Jonathan L Tilly

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi A central role for ceramide in the age-related acceleration of apoptosis in the female germline
    Gloria I Perez
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 19:860-2. 2005
  2. pmc Systemic signals in aged males exert potent rejuvenating effects on the ovarian follicle reserve in mammalian females
    Yuichi Niikura
    Vincent Center for Reproductive Biology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Aging (Albany NY) 2:999-1003. 2010
  3. pmc Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age
    Kaisa Selesniemi
    Vincent Center for Reproductive Biology, Vincent OB GYN Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Aging Cell 7:622-9. 2008
  4. pmc Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment
    Yuichi Niikura
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Aging (Albany NY) 1:971-8. 2009
  5. pmc Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
    Yvonne A R White
    Vincent Center for Reproductive Biology, Massachusetts General Hospital Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 18:413-21. 2012
  6. pmc Germline energetics, aging, and female infertility
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 17:838-50. 2013
  7. pmc The current status of evidence for and against postnatal oogenesis in mammals: a case of ovarian optimism versus pessimism?
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Reprod 80:2-12. 2009
  8. ncbi Emerging technologies to control oocyte apoptosis are finally treading on fertile ground
    J L Tilly
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
    ScientificWorldJournal 1:181-3. 2001
  9. pmc Minireview: stem cell contribution to ovarian development, function, and disease
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 149:4307-11. 2008
  10. ncbi Recent arguments against germ cell renewal in the adult human ovary: is an absence of marker gene expression really acceptable evidence of an absence of oogenesis?
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell Cycle 6:879-83. 2007

Research Grants

Collaborators

Detail Information

Publications49

  1. ncbi A central role for ceramide in the age-related acceleration of apoptosis in the female germline
    Gloria I Perez
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    FASEB J 19:860-2. 2005
    ..Thus, the force driving the age-related increase in female germ cell death is multifactorial, but changes in the intercellular trafficking of ceramide, along with hypersensitivity of oocytes to ceramide, are key factors in this process...
  2. pmc Systemic signals in aged males exert potent rejuvenating effects on the ovarian follicle reserve in mammalian females
    Yuichi Niikura
    Vincent Center for Reproductive Biology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Aging (Albany NY) 2:999-1003. 2010
    ..Thus, factors in male blood exert dramatic effects on ovarian follicle dynamics, and aging males possess a beneficial systemic factor that significantly expands the ovarian follicle reserve in females through enhanced oogenesis...
  3. pmc Moderate caloric restriction initiated in rodents during adulthood sustains function of the female reproductive axis into advanced chronological age
    Kaisa Selesniemi
    Vincent Center for Reproductive Biology, Vincent OB GYN Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Aging Cell 7:622-9. 2008
    ..These data indicate that in mice adult-onset CR maintains function of the female reproductive axis into advanced age and dramatically improves postnatal survival of offspring delivered by aged females...
  4. pmc Aged mouse ovaries possess rare premeiotic germ cells that can generate oocytes following transplantation into a young host environment
    Yuichi Niikura
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Aging (Albany NY) 1:971-8. 2009
    ..Thus, aged mouse ovaries possess a rare population of premeiotic germ cells that retain the capacity to form oocytes if exposed to a young host environment...
  5. pmc Oocyte formation by mitotically active germ cells purified from ovaries of reproductive-age women
    Yvonne A R White
    Vincent Center for Reproductive Biology, Massachusetts General Hospital Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Nat Med 18:413-21. 2012
    ..Thus, ovaries of reproductive-age women, similar to adult mice, possess rare mitotically active germ cells that can be propagated in vitro as well as generate oocytes in vitro and in vivo...
  6. pmc Germline energetics, aging, and female infertility
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Cell Metab 17:838-50. 2013
    ....
  7. pmc The current status of evidence for and against postnatal oogenesis in mammals: a case of ovarian optimism versus pessimism?
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Biol Reprod 80:2-12. 2009
    ..Never discourage anyone who continually makes progress, no matter how slow."-Plato (427-347 BC)...
