding of novel information for fast learning of one-time experience...
  7. ncbi request reprint Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic mice
    Mansuo L Hayashi
    The Picower Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Neuron 42:773-87. 2004
    ..Thus, our results provide evidence for critical relationships between synaptic morphology and bidirectional modifiability of synaptic strength in the cortex and consolidation of long-term memory...
  8. pmc CA3 NMDA receptors are required for the rapid formation of a salient contextual representation
    Thomas J McHugh
    The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Hippocampus 19:1153-8. 2009
    ..Our results suggest CA3 contributes both speed and salience to contextual processing and support the theory of competition between multimodal and unimodal conditioned stimuli for associative learning...
  9. pmc Cell type-specific genetic and optogenetic tools reveal hippocampal CA2 circuits
    Keigo Kohara
    1 RIKEN MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA 2
    Nat Neurosci 17:269-79. 2014
    ..Furthermore, contrary to existing knowledge, ECIII did not project to CA2. Our results allow a deeper understanding of the biology of learning and memory. ..
  10. ncbi request reprint Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning
    Toshiaki Nakashiba
    Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 319:1260-4. 2008
    ..In contrast, the full trisynaptic pathway containing CA3 is required for rapid one-trial contextual learning, for pattern completion-based memory recall, and for spatial tuning of CA1 cells...
  11. doi request reprint Creating a false memory in the hippocampus
    Steve Ramirez
    RIKEN Massachusetts Institute of Technology Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology, MIT, Cambridge, MA 02139, USA
    Science 341:387-91. 2013
    ..Our data demonstrate that it is possible to generate an internally represented and behaviorally expressed fear memory via artificial means. ..
  12. doi request reprint Island cells control temporal association memory
    Takashi Kitamura
    RIKEN MIT Center for Neural Circuit Genetics at The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology MIT, Cambridge, MA 02139, USA
    Science 343:896-901. 2014
    ..Together, the two EC inputs compose a control circuit for temporal association memory. ..
  13. doi request reprint Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memory
    Junghyup Suh
    The Picower Institute for Learning and Memory, RIKEN MIT Center for Neural Circuit Genetics, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 334:1415-20. 2011
    ..These results indicate a critical role of the entorhinal cortex layer III inputs to the hippocampus in temporal association memory...
  14. pmc Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice
    Mansuo L Hayashi
    The Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 104:11489-94. 2007
    ....
  15. ncbi request reprint NMDA receptor-dependent ocular dominance plasticity in adult visual cortex
    Nathaniel B Sawtell
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 38:977-85. 2003
    ..These insights may force a revision in how data on ocular dominance plasticity in mutant mice have been interpreted...
  16. pmc Distinct preplay of multiple novel spatial experiences in the rat
    George Dragoi
    RIKEN MIT Center for Neural Circuit Genetics, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 110:9100-5. 2013
    ..We estimate that for the given context, the recorded hippocampal network activity has the capacity to preplay an extended repertoire of at least 15 future spatial experiences of similar distinctiveness and complexity...
  17. ncbi request reprint Translational control by MAPK signaling in long-term synaptic plasticity and memory
    Raymond J Kelleher
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Departments of Biology and Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA
    Cell 116:467-79. 2004
    ..These results suggest a crucial role for translational control by MAPK signaling in long-lasting forms of synaptic plasticity and memory...
  18. pmc Impaired hippocampal ripple-associated replay in a mouse model of schizophrenia
    Junghyup Suh
    RIKEN MIT Center for Neural Circuit Genetics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA Electronic address
    Neuron 80:484-93. 2013
    ....
  19. pmc Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486
    Bridget M Dolan
    RIKEN MIT Center for Neural Circuit Genetics, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 110:5671-6. 2013
    ..Finally, a single administration of FRAX486 is sufficient to rescue all of these phenotypes in adult Fmr1 KO mice, demonstrating the potential for rapid, postdiagnostic therapy in adults with FXS...
  20. pmc Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completion
    Toshiaki Nakashiba
    Department of Biology, RIKEN MIT Center for Neural Circuit Genetics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 149:188-201. 2012
    ..Our data suggest that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion...
  21. pmc Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep
    Matthew P Anderson
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 102:1743-8. 2005
    ..1 was deleted from cortical pyramidal neurons. These findings support the hypothesis that thalamic T-type Ca2+ channels are required to block transmission of arousal signals through the thalamus and to stabilize sleep...
  22. ncbi request reprint Spatial exploration is required for the formation of contextual fear memory
    Thomas J McHugh
    Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
    Behav Neurosci 121:335-9. 2007
    ..Our results indicate that spatial exploration is necessary for mice to benefit from contextual preexposure...
  23. pmc Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effects
    Arvind Govindarajan
    The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 103:13208-13. 2006
    ....
