Research Topics
Genomes and GenesSpecies | Usha B TedrowSummaryAffiliation: Massachusetts General Hospital Country: USA Publications
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Publications
Apical left ventricular aneurysm presenting with malignant ventricular tachycardia responsive to aneurysmectomyU Tedrow
Heart 91:623. 2005
The long- and short-term impact of elevated body mass index on the risk of new atrial fibrillation the WHS (women's health study)Usha B Tedrow
Center for Arrhythmia Prevention, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Am Coll Cardiol 55:2319-27. 2010..The purpose of this study was to characterize the relationship between changes in body mass index (BMI) and incident atrial fibrillation (AF) in a large cohort of women...
Strategies for epicardial mapping and ablation of ventricular tachycardiaUsha Tedrow
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Cardiovasc Electrophysiol 20:710-3. 2009..Potential risks include risk of injury to an epicardial coronary artery, the phrenic nerve, subdiaphragmatic vessels, and right ventricle. We describe the indications for and approach to catheter ablation of VT for the pericardial space...
Activation sequence modification during cardiac resynchronization by manipulation of left ventricular epicardial pacing stimulus strengthUsha B Tedrow
Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Pacing Clin Electrophysiol 30:65-9. 2007..That increases in stimulus strength (SS) can affect VA has been demonstrated previously in cardiomyopathy patients undergoing ablation...
Relation of right ventricular peak systolic pressure to major adverse events in patients undergoing cardiac resynchronization therapyUsha B Tedrow
Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Cardiol 97:1737-40. 2006..22, 95% confidence interval 1.54 to 11.6) remained significant. In conclusion, despite resynchronization, patients with high RV pressures have significantly decreased survival after adjusting for significant contributing influences...
Transcoronary ethanol ablation for recurrent ventricular tachycardia after failed catheter ablation: an updateMichifumi Tokuda
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circ Arrhythm Electrophysiol 4:889-96. 2011..After encouraging results with transcoronary ethanol ablation (TCEA), we began offering TCEA routinely when endocardial and epicardial RFCA failed or a deep intramural substrate was likely...
Catheter ablation of ventricular tachycardia in nonischemic heart diseaseMichifumi Tokuda
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA
Circ Arrhythm Electrophysiol 5:992-1000. 2012..Conclusions- In patients with recurrent VT due to nonischemic heart disease, catheter ablation is often useful, although the outcome varies according to the nature of the underlying heart disease...
Ventricular tachycardia arising from the aortomitral continuity in structural heart disease: characteristics and therapeutic considerations for an anatomically challenging area of originDaniel Steven
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circ Arrhythm Electrophysiol 2:660-6. 2009..There is a paucity of data on the contribution of this region to VTs in patients with structural heart disease...
Incidence and predictors of major complications from contemporary catheter ablation to treat cardiac arrhythmiasMarius Bohnen
Cardiac Arrhythmia Service, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Heart Rhythm 8:1661-6. 2011..Updated understanding of the risks of catheter ablation is important because techniques have evolved for procedures treating non-life-threatening as well as potentially lethal arrhythmias...
Right ventricular dysfunction and adverse outcome in patients with advanced heart failureMichael E Field
Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
J Card Fail 12:616-20. 2006..Wider use of this simple nongeometric parameter may help to identify patients for whom options for further intervention should be carefully evaluated...
Percutaneous access of the epicardial space for mapping ventricular and supraventricular arrhythmias in patients with and without prior cardiac surgeryKurt C Roberts-Thomson
Department of Cardiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Cardiovasc Electrophysiol 21:406-11. 2010..There is a paucity of data on the success rates of achieving percutaneous epicardial access in different groups of patients...
Ventricular arrhythmias and sudden cardiac deathRoy M John
Department of Medicine, Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Lancet 380:1520-9. 2012..Advances in understanding of genetic arrhythmia syndromes and in technology for mapping and ablation of ventricular arrhythmias, and enhanced algorithms in implantable devices for rhythm management, have contributed to improved outcomes...
