Elizabeth Thiele

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Stressor-related disorders in tuberous sclerosis
    Susana Boronat
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA, Department of Pediatric Neurology, Vall d Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain E mail
    Ann Clin Psychiatry 25:243-9. 2013
  2. doi request reprint Implications of dietary therapy into the 21st century: conclusion to special issue
    Elizabeth A Thiele
    MGH Center for Dietary Therapy of Epilepsy, Pediatric Epilepsy Program, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Child Neurol 28:1054-5. 2013
  3. ncbi request reprint Assessing the efficacy of antiepileptic treatments: the ketogenic diet
    Elizabeth A Thiele
    Pediatric Epilepsy Service, Departments of Neurology and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Epilepsia 44:26-9. 2003
  4. ncbi request reprint Managing epilepsy in tuberous sclerosis complex
    Elizabeth Anne Thiele
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    J Child Neurol 19:680-6. 2004
  5. ncbi request reprint Low glycemic index treatment: implementation and new insights into efficacy
    Heidi H Pfeifer
    Pediatric Epilepsy Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsia 49:42-5. 2008
  6. ncbi request reprint Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex
    Suzanne Goh
    Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA 02114 3117, USA
    Neurology 65:235-8. 2005
  7. ncbi request reprint Psychological profile of adults with tuberous sclerosis complex
    Margaret B Pulsifer
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsy Behav 10:402-6. 2007
  8. doi request reprint Tolerability and dosing experience of intravenous levetiracetam in children and infants
    Costas Michaelides
    Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States
    Epilepsy Res 81:143-7. 2008
  9. doi request reprint Vigabatrin in the treatment of childhood epilepsy: a retrospective chart review of efficacy and safety profile
    Susana E Camposano
    Pediatric Epilepsy Service, Neurology Department, Massachusettes General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 49:1186-91. 2008
  10. ncbi request reprint Concomitant treatment with topiramate and ketogenic diet in pediatric epilepsy
    Masanori Takeoka
    Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children s Hospital, Boston, Massachusetts, USA
    Epilepsia 43:1072-5. 2002

Collaborators

Detail Information

Publications48

  1. ncbi request reprint Stressor-related disorders in tuberous sclerosis
    Susana Boronat
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA, Department of Pediatric Neurology, Vall d Hebron Hospital, Universitat Autonoma de Barcelona, Barcelona, Spain E mail
    Ann Clin Psychiatry 25:243-9. 2013
    ..The aim of this study is to identify patients with stressor-related disorders such as posttraumatic stress disorder (PTSD) or adjustment disorder (AD) and to describe their clinical picture in the setting of TSC...
  2. doi request reprint Implications of dietary therapy into the 21st century: conclusion to special issue
    Elizabeth A Thiele
    MGH Center for Dietary Therapy of Epilepsy, Pediatric Epilepsy Program, Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    J Child Neurol 28:1054-5. 2013
    ..As the utilization of dietary therapy expands, there are several issues that need to be addressed and better characterized to better understand the role of diet in the treatment of epilepsy and other disease...
  3. ncbi request reprint Assessing the efficacy of antiepileptic treatments: the ketogenic diet
    Elizabeth A Thiele
    Pediatric Epilepsy Service, Departments of Neurology and Pediatrics, Massachusetts General Hospital, Boston, Massachusetts 02115, USA
    Epilepsia 44:26-9. 2003
    ..To evaluate the evidence for determining if the ketogenic diet is an effective treatment for epilepsy...
  4. ncbi request reprint Managing epilepsy in tuberous sclerosis complex
    Elizabeth Anne Thiele
    Department of Neurology, Harvard Medical School, Boston, MA, USA
    J Child Neurol 19:680-6. 2004
    ..Epilepsy surgery has a very important role in the management of children and adults with pharmacoresistant epilepsy in tuberous sclerosis complex...
  5. ncbi request reprint Low glycemic index treatment: implementation and new insights into efficacy
    Heidi H Pfeifer
    Pediatric Epilepsy Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsia 49:42-5. 2008
    ..The LGIT approach produces comparable efficacy to the classic KD, but tolerability is improved and implementation is much simpler. The LGIT appears to be a viable first-line dietary therapy for epilepsy...
  6. ncbi request reprint Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex
    Suzanne Goh
    Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA 02114 3117, USA
    Neurology 65:235-8. 2005
    ..To assess intellectual outcomes in a clinic-based population of patients with tuberous sclerosis complex (TSC) who also have a history of infantile spasms (IS) and to identify clinical risk factors for mental retardation in these patients...
  7. ncbi request reprint Psychological profile of adults with tuberous sclerosis complex
    Margaret B Pulsifer
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsy Behav 10:402-6. 2007
    ..Symptoms were related to number of organ systems affected by TSC and, in some cases, to seizure history, but not to genotype, IQ, education, severity of epilepsy, or use of anticonvulsant or psychiatric medication...