  8. ncbi Emerging technologies to control oocyte apoptosis are finally treading on fertile ground
    J L Tilly
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston 02114, USA
    ScientificWorldJournal 1:181-3. 2001
    ....
  9. pmc Minireview: stem cell contribution to ovarian development, function, and disease
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 149:4307-11. 2008
    ..Our objective is to explore these concepts in greater detail, with the hope of stimulating further research efforts into understanding what role stem cells may play in the physiology and pathology of the mammalian female gonads...
  10. ncbi Recent arguments against germ cell renewal in the adult human ovary: is an absence of marker gene expression really acceptable evidence of an absence of oogenesis?
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell Cycle 6:879-83. 2007
    ..Further, the interpretations offered by Liu et al. of their results are not as straightforward as they contend since some of their data can also be viewed as supportive of postnatal oogenesis in reproductive age women...
  11. pmc Purification of germline stem cells from adult mammalian ovaries: a step closer towards control of the female biological clock?
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, Boston, MA, USA
    Mol Hum Reprod 15:393-8. 2009
    ..If equivalent cells can be found in human ovaries, stem cell-based rejuvenation of the oocyte reserve in ovaries on the verge of failure may one day be realized...
  12. ncbi Sphingolipid signaling in gonadal development and function
    J L Tilly
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Chem Phys Lipids 102:149-55. 1999
    ..Collectively, these areas represent exciting research directions that may ultimately lead to the development of new therapeutics to coordinate and control fertility in males and females...
  13. pmc Ovarian follicle counts--not as simple as 1, 2, 3
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Reprod Biol Endocrinol 1:11. 2003
  14. ncbi Sphingolipids, apoptosis, cancer treatments and the ovary: investigating a crime against female fertility
    Jonathan L Tilly
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, VBK137E GYN, Boston, MA 02114 2696, USA
    Biochim Biophys Acta 1585:135-8. 2002
    ....
  15. ncbi Oocyte apoptosis: prevention strategies, and implications for female aging and the menopause
    J L Tilly
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Endocrinol (Paris) 64:82-4. 2003
  16. ncbi Commuting the death sentence: how oocytes strive to survive
    J L Tilly
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Nat Rev Mol Cell Biol 2:838-48. 2001
    ..With new therapeutic tools to control fertility, oocyte quality and ovarian lifespan on the horizon, understanding how and why the female body creates, only to delete, so many germ cells is imperative...
  17. ncbi Personal reflections on Stan Korsmeyer and his continuing impact on our work to delineate the role of Bax in female reproduction
    J L Tilly
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, 02114, USA
    Cell Death Differ 13:1296-8. 2006
  18. ncbi Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo
    Yasushi Takai
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 144:69-74. 2003
    ....
  19. pmc Young adult donor bone marrow infusions into female mice postpone age-related reproductive failure and improve offspring survival
    Kaisa Selesniemi
    Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Aging (Albany NY) 1:49-57. 2009
    ....
  20. ncbi Bone marrow transplantation generates immature oocytes and rescues long-term fertility in a preclinical mouse model of chemotherapy-induced premature ovarian failure
    Ho Joon Lee
    Vincent Center for Reproductive Biology and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Clin Oncol 25:3198-204. 2007
    ..This study was conducted to further clarify the impact of BMT on female reproductive function after CTx using a preclinical mouse model...
  21. ncbi Germline stem cells and follicular renewal in the postnatal mammalian ovary
    Joshua Johnson
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 428:145-50. 2004
    ..Collectively, these data establish the existence of proliferative germ cells that sustain oocyte and follicle production in the postnatal mammalian ovary...
  22. doi Induction of proapoptotic gene expression and recruitment of p53 herald ovarian follicle loss caused by polycyclic aromatic hydrocarbons
    James K Pru
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts, USA
    Reprod Sci 16:347-56. 2009
    ....
  23. ncbi Serious doubts over "Eggs forever?"
