Research Topics
Genomes and GenesSpecies | Jonathan L TillySummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
A central role for ceramide in the age-related acceleration of apoptosis in the female germlineGloria I Perez
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
FASEB J 19:860-2. 2005..Thus, the force driving the age-related increase in female germ cell death is multifactorial, but changes in the intercellular trafficking of ceramide, along with hypersensitivity of oocytes to ceramide, are key factors in this process...- Sphingolipid signaling in gonadal development and functionJ L Tilly
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Chem Phys Lipids 102:149-55. 1999..Collectively, these areas represent exciting research directions that may ultimately lead to the development of new therapeutics to coordinate and control fertility in males and females... - Recent arguments against germ cell renewal in the adult human ovary: is an absence of marker gene expression really acceptable evidence of an absence of oogenesis?Jonathan L Tilly
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Cell Cycle 6:879-83. 2007..Further, the interpretations offered by Liu et al. of their results are not as straightforward as they contend since some of their data can also be viewed as supportive of postnatal oogenesis in reproductive age women... 
The current status of evidence for and against postnatal oogenesis in mammals: a case of ovarian optimism versus pessimism?Jonathan L Tilly
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Biol Reprod 80:2-12. 2009..quot;Never discourage anyone who continually makes progress, no matter how slow."-Plato (427-347 BC)...- Personal reflections on Stan Korsmeyer and his continuing impact on our work to delineate the role of Bax in female reproductionJ L Tilly
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital/Harvard Medical School, Boston, 02114, USA
Cell Death Differ 13:1296-8. 2006 - Minireview: stem cell contribution to ovarian development, function, and diseaseJonathan L Tilly
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 149:4307-11. 2008..Our objective is to explore these concepts in greater detail, with the hope of stimulating further research efforts into understanding what role stem cells may play in the physiology and pathology of the mammalian female gonads... - Purification of germline stem cells from adult mammalian ovaries: a step closer towards control of the female biological clock?Jonathan L Tilly
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA, USA
Mol Hum Reprod 15:393-8. 2009..If equivalent cells can be found in human ovaries, stem cell-based rejuvenation of the oocyte reserve in ovaries on the verge of failure may one day be realized... - Emerging technologies to control oocyte apoptosis are finally treading on fertile groundJ L Tilly
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
ScientificWorldJournal 1:181-3. 2001.... - Oocyte apoptosis: prevention strategies, and implications for female aging and the menopauseJ L Tilly
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
Ann Endocrinol (Paris) 64:82-4. 2003 - Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertilityJonathan L Tilly
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, VBK137E GYN, Boston, MA 02114 2696, USA
Biochim Biophys Acta 1585:135-8. 2002.... - Ovarian follicle counts--not as simple as 1, 2, 3Jonathan L Tilly
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA
Reprod Biol Endocrinol 1:11. 2003 - Commuting the death sentence: how oocytes strive to surviveJ L Tilly
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Nat Rev Mol Cell Biol 2:838-48. 2001..With new therapeutic tools to control fertility, oocyte quality and ovarian lifespan on the horizon, understanding how and why the female body creates, only to delete, so many germ cells is imperative... - Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivoYasushi Takai
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 144:69-74. 2003.... - Serious doubts over "Eggs forever?"Malgorzata Skaznik-Wikiel
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Differentiation 75:93-9. 2007.... - Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survivalKaisa Selesniemi
Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Aging (Albany NY) 1:49-57. 2009.... - Germline stem cells and follicular renewal in the postnatal mammalian ovaryJoshua Johnson
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
Nature 428:145-50. 2004..Collectively, these data establish the existence of proliferative germ cells that sustain oocyte and follicle production in the postnatal mammalian ovary... - Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient miceSilvia F Carambula
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Reprod Biol Endocrinol 1:15. 2003.... 
Induction of proapoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbonsJames K Pru
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts, USA
Reprod Sci 16:347-56. 2009....- Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failureHo Joon Lee
Vincent Center for Reproductive Biology and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Clin Oncol 25:3198-204. 2007..This study was conducted to further clarify the impact of BMT on female reproductive function after CTx using a preclinical mouse model... - Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environmentYuichi Niikura
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Aging (Albany NY) 1:971-8. 2009..Thus, aged mouse ovaries possess a rare population of premeiotic germ cells that retain the capacity to form oocytes if exposed to a young host environment... - Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female miceHo Joon Lee
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Cell Cycle 6:2678-84. 2007..This work also reveals cell lineage specificity with respect to the role that specific CDK-interacting proteins play in restraining the activity of adult germline versus somatic stem cells... - Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age womenYvonne A R White
Vincent Center for Reproductive Biology, Massachusetts General Hospital Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA
Nat Med 18:413-21. 2012..Thus, ovaries of reproductive-age women, similar to adult mice, possess rare mitotically active germ cells that can be propagated in vitro as well as generate oocytes in vitro and in vivo... - Systemic signals in aged males exert potent rejuvenating effects on the ovarian follicle reserve in mammalian femalesYuichi Niikura
Vincent Center for Reproductive Biology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Aging (Albany NY) 2:999-1003. 2010..Thus, factors in male blood exert dramatic effects on ovarian follicle dynamics, and aging males possess a beneficial systemic factor that significantly expands the ovarian follicle reserve in females through enhanced oogenesis... - Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stressNing Wang
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