  8. doi request reprint Tolerability and dosing experience of intravenous levetiracetam in children and infants
    Costas Michaelides
    Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, United States
    Epilepsy Res 81:143-7. 2008
    ..To evaluate the use and tolerability of intravenous (IV) levetiracetam (LEV) in a pediatric cohort under 14 years of age...
  9. doi request reprint Vigabatrin in the treatment of childhood epilepsy: a retrospective chart review of efficacy and safety profile
    Susana E Camposano
    Pediatric Epilepsy Service, Neurology Department, Massachusettes General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 49:1186-91. 2008
    ..To review the efficacy, cognitive outcome and safety profile in children treated with vigabatrin (VGB) for infantile spasms (IS) and partial epilepsies related to tuberous sclerosis complex (TSC) and other etiologies...
  10. ncbi request reprint Concomitant treatment with topiramate and ketogenic diet in pediatric epilepsy
    Masanori Takeoka
    Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children s Hospital, Boston, Massachusetts, USA
    Epilepsia 43:1072-5. 2002
    ..We report our experience in 14 children cotreated with TPM and the KGD...
  11. pmc Urolithiasis on the ketogenic diet with concurrent topiramate or zonisamide therapy
    Elahna Paul
    Pediatric Nephrology Unit, Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsy Res 90:151-6. 2010
    ..Non-fasting KD initiation, fluid liberalization, potassium citrate prophylaxis as well as regular laboratory surveillance are indicated in this high risk population...
  12. ncbi request reprint Intrafamilial phenotypic variability in tuberous sclerosis complex
    David A Lyczkowski
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    J Child Neurol 22:1348-55. 2007
    ..Familial variation in tuberous sclerosis complex phenotype has important implications for genetic counseling...
  13. ncbi request reprint Seizures in children: laboratory diagnosis and management
    Philippe Major
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Pediatr Rev 28:405-14. 2007
  14. ncbi request reprint Tuberous sclerosis complex and the ketogenic diet
    Eric H Kossoff
    Departments of Neurology and Pediatrics, The John M Freeman Pediatric Epilepsy Center, Johns Hopkins University, Baltimore, MD 212871000, USA
    Epilepsia 46:1684-6. 2005
    ..If medications fail and no clear epileptogenic tuber is identified, nonpharmacologic therapies are often attempted. The use of the ketogenic diet specifically for children with TSC and epilepsy has not been previously described...
  15. doi request reprint Epilepsy and the sleep-wake patterns found in Angelman syndrome
    Kerry D Conant
    Department of Neurology, Pediatric Epilepsy Program, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 50:2497-500. 2009
    ..Results were consistent with those of prior studies assessing sleep in AS. Severity of epilepsy and use of anticonvulsant drugs may be related to a higher degree of sleep disturbance in this population...
  16. doi request reprint Infantile spasms in tuberous sclerosis complex: prognostic utility of EEG
    David A Muzykewicz
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 50:290-6. 2009
    ....
  17. ncbi request reprint General anesthesia and the ketogenic diet: clinical experience in nine patients
    Ignacio Valencia
    Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Epilepsia 43:525-9. 2002
    ..To determine if children actively on the ketogenic diet (KD) can safely undergo general anesthesia (GA) for surgical procedures...
  18. ncbi request reprint Safety and tolerability of the ketogenic diet in pediatric epilepsy: effects of valproate combination therapy
    David A Lyczkowski
    Pediatric Epilepsy Program, Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 46:1533-8. 2005
    ..To evaluate safety and tolerability of ketogenic diet (KGD) and valproate (VPA) cotherapy in the treatment of intractable seizures...
  19. pmc Ultra deep sequencing detects a low rate of mosaic mutations in tuberous sclerosis complex
    Wei Qin
    Translational Medicine Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Hum Genet 127:573-82. 2010
    ..These findings indicate the ability of deep sequencing, coupled with secondary confirmatory analyses, to detect low-frequency mosaic mutations...
  20. doi request reprint Behavior problems in children with tuberous sclerosis complex and parental stress
    Claudine M C Kopp
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsy Behav 13:505-10. 2008
    ..Clinicians should be aware that behavioral problems are prominent in children with TSC. Referrals for behavioral intervention and monitoring of parental stress should be included in the medical management of children with TSC...
  21. doi request reprint Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options
    Ronald L Thibert
    Department of Neurology, Pediatric Epilepsy Program, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Epilepsia 50:2369-76. 2009
    ..Angelman syndrome (AS) commonly presents with epilepsy (>80%). The goal of this study was to examine the natural history and various treatments of epilepsy in AS in a large population...
