Ravi Thadhani

Summary

Affiliation: Massachusetts General Hospital
Country: USA

Publications

  1. ncbi request reprint Activated injectable vitamin D and hemodialysis survival: a historical cohort study
    Ming Teng
    Fresenius Medical Care North America, Lexington, Massachusetts, USA
    J Am Soc Nephrol 16:1115-25. 2005
  2. pmc Trace elements in hemodialysis patients: a systematic review and meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Med 7:25. 2009
  3. ncbi request reprint Vitamin D in patients with kidney disease: cautiously optimistic
    Ravi Thadhani
    Center for D receptor Activation Research and Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Adv Chronic Kidney Dis 14:22-6. 2007
  4. ncbi request reprint Prospective study of moderate alcohol consumption and risk of hypertension in young women
    Ravi Thadhani
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Intern Med 162:569-74. 2002
  5. ncbi request reprint Cohort studies: marching forward
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 1:1117-23. 2006
  6. pmc First-trimester follistatin-like-3 levels in pregnancies complicated by subsequent gestational diabetes mellitus
    Ravi Thadhani
    Division of Nephrology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 33:664-9. 2010
  7. ncbi request reprint Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsia
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Hypertension 43:988-92. 2004
  8. ncbi request reprint Predicting gestational diabetes: choosing the optimal early serum marker
    Karen V Smirnakis
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 196:410.e1-6; discussion 410.e6-7. 2007
  9. doi request reprint Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial
    Ravi Thadhani
    Division of Nephrology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    JAMA 307:674-84. 2012
  10. ncbi request reprint Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital and the Renal Division, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02114, USA
    Am J Obstet Gynecol 193:16-22. 2005

Detail Information

Publications94

  1. ncbi request reprint Activated injectable vitamin D and hemodialysis survival: a historical cohort study
    Ming Teng
    Fresenius Medical Care North America, Lexington, Massachusetts, USA
    J Am Soc Nephrol 16:1115-25. 2005
    ..Randomized clinical trials would permit definitive conclusions...
  2. pmc Trace elements in hemodialysis patients: a systematic review and meta-analysis
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    BMC Med 7:25. 2009
    ..We conducted a systematic review to summarize existing literature on trace element status in hemodialysis patients...
  3. ncbi request reprint Vitamin D in patients with kidney disease: cautiously optimistic
    Ravi Thadhani
    Center for D receptor Activation Research and Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Adv Chronic Kidney Dis 14:22-6. 2007
    ..If consistent with the recent observations, these studies may provide nephrologists with an intervention to alter the otherwise poor outcomes in patients with kidney disease...
  4. ncbi request reprint Prospective study of moderate alcohol consumption and risk of hypertension in young women
    Ravi Thadhani
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, 181 Longwood Ave, Boston, MA 02115, USA
    Arch Intern Med 162:569-74. 2002
    ..However, the effect of moderate alcohol consumption; the specific effects of wine, beer, and liquor; and the pattern of drinking in relation to risk of hypertension among young women are unclear...
  5. ncbi request reprint Cohort studies: marching forward
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 1:1117-23. 2006
  6. pmc First-trimester follistatin-like-3 levels in pregnancies complicated by subsequent gestational diabetes mellitus
    Ravi Thadhani
    Division of Nephrology, Massachusetts General Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 33:664-9. 2010
    ..30, P < 0.001). CONCLUSIONS First-trimester FSTL3 levels are associated with glucose intolerance and GDM later in pregnancy...
  7. ncbi request reprint Insulin resistance and alterations in angiogenesis: additive insults that may lead to preeclampsia
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA
    Hypertension 43:988-92. 2004
    ..1, 95% CI 1.7 to 134.9; high PlGF and low SHBG, OR 4.1, 95% CI 0.45 to 38.2; low PlGF and high SHBG, OR 8.7, 95% CI 1.2 to 60.3. Altered angiogenesis and insulin resistance are additive insults that lead to preeclampsia...
  8. ncbi request reprint Predicting gestational diabetes: choosing the optimal early serum marker
    Karen V Smirnakis
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Obstet Gynecol 196:410.e1-6; discussion 410.e6-7. 2007
    ..To select an optimal early (<20 weeks) marker, we prospectively compared 3 serum markers examined simultaneously in a single cohort...