    Malgorzata Skaznik-Wikiel
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Differentiation 75:93-9. 2007
    ....
  24. pmc Prostaglandin F2alpha- and FAS-activating antibody-induced regression of the corpus luteum involves caspase-8 and is defective in caspase-3 deficient mice
    Silvia F Carambula
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Reprod Biol Endocrinol 1:15. 2003
    ....
  25. pmc Embryonic stem cell-derived granulosa cells participate in ovarian follicle formation in vitro and in vivo
    Dori C Woods
    Vincent Center for Reproductive Biology, MGH Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, USA
    Reprod Sci 20:524-35. 2013
    ....
  26. ncbi Loss of CABLES1, a cyclin-dependent kinase-interacting protein that inhibits cell cycle progression, results in germline expansion at the expense of oocyte quality in adult female mice
    Ho Joon Lee
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell Cycle 6:2678-84. 2007
    ..This work also reveals cell lineage specificity with respect to the role that specific CDK-interacting proteins play in restraining the activity of adult germline versus somatic stem cells...
  27. pmc Cables1 protects p63 from proteasomal degradation to ensure deletion of cells after genotoxic stress
    Ning Wang
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    EMBO Rep 11:633-9. 2010
    ..This in turn enhances the survival of these cells after ionizing radiation exposure. Thus, Cables1 modulates p63 protein stability and function during genotoxic stress...
  28. ncbi Oocyte generation in adult mammalian ovaries by putative germ cells in bone marrow and peripheral blood
    Joshua Johnson
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Harvard Medical School, Boston, Massachusetts 02114, USA
    Cell 122:303-15. 2005
    ..These results identify BM as a potential source of germ cells that could sustain oocyte production in adulthood...
  29. ncbi Comparative gene expression profiling of adult mouse ovary-derived oogonial stem cells supports a distinct cellular identity
    Anthony N Imudia
    Vincent Center for Reproductive Biology, Massachusetts General Hospital, and Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School, Boston, Massachusetts
    Fertil Steril 100:1451-8. 2013
    ..Perform gene expression profiling of adult mouse ovary-derived oogonial stem cells (OSCs)...
  30. ncbi Epigenetic status determines germ cell meiotic commitment in embryonic and postnatal mammalian gonads
    Ning Wang
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA, USA
    Cell Cycle 9:339-49. 2010
    ..These events not only coordinate the sex-specific timing of meiotic entry during embryogenesis, but also contribute to the regulation of oogenesis in adult female mammals...
  31. ncbi Setting the record straight on data supporting postnatal oogenesis in female mammals
    Joshua Johnson
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA
    Cell Cycle 4:1471-7. 2005
    ..Here we have attempted to clarify published misperceptions and misinterpretations of our data, and offer additional insights that challenge the idea of fixed endowment of oocytes at birth...
  32. ncbi Current concepts in Bcl-2 family member regulation of female germ cell development and survival
    Mee Ran Kim
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA 02114 2696, USA
    Biochim Biophys Acta 1644:205-10. 2004
    ..This review will highlight what is known of apoptosis in the female gonads, and the role that Bcl-2 family members play in regulating this process...
  33. doi Isolation, characterization and propagation of mitotically active germ cells from adult mouse and human ovaries
    Dori C Woods
    Vincent Center for Reproductive Biology, Department of Obstetrics, Gynecology and Reproductive Biology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Protoc 8:966-88. 2013
    ..The latter methods include analysis of germ cell-specific markers and in vitro oogenesis, as well as the use of intraovarian transplantation to test the oocyte-forming potential of OSCs in vivo...
  34. pmc Prevention of maternal aging-associated oocyte aneuploidy and meiotic spindle defects in mice by dietary and genetic strategies
    Kaisa Selesniemi
    Vincent Department of Obstetrics and Gynecology, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 108:12319-24. 2011
    ....