  22. doi request reprint Pyridoxine supplementation for the treatment of levetiracetam-induced behavior side effects in children: preliminary results
    Philippe Major
    Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsy Behav 13:557-9. 2008
    ..Pyridoxine is an easily available, inexpensive, and safe therapeutic option. Given these preliminary results, we plan to conduct a placebo-controlled cross-over study to better characterize these observations...
  23. ncbi request reprint Subependymal giant cell tumors in tuberous sclerosis complex
    Suzanne Goh
    Massachusetts General Hospital, Department of Neurology, Boston, MA 02114 3117, USA
    Neurology 63:1457-61. 2004
    ....
  24. doi request reprint Associations between electroencephalographic and magnetic resonance imaging findings in tuberous sclerosis complex
    Anne Gallagher
    Carol and James Herscot Center for Tuberous Sclerosis Complex, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Epilepsy Res 87:197-202. 2009
    ..Furthermore, quadrants without any apparent tuber co-registered with interictal epileptiform discharges in two patients, suggesting a multifactorial component of epileptogenicity in TSC...
  25. ncbi request reprint Psychiatric comorbid conditions in a clinic population of 241 patients with tuberous sclerosis complex
    David A Muzykewicz
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Epilepsy Behav 11:506-13. 2007
    ..Citalopram demonstrated efficacy in treating anxiety and depression, and risperidone, in treating problematic behaviors...
  26. ncbi request reprint The use of diet in the treatment of epilepsy
    Elizabeth E Bailey
    Harvard College, Cambridge, MA, USA
    Epilepsy Behav 6:4-8. 2005
    ..Despite challenges to implementation of the treatment, the ketogenic diet has significant potential as a powerful tool for fighting epilepsy...
  27. ncbi request reprint Low-glycemic-index treatment: a liberalized ketogenic diet for treatment of intractable epilepsy
    Heidi H Pfeifer
    Pediatric Epilepsy Program, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:1810-2. 2005
    ..Ten of 20 patients treated with this regimen experienced a greater than 90% reduction in seizure frequency...
  28. doi request reprint Cyst-like tubers are associated with TSC2 and epilepsy in tuberous sclerosis complex
    Catherine J Chu-Shore
    Carol and James Herscot Center for Tuberous Sclerosis Complex, 175 Cambridge Street, Suite 340, Boston, MA 02114, USA
    Neurology 72:1165-9. 2009
    ....
  29. doi request reprint Progressive multifocal cystlike cortical tubers in tuberous sclerosis complex: Clinical and neuropathologic findings
    Catherine J Chu-Shore
    Departments of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Epilepsia 50:2648-51. 2009
    ..These cases support the notion that cystlike tubers in TSC are not static lesions and can exhibit evolving characteristics over time. Further work evaluating how these lesions relate to epileptogenesis needs to be done...
  30. ncbi request reprint Treatments and perceptions of epilepsy in Kashmir and the United States: a cross-cultural analysis
    Alisa Khan
    Department of Neurology, Pediatric Epilepsy Program, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsy Behav 5:580-6. 2004
    ..Although the two patient populations interviewed differed in their access to resources and approaches to the disorder, both samples were found to be similar overall in many attitudes and practices relating to epilepsy and its treatment...
  31. doi request reprint Efficacy, safety, and tolerability of the low glycemic index treatment in pediatric epilepsy
    David A Muzykewicz
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Epilepsia 50:1118-26. 2009
    ..To report the efficacy, safety, and tolerability of the low glycemic index treatment (LGIT) in pediatric epilepsy...
  32. doi request reprint Are cortical tubers epileptogenic? Evidence from electrocorticography
    Philippe Major
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Epilepsia 50:147-54. 2009
    ..The patients experienced a drastic reduction in seizure frequency postsurgery. Epileptogenicity of cortical tubers may derive not from the lesion itself, but rather from the perturbation or abnormal development of the surrounding cortex...
  33. ncbi request reprint Prognostic significance of tuber count and location in tuberous sclerosis complex
    Colin Doherty
    Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, VBK 830, Boston, 02114 3117, USA
    J Child Neurol 20:837-41. 2005
    ..01). In summary, increased tuber count is strongly associated with infantile spasms and a TSC2 gene mutation. Seizure control and developmental delay do not show the strong association with tuber count suggested by the earlier literature...
  34. doi request reprint Vagus nerve stimulation for intractable epilepsy in tuberous sclerosis complex
    Philippe Major
    Department of Neurology and Pediatrics, Massachusetts General Hospital, Boston, MA 02114, USA
    Epilepsy Behav 13:357-60. 2008
    ..The aim of the study described here was to characterize the efficacy and safety of vagus nerve stimulation in a population of patients with tuberous sclerosis complex (TSC) and intractable epilepsy...