  9. doi request reprint Vitamin D therapy and cardiac structure and function in patients with chronic kidney disease: the PRIMO randomized controlled trial
    Ravi Thadhani
    Division of Nephrology, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    JAMA 307:674-84. 2012
    ..Vitamin D is associated with decreased cardiovascular-related morbidity and mortality, possibly by modifying cardiac structure and function, yet firm evidence for either remains lacking...
  10. ncbi request reprint Circulating levels of the antiangiogenic marker sFLT-1 are increased in first versus second pregnancies
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital and the Renal Division, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston 02114, USA
    Am J Obstet Gynecol 193:16-22. 2005
    ..Additional studies are needed to verify these findings and to further examine ethnic differences in angiogenesis factors and their potential impact on the incidence of preeclampsia...
  11. pmc Clinical measures identify vitamin D deficiency in dialysis
    Ishir Bhan
    Department of Medicine, Massachusetts General Hospital, 50 Staniford Street, Suite 750, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 5:460-7. 2010
    ..This study was conducted to determine whether routinely measured clinical and demographic parameters could identify dialysis patients who are vitamin D deficient...
  12. doi request reprint Vitamin D-binding protein and vitamin D status of black Americans and white Americans
    Camille E Powe
    From the Department of Medicine, Brigham and Women s Hospital C E P, Division of Nephrology, Massachusetts General Hospital J W, H T, I B, R T, Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School A H B, Division of Nephrology, Beth Israel Deaconess Medical Center D Z, S A K, and Howard Hughes Medical Institute D Z, S A K all in Boston the Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, Baltimore M K E, A B Z the Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD M N and the Department of Medicine, San Francisco General Hospital and University of California, San Francisco, San Francisco N R P
    N Engl J Med 369:1991-2000. 2013
    ..Low levels of total 25-hydroxyvitamin D are common among black Americans. Vitamin D-binding protein has not been considered in the assessment of vitamin D deficiency...
  13. pmc First trimester vitamin D, vitamin D binding protein, and subsequent preeclampsia
    Camille E Powe
    Division of Nephrology, Massachusetts General Hospital and Harvard Medical School, Boston, Mass 02114, USA
    Hypertension 56:758-63. 2010
    ..These data suggest that first trimester total and free 25(OH)D levels are not independently associated with first trimester blood pressure or subsequent preeclampsia...
  14. pmc Inverse relationship between long-chain n-3 fatty acids and risk of sudden cardiac death in patients starting hemodialysis
    Allon N Friedman
    Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Kidney Int 83:1130-5. 2013
    ..Thus, long-chain n-3 fatty acids are strongly and independently associated with a lower risk of sudden cardiac death in hemodialysis patients throughout the first year of hemodialysis...
  15. pmc Impact of activated vitamin D and race on survival among hemodialysis patients
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 19:1379-88. 2008
    ..Further studies should determine whether treatment differences based on biologic differences contribute to disparities in other conditions...
  16. ncbi request reprint First-trimester sex hormone binding globulin and subsequent gestational diabetes mellitus
    Ravi Thadhani
    Departments of Medicine and Obstetrics and Gynecology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Obstet Gynecol 189:171-6. 2003
    ..We sought to examine the association between early pregnancy levels of sex hormone binding globulin and subsequent gestational diabetes mellitus, an association that has not been studied previously...
  17. pmc 1,25-Dihydroxyvitamin D promotes negative feedback regulation of TLR signaling via targeting microRNA-155-SOCS1 in macrophages
    Yunzi Chen
    Division of Biological Sciences, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Immunol 190:3687-95. 2013
    ..Together, these data identify a novel regulatory mechanism for vitamin D to control innate immunity...
  18. pmc Plasma gelsolin and circulating actin correlate with hemodialysis mortality
    Po Shun Lee
    Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:1140-8. 2009
    ..9 to 33.5). Worsening renal function correlated with pGSN decline in 53 subjects with CKD not on dialysis. In summary, low pGSN and detectable circulating actin identify chronic hemodialysis patients at highest risk for 1-yr mortality...
  19. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
    ..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown...
  20. ncbi request reprint Postpartum diabetes screening in women with a history of gestational diabetes
    Karen V Smirnakis
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Obstet Gynecol 106:1297-303. 2005
    ..We sought to examine postpartum glycemic testing in women diagnosed with GDM...
  21. pmc Phosphorus binders and survival on hemodialysis
    Tamara Isakova
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 20:388-96. 2009
    ..Although confirmatory studies are needed in the dialysis setting, future placebo-controlled, randomized trials of phosphorus binders might focus on predialysis patients with chronic kidney disease and normal serum phosphate levels...
