Research Topics
Genomes and Genes | Susumu TonegawaSummaryAffiliation: Massachusetts Institute of Technology Country: USA Publications
Research Grants
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Publications
Genetic neuroscience of mammalian learning and memorySusumu Tonegawa
Picower Center for Learning and Memory, Howard Hughes Medical Institute, and RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Philos Trans R Soc Lond B Biol Sci 358:787-95. 2003....
The ins and outs of hippocampal circuitsSusumu Tonegawa
The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 57:175-7. 2008....
That great time in BaselSusumu Tonegawa
The Picower Center for Learning and Memory, E17-353, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
Cell 116:S99-101, 1 p following S106. 2004- Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal networkThomas J McHugh
Picower Institute for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 317:94-9. 2007..These results provide evidence that NMDA receptors in the granule cells of the dentate gyrus play a crucial role in the process of pattern separation... - Hippocampal CA3 output is crucial for ripple-associated reactivation and consolidation of memoryToshiaki Nakashiba
The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 62:781-7. 2009..Collectively, these results suggest that the posttraining integrity of the trisynaptic pathway and the ripple-associated reactivation of hippocampal memory engram are crucial for memory consolidation... - Hippocampal CA3 NMDA receptors are crucial for memory acquisition of one-time experienceKazu Nakazawa
Howard Hughes Medical Institute, 77 Massachusetts Avenue, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 38:305-15. 2003..These results suggest that CA3 NRs play a crucial role in rapid hippocampal encoding of novel information for fast learning of one-time experience... - CA3 NMDA receptors are required for the rapid formation of a salient contextual representationThomas J McHugh
The RIKEN MIT Center for Neural Circuit Genetics, Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Hippocampus 19:1153-8. 2009..Our results suggest CA3 contributes both speed and salience to contextual processing and support the theory of competition between multimodal and unimodal conditioned stimuli for associative learning... - Altered cortical synaptic morphology and impaired memory consolidation in forebrain- specific dominant-negative PAK transgenic miceMansuo L Hayashi
The Picower Center for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Neuron 42:773-87. 2004..Thus, our results provide evidence for critical relationships between synaptic morphology and bidirectional modifiability of synaptic strength in the cortex and consolidation of long-term memory... - Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learningToshiaki Nakashiba
Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 319:1260-4. 2008..In contrast, the full trisynaptic pathway containing CA3 is required for rapid one-trial contextual learning, for pattern completion-based memory recall, and for spatial tuning of CA1 cells... - Entorhinal cortex layer III input to the hippocampus is crucial for temporal association memoryJunghyup Suh
The Picower Institute for Learning and Memory, RIKEN MIT Center for Neural Circuit Genetics, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 334:1415-20. 2011..These results indicate a critical role of the entorhinal cortex layer III inputs to the hippocampus in temporal association memory... - Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in miceMansuo L Hayashi
The Picower Institute for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 104:11489-94. 2007.... - NMDA receptor-dependent ocular dominance plasticity in adult visual cortexNathaniel B Sawtell
Howard Hughes Medical Institute, The Picower Center for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 38:977-85. 2003..These insights may force a revision in how data on ocular dominance plasticity in mutant mice have been interpreted... - Translational control by MAPK signaling in long-term synaptic plasticity and memoryRaymond J Kelleher
Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Center for Cancer Research, Departments of Biology and Brain and Cognitive Sciences, MIT, Cambridge, MA 02139, USA
Cell 116:467-79. 2004..These results suggest a crucial role for translational control by MAPK signaling in long-lasting forms of synaptic plasticity and memory... - Young dentate granule cells mediate pattern separation, whereas old granule cells facilitate pattern completionToshiaki Nakashiba
Department of Biology, RIKEN MIT Center for Neural Circuit Genetics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 149:188-201. 2012..Our data suggest that as adult-born GCs age, their function switches from pattern separation to rapid pattern completion... - In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortexKuan Hong Wang
Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cell 126:389-402. 2006..These results suggest a physiological function of Arc in enhancing the overall orientation specificity of visual cortical neurons during the post-eye-opening life of an animal... - Transgenic brain-derived neurotrophic factor expression causes both anxiogenic and antidepressant effectsArvind Govindarajan
The Picower Institute for Learning and Memory, Howard Hughes Medical Institute, RIKEN MIT Neuroscience Research Center, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 103:13208-13. 2006.... - Spatial exploration is required for the formation of contextual fear memoryThomas J McHugh
Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA 02139 4307, USA
Behav Neurosci 121:335-9. 2007..Our results indicate that spatial exploration is necessary for mice to benefit from contextual preexposure... - Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleepMatthew P Anderson
Howard Hughes Medical Institute, The Picower Center for Learning and Memory, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 102:1743-8. 2005..1 was deleted from cortical pyramidal neurons. These findings support the hypothesis that thalamic T-type Ca2+ channels are required to block transmission of arousal signals through the thalamus and to stabilize sleep... - NMDA receptors, place cells and hippocampal spatial memoryKazu Nakazawa
Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Center for Cancer Research, Cambridge, Massachusetts 02139, USA
Nat Rev Neurosci 5:361-72. 2004 - The dendritic branch is the preferred integrative unit for protein synthesis-dependent LTPArvind Govindarajan
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 69:132-46. 2011..Thus, dendritic branches rather than individual synapses are the primary functional units for long-term memory storage... - Preplay of future place cell sequences by hippocampal cellular assembliesGeorge Dragoi
The Picower Institute for Learning and Memory, RIKEN MIT Center for Neural Circuit Genetics, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 469:397-401. 2011..These results suggest that internal neuronal dynamics during resting or sleep organize hippocampal cellular assemblies into temporal sequences that contribute to the encoding of a related novel experience occurring in the future... - Optogenetic stimulation of a hippocampal engram activates fear memory recallXu Liu
RIKEN MIT Center for Neural Circuit Genetics at The Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nature 484:381-5. 2012..Moreover, our experimental approach offers a general method of mapping cellular populations bearing memory engrams... - Translational regulatory mechanisms in persistent forms of synaptic plasticityRaymond J Kelleher
Howard Hughes Medical Institute, The Picower Center for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Center for Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 44:59-73. 2004..These findings have important implications for the synapse specificity and associativity of protein synthesis-dependent changes in synaptic strength... - Essential function of alpha-calcium/calmodulin-dependent protein kinase II in neurotransmitter release at a glutamatergic central synapseHeather L Hinds
Howard Hughes Medical Institute, Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 100:4275-80. 2003.... - Acceleration of visually cued conditioned fear through the auditory pathwayJessica R Newton
The Picower Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Neurosci 7:968-73. 2004..Thus, the rewired auditory pathway conveys visual information and mediates rapid activity-dependent plasticity in central structures that influence learned behavior... - Rescue of fragile X syndrome phenotypes in Fmr1 KO mice by the small-molecule PAK inhibitor FRAX486Bridget M Dolan
Picower Institute for Learning and Memory, RIKEN MIT Center for Neural Circuit Genetics, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139
Proc Natl Acad Sci U S A 110:5671-6. 2013..Finally, a single administration of FRAX486 is sufficient to rescue all of these phenotypes in adult Fmr1 KO mice, demonstrating the potential for rapid, postdiagnostic therapy in adults with FXS... - Presynaptic m1 muscarinic receptors are necessary for mGluR long-term depression in the hippocampusAriel Kamsler
RIKEN MIT Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 107:1618-23. 2010..mGluR LTD was rescued by stimulating PKC activity pharmacologically in CA3-m1KO mice. These data confirm a role for PKC activation in presynaptic induction of mGluR LTD and distinguish between the roles of mGluRs and m1 receptors... - Requirement for hippocampal CA3 NMDA receptors in associative memory recallKazu Nakazawa
Picower Center for Learning and Memory, RIKEN MIT Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Science 297:211-8. 2002..These results provide direct evidence for CA3 NMDA receptor involvement in associative memory recall... - A clustered plasticity model of long-term memory engramsArvind Govindarajan
The Picower Institute for Learning and Memory, RIKEN-MIT Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
Nat Rev Neurosci 7:575-83. 2006.... - Psychotomimetic effects of drugs--a common pathway to schizophrenia?David J Gerber
Picower Center, Massachusetts Institute of Technology, Boston, USA
N Engl J Med 350:1047-8. 2004 - Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunitDavid J Gerber
Howard Hughes Medical Institute, RIKEN Massachusetts Institute of Technology Neuroscience Research Center, The Picower Center for Learning and Memory, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 100:8993-8. 2003..Our results identify PPP3CC, located at 8p21.3, as a potential schizophrenia susceptibility gene and support the proposal that alterations in calcineurin signaling contribute to schizophrenia pathogenesis... - Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophreniaTsuyoshi Miyakawa