  35. ncbi request reprint Cognitive prognosis of patients with tuberous sclerosis complex
    Elisabeth B Winterkorn
    Departments of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurology 68:62-4. 2007
    ..Cognitive outcome was strongly associated with refractory seizures and TSC2 mutation. In TSC, IQ/DQ is bimodally distributed, and more than half of individuals are in the normal range...
  36. ncbi request reprint Seizures in children: determining the variation
    Philippe Major
    Department of Neurology, Massachusetts General Hospital, Boston, Mass, USA
    Pediatr Rev 28:363-71. 2007
  37. pmc The natural history of epilepsy in tuberous sclerosis complex
    Catherine J Chu-Shore
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Epilepsia 51:1236-41. 2010
    ..Although epilepsy affects most patients with tuberous sclerosis complex (TSC), little is known about the natural history of epilepsy in this genetic disease...
  38. pmc Tuberous sclerosis complex: diagnostic challenges, presenting symptoms, and commonly missed signs
    Brigid A Staley
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA
    Pediatrics 127:e117-25. 2011
    ..To describe presenting symptoms and signs according to age group in a cohort of 243 patients with tuberous sclerosis complex (TSC) and identify earlier symptoms and signs that did not lead to immediate diagnosis...
  39. pmc Identification of risk factors for autism spectrum disorders in tuberous sclerosis complex
    A L Numis
    Department of Neurology, Massachusetts General Hospital, Boston, USA
    Neurology 76:981-7. 2011
    ....
  40. pmc Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients
    Sandra L Dabora
    Division of Hematology, Brigham and Women Hospital, Boston, MA 02115, USA
    Am J Hum Genet 71:750-8. 2002
    ..Although these results should be replicated in other populations with TSC, the present study suggests that modifier genes play a role in the variable expression of TSC and also suggests a potential therapy for KAMLs in patients with TSC...
  41. ncbi request reprint SNP identification, haplotype analysis, and parental origin of mutations in TSC2
    Penelope S Roberts
    Hematology Division, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Hum Genet 111:96-101. 2002
    ..The observations have implications for genetic counseling in TSC...
  42. pmc Magnetoencephalographic analysis in patients with vagus nerve stimulator
    Naoaki Tanaka
    Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Pediatr Neurol 41:383-7. 2009
    ..These findings supported the diagnosis of symptomatic generalized epilepsy in this patient. Magnetoencephalography may thus be a useful option for evaluating patients with intractable epilepsy who have a vagus nerve stimulator...
  43. ncbi request reprint Anorexia nervosa in a child with tuberous sclerosis complex
    Suzanne Goh
    Massachusetts General Hospital, Boston 02114 3117, USA
    J Child Neurol 20:457-60. 2005
    ..To understand psychiatric disturbances in tuberous sclerosis complex, we must consider each of the following factors: cerebral pathology, seizure history, cognitive impairment, psychosocial stressors, and medications...
  44. ncbi request reprint Atypical GLUT1 deficiency with prominent movement disorder responsive to ketogenic diet
    Jennifer R L Friedman
    Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, and Department of Neurology, Colleen Giblin Laboratories for Pediatric Neurology Research, Columbia University, New York, NY, USA
    Mov Disord 21:241-5. 2006
    ..This case broadens the phenotype of GLUT1 deficiency and illustrates the importance of cerebrospinal fluid (CSF) evaluation in detecting potentially treatable conditions in children with undiagnosed movement disorders...
  45. doi request reprint Self-injurious behavior and tuberous sclerosis complex: frequency and possible associations in a population of 257 patients
    Brigid A Staley
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Epilepsy Behav 13:650-3. 2008
    ..We also found that frequency of TSC2 mutation, history of infantile spasms, history of seizures, mental retardation, and autism are significantly associated with SIB...
  46. ncbi request reprint Tuberous sclerosis complex and renal angiomyolipoma: case report and review of the literature
    Elisabeth B Winterkorn
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Pediatr Nephrol 21:1189-93. 2006
    ..Our experience adds to the literature on young pediatric patients requiring embolization for treatment of large renal angiomyolipomas...
  47. ncbi request reprint A karate program for improving self-concept and quality of life in childhood epilepsy: results of a pilot study
    Kerry D Conant
    Department of Neurology, Massachusetts General Hospital for Children, Boston, MA, USA
    Epilepsy Behav 12:61-5. 2008
    ..By child report, intellectual self-esteem and social confidence also improved. Parental stress decreased, although not significantly, suggesting a potential benefit and indicating a role for future interventions targeting family anxiety...
  48. doi request reprint Tumor growth in patients with tuberous sclerosis complex on the ketogenic diet
    Catherine J Chu-Shore
    Harvard Medical School, Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA 02114, USA
    Brain Dev 32:318-22. 2010
    ....