  22. pmc Fatty acids and other risk factors for sudden cardiac death in patients starting hemodialysis
    Allon N Friedman
    Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Am J Nephrol 38:12-8. 2013
    ..We therefore undertook to identify such risk factors in a nationally representative cohort and were able to include baseline levels of blood fatty acids, some of which influence arrhythmogenicity and sudden cardiac death risk...
  23. doi request reprint Vitamin D reduces left atrial volume in patients with left ventricular hypertrophy and chronic kidney disease
    Hector Tamez
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, USA
    Am Heart J 164:902-9.e2. 2012
    ..We assessed the effect of an activated vitamin D analog on left atrial volume index (LAVi) in a post hoc analysis of the PRIMO trial (clinicaltrials.gov: NCT00497146)...
  24. doi request reprint Preeclampsia and the risk of large-for-gestational-age infants
    Camille E Powe
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    Am J Obstet Gynecol 204:425.e1-6. 2011
    ..We sought to compare the risk of giving birth to large-for-gestational-age (LGA) infants in women with and without preeclampsia, after adjustment for obesity and glucose intolerance...
  25. ncbi request reprint Early pregnancy insulin resistance and subsequent gestational diabetes mellitus
    Karen V Smirnakis
    GRB 1003, Renal Unit, Department of Medicine, Massachusetts General Hospital, 55 Fruit St, Boston, MA 02114, USA
    Diabetes Care 28:1207-8. 2005
  26. ncbi request reprint Inflammation and glucose intolerance: a prospective study of gestational diabetes mellitus
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 27:21-7. 2004
    ..Although gestational diabetes mellitus (GDM) and type 2 diabetes share certain pathophysiological mechanisms, few studies have examined inflammation and risk of GDM...
  27. ncbi request reprint Differential risk of hypertensive disorders of pregnancy among Hispanic women
    Myles Wolf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Am Soc Nephrol 15:1330-8. 2004
    ..The initial presentation of hypertension during pregnancy in Hispanic women most likely represents early preeclampsia...
  28. pmc Modeling the 4D Study: statins and cardiovascular outcomes in long-term hemodialysis patients with diabetes
    Kevin E Chan
    Fresenius Medical Care North America, Waltham, Massachusetts, USA
    Clin J Am Soc Nephrol 5:856-66. 2010
    ....
  29. doi request reprint N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations in hemodialysis patients: prognostic value of baseline and follow-up measurements
    ORLANDO M GUTIERREZ
    Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Clin Chem 54:1339-48. 2008
    ..Previous studies focused on prevalent dialysis patients and examined single measurements of NT-proBNP in time...
  30. doi request reprint The potential role of plasma gelsolin in dialysis-related protein-energy wasting
    Po Shun Lee
    Brigham and Women s Hospital, Boston, Mass, USA
    Blood Purif 29:99-101. 2010
    ..Therefore, pGSN deficiency appears to be a powerful biomarker and a potential therapeutic target in CKD patients...
  31. doi request reprint Early-pregnancy soluble Fas levels in idiopathic small-for-gestational-age pregnancies
    Guy Steinberg
    Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Obstet Gynecol 202:299.e1-7. 2010
    ..We sought to determine first- and second-trimester serum soluble Fas (sFas) and placental growth factor (PlGF) levels in idiopathic small-for-gestational-age (SGA) pregnancies...
  32. doi request reprint Risk for developing gestational diabetes in women with twin pregnancies
    Jose A Rauh-Hain
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Matern Fetal Neonatal Med 22:293-9. 2009
    ..To examine the risk of developing gestational diabetes mellitus (GDM) in women with twin compared with singleton pregnancies...
  33. pmc Soluble erythropoietin receptor contributes to erythropoietin resistance in end-stage renal disease
    Eliyahu V Khankin
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e9246. 2010
    ..Erythropoietin acts through the erythropoietin receptor (EpoR) present in erythroblasts. Alternative mRNA splicing produces a soluble form of EpoR (sEpoR) found in human blood, however its role in anemia is not known...
  34. ncbi request reprint Insulin resistance but not inflammation is associated with gestational hypertension
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass 02114, USA
    Hypertension 40:886-91. 2002
    ..Furthermore, important mechanistic differences exist in the pathogenesis of gestational hypertension comparing nulliparous and multiparous women...
