Research Topics
Genomes and GenesSpecies | Kathryn TerrySummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Detail Information
Publications
Telomere length and genetic variation in telomere maintenance genes in relation to ovarian cancer riskKathryn L Terry
Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 21:504-12. 2012..Shorter telomeres in peripheral blood leukocytes (PBL) have been associated with elevated cancer risk. Furthermore, genetic variants in and around the TERT gene have been implicated in carcinogenesis...
MTHFR polymorphisms in relation to ovarian cancer riskKathryn L Terry
Ob Gyn Epidemiology Center, Brigham and Women s Hospital, Boston, MA 02115, USA
Gynecol Oncol 119:319-24. 2010..Thus, we examined ovarian cancer risk in relation to two functional polymorphisms (C677T and A1298C) in the MTHFR gene...
Reproductive characteristics and risk of uterine leiomyomataKathryn L Terry
Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Fertil Steril 94:2703-7. 2010..To evaluate whether menstrual and reproductive characteristics may influence development of uterine leiomyomata since sex steroid hormones have been hypothesized to play a role in their development...
Genetic variation in CYP11A1 and StAR in relation to endometrial cancer riskKathryn Terry
Department of Epidemiology, Harvard School of Public Health, Boston, MA, United States
Gynecol Oncol 117:255-9. 2010..Given the role of estrogens in endometrial carcinogenesis, we hypothesized that genetic variation in StAR and CYP11A1 genes may influence endometrial cancer risk...
Common genetic variation in IGF1, IGFBP1 and IGFBP3 and ovarian cancer riskKathryn L Terry
Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA 02115, USA
Carcinogenesis 30:2042-6. 2009..Of particular interest was the IGFBP3 SNP rs2270628, which was associated with both increased IGF1 plasma levels and higher ovarian cancer risk...
MDM2 SNP309 is associated with endometrial cancer riskKathryn Terry
Department of Epidemiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 17:983-6. 2008..87; 95% confidence interval, 1.29-2.73) for endometrial cancer. We observed no association between age at diagnosis and genotype. Women carrying two copies of the MDM2 SNP309 variant may be at greater risk of endometrial cancer...
Coffee intake, variants in genes involved in caffeine metabolism, and the risk of epithelial ovarian cancerJoanne Kotsopoulos
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA
Cancer Causes Control 20:335-44. 2009..Furthermore, we did not observe any clear gene-environment interactions between caffeine metabolizing genes and ovarian cancer. Future studies evaluating mechanisms by which coffee mediates this relationship are warranted...
Genetic variation in the progesterone receptor gene and ovarian cancer riskKathryn L Terry
Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Epidemiol 161:442-51. 2005..76, 95% confidence interval: 0.62, 0.92). Associations were similar after stratifying by ovarian cancer histologies and risk factors...
Correlates of the preoperative level of CA125 at presentation of ovarian cancerDaniel W Cramer
Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, MA, USA
Gynecol Oncol 119:462-8. 2010..We examined the effect of epidemiologic variables and tumor features on CA125 at diagnosis and their effects on survival...
Talc use, variants of the GSTM1, GSTT1, and NAT2 genes, and risk of epithelial ovarian cancerMargaret A Gates
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 17:2436-44. 2008..These results suggest that women with certain genetic variants may have a higher risk of ovarian cancer associated with genital talc use. Additional research is needed on these interactions and the underlying biological mechanisms...
Androgen receptor cytosine, adenine, guanine repeats, and haplotypes in relation to ovarian cancer riskKathryn L Terry
Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Cancer Res 65:5974-81. 2005..Our results suggest that possession of two long AR alleles (> or = 22 CAG repeats) may be associated with increased risk of ovarian cancer compared with women with two short AR alleles (<22 CAG repeats)...
Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populationsMargaret A Gates
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Int J Cancer 124:729-33. 2009..16-1.18 per allele at the alpha=0.05 level in the pooled analysis. Our results do not provide strong support for an association between these breast cancer susceptibility alleles and epithelial ovarian cancer risk...
Interaction between CYP1A1 polymorphic variants and dietary exposures influencing ovarian cancer riskKathryn L Terry
Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:187-90. 2003..Significant interaction may exist between polymorphic variants of CYP1A1 and caffeine that could explain weak or inconsistent associations between caffeine and ovarian cancer when genotype has not been considered...
Lycopene and other carotenoid intake in relation to risk of uterine leiomyomataKathryn L Terry
Channing Laboratory, The Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Am J Obstet Gynecol 198:37.e1-8. 2008..Carotenoids have antioxidant properties and have been associated with reduced risks of some cancers. We hypothesized that carotenoid intake may reduce the risk of diagnosed uterine leiomyoma (UL)...
A prospective study of infertility due to ovulatory disorders, ovulation induction, and incidence of breast cancerKathryn L Terry
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
Arch Intern Med 166:2484-9. 2006..Anovulation has been hypothesized to decrease the risk of breast cancer. Therefore, infertility attributed to ovulatory disorders and ovulation-induction therapy may influence breast cancer risk...
Incessant ovulation, mucin 1 immunity, and risk for ovarian cancerKathryn L Terry
Obstetrics and Gynecology Epidemiology Center, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 16:30-5. 2007..In this study, we examined whether the total number of ovulatory cycles decreases the likelihood of anti-MUC1 antibodies and provides an immune basis for the association between "incessant ovulation" and ovarian cancer risk...
Blood and urine markers for ovarian cancer: a comprehensive reviewKathryn L Terry
Ob-Gyn Center Epidemiology Center, Department of Obstetrics, Gynecology, and Reproductive Biology, Brigham and Women's Hospital, Boston, MA, USA
Dis Markers 20:53-70. 2004