  35. pmc Absence of the proapoptotic Bax protein extends fertility and alleviates age-related health complications in female mice
    Gloria I Perez
    Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology Service, Massachusetts General Hospital Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 104:5229-34. 2007
    ..Thus, the development of methods for postponing ovarian failure at menopause may represent an attractive option for improving the quality of life in aging females...
  36. doi Granulocyte colony-stimulating factor in conjunction with vascular endothelial growth factor maintains primordial follicle numbers in transplanted mouse ovaries
    Malgorzata E Skaznik-Wikiel
    Obstetrics, Gynecology, and Women s Health Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Fertil Steril 95:1405-9. 2011
    ..To determine whether granulocyte colony-stimulating factor (G-CSF), stem cell factor (SCF), or vascular endothelial growth factor (VEGF) improve the outcome of ovarian grafting...
  37. ncbi Evidence for genetic modifiers of ovarian follicular endowment and development from studies of five inbred mouse strains
    Jacqueline Canning
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 144:9-12. 2003
    ..These results indicate that genetic modifiers play a major role in follicle endowment, development and atresia in the mouse ovary...
  38. pmc Purification of oogonial stem cells from adult mouse and human ovaries: an assessment of the literature and a view toward the future
    Dori C Woods
    Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA
    Reprod Sci 20:7-15. 2013
    ..This article evaluates the current literature regarding postnatal oogenesis in mammals and discusses important next steps for future work on OSC biology and function...
  39. doi Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling
    Eun Sil Park
    Vincent Center for Reproductive Biology, Massachusetts General Hospital, and Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts
    Fertil Steril 100:1468-75. 2013
    ..To test whether bone morphogenetic protein 4 (BMP4) directly regulates differentiation of adult mouse ovary-derived oogonial stem cells (OSCs) in vitro...
  40. doi An evolutionary perspective on adult female germline stem cell function from flies to humans
    Dori C Woods
    Vincent Center for Reproductive Biology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Semin Reprod Med 31:24-32. 2013
    ..Such insights derived from evaluation of nonmammalian species, in which postnatal oogenesis has been studied in depth, may aid in development of new strategies to alleviate ovarian failure and infertility in mammals...
  41. doi Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids
    Deepika Nehra
    Department of Surgery and the Vascular Biology Program, Children s Hospital Boston, Boston, MA, 02115, USA
    Aging Cell 11:1046-54. 2012
    ..Thus, omega-3 fatty acids may provide an effective and practical avenue for delaying ovarian aging and improving oocyte quality at advanced maternal age...
  42. ncbi Ligand activation of the aromatic hydrocarbon receptor transcription factor drives Bax-dependent apoptosis in developing fetal ovarian germ cells
    Tiina M Matikainen
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 143:615-20. 2002
    ....
  43. doi The next (re)generation of ovarian biology and fertility in women: is current science tomorrow's practice?
    Dori C Woods
    Vincent Center for Reproductive Biology, Massachusetts General Hospital Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts 02114 2622, USA
    Fertil Steril 98:3-10. 2012
    ..Future research objectives for this area of work, as well as potential clinical applications involving the use of human OSCs, are discussed...
  44. ncbi Caspase-3 is a pivotal mediator of apoptosis during regression of the ovarian corpus luteum
    Silvia F Carambula
    Vincent Center for Reproductive Biology, Department of Obstetrics and Gynecology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02114, USA
    Endocrinology 143:1495-501. 2002
    ..However, caspase-3 is not a direct mediator of the decrease in steroidogenesis associated with luteolysis...
  45. ncbi Insulin and insulin-like growth factors inhibit and luteinizing hormone augments ovarian theca-interstitial cell apoptosis
    Robert Z Spaczynski
    Department of Gynecology and Obstetrics, Division of Infertility and Reproductive Endocrinology, Poznan University of Medical Sciences, 60 535 Poznan, Poland
    Mol Hum Reprod 11:319-24. 2005
    ..Moreover, excessive levels of insulin and free IGFs may lead to T-I cell hyperplasia characteristic of conditions such as polycystic ovary syndrome...