  35. ncbi request reprint First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia
    Ravi Thadhani
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:770-5. 2004
    ..7-fold (95% confidence interval, 2.3-351.0) in the third (<12 pg/ml) compared with the first (>39 pg/ml) PlGF tertile. First trimester serum levels of PlGF and sFlt1 may identify women at high risk for PE...
  36. pmc Angiogenic factors and the risk of adverse outcomes in women with suspected preeclampsia
    Sarosh Rana
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Kirstein 382, Boston, MA 02215, USA
    Circulation 125:911-9. 2012
    ..An imbalance in circulating angiogenic factors plays a central role in the pathogenesis of preeclampsia...
  37. doi request reprint Vitamin D receptor activation and left ventricular hypertrophy in advanced kidney disease
    Ravi Thadhani
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, USA
    Am J Nephrol 33:139-49. 2011
    ..In chronic kidney disease (CKD), left ventricular hypertrophy (LVH) is prevalent and is associated with increased cardiovascular morbidity and mortality. Vitamin D receptor (VDR) activation attenuates LVH progression in animal models...
  38. pmc Anticoagulant and antiplatelet usage associates with mortality among hemodialysis patients
    Kevin E Chan
    Fresenius Medical Care NA, Waltham, Massachusetts, USA
    J Am Soc Nephrol 20:872-81. 2009
    ..Given the possibility of confounding by indication, randomized trials are needed to determine definitively the risk and benefit of these medications...
  39. ncbi request reprint First-trimester C-reactive protein and subsequent gestational diabetes
    Myles Wolf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Diabetes Care 26:819-24. 2003
    ..We tested the hypothesis that increased inflammation, measured early in pregnancy, is associated with the subsequent development of gestational diabetes mellitus (GDM), a precursor of type 2 diabetes...
  40. doi request reprint Impact of new vitamin D data on future studies and treatment
    Ishir Bhan
    Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Curr Opin Nephrol Hypertens 22:377-82. 2013
    ..This review evaluates recently published data on clinical effects of vitamin D supplementation, focusing on randomized, placebo-controlled trials and nontraditional actions on the cardiovascular and immune systems...
  41. ncbi request reprint Preeclampsia and future cardiovascular disease: potential role of altered angiogenesis and insulin resistance
    Myles Wolf
    Renal Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 89:6239-43. 2004
    ..Women with a history of preeclampsia demonstrate altered expression of angiogenesis-related proteins and increased HOMA(IR) more than 1 yr postpartum. These factors may contribute to their risk of future CVD...
  42. doi request reprint Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis
    Adrian F Gombart
    Department of Medicine, Division of Hematology Oncology, Cedars Sinai Medical Center, David Geffen School of Medicine at Univeristy of California, Los Angeles, USA
    Clin Infect Dis 48:418-24. 2009
    ....
  43. pmc Preventing progression of cardiac hypertrophy and development of heart failure by paricalcitol therapy in rats
    Soochan Bae
    Cardiovascular Division, Beth Israel Deaconess Medical Center, 3 Blackfan Circle, CLS 910, Boston, MA 02215, USA
    Cardiovasc Res 91:632-9. 2011
    ..Here, we examine whether vitamin D therapy prevents progression of pre-existing cardiac hypertrophy and development of heart failure...
  44. pmc Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship
    Camille E Powe
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Bone Miner Res 26:1609-16. 2011
    ..These findings have important implications for vitamin D supplementation in vitamin D-deficient states. Future studies should continue to explore the relationship between free and bioavailable 25(OH)D and health outcomes...
  45. pmc Metabolite profiling identifies markers of uremia
    Eugene P Rhee
    Massachusetts General Hospital, 149 13th Street, 8th Floor, Boston, MA, USA
    J Am Soc Nephrol 21:1041-1051. 2010
    ..In summary, this study demonstrates the application of metabolite profiling to identify markers of ESRD, provide perspective on uremic dyslipidemia, and broaden our understanding of the biochemical effects of hemodialysis...
  46. pmc Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity
    Oded Shaham
    Broad Institute of MIT and Harvard, Cambridge, MA, USA
    Mol Syst Biol 4:214. 2008
    ..Our findings lay the groundwork for using metabolic profiling to define an individual's 'insulin response profile', which could have value in predicting diabetes, its complications, and in guiding therapy...