Role of repeat procedures for catheter ablation of postinfarction ventricular tachycardiaIoanna Kosmidou
Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Heart Rhythm 8:1516-22. 2011..In patients with ischemic heart disease, ventricular tachycardia (VT) is associated with increased mortality and morbidity. Catheter ablation is useful for reducing VT therapies but remains challenging, and recurrences are common...
Outcomes of cardiac perforation complicating catheter ablation of ventricular arrhythmiasMichifumi Tokuda
Arrhythmia Unit, Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Circ Arrhythm Electrophysiol 4:660-6. 2011..The study aims to investigate the incidence, management, and hospital outcomes of cardiac perforation complicating catheter ablation for ventricular arrhythmias...
Influence of systolic and diastolic blood pressure on the risk of incident atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Circulation 119:2146-52. 2009..The influence of systolic and diastolic blood pressure (BP) on incident atrial fibrillation (AF) is not well studied among initially healthy, middle-aged women...
Substrate characterization and catheter ablation for monomorphic ventricular tachycardia in patients with apical hypertrophic cardiomyopathyKeiichi Inada
Cardiac Arrhythmia Division, Cardiovascular Division, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA02115, USA
J Cardiovasc Electrophysiol 22:41-8. 2011..VT Ablation in Apical Hypertrophic Cardiomyopathy. ..
QRS characteristics fail to reliably identify ventricular tachycardias that require epicardial ablation in ischemic heart diseaseMartin Martinek
Cardiac Arrhythmia Division, Brigham and Women s Hospital, Boston, Massachusetts, USA
J Cardiovasc Electrophysiol 23:188-93. 2012..We tested proposed algorithms for idiopathic and nonischemic tachycardias for their ability to identify epicardial LV-VT origins...
Relation of high-pass filtered unipolar electrograms to bipolar electrograms during ventricular mappingKeiichi Inada
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Pacing Clin Electrophysiol 35:157-63. 2012..Unipolar recordings are not subject to directional influence. We hypothesized that high-pass filtered unipolar EGs would provide similar information to bipolar EGs, without potential errors related to wavefront direction...
Long-term follow-up in patients with presumptive Brugada syndrome treated with implanted defibrillatorsDaniel Steven
Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Cardiovasc Electrophysiol 22:1115-9. 2011..Risk stratification for patients with suspected Brugada syndrome (BS) remains difficult. Implantation of cardioverter-defibrillators (ICDs) in high-risk patients provides continuous long-term arrhythmia protection...
Mortality and safety of catheter ablation for antiarrhythmic drug-refractory ventricular tachycardia in elderly patients with coronary artery diseaseKeiichi Inada
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
Heart Rhythm 7:740-4. 2010..Radiofrequency catheter ablation is useful for reducing VT therapy in patients with an implantable defibrillator. The utility of radiofrequency catheter ablation in the elderly is not well defined...
Ventricular tachycardia ablation: evolution of patients and procedures over 8 yearsFrederic Sacher
Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Circ Arrhythm Electrophysiol 1:153-61. 2008..We investigated the substrate, procedure, and outcome evolution of all patients referred for VT ablation during the past 8 years...
Resetting criteria during ventricular overdrive pacing successfully differentiate orthodromic reentrant tachycardia from atrioventricular nodal reentrant tachycardia despite interobserver disagreement concerning QRS fusionJonathan Z Rosman
Department of Cardiovascular Medicine at Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
Heart Rhythm 8:2-7. 2011..The end of the TZ is marked by the first beat with a stable QRS morphology but is a subjective assessment. Disagreement concerning this beat may change tachycardia diagnosis...
Coronary artery injury due to catheter ablation in adults: presentations and outcomesKurt C Roberts-Thomson
Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Circulation 120:1465-73. 2009..Currently, only anecdotal information exists on the presentation and outcome of coronary arterial injury after ablation procedures...