Howard Hughes Medical Institute, The Picower Center for Learning and Memory and RIKEN Massachusetts Institute of Technology Neuroscience Research Center, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Proc Natl Acad Sci U S A 100:8987-92. 2003..Collectively, the abnormalities of CN mutant mice are strikingly similar to those described for schizophrenia. We propose that alterations affecting CN signaling could comprise a contributing factor in schizophrenia pathogenesis... - Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathwaysCatherine A Leamey
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Cereb Cortex 18:53-66. 2008..Overexpression demonstrated that Ten_m3 promotes homophilic adhesion and neurite outgrowth in vivo. This suggests an important role for Ten_m3 in the development of the visual pathway... - Enhancement of learning and memory by elevating brain magnesiumInna Slutsky
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
Neuron 65:165-77. 2010..Our findings suggest that an increase in brain magnesium enhances both short-term synaptic facilitation and long-term potentiation and improves learning and memory functions... - Cre/loxP recombination-activated neuronal markers in mouse neocortex and hippocampusZ Josh Huang
Howard Hughes Medical Institute, RIKEN-MIT Neuroscience Research Center, Departments of Biology, and Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Genesis 32:209-17. 2002..With its combinatorial property, this binary recombination-activated neuronal marker system should facilitate the study of detailed morphology, connectivity, and plasticity of defined classes of live neurons in vitro and in vivo... - Impaired sequential egocentric and allocentric memories in forebrain-specific-NMDA receptor knock-out mice during a new task dissociating strategies of navigationLaure Rondi-Reig
College de France, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7152, Laboratoire de Physiologie de la Perception et de l Action, F 75005 Paris, France
J Neurosci 26:4071-81. 2006..Our findings suggest that memories composed of multiple spatiotemporal events require intact NMDA receptors-dependent mechanisms in CA1 and possibly in the deep cortical layers... - Hippocampal neurons express a calcineurin-activated adenylyl cyclaseGuy C K Chan
Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA
J Neurosci 25:9913-8. 2005..Analysis of cultured neurons from calcineurin(-/-) mice confirmed that hippocampal neurons exhibit a calcineurin-dependent cAMP increase, which may contribute to some forms of neuroplasticity... - Role of protein kinase C family in the cerebellum-dependent adaptive learning of horizontal optokinetic response eye movements in miceFumihiro Shutoh
Department of Physiology, Jichi Medical School, Yakushiji 3311, Minamikawachi, Tochigi 329 0498, Japan
Eur J Neurosci 18:134-42. 2003..These results suggest that PKCgamma has a modulatory role in determining retinal slip dependency, and other PKC subtypes, e.g. PKCalpha, may play a crucial role in the adaptation of the HOKR... - Hippocampal CA3 NMDA receptors are crucial for adaptive timing of trace eyeblink conditioned responseYasushi Kishimoto
Department of Cellular Neurophysiology, Graduate School of Medical Science, Kanazawa University, Kanazawa 920-8640, Japan
J Neurosci 26:1562-70. 2006..These results indicate that CA3-NR1 KO mice are unable to rapidly retrieve adaptive CR timing, suggesting that CA3 NRs play a crucial role in the memory of adaptive CR timing in trace conditioning... - CA3 NMDA receptors are required for experience-dependent shifts in hippocampal activityKelly Kent
Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Department of Neurology, Columbia University College of Physicians and Surgeons, New York, New York, USA
Hippocampus 17:1003-11. 2007..These findings establish a cellular mechanism for the plasticity imaged in the hippocampal long-axis, suggesting how experience-dependent modifications of hippocampal activity can contribute to its mnemonic function... - Retention of NMDA receptor NR2 subunits in the lumen of endoplasmic reticulum in targeted NR1 knockout miceMasahiro Fukaya
Department of Anatomy, Hokkaido University School of Medicine, Sapporo 060 8638, Japan
Proc Natl Acad Sci U S A 100:4855-60. 2003.... - Evidence for somatic rearrangement of immunoglobulin genes coding for variable and constant regions. 1976 [classical article]N Hozumi
Basel Institute for Immunology, Switzerland
J Immunol 173:4260-4. 2004
Research Grants
- MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORYSusumu Tonegawa; Fiscal Year: 2009..The present proposal serves this purpose using cutting edge technologies. ..
- CORE 2: Maintaining Genetically Engineered Mice for CollaborationsSusumu Tonegawa; Fiscal Year: 2007..Core #2 will permit supplies of identically maintained mouse strains to the collaborating labs within the Center and sometimes beyond the Center. ..
- MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORYSusumu Tonegawa; Fiscal Year: 2007..The present proposal serves this purpose using cutting edge technologies. ..
- MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORYSusumu Tonegawa; Fiscal Year: 2005....
- MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORYSusumu Tonegawa; Fiscal Year: 2000..Information obtained is expected to be useful for the development of diagnostic and therapeutic methods for neurological diseases such as Alzheimer's disease and epilepsy. ..
- MOLECULAR GENETIC APPROACHES TO LEARNING AND MEMORYSusumu Tonegawa; Fiscal Year: 2010..The present proposal serves this purpose using cutting edge technologies. ..