  47. pmc Genetic variation in APOL1 associates with younger age at hemodialysis initiation
    Zahra Kanji
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    J Am Soc Nephrol 22:2091-7. 2011
    ..In conclusion, genetic variations in APOL1 identify African Americans that initiate chronic hemodialysis at a younger age. Early interventions to prevent progression of kidney disease may benefit this high-risk population...
  48. pmc Optimizing a proteomics platform for urine biomarker discovery
    Maryam Afkarian
    Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Mol Cell Proteomics 9:2195-204. 2010
    ..We also identified several previously reported candidate biomarkers that showed trends toward differential expression, albeit not reaching statistical significance in this small sample set...
  49. ncbi request reprint Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey
    David Martins
    Department of Medicine, Charles R Drew University of Medicine and Science, Los Angeles, Calif, 90262, USA
    Arch Intern Med 167:1159-65. 2007
    ..Results of several epidemiologic and clinical studies have suggested that there is an excess risk of hypertension and diabetes mellitus in persons with suboptimal intake of vitamin D...
  50. pmc Doxercalciferol, a pro-hormone of vitamin D, prevents the development of cardiac hypertrophy in rats
    Jun H Choi
    Cardiovascular Division, Beth Israel Deaconess Med Center, Boston, MA 02215, USA
    J Card Fail 17:1051-8. 2011
    ..To determine whether an antihypertrophic effect is class specific, we tested if doxercalciferol (a pro-hormone vitamin D2 analog) could also attenuate the development of cardiac hypertrophy in DSS rats...
  51. pmc Klotho variants and chronic hemodialysis mortality
    David J Friedman
    Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
    J Bone Miner Res 24:1847-55. 2009
    ..Our data suggest that a specific Klotho variant (rs577912) is linked to survival in ESRD patients initiating chronic hemodialysis and that therapy with activated vitamin D may modify this risk...
  52. ncbi request reprint Effects of short daily versus conventional hemodialysis on left ventricular hypertrophy and inflammatory markers: a prospective, controlled study
    Juan Carlos Ayus
    Division of Nephrology, Texas Diabetes Institute, University of Texas Health Science Center San Antonio, San Antonio, TX 78229 3900, USA
    J Am Soc Nephrol 16:2778-88. 2005
    ..Future trials are needed to determine whether short daily hemodialysis can reduce morbidity and mortality in this high-risk population...
  53. doi request reprint Dietary vitamin D intake in advanced CKD/ESRD
    Ishir Bhan
    Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
    Semin Dial 23:407-10. 2010
    ..This article reviews vitamin D metabolism, emerging new roles for vitamin D, and data surrounding the potential importance of nutritional sources of vitamin D in the management of patients with CKD...
  54. pmc Active vitamin D treatment for reduction of residual proteinuria: a systematic review
    Martin H de Borst
    Division of Nephrology, Department of Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 24:1863-71. 2013
    ..07]; P<0.001). Thus, active vitamin D analogs may further reduce proteinuria in CKD patients in addition to current regimens. Future studies should address whether vitamin D therapy also retards progressive renal functional decline. ..
  55. doi request reprint Hyponatremia, mineral metabolism, and mortality in incident maintenance hemodialysis patients: a cohort study
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, MA Scholars in Clinical Science Program, Harvard Medical School, Boston, MA Electronic address
    Am J Kidney Dis 62:755-62. 2013
    ..Recent animal studies also implicate hyponatremia in bone abnormalities. However, associations between hyponatremia, mineral bone abnormalities, and mortality in incident hemodialysis patients are unknown...
  56. pmc VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system
    Juan Kong
    Laboratory of Metabolic Disease Research and Drug Development and Shengjing Hospital, China Medical University, Shenyang, 110000, China Ravi Thadhani, M P H, Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114 E mail and Yan Chun Li, Department of Medicine, The University of Chicago, 900 East 57th Street, KCBD 9110, Chicago, Illinois 60637 E mail
    Mol Endocrinol 27:2116-25. 2013
    ..Taken together, these observations provide evidence that the vitamin D-VDR signaling prevents lung injury by blocking the Ang-2-Tie-2-MLC kinase cascade and the renin-angiotensin system. ..
  57. pmc Clinical characterization and outcomes of preeclampsia with normal angiogenic profile
    Sarosh Rana
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Hypertens Pregnancy 32:189-201. 2013
    ..To compare the clinical characteristics and outcomes of preeclamptic women presenting with a normal plasma angiogenic profile with those subjects who are characterized by an abnormal angiogenic profile...