EMBO Rep 11:633-9. 2010..This in turn enhances the survival of these cells after ionizing radiation exposure. Thus, Cables1 modulates p63 protein stability and function during genotoxic stress... - Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral bloodJoshua Johnson
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Harvard Medical School, Boston, Massachusetts 02114, USA
Cell 122:303-15. 2005..These results identify BM as a potential source of germ cells that could sustain oocyte production in adulthood... - Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonadsNing Wang
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA
Cell Cycle 9:339-49. 2010..These events not only coordinate the sex-specific timing of meiotic entry during embryogenesis, but also contribute to the regulation of oogenesis in adult female mammals... - Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female miceGloria I Perez
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 104:5229-34. 2007..Thus, the development of methods for postponing ovarian failure at menopause may represent an attractive option for improving the quality of life in aging females... - Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological ageKaisa Selesniemi
Vincent Center for Reproductive Biology, Vincent OB GYN Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
Aging Cell 7:622-9. 2008..These data indicate that in mice adult-onset CR maintains function of the female reproductive axis into advanced age and dramatically improves postnatal survival of offspring delivered by aged females... - Setting the record straight on data supporting postnatal oogenesis in female mammalsJoshua Johnson
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA
Cell Cycle 4:1471-7. 2005..Here we have attempted to clarify published misperceptions and misinterpretations of our data, and offer additional insights that challenge the idea of fixed endowment of oocytes at birth... - Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategiesKaisa Selesniemi
Vincent Department of Obstetrics and Gynecology, Harvard Medical School, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 108:12319-24. 2011.... - Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acidsDeepika Nehra
Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Boston, MA, 02115, USA
Aging Cell 11:1046-54. 2012..Thus, omega-3 fatty acids may provide an effective and practical avenue for delaying ovarian aging and improving oocyte quality at advanced maternal age... - Current concepts in Bcl-2 family member regulation of female germ cell development and survivalMee-Ran Kim
Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA 02114-2696, USA
Biochim Biophys Acta 1644:205-10. 2004..This review will highlight what is known of apoptosis in the female gonads, and the role that Bcl-2 family members play in regulating this process... - Embryonic stem cell-derived granulosa cells participate in ovarian follicle formation in vitro and in vivoDori C Woods
1The Vincent Center for Reproductive Biology, MGH Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA
Reprod Sci 20:524-35. 2013.... - The next (re)generation of ovarian biology and fertility in women: is current science tomorrow's practice?Dori C Woods
Vincent Center for Reproductive Biology, Massachusetts General Hospital Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts 02114 2622, USA
Fertil Steril 98:3-10. 2012..Future research objectives for this area of work, as well as potential clinical applications involving the use of human OSCs, are discussed... - Evidence for genetic modifiers of ovarian follicular endowment and development from studies of five inbred mouse strainsJacqueline Canning
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 144:9-12. 2003..These results indicate that genetic modifiers play a major role in follicle endowment, development and atresia in the mouse ovary... - Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteumSilvia F Carambula
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 143:1495-501. 2002..However, caspase-3 is not a direct mediator of the decrease in steroidogenesis associated with luteolysis... - Purification of oogonial stem cells from adult mouse and human ovaries: an assessment of the literature and a view toward the futureDori C Woods
Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA
Reprod Sci 20:7-15. 2013..This article evaluates the current literature regarding postnatal oogenesis in mammals and discusses important next steps for future work on OSC biology and function... - Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cellsTiina M Matikainen
Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts 02114, USA
Endocrinology 143:615-20. 2002.... - Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovariesDori C Woods
Vincent Center for Reproductive Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
Nat Protoc 8:966-88. 2013..The latter methods include analysis of germ cell-specific markers and in vitro oogenesis, as well as the use of intraovarian transplantation to test the oocyte-forming potential of OSCs in vivo... - An evolutionary perspective on adult female germline stem cell function from flies to humansDori C Woods
Vincent Center for Reproductive Biology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Semin Reprod Med 31:24-32. 2013..Such insights derived from evaluation of nonmammalian species, in which postnatal oogenesis has been studied in depth, may aid in development of new strategies to alleviate ovarian failure and infertility in mammals... - The Endocrine Society 2002 Annual AwardsJan-Ake Gustafsson
Endocr Rev 23:582-93. 2002 - Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentationAndrea Jurisicova
Departments of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
Mol Hum Reprod 9:133-41. 2003..These findings suggest that cellular fragmentation in a subset of human preimplantation embryos could be regulated by certain components of a genetic programme of cell death... - Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspringFrancois Paris
Nat Med 8:901-2. 2002 - Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosisRobert Z Spaczynski
Department of Gynecology and Obstetrics, Division of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, 60 535 Poznan, Poland
Mol Hum Reprod 11:319-24. 2005..Moreover, excessive levels of insulin and free IGFs may lead to T-I cell hyperplasia characteristic of conditions such as polycystic ovary syndrome...
Research Grants
- APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALEJonathan Tilly; Fiscal Year: 2003..It is anticipated these data will provide the first unequivocal proof that exhaustion of the follicle reserve can be delayed, if not prevented, by manipulating apoptosis-regulatory genes. ..
- Mechanisms of Aryl-Hydrocarbon-Induced OvotoxicityJonathan Tilly; Fiscal Year: 2005....
- Mechanisms of Female Germline Stem Cell SenescenceJonathan Tilly; Fiscal Year: 2006..abstract_text> ..
- Pre-clinical Trials for Female Fertility PreservationJonathan Tilly; Fiscal Year: 2007..abstract_text> ..
- Origins and Functions of Mammalian Female Germline Stem CellsJonathan Tilly; Fiscal Year: 2007....
- MECHANISMS OF ARYL HYDROCARBON INDUCED OVOTOXICITYJonathan Tilly; Fiscal Year: 2000....