  24. ncbi request reprint In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex
    Kuan Hong Wang
    Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 126:389-402. 2006
    ..These results suggest a physiological function of Arc in enhancing the overall orientation specificity of visual cortical neurons during the post-eye-opening life of an animal...
  25. pmc Preplay of future place cell sequences by hippocampal cellular assemblies
    George Dragoi
    The Picower Institute for Learning and Memory, RIKEN MIT Center for Neural Circuit Genetics, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 469:397-401. 2011
    ..These results suggest that internal neuronal dynamics during resting or sleep organize hippocampal cellular assemblies into temporal sequences that contribute to the encoding of a related novel experience occurring in the future...
  26. pmc The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTP
    Arvind Govindarajan
    Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 69:132-46. 2011
    ..Thus, dendritic branches rather than individual synapses are the primary functional units for long-term memory storage...
  27. ncbi request reprint NMDA receptors, place cells and hippocampal spatial memory
    Kazu Nakazawa
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Cambridge, Massachusetts 02139, USA
    Nat Rev Neurosci 5:361-72. 2004
  28. pmc Inception of a false memory by optogenetic manipulation of a hippocampal memory engram
    Xu Liu
    RIKEN MIT Center for Neural Circuit Genetics at The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 369:20130142. 2014
    ....
  29. ncbi request reprint Acceleration of visually cued conditioned fear through the auditory pathway
    Jessica R Newton
    The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Neurosci 7:968-73. 2004
    ..Thus, the rewired auditory pathway conveys visual information and mediates rapid activity-dependent plasticity in central structures that influence learned behavior...
  30. pmc Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapse
    Heather L Hinds
    Howard Hughes Medical Institute, Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:4275-80. 2003
    ....
  31. ncbi request reprint Successful execution of working memory linked to synchronized high-frequency gamma oscillations
    Jun Yamamoto
    RIKEN MIT Center for Neural Circuit Genetics at The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 157:845-57. 2014
    ..Furthermore, our data are consistent with an association between transient high gamma synchrony and explicit awareness of the working memory content...
  32. pmc Optogenetic stimulation of a hippocampal engram activates fear memory recall
    Xu Liu
    RIKEN MIT Center for Neural Circuit Genetics at The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 484:381-5. 2012
    ..Moreover, our experimental approach offers a general method of mapping cellular populations bearing memory engrams...
  33. ncbi request reprint Translational regulatory mechanisms in persistent forms of synaptic plasticity
    Raymond J Kelleher
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 44:59-73. 2004
    ..These findings have important implications for the synapse specificity and associativity of protein synthesis-dependent changes in synaptic strength...
  34. pmc Requirement for hippocampal CA3 NMDA receptors in associative memory recall
    Kazu Nakazawa
    Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Science 297:211-8. 2002
    ..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall...
  35. pmc Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampus
    Ariel Kamsler
    RIKEN MIT Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 107:1618-23. 2010
    ..mGluR LTD was rescued by stimulating PKC activity pharmacologically in CA3-m1KO mice. These data confirm a role for PKC activation in presynaptic induction of mGluR LTD and distinguish between the roles of mGluRs and m1 receptors...
  36. ncbi request reprint A clustered plasticity model of long-term memory engrams
    Arvind Govindarajan
    The Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nat Rev Neurosci 7:575-83. 2006
    ....
  37. ncbi request reprint Psychotomimetic effects of drugs--a common pathway to schizophrenia?
    David J Gerber
    Picower Center, Massachusetts Institute of Technology, Boston, USA
    N Engl J Med 350:1047-8. 2004
  38. pmc Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit
    David J Gerber
    Howard Hughes Medical Institute, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:8993-8. 2003
    ..Our results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis...
  39. ncbi request reprint Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways
    Catherine A Leamey
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cereb Cortex 18:53-66. 2008
    ..Overexpression demonstrated that Ten_m3 promotes homophilic adhesion and neurite outgrowth in vivo. This suggests an important role for Ten_m3 in the development of the visual pathway...
  40. pmc Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia
    Tsuyoshi Miyakawa
    Howard Hughes Medical Institute, The Picower Center for Learning and Memory and RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Proc Natl Acad Sci U S A 100:8987-92. 2003
    ..Collectively, the abnormalities of CN mutant mice are strikingly similar to those described for schizophrenia. We propose that alterations affecting CN signaling could comprise a contributing factor in schizophrenia pathogenesis...
  41. doi request reprint Enhancement of learning and memory by elevating brain magnesium
    Inna Slutsky
    Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Neuron 65:165-77. 2010
    ..Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions...
  42. pmc Differential roles of the dopamine 1-class receptors, D1R and D5R, in hippocampal dependent memory
    Joshua Sarinana
    RIKEN MIT Center for Neural Circuit Genetics at The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139 and
    Proc Natl Acad Sci U S A 111:8245-50. 2014
    ..These results suggest that DG D1Rs, but not D5Rs, contribute to the formation of distinct contextual representations of novel environments. ..