  58. doi request reprint Ergocalciferol and cholecalciferol in CKD
    Sagar U Nigwekar
    Division of Nephrology, Massachusetts General Hospital, Boston, USA
    Am J Kidney Dis 60:139-56. 2012
    ..Based on the current state of the evidence, we provide suggestions for clinical practice and address areas of uncertainty that need further research...
  59. pmc Early outcomes among those initiating chronic dialysis in the United States
    Kevin E Chan
    Fresenius Medical Care North America, Waltham, Massachusetts, USA
    Clin J Am Soc Nephrol 6:2642-9. 2011
    ..S. Renal Data System was 19.6% in 2007. This estimate has historically excluded the first 90 days of chronic dialysis...
  60. ncbi request reprint Moderate alcohol consumption and lower levels of inflammatory markers in US men and women
    Jennifer K Pai
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Atherosclerosis 186:113-20. 2006
    ..Moderate alcohol consumption is associated with substantially lower risk of cardiovascular disease (CVD). We assessed the relationship between alcohol intake and inflammatory markers to partially explain this beneficial effect...
  61. ncbi request reprint Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia
    Sharon E Maynard
    Department of Medicine, University of Massachusetts Medical School, Worcester 01655, USA
    Pediatr Res 57:1R-7R. 2005
    ....
  62. doi request reprint Second trimester insulin resistance, early pregnancy body mass index and gestational weight gain
    Alison M Stuebe
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
    Matern Child Health J 14:254-60. 2010
    ..Because prior work suggests an association between high insulin concentrations in early pregnancy and excess gestational weight gain, we examined such associations in a prospective cohort...
  63. ncbi request reprint End-stage renal disease in patients with Fabry disease
    Gregorio T Obrador
    Division of Nephrology, New England Medical Center, Boston, Massachusetts, USA
    J Am Soc Nephrol 13:S144-6. 2002
  64. doi request reprint Vascular calcification and ESRD: a hard target
    Ishir Bhan
    Department of Medicine, Massachusetts General Hospital, Bullfinch 127, Boston, MA 02114, USA
    Clin J Am Soc Nephrol 4:S102-5. 2009
    ..Reviewed here is the current state of research on the biology and the significance of vascular calcification in ESRD, the role of vitamin D therapy in its development, and options for management...
  65. pmc Activated vitamin D attenuates left ventricular abnormalities induced by dietary sodium in Dahl salt-sensitive animals
    Natalya Bodyak
    Cardiovascular Division and Division of Nephrology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Proc Natl Acad Sci U S A 104:16810-5. 2007
    ..In summary, PC attenuates the development of LV alterations in DSS rats, and these effects should be examined in human clinical trials...
  66. ncbi request reprint Beyond minerals and parathyroid hormone: role of active vitamin D in end-stage renal disease
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Semin Dial 18:302-6. 2005
    ..Several of these nontraditional actions are reviewed with an emphasis on those that might impact hemodialysis outcomes...
  67. doi request reprint Diabetes and the kidney in pregnancy
    Camille E Powe
    Division of Nephrology, Massachusetts General Hospital, 55 Fruit St Bullfinch 127, Boston, MA 02114, USA
    Semin Nephrol 31:59-69. 2011
    ....
  68. doi request reprint Activated vitamin D sterols in kidney disease
    Ravi Thadhani
    Renal Unit and Center for D Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Lancet 371:542-4. 2008
  69. ncbi request reprint Prediction of diabetic nephropathy using urine proteomic profiling 10 years prior to development of nephropathy
    Hasan H Otu
    Genomics Center and DF HCC Cancer Proteomics Core, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 30:638-43. 2007
    ..We examined whether proteomic technologies identify novel urine proteins associated with subsequent development of diabetic nephropathy in subjects with type 2 diabetes before evidence of microalbuminuria...
  70. doi request reprint Vitamin D therapy for chronic kidney disease
    Ishir Bhan
    Department of Medicine, Renal Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Nephrol 29:85-93. 2009
    ..This article reviews the role of vitamin D therapy in CKD and looks to the answers that future research may bring...
  71. ncbi request reprint Patients with Fabry disease on dialysis in the United States
    Ravi Thadhani
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 61:249-55. 2002
    ..Little is known about the characteristics of patients with Fabry disease that initiate dialysis in the United States, although data from Europe suggests these individuals have a poor survival...