  46. ncbi Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring
    Francois Paris
    Nat Med 8:901-2. 2002
  47. ncbi Expression of apoptosis-related genes during human preimplantation embryo development: potential roles for the Harakiri gene product and Caspase-3 in blastomere fragmentation
    Andrea Jurisicova
    Departments of Obstetrics and Gynecology, University of Toronto, Ontario, Canada
    Mol Hum Reprod 9:133-41. 2003
    ..These findings suggest that cellular fragmentation in a subset of human preimplantation embryos could be regulated by certain components of a genetic programme of cell death...

Research Grants31

  1. Origins and Functions of Mammalian Female Germline Stem Cells
    Jonathan Tilly; Fiscal Year: 2007
    ....
  2. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 1999
    ..It is anticipated these data will provide the first unequivocal proof that exhaustion of the follicle reserve can be delayed, if not prevented, by manipulating apoptosis-regulatory genes. ..
  3. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 2000
    ..It is anticipated these data will provide the first unequivocal proof that exhaustion of the follicle reserve can be delayed, if not prevented, by manipulating apoptosis-regulatory genes. ..
  4. Pre-clinical Trials for Female Fertility Preservation
    Jonathan Tilly; Fiscal Year: 2007
    ..abstract_text> ..
  5. Pre-clinical Trials for Female Fertility Preservation
    Jonathan Tilly; Fiscal Year: 2006
    ..abstract_text> ..
  6. MECHANISMS OF ARYL HYDROCARBON INDUCED OVOTOXICITY
    Jonathan Tilly; Fiscal Year: 1999
    ....
  7. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 2001
    ..It is anticipated these data will provide the first unequivocal proof that exhaustion of the follicle reserve can be delayed, if not prevented, by manipulating apoptosis-regulatory genes. ..
  8. Mechanisms of Female Germline Stem Cell Senescence
    Jonathan Tilly; Fiscal Year: 2005
    ..abstract_text> ..
  9. Pre-clinical Trials for Female Fertility Preservation
    Jonathan Tilly; Fiscal Year: 2004
    ..abstract_text> ..
  10. Mechanisms of Aryl-Hydrocarbon-Induced Ovotoxicity
    Jonathan Tilly; Fiscal Year: 2002
    ....
  11. MECHANISMS OF ARYL HYDROCARBON INDUCED OVOTOXICITY
    Jonathan Tilly; Fiscal Year: 2000
    ....
  12. Pre-clinical Trials for Female Fertility Preservation
    Jonathan Tilly; Fiscal Year: 2005
    ..abstract_text> ..
  13. Mechanisms of Female Germline Stem Cell Senescence
    Jonathan Tilly; Fiscal Year: 2006
    ..abstract_text> ..
  14. Mechanisms of Aryl-Hydrocarbon-Induced Ovotoxicity
    Jonathan Tilly; Fiscal Year: 2005
    ....
  15. Mechanisms of Aryl-Hydrocarbon-Induced Ovotoxicity
    Jonathan Tilly; Fiscal Year: 2003
    ....
  16. Mechanisms of Aryl-Hydrocarbon-Induced Ovotoxicity
    Jonathan Tilly; Fiscal Year: 2001
    ....
  17. Mechanisms of Aryl-Hydrocarbon-Induced Ovotoxicity
    Jonathan Tilly; Fiscal Year: 2004
    ....
  18. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 2002
    ..It is anticipated these data will provide the first unequivocal proof that exhaustion of the follicle reserve can be delayed, if not prevented, by manipulating apoptosis-regulatory genes. ..
  19. APOPTOSIS AND REPRODUCTIVE AGING OF THE FEMALE
    Jonathan Tilly; Fiscal Year: 2003
    ..It is anticipated these data will provide the first unequivocal proof that exhaustion of the follicle reserve can be delayed, if not prevented, by manipulating apoptosis-regulatory genes. ..
  20. MECHANISMS OF ARYL HYDROCARBON INDUCED OVOTOXICITY
    Jonathan Tilly; Fiscal Year: 2000
    ....