  43. ncbi request reprint Optogenetics 3.0
    Xu Liu
    The Picower Institute for Learning and Memory, The RIKEN MIT Center for Neural Circuit Genetics, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Cell 141:22-4. 2010
    ..2010) have developed a new generation of optogenetic tools capable of regulating the activity of targeted neurons with exquisite precision and efficiency...
  44. ncbi request reprint Cre/loxP recombination-activated neuronal markers in mouse neocortex and hippocampus
    Z Josh Huang
    Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Departments of Biology, and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Genesis 32:209-17. 2002
    ..With its combinatorial property, this binary recombination-activated neuronal marker system should facilitate the study of detailed morphology, connectivity, and plasticity of defined classes of live neurons in vitro and in vivo...
  45. pmc Selection of preconfigured cell assemblies for representation of novel spatial experiences
    George Dragoi
    The Picower Institute for Learning and Memory, RIKEN MIT Center for Neural Circuit Genetics, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Philos Trans R Soc Lond B Biol Sci 369:20120522. 2014
    ..Conceptually, this indicates that novel stimuli from the external world select from their pre-representations rather than create de novo our internal representations of the world. ..
  46. ncbi request reprint Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigation
    Laure Rondi-Reig
    College de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7152, Laboratoire de Physiologie de la Perception et de l Action, F 75005 Paris, France
    J Neurosci 26:4071-81. 2006
    ..Our findings suggest that memories composed of multiple spatiotemporal events require intact NMDA receptors-dependent mechanisms in CA1 and possibly in the deep cortical layers...
  47. pmc Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout mice
    Masahiro Fukaya
    Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
    Proc Natl Acad Sci U S A 100:4855-60. 2003
    ....
  48. ncbi request reprint Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned response
    Yasushi Kishimoto
    Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920 8640, Japan
    J Neurosci 26:1562-70. 2006
    ..These results indicate that CA3-NR1 KO mice are unable to rapidly retrieve adaptive CR timing, suggesting that CA3 NRs play a crucial role in the memory of adaptive CR timing in trace conditioning...
  49. ncbi request reprint Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response eye movements in mice
    Fumihiro Shutoh
    Department of Physiology, Jichi Medical School, Yakushiji 3311, Minamikawachi, Tochigi 329 0498, Japan
    Eur J Neurosci 18:134-42. 2003
    ..These results suggest that PKCgamma has a modulatory role in determining retinal slip dependency, and other PKC subtypes, e.g. PKCalpha, may play a crucial role in the adaptation of the HOKR...
  50. ncbi request reprint Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. 1976 [classical article]
    N Hozumi
    Basel Institute for Immunology, Switzerland
    J Immunol 173:4260-4. 2004
  51. ncbi request reprint Hippocampal neurons express a calcineurin-activated adenylyl cyclase
    Guy C K Chan
    Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
    J Neurosci 25:9913-8. 2005
    ..Analysis of cultured neurons from calcineurin(-/-) mice confirmed that hippocampal neurons exhibit a calcineurin-dependent cAMP increase, which may contribute to some forms of neuroplasticity...
  52. ncbi request reprint CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activity
    Kelly Kent
    Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Hippocampus 17:1003-11. 2007
    ..These findings establish a cellular mechanism for the plasticity imaged in the hippocampal long-axis, suggesting how experience-dependent modifications of hippocampal activity can contribute to its mnemonic function...

Research Grants18

  1. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2009
    ..The present proposal serves this purpose using cutting edge technologies. ..
  2. CORE 2: Maintaining Genetically Engineered Mice for Collaborations
    Susumu Tonegawa; Fiscal Year: 2007
    ..Core #2 will permit supplies of identically maintained mouse strains to the collaborating labs within the Center and sometimes beyond the Center. ..
  3. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2008
    ..The present proposal serves this purpose using cutting edge technologies. ..
  4. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2007
    ..The present proposal serves this purpose using cutting edge technologies. ..
  5. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2006
    ..The present proposal serves this purpose using cutting edge technologies. ..
  6. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2005
    ....
  7. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2004
    ....
  8. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2003
    ....
  9. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2002
    ....
  10. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2001
    ....
  11. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2000
    ..Information obtained is expected to be useful for the development of diagnostic and therapeutic methods for neurological diseases such as Alzheimer's disease and epilepsy. ..
  12. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 1999
    ..Information obtained is expected to be useful for the development of diagnostic and therapeutic methods for neurological diseases such as Alzheimer's disease and epilepsy. ..
  13. MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORY
    Susumu Tonegawa; Fiscal Year: 2010
    ..The present proposal serves this purpose using cutting edge technologies. ..