  72. doi request reprint Cord-blood 25-hydroxyvitamin D levels and risk of respiratory infection, wheezing, and asthma
    Carlos A Camargo
    Center for D receptor Activation Research, Massachusetts General Hospital, 326 Cambridge St, Suite 410, Boston, MA 02114, USA
    Pediatrics 127:e180-7. 2011
    ..The relationship between cord-blood levels of 25-hydroxyvitamin D (25[OH]D) and childhood wheezing is unknown. We hypothesized that cord-blood levels would be inversely associated with risk of respiratory infection, wheezing, and asthma...
  73. pmc Thiazolidinedione use is associated with better survival in hemodialysis patients with non-insulin dependent diabetes
    Steven M Brunelli
    Renal, Electrolyte and Hypertension Division, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Kidney Int 75:961-8. 2009
    ..The mechanism of this decline in all-cause mortality will need to be examined after these studies are confirmed...
  74. doi request reprint New insights into uremia-induced alterations in metabolic pathways
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    Curr Opin Nephrol Hypertens 20:593-8. 2011
    ..This article summarizes recent studies on uremia-induced alterations in metabolism, with particular emphasis on the application of emerging metabolomics technologies...
  75. pmc 1,25-Dihydroxyvitamin D₃ suppresses inflammation-induced expression of plasminogen activator inhibitor-1 by blocking nuclear factor-κB activation
    Yunzi Chen
    Department of Medicine, Division of Biological Sciences, The University of Chicago, Chicago, IL, USA
    Arch Biochem Biophys 507:241-7. 2011
    ..Together these data demonstrate that 1,25(OH)₂D₃ down-regulates PAI-1 by blocking NF-κB activation. Inhibition of PAI-1 production may contribute to the reno- and cardio-protective effects of vitamin D...
  76. pmc Vitamin D in patients with renal failure: a summary of observational mortality studies and steps moving forward
    Myles Wolf
    Renal Unit, Department of Medicine, Massachusetts General Hospital Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    J Steroid Biochem Mol Biol 103:487-90. 2007
    ..Potential steps moving forward in light of these observational studies are subsequently discussed...
  77. ncbi request reprint First trimester insulin resistance and subsequent preeclampsia: a prospective study
    Myles Wolf
    Renal Unit, Departments of Medicine and Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    J Clin Endocrinol Metab 87:1563-8. 2002
    ..First trimester SHBG levels may be a useful biomarker for preeclampsia, especially among lean women who otherwise would be perceived to be at low risk...
  78. ncbi request reprint Fabry disease in genetic counseling practice: recommendations of the National Society of Genetic Counselors
    Robin L Bennett
    Department of Medicine, Division of Medical Genetics, University of Washington Medical Center, Box 357720, Seatlle, Washington 98195 7720, USA
    J Genet Couns 11:121-46. 2002
    ..The professional judgment of a healthcare provider, familiar with the facts and circumstances of a specific case, will always supersede these recommendations...
  79. pmc Shorter dialysis times are associated with higher mortality among incident hemodialysis patients
    Steven M Brunelli
    Renal Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Kidney Int 77:630-6. 2010
    ..Further studies are needed to confirm these findings and determine causality...
  80. doi request reprint Targeted ablation of the vitamin D 1alpha-hydroxylase gene: getting to the heart of the matter
    Ravi Thadhani
    Renal Unit and the Center for D Receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
    Kidney Int 74:141-3. 2008
    ..In a study by Zhou et al., ablation of the 1alpha-hydroxylase gene led to hypertension, cardiac hypertrophy, and systolic dysfunction, and this cardiac phenotype was rescued with exogenous 1,25-dihydroxyvitamin D administration...
  81. ncbi request reprint Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury
    Won K Han
    Medical Services, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA
    Kidney Int 62:237-44. 2002
    ..The ectodomain of KIM-1 is shed from cells. The current studies were carried out to evaluate whether KIM-1 is present in human acute renal failure and might serve as a urinary marker of acute renal tubular injury...
  82. pmc Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma
    Won K Han
    Renal Division, Brigham and Women s Hospital, Medical Service, Massachusetts General Hospital, Boston, USA
    J Am Soc Nephrol 16:1126-34. 2005
    ..In conclusion, the cleaved ectodomain of hKIM-1 can be detected in the urine of patients with RCC and may serve as a new biomarker for early detection of RCC...