Alcohol consumption and risk of incident atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention, Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
JAMA 300:2489-96. 2008..However, these studies were not powered to investigate the association of alcohol consumption and atrial fibrillation among women...
Quality of life with atrial fibrillation: do the spouses suffer as much as the patients?Marius Bohnen
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Pacing Clin Electrophysiol 34:804-9. 2011..Other chronic diseases are known to not only affect the patient but to also impact the QoL of persons living with them. Scant data exist on the QoL effect of AF in spouses/significant others (SOs)...
Birth weight is a significant risk factor for incident atrial fibrillationDavid Conen
Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
Circulation 122:764-70. 2010..Few if any studies have assessed the relationship between birth weight and incident atrial fibrillation (AF)...
A multimarker approach to assess the influence of inflammation on the incidence of atrial fibrillation in womenDavid Conen
Center for Arrhythmia Prevention Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
Eur Heart J 31:1730-6. 2010..To assess the joint influence of inflammatory biomarkers on the risk of incident atrial fibrillation (AF) in women...
Sustained ventricular tachycardia associated with corrective valve surgeryRobert E Eckart
Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
Circulation 116:2005-11. 2007..The causes of sustained monomorphic ventricular tachycardia (VT) after cardiac valve surgeries have not been studied extensively, although bundle-branch reentry has been reported...
ICD lead proarrhythmia cured by lead extractionJoseph C Lee
Cardiac Arrhythmia Service, Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Heart Rhythm 6:613-8. 2009..However, clinical trials report higher rates of appropriate ICD therapies in implanted patients than untreated patient mortality rates would predict...
Management of ventricular tachycardia complicating cardiac surgeryWilliam G Stevenson
Arrhythmia Service, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Heart Rhythm 6:S66-9. 2009..The electrocardiographic characteristics of the arrhythmia and clinical characteristics of the patient are important considerations in the immediate and long-term management considerations...
Atrial tachycardias adjacent to the phrenic nerve: recognition, potential problems, and solutionsJoseph C Lee
Cardiac Arrhythmia Service, Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Heart Rhythm 6:1186-91. 2009..Ablation of atrial tachycardias (AT) arising from the crista terminalis region (CT) can be complicated by phrenic nerve (PN) injury...
Catheter Ablation of Atrial Arrhythmias After Cardiac Transplantation: Findings at EP Study Utility of 3-D Mapping and OutcomesEyal Nof
Department of Medicine, Cardiovascular Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Cardiovasc Electrophysiol 24:498-502. 2013..Management of atrial arrhythmias (AA) in orthotopic heart transplant (OHT) patients is challenging...
The origin of epicardial ventricular tachycardia revealed by entrainment from a permanent epicardial left ventricular pacing leadKeiichi Inada
Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Cardiovasc Electrophysiol 21:1293-5. 2010..Surgical cryoablation targeting the area around the LV lead eliminated VT. Thus pacing maneuvers from permanent epicardial leads can occasionally help identify an epicardial VT origin...
Diagnosis and ablation of multiform fascicular tachycardiaRaphael K Sung
Electrophysiology Section, Division of Cardiology, Department of Medicine, University of Colorado, Denver, Colorado 80045, USA
J Cardiovasc Electrophysiol 24:297-304. 2013..Fascicular tachycardia (FT) is an uncommon cause of monomorphic sustained ventricular tachycardia (VT). We describe 6 cases of FT with multiform QRS morphologies...
Meta-analysis identifies six new susceptibility loci for atrial fibrillationPatrick T Ellinor
Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA
Nat Genet 44:670-5. 2012..The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules...
Catheter ablation of ventricular tachycardia after repair of congenital heart disease: electroanatomic identification of the critical right ventricular isthmusKatja Zeppenfeld
Department of Cardiology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
Circulation 116:2241-52. 2007..Insights into the relation between anatomic isthmuses identified by delineating unexcitable tissue using substrate mapping techniques and critical reentry circuit isthmuses might facilitate ablation...