  83. ncbi request reprint Circulating angiogenic factors and the risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 350:672-83. 2004
    ..Limited data suggest that excess circulating soluble fms-like tyrosine kinase 1 (sFlt-1), which binds placental growth factor (PlGF) and vascular endothelial growth factor (VEGF), may have a pathogenic role...
  84. ncbi request reprint Urinary placental growth factor and risk of preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD, USA
    JAMA 293:77-85. 2005
    ..In the absence of glomerular disease leading to proteinuria, sFlt1 is too large a molecule to be filtered into the urine, while PlGF is readily filtered...
  85. ncbi request reprint Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy
    Ming Teng
    Fresenius Medical Care North America, Lexington, Mass, USA
    N Engl J Med 349:446-56. 2003
    ..Paricalcitol, a new vitamin D analogue, appears to lessen the elevations in serum calcium and phosphorus levels, as compared with calcitriol, the standard form of injectable vitamin D...
  86. ncbi request reprint Pregnancy hormone concentrations across ethnic groups: implications for later cancer risk
    Nancy Potischman
    Applied Research Program, Division of Cancer Control and Population Sciences, National Cancer Institute, 4005 EPN, 6130 Executive Boulevard, Bethesda, Maryland 20892 7344, USA
    Cancer Epidemiol Biomarkers Prev 14:1514-20. 2005
    ..These data are consistent with hypotheses that in utero hormonal exposures may explain some of the ethnic group differences in cancer risk...
  87. ncbi request reprint Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
    Richard J Levine
    Division of Epidemiology, Statistics, and Prevention Research, National Institute of Child Health and Human Development, Department of Health and Human Services, Bethesda, MD 20892, USA
    N Engl J Med 355:992-1005. 2006
    ..Since soluble endoglin, another antiangiogenic protein, acts together with sFlt1 to induce a severe preeclampsia-like syndrome in pregnant rats, we examined whether it is associated with preeclampsia in women...
  88. ncbi request reprint Agonistic angiotensin II type 1 receptor autoantibodies in postpartum women with a history of preeclampsia
    Carl A Hubel
    Magee Womens Research Institute and Department of Obstetrics and Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, PA, USA
    Hypertension 49:612-7. 2007
    ..The impact of AT1-AA after preeclampsia, especially in the context of cardiovascular risk, remains to be determined...
  89. ncbi request reprint Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia
    Sarosh Rana
    Maternal Fetal Medicine Division, Women and Infants Hospital, Brown University, Providence, RI, USA
    Hypertension 50:137-42. 2007
    ..In conclusion, sequential changes in antiangiogenic factors during early pregnancy may be useful for predicting preterm preeclampsia...
  90. pmc An integrated approach to prognosis using protein microarrays and nonparametric methods
    Tanya Knickerbocker
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Mol Syst Biol 3:123. 2007
    ..Just as treatments are now being tailored to specific subsets of patients, our results show that prognosis can also benefit from a 'personalized' approach...
  91. ncbi request reprint Preeclampsia--a glimpse into the future?
    Ravi Thadhani
    N Engl J Med 359:858-60. 2008
  92. ncbi request reprint Transesophageal echocardiography improves risk assessment of thrombolysis of prosthetic valve thrombosis: results of the international PRO-TEE registry
    Ann T Tong
    Baylor College of Medicine, Houston, Texas, USA
    J Am Coll Cardiol 43:77-84. 2004
    ..The goal of this study was to evaluate whether quantitation of thrombus burden with transesophageal echocardiography (TEE) can help risk-stratify patients undergoing thrombolysis of prosthetic valve thrombosis (PVT)...
  93. ncbi request reprint Vitamin D receptor and analogs
    Adriana S Dusso
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Semin Nephrol 24:10-6. 2004
    ..Although not all analog formulations are equally effective, they offer a wider therapeutic window in counteracting vitamin D resistance and survival advantage over exclusive calcitriol therapy...
  94. doi request reprint Levels of angiogenic factors in pregnancy and post-partum bleeding
    Anne Eskild
    Department of Obstetrics and Gynecology, Akershus University Hospital and the Faculty of Medicine, University of Oslo, Norway
    Acta Obstet Gynecol Scand 87:1081-3. 2008
    ..High concentrations of the anti-angiogenic factor sFlt-1 in maternal circulation during pregnancy may be associated with an increased risk of excess post-partum bleeding...